Summary

A0A1B0GVG6

Homolog: Q6P791.
Function: Ragulator complex protein LAMTOR1.

Statistics

Total GO Annotation: 48
Unique PROST Go: 48
Unique BLAST Go: 0

Total Homologs: 24
Unique PROST Homologs: 22
Unique BLAST Homologs: 0

Structures and Sequence Alignment

The best structural homolog that predicted by 2. P was Q6P791 (Ragulator complex protein LAMTOR1) with a FATCAT P-Value: 0.03 and RMSD of 3.54 angstrom. The sequence alignment identity is 19.8%.
Structural alignment shown in left. Query protein A0A1B0GVG6 colored as red in alignment, homolog Q6P791 colored as blue. Query protein A0A1B0GVG6 is also shown in right top, homolog Q6P791 showed in right bottom. They are colored based on secondary structures. 

  A0A1B0GVG6 MGCCQDKDFEMSDEQSKEEESEDGRE---DET-TDTQ--RGPRECERGLPEGRGE----LRGLVVPSGAEDIDLNSPD------HP------NHKSNESL 78
      Q6P791 MGCCYSSENEDSD-QDQEE-----RKLLLDPSNTPTKALNGAEPSYHSLPSARTDEQALLSSILAKTASNIIDVSAADSQGMEQHEYMDRARQYSTRLAV 94

  A0A1B0GVG6 LITVL--WRRLSTFGRRGSSRPS-KRQPDQIRKQESPIREGNQEEPEKG--------------------------------- 124
      Q6P791 LSSSLTHWKKLPPL-------PSLTSQPHQVLASE-PI-------PFSDLQQVSRIAAYAYSALSQIRVDAKEELVVQFGIP 161

Go Annotations

1. PB indicates the go terms that are found by both PROST and BLAST.
2. P indicates the go terms that are found by only PROST.
3. B indicates the go terms that are only annotated by BLAST.
Source GO Description
2. P GO:0034613 cellular protein localization
2. P GO:0042246 tissue regeneration
2. P GO:0030326 embryonic limb morphogenesis
2. P GO:0007040 lysosome organization
2. P GO:0051020 GTPase binding
2. P GO:0016020 membrane
2. P GO:0042632 cholesterol homeostasis
2. P GO:0060090 molecular adaptor activity
2. P GO:0043005 neuron projection
2. P GO:0043410 positive regulation of MAPK cascade
2. P GO:0010872 regulation of cholesterol esterification
2. P GO:0005085 guanyl-nucleotide exchange factor activity
2. P GO:0045121 membrane raft
2. P GO:0035579 specific granule membrane
2. P GO:0005764 lysosome
2. P GO:0071986 Ragulator complex
2. P GO:0007035 vacuolar acidification
2. P GO:0031902 late endosome membrane
2. P GO:0016197 endosomal transport
2. P GO:0020002 host cell plasma membrane
2. P GO:0032418 lysosome localization
2. P GO:0032008 positive regulation of TOR signaling
2. P GO:0071230 cellular response to amino acid stimulus
2. P GO:0044178 host cell Golgi membrane
2. P GO:0072665 protein localization to vacuole
2. P GO:0032332 positive regulation of chondrocyte differentiation
2. P GO:0101003 ficolin-1-rich granule membrane
2. P GO:0014069 postsynaptic density
2. P GO:0009653 anatomical structure morphogenesis
2. P GO:0035988 chondrocyte proliferation
2. P GO:0000329 fungal-type vacuole membrane
2. P GO:0002062 chondrocyte differentiation
2. P GO:1902730 positive regulation of proteoglycan biosynthetic process
2. P GO:0019033 viral tegument
2. P GO:0007032 endosome organization
2. P GO:0016237 lysosomal microautophagy
2. P GO:1903778 protein localization to vacuolar membrane
2. P GO:0050790 regulation of catalytic activity
2. P GO:0060620 regulation of cholesterol import
2. P GO:0035577 azurophil granule membrane
2. P GO:0032006 regulation of TOR signaling
2. P GO:0046760 viral budding from Golgi membrane
2. P GO:0001919 regulation of receptor recycling
2. P GO:0001558 regulation of cell growth
2. P GO:1902732 positive regulation of chondrocyte proliferation
2. P GO:0055036 virion membrane
2. P GO:0005765 lysosomal membrane
2. P GO:0010874 regulation of cholesterol efflux

Homologs

1. PB indicates the homologs that are found by both PROST and BLAST.
2. P indicates homologs that are only found by PROST.
3. B indicates homologs that are only found by BLAST.

Source Homolog Description FATCAT p-val PROST Evalue BLAST Evalue
1. PB G3UW99 Testis-expressed protein 54 3.73e-02 4.71e-12 5.03e-16
1. PB A0A1B0GVG6 Testis-expressed protein 54 0 2.18e-116 1.56e-85
2. P Q02205 Protein MEH1 1.53e-01 7.38e-04 NA
2. P Q1G3Y0 CRIB domain-containing protein RIC9 4.33e-02 3.28e-02 NA
2. P Q1ZXA8 Uncharacterized protein DDB_G0292160 1.19e-01 2.29e-02 NA
2. P Q6P791 Ragulator complex protein LAMTOR1 3.00e-02 5.40e-03 NA
2. P Q8K207 Uncharacterized protein C1orf21 homolog 1.92e-01 9.62e-03 NA
2. P P13294 Cytoplasmic envelopment protein 3 NA 1.60e-04 NA
2. P Q9H246 Uncharacterized protein C1orf21 1.93e-01 9.37e-03 NA
2. P Q9CQ22 Ragulator complex protein LAMTOR1 1.02e-01 2.15e-03 NA
2. P Q8IV56 Proline-rich protein 15 3.48e-01 6.44e-03 NA
2. P Q80XX4 Musculoskeletal embryonic nuclear protein 1 7.05e-01 3.45e-02 NA
2. P C5DII3 Altered inheritance of mitochondria protein 4 3.24e-01 1.04e-02 NA
2. P Q8WNE9 Brain and acute leukemia cytoplasmic protein 1.63e-01 4.18e-02 NA
2. P P38612 Protein C4 NA 7.21e-03 NA
2. P C6Y4C6 Uncharacterized protein C29A10.17 2.19e-01 4.35e-02 NA
2. P Q3T0D8 Ragulator complex protein LAMTOR1 5.90e-02 3.43e-03 NA
2. P Q6IAA8 Ragulator complex protein LAMTOR1 9.33e-02 4.06e-03 NA
2. P Q67621 Protein C4 NA 2.33e-03 NA
2. P Q68980 Cytoplasmic envelopment protein 3 NA 1.08e-04 NA
2. P Q920K5 Brain and acute leukemia cytoplasmic protein 3.20e-02 2.11e-03 NA
2. P P04289 Cytoplasmic envelopment protein 3 NA 7.01e-05 NA
2. P Q8VHV1 Brain and acute leukemia cytoplasmic protein 9.73e-02 2.42e-04 NA
2. P Q5R766 Ragulator complex protein LAMTOR1 1.25e-01 4.06e-03 NA