Summary

A0A0J9YX94

Homolog: P0CW24.
Function: Paraneoplastic antigen-like protein 6A.

Statistics

Total GO Annotation: 110
Unique PROST Go: 14
Unique BLAST Go: 83

Total Homologs: 78
Unique PROST Homologs: 17
Unique BLAST Homologs: 43

Structures and Sequence Alignment

The best structural homolog that predicted by 1. PB was P0CW24 (Paraneoplastic antigen-like protein 6A) with a FATCAT P-Value: 3.12e-11 and RMSD of 2.46 angstrom. The sequence alignment identity is 36.3%.
Structural alignment shown in left. Query protein A0A0J9YX94 colored as red in alignment, homolog P0CW24 colored as blue. Query protein A0A0J9YX94 is also shown in right top, homolog P0CW24 showed in right bottom. They are colored based on secondary structures.

  A0A0J9YX94 ----MLQDWCRRMGVNAERSLLILDIPDDCEEHEFQEAVRAALSPLGRYRVLIKVFRKELGARAALVEFAEGLNQSLIPRQIAGKGGPWKVISLPQALDA 96
      P0CW24 MAVTMLQDWCRWMGVNARRGLLILGIPEDCDDAEFQESLEAALRPMGHFTVLGKAFREEDNATAALVELDREVNYALVPREIPGTGGPWNVVFVP----- 95

  A0A0J9YX94 EFQDIPSFPAQPQGQAVARGAGEAGAAGEAGSVGEAGGVNEERSAGEDEAGGIGEAGGVGEAGAAGEAGAAGEAGAAGEAGGAGEAGGAGEAGGAGEEGG 196
      P0CW24 ------------------------------------------RCSGE-------EFLGLGRVFHFPE--------------------------------- 113

  A0A0J9YX94 TGEEGGAGEAGGAGEEGGEDEAGAAGEAVGAGVVE-AWTQSWRQTLRPLVKTMAYRELRPFSGREQ--PGCVEESFESWLEDAKDMLQLWCHASERERRR 293
      P0CW24 --QEGQMVES-------------VAG-ALGVGLRRVCWLRSIGQAVQPWVEAVRCQSLGVFSGRDQPAPG--EESFEVWLDHTTEMLHVWQGVSERERRR 195

  A0A0J9YX94 RLLDSLDGLALDIVSGLLEEDPDFSAQDCLTALGQVFRSRDTWMTSRMKFLTCTQGPQEG--LFAFVVRLEGLLQKAVEKGAVHPAMANHLRLRQVLSRA 391
      P0CW24 RLLEGLRGTALQLVHALLAENPARTAQDCLAALAQVFGDNESQATIRVKCLTAQQ--QSGERLSAFVLRLEVLLQKAMEKEALARASADRVRLRQMLTRA 293

  A0A0J9YX94 RPSEALQDTLRRMQLERRPPDFLRLLRLIRDMEAWAASLARSQQGVAWAAAPVESEDPAAAQASPAQGDASEADPGAEDADEAASTTKEAARVAPATGED 491
      P0CW24 HLTEPLDEALRKLRMAGRSPSFLEMLGLVRESEAWEASLARS----------VR------AQ------------------------TQEGA------G-- 345

  A0A0J9YX94 ENAPAGLEGLGQGRSPDAPGGLPARMGSAVDMAPGGPSWEPEGLVQVGGQEAEEPPQEGLKPILEESENEDEDGAGEAGKPKSPPGK 578
      P0CW24 --ARAGAQAV-------------ARASTKVEAVPGGPGREPEGLLQAGGQEAEELLQEGLKPVLEECDN------------------ 399

Go Annotations

1. PB indicates the go terms that are found by both PROST and BLAST.
2. P indicates the go terms that are found by only PROST.
3. B indicates the go terms that are only annotated by BLAST.
Source GO Description
1. PB GO:0031625 ubiquitin protein ligase binding
1. PB GO:0090200 positive regulation of release of cytochrome c from mitochondria
1. PB GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
1. PB GO:0002437 inflammatory response to antigenic stimulus
1. PB GO:0005741 mitochondrial outer membrane
1. PB GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
1. PB GO:0097190 apoptotic signaling pathway
1. PB GO:0042981 regulation of apoptotic process
1. PB GO:0005730 nucleolus
1. PB GO:0001844 protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
1. PB GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
1. PB GO:0043065 positive regulation of apoptotic process
1. PB GO:0003676 nucleic acid binding
2. P GO:0042025 host cell nucleus
2. P GO:0005198 structural molecule activity
2. P GO:0003723 RNA binding
2. P GO:0016032 viral process
2. P GO:0008270 zinc ion binding
2. P GO:0016020 membrane
2. P GO:0005829 cytosol
2. P GO:0072494 host multivesicular body
2. P GO:0030430 host cell cytoplasm
2. P GO:0019013 viral nucleocapsid
2. P GO:0055036 virion membrane
2. P GO:0005654 nucleoplasm
2. P GO:0039702 viral budding via host ESCRT complex
2. P GO:0020002 host cell plasma membrane
3. B GO:0030198 extracellular matrix organization
3. B GO:0032183 SUMO binding
3. B GO:0099184 structural constituent of postsynaptic intermediate filament cytoskeleton
3. B GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
3. B GO:0060021 roof of mouth development
3. B GO:0048407 platelet-derived growth factor binding
3. B GO:0007601 visual perception
3. B GO:0001886 endothelial cell morphogenesis
3. B GO:0001958 endochondral ossification
3. B GO:0097418 neurofibrillary tangle
3. B GO:0097440 apical dendrite
3. B GO:0005201 extracellular matrix structural constituent
3. B GO:0060272 embryonic skeletal joint morphogenesis
3. B GO:0033693 neurofilament bundle assembly
3. B GO:0045299 otolith mineralization
3. B GO:0038187 pattern recognition receptor activity
3. B GO:0003713 transcription coactivator activity
3. B GO:0045162 clustering of voltage-gated sodium channels
3. B GO:0006029 proteoglycan metabolic process
3. B GO:1902513 regulation of organelle transport along microtubule
3. B GO:0030424 axon
3. B GO:0060174 limb bud formation
3. B GO:0048570 notochord morphogenesis
3. B GO:0030903 notochord development
3. B GO:0035987 endodermal cell differentiation
3. B GO:0045110 intermediate filament bundle assembly
3. B GO:0007605 sensory perception of sound
3. B GO:0150017 basal proximal dendrite
3. B GO:0005576 extracellular region
3. B GO:0005590 collagen type VII trimer
3. B GO:0001502 cartilage condensation
3. B GO:0031012 extracellular matrix
3. B GO:0005518 collagen binding
3. B GO:0031103 axon regeneration
3. B GO:0003431 growth plate cartilage chondrocyte development
3. B GO:0097242 amyloid-beta clearance
3. B GO:0001552 ovarian follicle atresia
3. B GO:0086080 protein binding involved in heterotypic cell-cell adhesion
3. B GO:0034113 heterotypic cell-cell adhesion
3. B GO:0005788 endoplasmic reticulum lumen
3. B GO:0008582 regulation of synaptic assembly at neuromuscular junction
3. B GO:0005615 extracellular space
3. B GO:0007155 cell adhesion
3. B GO:0097065 anterior head development
3. B GO:1903935 response to sodium arsenite
3. B GO:0048936 peripheral nervous system neuron axonogenesis
3. B GO:0061564 axon development
3. B GO:0060351 cartilage development involved in endochondral bone morphogenesis
3. B GO:0015643 toxic substance binding
3. B GO:0099160 postsynaptic intermediate filament cytoskeleton
3. B GO:0043277 apoptotic cell clearance
3. B GO:0005604 basement membrane
3. B GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway
3. B GO:0071599 otic vesicle development
3. B GO:0043394 proteoglycan binding
3. B GO:0016605 PML body
3. B GO:0045104 intermediate filament cytoskeleton organization
3. B GO:0071340 skeletal muscle acetylcholine-gated channel clustering
3. B GO:0004867 serine-type endopeptidase inhibitor activity
3. B GO:0005585 collagen type II trimer
3. B GO:0007417 central nervous system development
3. B GO:0001501 skeletal system development
3. B GO:0005583 fibrillar collagen trimer
3. B GO:0005883 neurofilament
3. B GO:0005581 collagen trimer
3. B GO:0030666 endocytic vesicle membrane
3. B GO:0042383 sarcolemma
3. B GO:0030199 collagen fibril organization
3. B GO:0005587 collagen type IV trimer
3. B GO:0042472 inner ear morphogenesis
3. B GO:0071773 cellular response to BMP stimulus
3. B GO:0003007 heart morphogenesis
3. B GO:0032528 microvillus organization
3. B GO:0030509 BMP signaling pathway
3. B GO:0002062 chondrocyte differentiation
3. B GO:0042289 MHC class II protein binding
3. B GO:0062023 collagen-containing extracellular matrix
3. B GO:0042135 neurotransmitter catabolic process
3. B GO:0001894 tissue homeostasis
3. B GO:0030020 extracellular matrix structural constituent conferring tensile strength
3. B GO:0060052 neurofilament cytoskeleton organization
3. B GO:0038024 cargo receptor activity
3. B GO:0090150 establishment of protein localization to membrane

Homologs

1. PB indicates the homologs that are found by both PROST and BLAST.
2. P indicates homologs that are only found by PROST.
3. B indicates homologs that are only found by BLAST.

Source Homolog Description FATCAT p-val PROST Evalue BLAST Evalue
1. PB Q95KI4 Modulator of apoptosis 1 2.49e-08 1.36e-02 1.29e-24
1. PB Q8ND90 Paraneoplastic antigen Ma1 5.79e-08 1.19e-06 4.12e-31
1. PB Q9ERH6 Modulator of apoptosis 1 3.71e-06 5.83e-04 5.30e-28
1. PB Q8BHK0 Paraneoplastic antigen Ma2 homolog 7.18e-11 2.82e-09 6.37e-23
1. PB A6QLK5 Paraneoplastic antigen Ma1 homolog 9.44e-06 3.04e-07 1.70e-32
1. PB Q5R486 Paraneoplastic antigen Ma2 homolog 1.53e-09 4.25e-09 4.18e-27
1. PB Q96PV4 Paraneoplastic antigen-like protein 5 2.25e-06 6.16e-29 9.43e-32
1. PB Q8VHZ4 Paraneoplastic antigen Ma1 homolog 2.48e-05 2.43e-07 1.38e-30
1. PB Q9UL42 Paraneoplastic antigen Ma2 9.27e-10 7.23e-09 1.73e-28
1. PB Q2KIT6 Paraneoplastic antigen Ma2 homolog 3.58e-10 9.59e-11 1.42e-31
1. PB Q9GMU3 Paraneoplastic antigen Ma2 homolog 6.44e-10 8.76e-10 2.08e-28
1. PB A0A0J9YXQ4 Paraneoplastic antigen Ma6E 6.95e-05 3.64e-32 2.36e-53
1. PB A0A0J9YX94 Paraneoplastic antigen Ma6F 0 1.28e-171 0.0
1. PB Q96BY2 Modulator of apoptosis 1 4.79e-10 8.95e-04 2.18e-27
1. PB Q9UL41 Paraneoplastic antigen Ma3 2.98e-06 6.02e-13 4.50e-37
1. PB P0CW24 Paraneoplastic antigen-like protein 6A 3.12e-11 7.96e-19 2.61e-41
1. PB Q8C1C8 Paraneoplastic antigen Ma1 homolog 2.46e-08 3.94e-07 2.23e-29
1. PB Q8JZW8 Paraneoplastic antigen Ma3 homolog 2.63e-06 1.40e-15 3.60e-35
2. P P12494 Gag polyprotein NA 2.45e-02 NA
2. P Q02843 Gag polyprotein NA 1.83e-02 NA
2. P P27972 Gag polyprotein NA 6.22e-03 NA
2. P Q8AII2 Gag polyprotein NA 4.60e-02 NA
2. P P03346 Gag polyprotein NA 4.62e-05 NA
2. P P27536 Posterior protein 1.32e-01 2.55e-04 NA
2. P P03345 Gag polyprotein NA 4.01e-03 NA
2. P P27978 Gag polyprotein NA 4.17e-02 NA
2. P P14076 Gag polyprotein NA 4.19e-03 NA
2. P Q0R5R4 Gag polyprotein NA 4.34e-02 NA
2. P P03349 Gag polyprotein NA 2.13e-02 NA
2. P P20889 Gag polyprotein NA 3.02e-02 NA
2. P P0C209 Gag polyprotein NA 6.62e-03 NA
2. P P05888 Gag polyprotein NA 2.90e-02 NA
2. P P14077 Gag polyprotein NA 3.61e-03 NA
2. P P19027 Gag polyprotein NA 2.03e-02 NA
2. P Q09T00 Gag polyprotein NA 4.60e-03 NA
3. B Q5UNS9 Collagen-like protein 7 NA NA 8.10e-10
3. B A0MSJ1 Collagen alpha-1(XXVII) chain B 9.66e-01 NA 0.003
3. B Q63870 Collagen alpha-1(VII) chain NA NA 0.005
3. B Q5UPE4 Collagen-like protein 1 NA NA 5.89e-04
3. B O35167 Acetylcholinesterase collagenic tail peptide 2.45e-01 NA 0.044
3. B A0A1B0GUJ8 Paraneoplastic antigen-like protein 8C 2.54e-04 NA 3.17e-22
3. B Q08DL1 Zinc finger CCHC domain-containing protein 12 1.14e-04 NA 9.20e-23
3. B Q02788 Collagen alpha-2(VI) chain 4.60e-01 NA 0.002
3. B Q28668 Collagen alpha-2(I) chain (Fragment) 1.19e-01 NA 0.033
3. B Q86V59 Paraneoplastic antigen-like protein 8A 3.19e-03 NA 2.69e-24
3. B P15989 Collagen alpha-3(VI) chain NA NA 0.001
3. B Q5R6R8 Paraneoplastic antigen-like protein 8A 3.33e-02 NA 8.04e-24
3. B Q4ZJM7 Otolin-1 6.23e-01 NA 0.021
3. B P02458 Collagen alpha-1(II) chain 8.66e-01 NA 0.013
3. B Q9ULN7 Paraneoplastic antigen-like protein 8B 9.35e-03 NA 2.89e-15
3. B Q09578 Putative cuticle collagen 75 2.44e-01 NA 0.006
3. B Q02388 Collagen alpha-1(VII) chain NA NA 0.036
3. B Q5DTT8 Paraneoplastic antigen-like protein 5 2.66e-07 NA 1.61e-32
3. B Q80ZF0 Collagen alpha-1(XXVII) chain 8.42e-01 NA 0.001
3. B Q8C6K9 Collagen alpha-6(VI) chain 9.08e-01 NA 1.11e-04
3. B A8TX70 Collagen alpha-5(VI) chain 9.61e-01 NA 8.13e-09
3. B Q9UEW3 Macrophage receptor MARCO 4.47e-01 NA 0.006
3. B Q6PEW1 Zinc finger CCHC domain-containing protein 12 1.31e-04 NA 4.38e-21
3. B A7E321 Paraneoplastic antigen-like protein 8A 3.89e-02 NA 3.07e-22
3. B B7Z0K8 Collagen alpha chain CG42342 1.36e-01 NA 7.14e-05
3. B A6H584 Collagen alpha-5(VI) chain 9.73e-01 NA 9.41e-05
3. B Q80WL1 Gliomedin 5.60e-01 NA 0.016
3. B Q8BMF8 Gliomedin 4.09e-01 NA 0.030
3. B Q5HZA3 Zinc finger CCHC domain-containing protein 12 1.19e-05 NA 3.56e-22
3. B Q8VD24 Zinc finger CCHC domain-containing protein 18 5.16e-05 NA 3.63e-22
3. B P19246 Neurofilament heavy polypeptide 5.32e-01 NA 0.008
3. B Q5QNQ9 Collagen alpha-1(XXVII) chain 9.64e-01 NA 0.002
3. B P15988 Collagen alpha-2(VI) chain 4.58e-01 NA 0.003
3. B Q30D77 Collagen alpha-1(XXIV) chain 9.20e-01 NA 4.69e-04
3. B Q17RW2 Collagen alpha-1(XXIV) chain 6.43e-01 NA 2.03e-04
3. B P02459 Collagen alpha-1(II) chain 8.81e-01 NA 0.010
3. B Q801S8 Collagen alpha-1(VI) chain 4.30e-01 NA 0.002
3. B P0CG32 Zinc finger CCHC domain-containing protein 18 2.81e-05 NA 1.51e-22
3. B Q80VM8 Paraneoplastic antigen-like protein 8A 1.52e-01 NA 1.05e-21
3. B A6NMZ7 Collagen alpha-6(VI) chain 8.94e-01 NA 0.004
3. B A2AX52 Collagen alpha-4(VI) chain 8.32e-01 NA 0.001
3. B Q9CZA5 Zinc finger CCHC domain-containing protein 12 4.75e-05 NA 7.70e-22
3. B Q641F3 Collagen alpha-1(XXI) chain 8.00e-01 NA 0.025