Summary
A0A1B0GVZ6
Homolog: A6NDZ8.
Function: Putative methyl-CpG-binding domain protein 3-like 4.
Statistics
Total GO Annotation: 48
Unique PROST Go: 15
Unique BLAST Go: 33
Total Homologs: 21
Unique PROST Homologs: 10
Unique BLAST Homologs: 6
Structures and Sequence Alignment
The best structural homolog that predicted by 1. PB was
A6NDZ8
(Putative methyl-CpG-binding domain protein 3-like 4) with a FATCAT P-Value: 4.13e-09 and RMSD of 2.87 angstrom. The sequence alignment identity is 96.6%.
Structural alignment shown in left. Query protein A0A1B0GVZ6 colored as red in alignment, homolog A6NDZ8 colored as blue.
Query protein A0A1B0GVZ6 is also shown in right top, homolog A6NDZ8 showed in right bottom. They are colored based on secondary structures.
A0A1B0GVZ6 MGEPAFTSFPSLPVLGKLKRNMMPWALQKKREIHMAKAHRRRAARSALPMRLTSCIFRRPVTRIRSHPDNQVRRRKGDEHLEKPQQLCAYRRLQALQPCS 100 A6NDZ8 MGEPAFTSFPSPPVLGKLKRNMMPWALQKKREIHMAKAHRRRAARSALPMRLTSCIFRRPVTRIRSHPDNQVRRRKGDEHLEKPQQLCAYRRLQALQPCS 100 A0A1B0GVZ6 SQGEGSSPLHLESVLSILAPGTAGESLDRAGAERVRSPLEPTPGRFPAVAGGPTPGMGCQLPPPLSGQLVTPADIRRQARRVKKARERLAKALQADRLAR 200 A6NDZ8 SQGEGSSPLHLESVLSILAPGTAGESLDRAGAERVRIPLEPTPGRFPAVAGGPTPGMGCQLPPPLSGQLVTPADIRRQARRVKKARERLAKALQADRLAR 200 A0A1B0GVZ6 RAEM---- 204 A6NDZ8 QAEMLTCR 208
Go Annotations
1. PB indicates the go terms that are found by both PROST and BLAST.2. P indicates the go terms that are found by only PROST.
3. B indicates the go terms that are only annotated by BLAST.
| Source | GO | Description |
|---|---|---|
| 2. P | GO:0005783 | endoplasmic reticulum |
| 2. P | GO:0003723 | RNA binding |
| 2. P | GO:0060348 | bone development |
| 2. P | GO:0001824 | blastocyst development |
| 2. P | GO:0003735 | structural constituent of ribosome |
| 2. P | GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
| 2. P | GO:0005829 | cytosol |
| 2. P | GO:0005840 | ribosome |
| 2. P | GO:0000932 | P-body |
| 2. P | GO:0022625 | cytosolic large ribosomal subunit |
| 2. P | GO:0005730 | nucleolus |
| 2. P | GO:0006412 | translation |
| 2. P | GO:0097421 | liver regeneration |
| 2. P | GO:0002181 | cytoplasmic translation |
| 2. P | GO:0022626 | cytosolic ribosome |
| 3. B | GO:0003682 | chromatin binding |
| 3. B | GO:0019904 | protein domain specific binding |
| 3. B | GO:0007420 | brain development |
| 3. B | GO:0030177 | positive regulation of Wnt signaling pathway |
| 3. B | GO:0035197 | siRNA binding |
| 3. B | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| 3. B | GO:0009888 | tissue development |
| 3. B | GO:0035563 | positive regulation of chromatin binding |
| 3. B | GO:0008327 | methyl-CpG binding |
| 3. B | GO:0007507 | heart development |
| 3. B | GO:0016573 | histone acetylation |
| 3. B | GO:0003729 | mRNA binding |
| 3. B | GO:0048568 | embryonic organ development |
| 3. B | GO:0016581 | NuRD complex |
| 3. B | GO:0001701 | in utero embryonic development |
| 3. B | GO:0003696 | satellite DNA binding |
| 3. B | GO:0042711 | maternal behavior |
| 3. B | GO:0032991 | protein-containing complex |
| 3. B | GO:0000792 | heterochromatin |
| 3. B | GO:0043044 | |
| 3. B | GO:0032355 | response to estradiol |
| 3. B | GO:0006346 | DNA methylation-dependent heterochromatin assembly |
| 3. B | GO:0000118 | histone deacetylase complex |
| 3. B | GO:0042127 | regulation of cell population proliferation |
| 3. B | GO:0071407 | cellular response to organic cyclic compound |
| 3. B | GO:0007568 | aging |
| 3. B | GO:0044030 | regulation of DNA methylation |
| 3. B | GO:0031667 | response to nutrient levels |
| 3. B | GO:0070742 | C2H2 zinc finger domain binding |
| 3. B | GO:0034622 | |
| 3. B | GO:0000785 | chromatin |
| 3. B | GO:0009612 | response to mechanical stimulus |
| 3. B | GO:0005654 | nucleoplasm |
Homologs
1. PB indicates the homologs that are found by both PROST and BLAST.
2. P indicates homologs that are only found by PROST.
3. B indicates homologs that are only found by BLAST.
| Source | Homolog | Description | FATCAT p-val | PROST Evalue | BLAST Evalue |
|---|---|---|---|---|---|
| 1. PB | Q8NHZ7 | Methyl-CpG-binding domain protein 3-like 2 | 8.76e-07 | 5.91e-84 | 1.19e-145 |
| 1. PB | A6NE82 | Putative methyl-CpG-binding domain protein 3-like 3 | 2.39e-08 | 1.92e-66 | 7.79e-144 |
| 1. PB | A6NDZ8 | Putative methyl-CpG-binding domain protein 3-like 4 | 4.13e-09 | 3.98e-61 | 8.71e-143 |
| 1. PB | A6NJ08 | Putative methyl-CpG-binding domain protein 3-like 5 | 1.22e-07 | 2.12e-63 | 7.80e-143 |
| 1. PB | A0A1B0GVZ6 | Methyl-CpG-binding domain protein 3-like 2B | 0 | 1.68e-131 | 1.26e-145 |
| 2. P | O48513 | 60S ribosomal protein L13 | 6.45e-02 | 2.84e-03 | NA |
| 2. P | P91128 | 60S ribosomal protein L13 | 8.55e-02 | 5.07e-03 | NA |
| 2. P | Q90YV5 | 60S ribosomal protein L13 | 9.92e-02 | 5.67e-03 | NA |
| 2. P | P41129 | 60S ribosomal protein L13-2 | 8.96e-02 | 2.55e-02 | NA |
| 2. P | B5X392 | Proline-rich nuclear receptor coactivator 2 | 3.12e-01 | 8.01e-03 | NA |
| 2. P | P26373 | 60S ribosomal protein L13 | 8.02e-02 | 3.87e-02 | NA |
| 2. P | P47963 | 60S ribosomal protein L13 | 8.07e-02 | 1.40e-02 | NA |
| 2. P | Q876B2 | 60S ribosomal protein L13 | 4.20e-02 | 3.21e-02 | NA |
| 2. P | P41123 | 60S ribosomal protein L13 | 1.07e-01 | 1.58e-02 | NA |
| 2. P | Q9Z313 | 60S ribosomal protein L13 | 7.97e-02 | 2.42e-02 | NA |
| 3. B | Q9UBB5 | Methyl-CpG-binding domain protein 2 | 2.38e-01 | NA | 2.67e-16 |
| 3. B | O95983 | Methyl-CpG-binding domain protein 3 | 2.10e-01 | NA | 6.10e-17 |
| 3. B | Q8WWY6 | Methyl-CpG-binding domain protein 3-like 1 | 4.51e-02 | NA | 8.39e-31 |
| 3. B | Q9D9H3 | Methyl-CpG-binding domain protein 3-like 1 | 9.89e-04 | NA | 1.28e-21 |
| 3. B | Q9Z2D8 | Methyl-CpG-binding domain protein 3 | 1.65e-01 | NA | 5.07e-17 |
| 3. B | Q9Z2E1 | Methyl-CpG-binding domain protein 2 | 4.22e-01 | NA | 6.81e-16 |