Summary

A0A2R8Y7D0

Homolog: Q54L35.
Function: NEDD8-like protein 2.

Statistics

Total GO Annotation: 60
Unique PROST Go: 56
Unique BLAST Go: 2

Total Homologs: 93
Unique PROST Homologs: 89
Unique BLAST Homologs: 3

Structures and Sequence Alignment

The best structural homolog that predicted by 2. P was Q54L35 (NEDD8-like protein 2) with a FATCAT P-Value: 2.95e-11 and RMSD of 1.31 angstrom. The sequence alignment identity is 15.1%.
Structural alignment shown in left. Query protein A0A2R8Y7D0 colored as red in alignment, homolog Q54L35 colored as blue. Query protein A0A2R8Y7D0 is also shown in right top, homolog Q54L35 showed in right bottom. They are colored based on secondary structures. 

  A0A2R8Y7D0 ME-GLR---RGLSRWKRYHIKVHLADEALLLPLTVRPRDTLSDL-RAQL-VGQGVSSWKRAFYYNARRLDDHQTVRDARLQDGSVLLLVSDPSEAQRLTP 94
      Q54L35 MNINLQFHSTG----KRTELNF---DE------T----DKI-ELIKNSIRIMEGINPQEQKLIFDGKVLKDTSTLKSCGIKDGSTISVLFEKS-SNFLK- 80

  A0A2R8Y7D0 AIPALWEAEASRSLESRSSRPAWPTW 120
      Q54L35 -------------------------- 80

Go Annotations

1. PB indicates the go terms that are found by both PROST and BLAST.
2. P indicates the go terms that are found by only PROST.
3. B indicates the go terms that are only annotated by BLAST.
Source GO Description
1. PB GO:0043066 negative regulation of apoptotic process
1. PB GO:0005654 nucleoplasm
2. P GO:0050905 neuromuscular process
2. P GO:0030162 regulation of proteolysis
2. P GO:0034045 phagophore assembly site membrane
2. P GO:0071569 protein ufmylation
2. P GO:1900180 regulation of protein localization to nucleus
2. P GO:0030431 sleep
2. P GO:0070449 elongin complex
2. P GO:0044389 ubiquitin-like protein ligase binding
2. P GO:0031466 Cul5-RING ubiquitin ligase complex
2. P GO:0007420 brain development
2. P GO:0000422 autophagy of mitochondrion
2. P GO:0019789 SUMO transferase activity
2. P GO:0006357 regulation of transcription by RNA polymerase II
2. P GO:0005762 mitochondrial large ribosomal subunit
2. P GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide
2. P GO:0042308 negative regulation of protein import into nucleus
2. P GO:0005667 transcription regulator complex
2. P GO:0006368 transcription elongation from RNA polymerase II promoter
2. P GO:0033146 regulation of intracellular estrogen receptor signaling pathway
2. P GO:0006501 C-terminal protein lipidation
2. P GO:0042203 toluene catabolic process
2. P GO:0045116 protein neddylation
2. P GO:0031625 ubiquitin protein ligase binding
2. P GO:0003713 transcription coactivator activity
2. P GO:0016605 PML body
2. P GO:0031386 protein tag
2. P GO:0043392 negative regulation of DNA binding
2. P GO:2000736 regulation of stem cell differentiation
2. P GO:0001650 fibrillar center
2. P GO:0008589 regulation of smoothened signaling pathway
2. P GO:0034976 response to endoplasmic reticulum stress
2. P GO:0018645 alkene monooxygenase activity
2. P GO:0036099 female germ-line stem cell population maintenance
2. P GO:0005761 mitochondrial ribosome
2. P GO:0051438 regulation of ubiquitin-protein transferase activity
2. P GO:0016567 protein ubiquitination
2. P GO:0005783 endoplasmic reticulum
2. P GO:0061709 reticulophagy
2. P GO:1990592 protein K69-linked ufmylation
2. P GO:0045879 negative regulation of smoothened signaling pathway
2. P GO:0008104 protein localization
2. P GO:0019941 modification-dependent protein catabolic process
2. P GO:0005634 nucleus
2. P GO:0006914 autophagy
2. P GO:0032543 mitochondrial translation
2. P GO:0030891 VCB complex
2. P GO:0034274 Atg12-Atg5-Atg16 complex
2. P GO:0016925 protein sumoylation
2. P GO:0016604 nuclear body
2. P GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process
2. P GO:0000045 autophagosome assembly
2. P GO:0014070 response to organic cyclic compound
2. P GO:0034504 protein localization to nucleus
2. P GO:0031462 Cul2-RING ubiquitin ligase complex
2. P GO:0050830 defense response to Gram-positive bacterium
2. P GO:0044804 autophagy of nucleus
3. B GO:0008284 positive regulation of cell population proliferation
3. B GO:0005789 endoplasmic reticulum membrane

Homologs

1. PB indicates the homologs that are found by both PROST and BLAST.
2. P indicates homologs that are only found by PROST.
3. B indicates homologs that are only found by BLAST.

Source Homolog Description FATCAT p-val PROST Evalue BLAST Evalue
1. PB A0A2R8Y7D0 Ubiquitin domain-containing protein TINCR 0 9.90e-121 7.00e-82
2. P A8DYH2 Ubiquitin-fold modifier 1 2.59e-05 2.21e-03 NA
2. P Q9LVK3 Ubiquitin-like protein ATG12B 2.19e-04 4.07e-02 NA
2. P Q4R4I2 Ubiquitin-fold modifier 1 3.07e-05 2.11e-04 NA
2. P Q15843 NEDD8 5.22e-10 2.42e-05 NA
2. P B9ENM6 Ubiquitin-fold modifier 1 7.29e-05 8.94e-15 NA
2. P Q54L35 NEDD8-like protein 2 2.95e-11 1.31e-03 NA
2. P Q32KX9 UPF0538 protein C2orf76 homolog 1.82e-04 5.23e-05 NA
2. P Q5ZMK7 Ubiquitin-fold modifier 1 3.63e-05 2.86e-04 NA
2. P Q15370 Elongin-B 2.75e-06 1.76e-04 NA
2. P P62868 Ubiquitin-like protein FUBI 4.14e-09 3.06e-04 NA
2. P Q9ZET6 Alkene monooxygenase system, oxygenase component subunit gamma 1.75e-05 2.00e-03 NA
2. P Q9CA23 Ubiquitin-fold modifier 1 4.11e-05 2.37e-04 NA
2. P Q17QV3 Small ubiquitin-related modifier 3 4.46e-08 1.05e-02 NA
2. P A8D888 Ubiquitin-fold modifier 1 4.49e-05 9.43e-12 NA
2. P P61960 Ubiquitin-fold modifier 1 3.05e-05 2.11e-04 NA
2. P Q5YKI7 Putative gametogenetin-binding protein 1 4.05e-03 3.54e-12 NA
2. P Q00457 Toluene-4-monooxygenase system, hydroxylase component subunit gamma 1.59e-06 3.41e-03 NA
2. P B5LVL2 Ubiquitin-fold modifier 1 4.53e-05 3.94e-04 NA
2. P P61961 Ubiquitin-fold modifier 1 3.46e-05 2.11e-04 NA
2. P Q54TK0 NEDD8-like protein 1 1.46e-08 3.12e-09 NA
2. P Q8GWJ6 Membrane-anchored ubiquitin-fold protein 6 4.30e-05 2.00e-12 NA
2. P B3H5R8 Putative small ubiquitin-related modifier 8 1.74e-06 6.04e-05 NA
2. P A2YAG8 Ubiquitin-like protein ATG12 2.68e-04 1.57e-04 NA
2. P B5FWC0 39S ribosomal protein L23, mitochondrial 3.64e-02 6.22e-05 NA
2. P P55812 Ubiquitin-like protein FUBI 4.06e-09 8.01e-05 NA
2. P Q8LCS8 Membrane-anchored ubiquitin-fold protein 2 3.38e-05 1.57e-10 NA
2. P Q5XIF4 Small ubiquitin-related modifier 3 1.16e-06 3.26e-12 NA
2. P Q53H64 Putative ANKRD40 C-terminal-like protein 5.88e-05 1.61e-10 NA
2. P B3DL37 Ubiquitin-fold modifier 1 2.81e-05 1.13e-03 NA
2. P P35544 Ubiquitin-like protein FUBI 5.98e-09 1.12e-03 NA
2. P Q9VJ33 NEDD8 5.66e-10 1.12e-05 NA
2. P P35545 Ubiquitin-like protein FUBI 3.89e-09 3.06e-04 NA
2. P Q7XRU4 Membrane-anchored ubiquitin-fold protein 4 1.37e-05 8.50e-04 NA
2. P Q63750 39S ribosomal protein L23, mitochondrial 1.36e-01 1.07e-04 NA
2. P C1BJ98 Ubiquitin-fold modifier 1 4.50e-05 3.97e-08 NA
2. P Q803Y4 Ubiquitin-fold modifier 1 8.03e-05 6.80e-07 NA
2. P Q05120 Ubiquitin-like protein NA 9.41e-08 NA
2. P Q9FLP6 Small ubiquitin-related modifier 2 3.09e-07 1.17e-06 NA
2. P Q2KJG2 Ubiquitin-fold modifier 1 3.15e-05 9.04e-05 NA
2. P Q16540 39S ribosomal protein L23, mitochondrial 4.81e-02 8.89e-03 NA
2. P Q5RBS7 UPF0538 protein C2orf76 homolog 2.26e-04 4.78e-05 NA
2. P Q5RJW4 Ubiquitin-fold modifier 1 2.84e-05 1.13e-03 NA
2. P Q05474 Ubiquitin-like protein FUBI 3.90e-09 9.32e-05 NA
2. P P62865 Ubiquitin-like protein FUBI 2.09e-09 1.91e-05 NA
2. P P29595 NEDD8 7.60e-10 1.20e-06 NA
2. P Q5I132 Uncharacterized protein M4 NA 3.02e-02 NA
2. P Q6DJH5 UPF0538 protein C2orf76 homolog 2.57e-04 2.01e-04 NA
2. P Q9LSD8 Membrane-anchored ubiquitin-fold protein 4 4.78e-06 2.59e-13 NA
2. P Q9Z172 Small ubiquitin-related modifier 3 1.45e-06 1.67e-11 NA
2. P Q9SW27 Membrane-anchored ubiquitin-fold protein 3 1.31e-05 1.21e-13 NA
2. P Q6IQS9 39S ribosomal protein L23, mitochondrial 5.20e-02 1.10e-02 NA
2. P Q9Z2M6 Ubiquitin-like protein 3 3.09e-05 8.49e-10 NA
2. P Q5BJP3 Ubiquitin-fold modifier 1 3.02e-05 1.04e-03 NA
2. P Q3E8A8 Putative small ubiquitin-related modifier 7 2.43e-08 4.27e-05 NA
2. P Q9Y7L9 Uncharacterized protein C685.08 6.18e-05 2.27e-02 NA
2. P Q9FLP5 Small ubiquitin-related modifier 3 1.44e-06 4.26e-08 NA
2. P Q60435 Ubiquitin-like protein FUBI 5.13e-09 2.92e-03 NA
2. P P62869 Elongin-B 2.78e-06 2.86e-05 NA
2. P P62870 Elongin-B 2.80e-06 2.86e-05 NA
2. P Q09JK2 Ubiquitin-fold modifier 1 4.87e-05 9.04e-05 NA
2. P Q9CRW3 UPF0538 protein C2orf76 homolog 2.32e-04 2.88e-04 NA
2. P Q9W021 39S ribosomal protein L23, mitochondrial 6.68e-03 6.75e-05 NA
2. P Q9SH14 Membrane-anchored ubiquitin-fold protein 5 2.25e-05 1.70e-12 NA
2. P Q54R16 UPF0538 protein 1.16e-04 2.72e-04 NA
2. P Q5R4N5 Ubiquitin-fold modifier 1 3.07e-05 2.11e-04 NA
2. P P55854 Small ubiquitin-related modifier 3 2.32e-07 6.62e-03 NA
2. P P61282 NEDD8 5.31e-10 2.42e-05 NA
2. P Q9MAB9 Membrane-anchored ubiquitin-fold protein 1 2.70e-05 4.55e-09 NA
2. P Q2TA46 Ubiquitin-like protein 3 3.77e-05 5.45e-11 NA
2. P A4IGN3 UPF0538 protein C2orf76 homolog 2.87e-04 5.11e-04 NA
2. P Q75GT2 Membrane-anchored ubiquitin-fold protein 1 1.30e-05 6.45e-11 NA
2. P Q69NP0 Ubiquitin-like protein ATG12 3.39e-04 1.57e-04 NA
2. P Q6Z8K4 Membrane-anchored ubiquitin-fold protein 3 2.55e-05 1.82e-12 NA
2. P Q67UI2 Membrane-anchored ubiquitin-fold protein 2 1.30e-05 7.78e-10 NA
2. P O35972 39S ribosomal protein L23, mitochondrial 8.31e-02 5.85e-04 NA
2. P Q04353 Uncharacterized protein CA_C3711 3.34e-05 6.51e-06 NA
2. P A5DWI6 Autophagy-related protein 8 4.79e-04 6.10e-05 NA
2. P Q3KRA6 UPF0538 protein C2orf76 2.20e-04 1.41e-05 NA
2. P Q4PLJ0 NEDD8 5.39e-10 2.42e-05 NA
2. P Q5TUE9 Probable 39S ribosomal protein L23, mitochondrial 4.23e-03 1.21e-02 NA
2. P Q6L0P8 30S ribosomal protein S24e 1.21e-01 4.63e-02 NA
2. P Q5BJT2 Ubiquitin-like protein 3 3.12e-05 8.49e-10 NA
2. P Q7PXE2 Ubiquitin-fold modifier 1 3.45e-05 1.61e-03 NA
2. P Q66IB8 UPF0538 protein C2orf76 homolog 2.08e-04 2.29e-06 NA
2. P P0C2F1 Ubiquitin-like protein FUBI 2.04e-09 2.80e-05 NA
2. P O95164 Ubiquitin-like protein 3 2.92e-05 5.45e-11 NA
2. P O14037 UPF0538 protein C2C4.04c 4.88e-04 1.38e-02 NA
2. P B8I7Y1 50S ribosomal protein L23 1.47e-01 1.68e-02 NA
2. P Q71UE8 NEDD8 6.79e-10 1.20e-06 NA
3. B Q96CB5 Putative uncharacterized protein C8orf44 2.67e-01 NA 2.72e-07
3. B Q9P1C3 Putative uncharacterized protein PRO2829 1.75e-02 NA 7.92e-06
3. B Q9NRJ1 Protein MOST-1 3.05e-01 NA 2.34e-05