Summary
A0A0J9YX94
Homolog: P0CW24.
Function: Paraneoplastic antigen-like protein 6A.
Statistics
Total GO Annotation: 110
Unique PROST Go: 14
Unique BLAST Go: 83
Total Homologs: 78
Unique PROST Homologs: 17
Unique BLAST Homologs: 43
Structures and Sequence Alignment
The best structural homolog that predicted by 1. PB was
P0CW24
(Paraneoplastic antigen-like protein 6A) with a FATCAT P-Value: 3.12e-11 and RMSD of 2.46 angstrom. The sequence alignment identity is 36.3%.
Structural alignment shown in left. Query protein A0A0J9YX94 colored as red in alignment, homolog P0CW24 colored as blue.
Query protein A0A0J9YX94 is also shown in right top, homolog P0CW24 showed in right bottom. They are colored based on secondary structures.
A0A0J9YX94 ----MLQDWCRRMGVNAERSLLILDIPDDCEEHEFQEAVRAALSPLGRYRVLIKVFRKELGARAALVEFAEGLNQSLIPRQIAGKGGPWKVISLPQALDA 96 P0CW24 MAVTMLQDWCRWMGVNARRGLLILGIPEDCDDAEFQESLEAALRPMGHFTVLGKAFREEDNATAALVELDREVNYALVPREIPGTGGPWNVVFVP----- 95 A0A0J9YX94 EFQDIPSFPAQPQGQAVARGAGEAGAAGEAGSVGEAGGVNEERSAGEDEAGGIGEAGGVGEAGAAGEAGAAGEAGAAGEAGGAGEAGGAGEAGGAGEEGG 196 P0CW24 ------------------------------------------RCSGE-------EFLGLGRVFHFPE--------------------------------- 113 A0A0J9YX94 TGEEGGAGEAGGAGEEGGEDEAGAAGEAVGAGVVE-AWTQSWRQTLRPLVKTMAYRELRPFSGREQ--PGCVEESFESWLEDAKDMLQLWCHASERERRR 293 P0CW24 --QEGQMVES-------------VAG-ALGVGLRRVCWLRSIGQAVQPWVEAVRCQSLGVFSGRDQPAPG--EESFEVWLDHTTEMLHVWQGVSERERRR 195 A0A0J9YX94 RLLDSLDGLALDIVSGLLEEDPDFSAQDCLTALGQVFRSRDTWMTSRMKFLTCTQGPQEG--LFAFVVRLEGLLQKAVEKGAVHPAMANHLRLRQVLSRA 391 P0CW24 RLLEGLRGTALQLVHALLAENPARTAQDCLAALAQVFGDNESQATIRVKCLTAQQ--QSGERLSAFVLRLEVLLQKAMEKEALARASADRVRLRQMLTRA 293 A0A0J9YX94 RPSEALQDTLRRMQLERRPPDFLRLLRLIRDMEAWAASLARSQQGVAWAAAPVESEDPAAAQASPAQGDASEADPGAEDADEAASTTKEAARVAPATGED 491 P0CW24 HLTEPLDEALRKLRMAGRSPSFLEMLGLVRESEAWEASLARS----------VR------AQ------------------------TQEGA------G-- 345 A0A0J9YX94 ENAPAGLEGLGQGRSPDAPGGLPARMGSAVDMAPGGPSWEPEGLVQVGGQEAEEPPQEGLKPILEESENEDEDGAGEAGKPKSPPGK 578 P0CW24 --ARAGAQAV-------------ARASTKVEAVPGGPGREPEGLLQAGGQEAEELLQEGLKPVLEECDN------------------ 399
Go Annotations
1. PB indicates the go terms that are found by both PROST and BLAST.2. P indicates the go terms that are found by only PROST.
3. B indicates the go terms that are only annotated by BLAST.
Source | GO | Description |
---|---|---|
1. PB | GO:0031625 | ubiquitin protein ligase binding |
1. PB | GO:0090200 | positive regulation of release of cytochrome c from mitochondria |
1. PB | GO:0008625 | extrinsic apoptotic signaling pathway via death domain receptors |
1. PB | GO:0002437 | inflammatory response to antigenic stimulus |
1. PB | GO:0005741 | mitochondrial outer membrane |
1. PB | GO:0097192 | extrinsic apoptotic signaling pathway in absence of ligand |
1. PB | GO:0097190 | apoptotic signaling pathway |
1. PB | GO:0042981 | regulation of apoptotic process |
1. PB | GO:0005730 | nucleolus |
1. PB | GO:0001844 | protein insertion into mitochondrial membrane involved in apoptotic signaling pathway |
1. PB | GO:0008630 | intrinsic apoptotic signaling pathway in response to DNA damage |
1. PB | GO:0043065 | positive regulation of apoptotic process |
1. PB | GO:0003676 | nucleic acid binding |
2. P | GO:0042025 | host cell nucleus |
2. P | GO:0005198 | structural molecule activity |
2. P | GO:0003723 | RNA binding |
2. P | GO:0016032 | viral process |
2. P | GO:0008270 | zinc ion binding |
2. P | GO:0016020 | membrane |
2. P | GO:0005829 | cytosol |
2. P | GO:0072494 | host multivesicular body |
2. P | GO:0030430 | host cell cytoplasm |
2. P | GO:0019013 | viral nucleocapsid |
2. P | GO:0055036 | virion membrane |
2. P | GO:0005654 | nucleoplasm |
2. P | GO:0039702 | viral budding via host ESCRT complex |
2. P | GO:0020002 | host cell plasma membrane |
3. B | GO:0030198 | extracellular matrix organization |
3. B | GO:0032183 | SUMO binding |
3. B | GO:0099184 | structural constituent of postsynaptic intermediate filament cytoskeleton |
3. B | GO:2001240 | negative regulation of extrinsic apoptotic signaling pathway in absence of ligand |
3. B | GO:0060021 | roof of mouth development |
3. B | GO:0048407 | platelet-derived growth factor binding |
3. B | GO:0007601 | visual perception |
3. B | GO:0001886 | endothelial cell morphogenesis |
3. B | GO:0001958 | endochondral ossification |
3. B | GO:0097418 | neurofibrillary tangle |
3. B | GO:0097440 | apical dendrite |
3. B | GO:0005201 | extracellular matrix structural constituent |
3. B | GO:0060272 | embryonic skeletal joint morphogenesis |
3. B | GO:0033693 | neurofilament bundle assembly |
3. B | GO:0045299 | otolith mineralization |
3. B | GO:0038187 | pattern recognition receptor activity |
3. B | GO:0003713 | transcription coactivator activity |
3. B | GO:0045162 | clustering of voltage-gated sodium channels |
3. B | GO:0006029 | proteoglycan metabolic process |
3. B | GO:1902513 | regulation of organelle transport along microtubule |
3. B | GO:0030424 | axon |
3. B | GO:0060174 | limb bud formation |
3. B | GO:0048570 | notochord morphogenesis |
3. B | GO:0030903 | notochord development |
3. B | GO:0035987 | endodermal cell differentiation |
3. B | GO:0045110 | intermediate filament bundle assembly |
3. B | GO:0007605 | sensory perception of sound |
3. B | GO:0150017 | basal proximal dendrite |
3. B | GO:0005576 | extracellular region |
3. B | GO:0005590 | collagen type VII trimer |
3. B | GO:0001502 | cartilage condensation |
3. B | GO:0031012 | extracellular matrix |
3. B | GO:0005518 | collagen binding |
3. B | GO:0031103 | axon regeneration |
3. B | GO:0003431 | growth plate cartilage chondrocyte development |
3. B | GO:0097242 | amyloid-beta clearance |
3. B | GO:0001552 | ovarian follicle atresia |
3. B | GO:0086080 | protein binding involved in heterotypic cell-cell adhesion |
3. B | GO:0034113 | heterotypic cell-cell adhesion |
3. B | GO:0005788 | endoplasmic reticulum lumen |
3. B | GO:0008582 | regulation of synaptic assembly at neuromuscular junction |
3. B | GO:0005615 | extracellular space |
3. B | GO:0007155 | cell adhesion |
3. B | GO:0097065 | anterior head development |
3. B | GO:1903935 | response to sodium arsenite |
3. B | GO:0048936 | peripheral nervous system neuron axonogenesis |
3. B | GO:0061564 | axon development |
3. B | GO:0060351 | cartilage development involved in endochondral bone morphogenesis |
3. B | GO:0015643 | toxic substance binding |
3. B | GO:0099160 | postsynaptic intermediate filament cytoskeleton |
3. B | GO:0043277 | apoptotic cell clearance |
3. B | GO:0005604 | basement membrane |
3. B | GO:0038063 | collagen-activated tyrosine kinase receptor signaling pathway |
3. B | GO:0071599 | otic vesicle development |
3. B | GO:0043394 | proteoglycan binding |
3. B | GO:0016605 | PML body |
3. B | GO:0045104 | intermediate filament cytoskeleton organization |
3. B | GO:0071340 | skeletal muscle acetylcholine-gated channel clustering |
3. B | GO:0004867 | serine-type endopeptidase inhibitor activity |
3. B | GO:0005585 | collagen type II trimer |
3. B | GO:0007417 | central nervous system development |
3. B | GO:0001501 | skeletal system development |
3. B | GO:0005583 | fibrillar collagen trimer |
3. B | GO:0005883 | neurofilament |
3. B | GO:0005581 | collagen trimer |
3. B | GO:0030666 | endocytic vesicle membrane |
3. B | GO:0042383 | sarcolemma |
3. B | GO:0030199 | collagen fibril organization |
3. B | GO:0005587 | collagen type IV trimer |
3. B | GO:0042472 | inner ear morphogenesis |
3. B | GO:0071773 | cellular response to BMP stimulus |
3. B | GO:0003007 | heart morphogenesis |
3. B | GO:0032528 | microvillus organization |
3. B | GO:0030509 | BMP signaling pathway |
3. B | GO:0002062 | chondrocyte differentiation |
3. B | GO:0042289 | MHC class II protein binding |
3. B | GO:0062023 | collagen-containing extracellular matrix |
3. B | GO:0042135 | neurotransmitter catabolic process |
3. B | GO:0001894 | tissue homeostasis |
3. B | GO:0030020 | extracellular matrix structural constituent conferring tensile strength |
3. B | GO:0060052 | neurofilament cytoskeleton organization |
3. B | GO:0038024 | cargo receptor activity |
3. B | GO:0090150 | establishment of protein localization to membrane |
Homologs
1. PB indicates the homologs that are found by both PROST and BLAST.
2. P indicates homologs that are only found by PROST.
3. B indicates homologs that are only found by BLAST.
Source | Homolog | Description | FATCAT p-val | PROST Evalue | BLAST Evalue |
---|---|---|---|---|---|
1. PB | Q95KI4 | Modulator of apoptosis 1 | 2.49e-08 | 1.36e-02 | 1.29e-24 |
1. PB | Q8ND90 | Paraneoplastic antigen Ma1 | 5.79e-08 | 1.19e-06 | 4.12e-31 |
1. PB | Q9ERH6 | Modulator of apoptosis 1 | 3.71e-06 | 5.83e-04 | 5.30e-28 |
1. PB | Q8BHK0 | Paraneoplastic antigen Ma2 homolog | 7.18e-11 | 2.82e-09 | 6.37e-23 |
1. PB | A6QLK5 | Paraneoplastic antigen Ma1 homolog | 9.44e-06 | 3.04e-07 | 1.70e-32 |
1. PB | Q5R486 | Paraneoplastic antigen Ma2 homolog | 1.53e-09 | 4.25e-09 | 4.18e-27 |
1. PB | Q96PV4 | Paraneoplastic antigen-like protein 5 | 2.25e-06 | 6.16e-29 | 9.43e-32 |
1. PB | Q8VHZ4 | Paraneoplastic antigen Ma1 homolog | 2.48e-05 | 2.43e-07 | 1.38e-30 |
1. PB | Q9UL42 | Paraneoplastic antigen Ma2 | 9.27e-10 | 7.23e-09 | 1.73e-28 |
1. PB | Q2KIT6 | Paraneoplastic antigen Ma2 homolog | 3.58e-10 | 9.59e-11 | 1.42e-31 |
1. PB | Q9GMU3 | Paraneoplastic antigen Ma2 homolog | 6.44e-10 | 8.76e-10 | 2.08e-28 |
1. PB | A0A0J9YXQ4 | Paraneoplastic antigen Ma6E | 6.95e-05 | 3.64e-32 | 2.36e-53 |
1. PB | A0A0J9YX94 | Paraneoplastic antigen Ma6F | 0 | 1.28e-171 | 0.0 |
1. PB | Q96BY2 | Modulator of apoptosis 1 | 4.79e-10 | 8.95e-04 | 2.18e-27 |
1. PB | Q9UL41 | Paraneoplastic antigen Ma3 | 2.98e-06 | 6.02e-13 | 4.50e-37 |
1. PB | P0CW24 | Paraneoplastic antigen-like protein 6A | 3.12e-11 | 7.96e-19 | 2.61e-41 |
1. PB | Q8C1C8 | Paraneoplastic antigen Ma1 homolog | 2.46e-08 | 3.94e-07 | 2.23e-29 |
1. PB | Q8JZW8 | Paraneoplastic antigen Ma3 homolog | 2.63e-06 | 1.40e-15 | 3.60e-35 |
2. P | P12494 | Gag polyprotein | NA | 2.45e-02 | NA |
2. P | Q02843 | Gag polyprotein | NA | 1.83e-02 | NA |
2. P | P27972 | Gag polyprotein | NA | 6.22e-03 | NA |
2. P | Q8AII2 | Gag polyprotein | NA | 4.60e-02 | NA |
2. P | P03346 | Gag polyprotein | NA | 4.62e-05 | NA |
2. P | P27536 | Posterior protein | 1.32e-01 | 2.55e-04 | NA |
2. P | P03345 | Gag polyprotein | NA | 4.01e-03 | NA |
2. P | P27978 | Gag polyprotein | NA | 4.17e-02 | NA |
2. P | P14076 | Gag polyprotein | NA | 4.19e-03 | NA |
2. P | Q0R5R4 | Gag polyprotein | NA | 4.34e-02 | NA |
2. P | P03349 | Gag polyprotein | NA | 2.13e-02 | NA |
2. P | P20889 | Gag polyprotein | NA | 3.02e-02 | NA |
2. P | P0C209 | Gag polyprotein | NA | 6.62e-03 | NA |
2. P | P05888 | Gag polyprotein | NA | 2.90e-02 | NA |
2. P | P14077 | Gag polyprotein | NA | 3.61e-03 | NA |
2. P | P19027 | Gag polyprotein | NA | 2.03e-02 | NA |
2. P | Q09T00 | Gag polyprotein | NA | 4.60e-03 | NA |
3. B | Q5UNS9 | Collagen-like protein 7 | NA | NA | 8.10e-10 |
3. B | A0MSJ1 | Collagen alpha-1(XXVII) chain B | 9.66e-01 | NA | 0.003 |
3. B | Q63870 | Collagen alpha-1(VII) chain | NA | NA | 0.005 |
3. B | Q5UPE4 | Collagen-like protein 1 | NA | NA | 5.89e-04 |
3. B | O35167 | Acetylcholinesterase collagenic tail peptide | 2.45e-01 | NA | 0.044 |
3. B | A0A1B0GUJ8 | Paraneoplastic antigen-like protein 8C | 2.54e-04 | NA | 3.17e-22 |
3. B | Q08DL1 | Zinc finger CCHC domain-containing protein 12 | 1.14e-04 | NA | 9.20e-23 |
3. B | Q02788 | Collagen alpha-2(VI) chain | 4.60e-01 | NA | 0.002 |
3. B | Q28668 | Collagen alpha-2(I) chain (Fragment) | 1.19e-01 | NA | 0.033 |
3. B | Q86V59 | Paraneoplastic antigen-like protein 8A | 3.19e-03 | NA | 2.69e-24 |
3. B | P15989 | Collagen alpha-3(VI) chain | NA | NA | 0.001 |
3. B | Q5R6R8 | Paraneoplastic antigen-like protein 8A | 3.33e-02 | NA | 8.04e-24 |
3. B | Q4ZJM7 | Otolin-1 | 6.23e-01 | NA | 0.021 |
3. B | P02458 | Collagen alpha-1(II) chain | 8.66e-01 | NA | 0.013 |
3. B | Q9ULN7 | Paraneoplastic antigen-like protein 8B | 9.35e-03 | NA | 2.89e-15 |
3. B | Q09578 | Putative cuticle collagen 75 | 2.44e-01 | NA | 0.006 |
3. B | Q02388 | Collagen alpha-1(VII) chain | NA | NA | 0.036 |
3. B | Q5DTT8 | Paraneoplastic antigen-like protein 5 | 2.66e-07 | NA | 1.61e-32 |
3. B | Q80ZF0 | Collagen alpha-1(XXVII) chain | 8.42e-01 | NA | 0.001 |
3. B | Q8C6K9 | Collagen alpha-6(VI) chain | 9.08e-01 | NA | 1.11e-04 |
3. B | A8TX70 | Collagen alpha-5(VI) chain | 9.61e-01 | NA | 8.13e-09 |
3. B | Q9UEW3 | Macrophage receptor MARCO | 4.47e-01 | NA | 0.006 |
3. B | Q6PEW1 | Zinc finger CCHC domain-containing protein 12 | 1.31e-04 | NA | 4.38e-21 |
3. B | A7E321 | Paraneoplastic antigen-like protein 8A | 3.89e-02 | NA | 3.07e-22 |
3. B | B7Z0K8 | Collagen alpha chain CG42342 | 1.36e-01 | NA | 7.14e-05 |
3. B | A6H584 | Collagen alpha-5(VI) chain | 9.73e-01 | NA | 9.41e-05 |
3. B | Q80WL1 | Gliomedin | 5.60e-01 | NA | 0.016 |
3. B | Q8BMF8 | Gliomedin | 4.09e-01 | NA | 0.030 |
3. B | Q5HZA3 | Zinc finger CCHC domain-containing protein 12 | 1.19e-05 | NA | 3.56e-22 |
3. B | Q8VD24 | Zinc finger CCHC domain-containing protein 18 | 5.16e-05 | NA | 3.63e-22 |
3. B | P19246 | Neurofilament heavy polypeptide | 5.32e-01 | NA | 0.008 |
3. B | Q5QNQ9 | Collagen alpha-1(XXVII) chain | 9.64e-01 | NA | 0.002 |
3. B | P15988 | Collagen alpha-2(VI) chain | 4.58e-01 | NA | 0.003 |
3. B | Q30D77 | Collagen alpha-1(XXIV) chain | 9.20e-01 | NA | 4.69e-04 |
3. B | Q17RW2 | Collagen alpha-1(XXIV) chain | 6.43e-01 | NA | 2.03e-04 |
3. B | P02459 | Collagen alpha-1(II) chain | 8.81e-01 | NA | 0.010 |
3. B | Q801S8 | Collagen alpha-1(VI) chain | 4.30e-01 | NA | 0.002 |
3. B | P0CG32 | Zinc finger CCHC domain-containing protein 18 | 2.81e-05 | NA | 1.51e-22 |
3. B | Q80VM8 | Paraneoplastic antigen-like protein 8A | 1.52e-01 | NA | 1.05e-21 |
3. B | A6NMZ7 | Collagen alpha-6(VI) chain | 8.94e-01 | NA | 0.004 |
3. B | A2AX52 | Collagen alpha-4(VI) chain | 8.32e-01 | NA | 0.001 |
3. B | Q9CZA5 | Zinc finger CCHC domain-containing protein 12 | 4.75e-05 | NA | 7.70e-22 |
3. B | Q641F3 | Collagen alpha-1(XXI) chain | 8.00e-01 | NA | 0.025 |