Results | PROST

Summary

A0A1B0GVS7

Homolog: Q9NV29.
Function: Transmembrane protein 100.

Statistics

Total GO Annotation: 96
Unique PROST Go: 75
Unique BLAST Go: 8

Total Homologs: 77
Unique PROST Homologs: 72
Unique BLAST Homologs: 0

Structures and Sequence Alignment

The best structural homolog that predicted by 2. P was Q9NV29 (Transmembrane protein 100) with a FATCAT P-Value: 0.00342 and RMSD of 2.70 angstrom. The sequence alignment identity is 19.0%.
Structural alignment shown in left. Query protein A0A1B0GVS7 colored as red in alignment, homolog Q9NV29 colored as blue. Query protein A0A1B0GVS7 is also shown in right top, homolog Q9NV29 showed in right bottom. They are colored based on secondary structures.

  A0A1B0GVS7 MSETELEKIKVRTAEHLENDKNNISWLKEDTQLTNAKHADEKPINAIVINS---VSDFNI---TDGPAKENPNEKKLSESSTSLSSLEECQTTFS---YL 91
      Q9NV29 M--TE-EPIK----EILGAPKAHMA-------ATMEK----SPKSEVVITTVPLVSEIQLMAATGG---------------TELSCY-RCIIPFAVVVFI 66

  A0A1B0GVS7 Q--TDTSVHHR-DTDEECASLI----LACLFCQFWDCLLMLPGTCETVCTKMCCPSRRYHHTSDENHSRNDCSCNCDMDCSLFESCHETSECLELAMEIS 184
      Q9NV29 AGIVVTAVAYSFNSH---GSIISIFGLVVLS----SGLFLLASSA--LCWKV----RQRSKKAKRRESQTALVAN---QRSLFA---------------- 134

  A0A1B0GVS7 EICYR 189
      Q9NV29 ----- 134

Go Annotations

1. PB indicates the go terms that are found by both PROST and BLAST.
2. P indicates the go terms that are found by only PROST.
3. B indicates the go terms that are only annotated by BLAST.

Source	GO	Description
1. PB	GO:0030332	cyclin binding
1. PB	GO:0060707	trophoblast giant cell differentiation
1. PB	GO:0140416	transcription regulator inhibitor activity
1. PB	GO:0030957	Tat protein binding
1. PB	GO:0140297	DNA-binding transcription factor binding
1. PB	GO:0042994	cytoplasmic sequestering of transcription factor
1. PB	GO:0043392	negative regulation of DNA binding
1. PB	GO:0009950	dorsal/ventral axis specification
1. PB	GO:0050434	positive regulation of viral transcription
1. PB	GO:0030178	negative regulation of Wnt signaling pathway
1. PB	GO:0046328	regulation of JNK cascade
1. PB	GO:0042308	negative regulation of protein import into nucleus
1. PB	GO:0030111	regulation of Wnt signaling pathway
2. P	GO:0043491	protein kinase B signaling
2. P	GO:0001570	vasculogenesis
2. P	GO:1990830	cellular response to leukemia inhibitory factor
2. P	GO:1990752	microtubule end
2. P	GO:0043409	negative regulation of MAPK cascade
2. P	GO:0015629	actin cytoskeleton
2. P	GO:0003198	epithelial to mesenchymal transition involved in endocardial cushion formation
2. P	GO:0030001	metal ion transport
2. P	GO:0030291	protein serine/threonine kinase inhibitor activity
2. P	GO:0000132	establishment of mitotic spindle orientation
2. P	GO:0001816	cytokine production
2. P	GO:0008285	negative regulation of cell population proliferation
2. P	GO:0075513	caveolin-mediated endocytosis of virus by host cell
2. P	GO:0051387	negative regulation of neurotrophin TRK receptor signaling pathway
2. P	GO:0001701	in utero embryonic development
2. P	GO:0060940	epithelial to mesenchymal transition involved in cardiac fibroblast development
2. P	GO:0031397	negative regulation of protein ubiquitination
2. P	GO:0032587	ruffle membrane
2. P	GO:0048513	animal organ development
2. P	GO:0043539	protein serine/threonine kinase activator activity
2. P	GO:0007605	sensory perception of sound
2. P	GO:0070374	positive regulation of ERK1 and ERK2 cascade
2. P	GO:0150013	negative regulation of neuron projection arborization
2. P	GO:0004860	protein kinase inhibitor activity
2. P	GO:0003197	endocardial cushion development
2. P	GO:1900025	negative regulation of substrate adhesion-dependent cell spreading
2. P	GO:0042127	regulation of cell population proliferation
2. P	GO:0043204	perikaryon
2. P	GO:0030335	positive regulation of cell migration
2. P	GO:0050848	regulation of calcium-mediated signaling
2. P	GO:0045603	positive regulation of endothelial cell differentiation
2. P	GO:0043407	negative regulation of MAP kinase activity
2. P	GO:0048471	perinuclear region of cytoplasm
2. P	GO:0061564	axon development
2. P	GO:0070373	negative regulation of ERK1 and ERK2 cascade
2. P	GO:0009898	cytoplasmic side of plasma membrane
2. P	GO:0031345	negative regulation of cell projection organization
2. P	GO:0016020	membrane
2. P	GO:0001759	organ induction
2. P	GO:0001525	angiogenesis
2. P	GO:0060842	arterial endothelial cell differentiation
2. P	GO:0001657	ureteric bud development
2. P	GO:0060437	lung growth
2. P	GO:0007219	Notch signaling pathway
2. P	GO:2001214	positive regulation of vasculogenesis
2. P	GO:0016021	integral component of membrane
2. P	GO:0033138	positive regulation of peptidyl-serine phosphorylation
2. P	GO:0007034	vacuolar transport
2. P	GO:0060541	respiratory system development
2. P	GO:0098560	cytoplasmic side of late endosome membrane
2. P	GO:0039654	fusion of virus membrane with host endosome membrane
2. P	GO:0060449	bud elongation involved in lung branching
2. P	GO:0010719	negative regulation of epithelial to mesenchymal transition
2. P	GO:0035924	cellular response to vascular endothelial growth factor stimulus
2. P	GO:0042472	inner ear morphogenesis
2. P	GO:0071773	cellular response to BMP stimulus
2. P	GO:0015630	microtubule cytoskeleton
2. P	GO:0016525	negative regulation of angiogenesis
2. P	GO:0010801	negative regulation of peptidyl-threonine phosphorylation
2. P	GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway
2. P	GO:0030509	BMP signaling pathway
2. P	GO:0034260	negative regulation of GTPase activity
2. P	GO:0019062	virion attachment to host cell
2. P	GO:0051897	positive regulation of protein kinase B signaling
2. P	GO:1902747	negative regulation of lens fiber cell differentiation
2. P	GO:0045165	cell fate commitment
2. P	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
2. P	GO:0001656	metanephros development
2. P	GO:0098559	cytoplasmic side of early endosome membrane
2. P	GO:0098574	cytoplasmic side of lysosomal membrane
2. P	GO:0051930	regulation of sensory perception of pain
2. P	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway
2. P	GO:0046580	negative regulation of Ras protein signal transduction
2. P	GO:0055036	virion membrane
2. P	GO:0060425	lung morphogenesis
3. B	GO:0008134	transcription factor binding
3. B	GO:0045893	positive regulation of transcription, DNA-templated
3. B	GO:0000122	negative regulation of transcription by RNA polymerase II
3. B	GO:0005634	nucleus
3. B	GO:0005730	nucleolus
3. B	GO:0045892	negative regulation of transcription, DNA-templated
3. B	GO:0048704	embryonic skeletal system morphogenesis
3. B	GO:0007257	obsolete activation of JUN kinase activity

Homologs

1. PB indicates the homologs that are found by both PROST and BLAST.
2. P indicates homologs that are only found by PROST.
3. B indicates homologs that are only found by BLAST.

Source	Homolog	Description	FATCAT p-val	PROST Evalue	BLAST Evalue
1. PB	Q98SK0	MyoD family inhibitor domain-containing protein	4.72e-02	4.52e-13	8.42e-08
1. PB	A0A1B0GVS7	MyoD family inhibitor domain-containing protein 2	0	1.81e-154	1.21e-137
1. PB	Q99750	MyoD family inhibitor	1.09e-01	2.52e-11	7.48e-04
1. PB	Q8BX65	MyoD family inhibitor domain-containing protein	1.16e-01	2.76e-09	9.09e-09
1. PB	Q9P1T7	MyoD family inhibitor domain-containing protein	1.03e-01	3.29e-10	2.71e-08
2. P	Q05B54	Transmembrane protein 134	4.51e-02	1.81e-05	NA
2. P	Q9NV29	Transmembrane protein 100	3.42e-03	1.97e-03	NA
2. P	P12911	Large envelope protein	NA	8.49e-05	NA
2. P	Q08E39	Protein sprouty homolog 2	2.17e-01	1.85e-02	NA
2. P	Q9QXV8	Protein sprouty homolog 2	2.24e-01	6.96e-03	NA
2. P	Q8JMY6	Large envelope protein	NA	1.61e-02	NA
2. P	A2VDU1	Protein sprouty homolog 4	1.92e-01	5.27e-06	NA
2. P	P33884	Non-structural protein NS3	NA	3.73e-02	NA
2. P	Q4R1R8	Large envelope protein	NA	1.23e-03	NA
2. P	P03138	Large envelope protein	NA	1.18e-02	NA
2. P	Q1L0X2	Protein sprouty homolog 1	1.85e-01	2.79e-08	NA
2. P	Q8CBW7	Cysteine-rich hydrophobic domain-containing protein 1	1.35e-02	3.10e-02	NA
2. P	P87745	Large envelope protein	NA	6.41e-04	NA
2. P	Q9QXV9	Protein sprouty homolog 1	2.08e-01	1.49e-04	NA
2. P	O92921	Large envelope protein	NA	1.86e-04	NA
2. P	Q54UD3	Uncharacterized transmembrane protein DDB_G0281147	6.27e-03	6.89e-03	NA
2. P	Q8L9S1	60S ribosomal protein L18a-like protein	5.06e-02	1.35e-07	NA
2. P	O43609	Protein sprouty homolog 1	1.89e-01	6.10e-06	NA
2. P	Q9QAB7	Large envelope protein	NA	8.20e-05	NA
2. P	Q6P828	Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog	3.75e-01	1.84e-04	NA
2. P	Q8R0J4	Transmembrane protein 134	5.94e-02	7.63e-04	NA
2. P	Q9QMI0	Large envelope protein	NA	1.50e-04	NA
2. P	O43597	Protein sprouty homolog 2	1.56e-01	2.10e-03	NA
2. P	Q866R9	Protein sprouty homolog 2	2.12e-01	4.15e-03	NA
2. P	Q69603	Large envelope protein	NA	8.62e-03	NA
2. P	Q99HR4	Large envelope protein	NA	2.45e-02	NA
2. P	P03143	Large envelope protein	NA	4.44e-02	NA
2. P	Q77NU1	Large envelope protein	NA	2.54e-02	NA
2. P	P17399	Large envelope protein	NA	5.47e-05	NA
2. P	P03139	Large envelope protein	NA	5.09e-04	NA
2. P	Q55GT2	Putative transmembrane protein DDB_G0267530	1.61e-02	8.62e-03	NA
2. P	A5D992	Protein sprouty homolog 1	1.77e-01	7.94e-08	NA
2. P	Q998M2	Large envelope protein	NA	8.28e-03	NA
2. P	Q9CQG9	Transmembrane protein 100	3.90e-03	4.27e-02	NA
2. P	P17397	Large envelope protein	NA	7.98e-06	NA
2. P	Q569C0	Transmembrane protein 100	8.22e-03	3.59e-02	NA
2. P	Q67875	Large envelope protein	NA	4.23e-02	NA
2. P	Q9WKC4	Large envelope protein	NA	1.76e-02	NA
2. P	Q6GLN5	NEDD4 family-interacting protein 1	4.12e-02	1.43e-03	NA
2. P	Q67926	Large envelope protein	NA	8.62e-03	NA
2. P	Q9H6X4	Transmembrane protein 134	4.36e-02	4.51e-03	NA
2. P	Q99HS3	Large envelope protein	NA	2.15e-02	NA
2. P	Q9PTL2	Protein sprouty homolog 2	2.50e-01	1.73e-07	NA
2. P	Q8JXB9	Large envelope protein	NA	2.38e-03	NA
2. P	Q80IU3	Large envelope protein	NA	1.34e-03	NA
2. P	Q4V786	NEDD4 family-interacting protein 1	5.49e-02	6.69e-04	NA
2. P	P31869	Large envelope protein	NA	2.86e-02	NA
2. P	Q998L9	Large envelope protein	NA	9.74e-05	NA
2. P	Q9NPB0	SAYSvFN domain-containing protein 1	2.64e-02	3.22e-02	NA
2. P	P03141	Large envelope protein	NA	4.89e-02	NA
2. P	Q3UUD2	Protein sprouty homolog 3	1.23e-01	3.00e-09	NA
2. P	Q8QGW7	Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog	3.41e-01	1.50e-04	NA
2. P	Q9PWW3	Large envelope protein	NA	8.32e-04	NA
2. P	P03140	Large envelope protein	NA	5.06e-03	NA
2. P	Q8BGX4	Orofacial cleft 1 candidate gene 1 protein homolog	6.95e-02	7.71e-03	NA
2. P	O43610	Protein sprouty homolog 3	1.82e-01	2.36e-07	NA
2. P	Q913A6	Large envelope protein	NA	4.17e-04	NA
2. P	P17398	Large envelope protein	NA	1.45e-04	NA
2. P	Q9WTP2	Protein sprouty homolog 4	1.18e-01	1.83e-05	NA
2. P	Q9M9A5	Protein PLANT CADMIUM RESISTANCE 6	8.25e-02	2.35e-02	NA
2. P	Q91C35	Large envelope protein	NA	2.79e-03	NA
2. P	Q9QBF0	Large envelope protein	NA	3.98e-03	NA
2. P	Q5R959	Protein sprouty homolog 2	2.05e-01	2.56e-03	NA
2. P	P24025	Large envelope protein	NA	1.86e-04	NA
2. P	Q9C004	Protein sprouty homolog 4	2.03e-01	5.67e-06	NA
2. P	P31873	Large envelope protein	NA	3.86e-03	NA
2. P	Q2PFN5	Protein sprouty homolog 2	1.74e-01	2.56e-03	NA
2. P	Q4R1S6	Large envelope protein	NA	6.15e-03	NA
2. P	P31868	Large envelope protein	NA	3.98e-03	NA
2. P	O55734	Uncharacterized protein 120L	NA	3.80e-02	NA
2. P	P16820	Uncharacterized protein UL63	NA	1.69e-03	NA
2. P	Q80IU6	Large envelope protein	NA	3.16e-03	NA