Summary
Structures and Sequence Alignment
The best structural homolog that predicted by 1. PB was
Q8CFV2
(Protein FAM149A) with a FATCAT P-Value: 0.000378 and RMSD of 18.73 angstrom. The sequence alignment identity is 63.0%.
Structural alignment shown in left. Query protein A5PLN7 colored as red in alignment, homolog Q8CFV2 colored as blue.
Query protein A5PLN7 is also shown in right top, homolog Q8CFV2 showed in right bottom. They are colored based on secondary structures.
A5PLN7 MKAAVLDLGSLLAKLFETSTAPPAGPSSRPSGGAAAAGSGGSRAGTPLG---TAPTLLRALAPDSPSASRR--SP--APL-LSSPYSRGSAAS-R--AAG 89 Q8CFV2 MKVAVLDLGSLFAKIFKLSTASPA-VSSHP-GGAAATGSVDSGASTSLREAETL-TLLPSLPPDT-AASREPFTPVHTPLPASHP--RSSAAAQRVEATG 94 A5PLN7 AVGTLLSWPSSPRAGKAPPQPP-TP-SG-GGCSPARLVVPARP-------PS-----GPGGVWAALPRNP--LQPGPGERELGACVAPGAGPRTLFLTLP 172 Q8CFV2 CSGSL---PSS--SG-ASIAPPLTPYSGSAG-SVASVTLPS-PGVDWATLPSVTIPLGSNSVTASSPRNPRQLR-APGEREPSVWMAPGPVPKTLFFTLP 185 A5PLN7 DIGEEGASDGDS-GDGEARGLSEGRRRHGFTVRSKDSLPTHFTRNVQKAIDKYTCKSLSSFSSSGSHTPTGAHTSWSGSATQSSTTGSSTERGSVYSWRD 271 Q8CFV2 DIGEEWTSDSDSQDDPEGRGLSEGLRKQS-SEKSKDPLPTNFTRNVQKAIDKFASESPSSFSSSGSRTPTEAHNSWPGSSTQSSTTGLSTERSSVSSWRD 284 A5PLN7 DEFDEASSQSVQRLLWEVEEMLFEGKVNPQTQSLLAECGEWTRRSLHLRVLGRQLILPTDKGVQHFQGSTPASAVHR--P--PLSACGHSSNIRELCISG 367 Q8CFV2 DEFDKVSAQKVHQLFWEVEELLFEGKVSPQTQNLLAECSEWARRSLHLRVVGRQLVPPTDEGFQHFQGSLPSSATHEALPHVP----DHTSSSRELCISG 380 A5PLN7 SQIVPAALSASALPGPDDTGVADLTARSSLEEEVYHVDGKIEEYFAFDRKEDDDECLEQKPAQPGRKWRKLGLPPVSPRDCVKDAVAAEVFDHVWTNMVE 467 Q8CFV2 SQIVPEVHSASALTDPDGTESADLTSCSSLKEEVYHVDGNIEEYFAFDRKQDGDEHLGQSPALRGRKRHRHGLPPISPDDCIRDAVAAEVFDHVWTNVVE 480 A5PLN7 LLEELIRKHWETTLTEGKKQRETLKVAGNRFPHVLVPHAHADGASGPPSGHAEAHGISLASRLNP---PQIHHFSSSFYSDMNGVMTIQAKPLQRRPAYF 564 Q8CFV2 ILEDLIRKTWESALTGGKKHKEKLKVAENRSPHVLMSRLSTDVCSVPPSRSSDTLQPSLAPHFNPPQFPQLHRFSSNFYSDLSGVMTIQAKPLQQRPTYS 580 A5PLN7 ADRTQNEKEDKASGGGAGALSSAPHRLGRASDTHGLSPSAKKTPVPWRLPSLASDSQRLKTPNIYSDEVLRGTKLPTGVDHMASP-LVQTSRSRFPPLVT 663 Q8CFV2 ADRTQNDQDDKLPGGGVGA--SSRHRLGRILDARGPQTSVKKTPVHRRLPSIASDPQRLKTPTVYSDEILRGTKLQTGIDYLPSPAAVQTSRSRLPPIGS 678 A5PLN7 ETRGQ-NTAVPGCRLVSYRGRHLQNRVLSAMPDGTERSRLRERTATLERLSRPSTTHTFRQSDTPRKSSLTQMEFAAHTWTGQSILTGSQYVPKSFQRTT 762 Q8CFV2 ET-GEPNTAASGSRPVSYRGRHPQSRVFSAMPDSIERSPLRERTIVLEQLSRPSTTHTFR-SDTPRKGSLTPVEFVAHTWTGQSILTGSQYLPKSYQRAT 776 A5PLN7 LTFKRRFQVTS 773 Q8CFV2 LTARKRFQVAS 787
Go Annotations
1. PB indicates the go terms that are found by both PROST and BLAST.2. P indicates the go terms that are found by only PROST.
3. B indicates the go terms that are only annotated by BLAST.
| Source | GO | Description |
|---|---|---|
| 3. B | GO:0005929 | cilium |
| 3. B | GO:0061512 | protein localization to cilium |
| 3. B | GO:0060271 | cilium assembly |
Homologs
1. PB indicates the homologs that are found by both PROST and BLAST.
2. P indicates homologs that are only found by PROST.
3. B indicates homologs that are only found by BLAST.
| Source | Homolog | Description | FATCAT p-val | PROST Evalue | BLAST Evalue |
|---|---|---|---|---|---|
| 1. PB | Q8CFV2 | Protein FAM149A | 3.78e-04 | 2.13e-29 | 0.0 |
| 1. PB | A5PLN7 | Protein FAM149A | 0 | 5.28e-135 | 0.0 |
| 2. P | Q6AXX2 | Uncharacterized protein C16orf46 homolog | 4.67e-01 | 3.51e-02 | NA |
| 3. B | Q96BN6 | Primary cilium assembly protein FAM149B1 | 8.25e-03 | NA | 1.30e-31 |
| 3. B | A1L253 | Protein FAM149B1 | 9.57e-02 | NA | 2.65e-50 |
| 3. B | Q5PQL8 | Primary cilium assembly protein FAM149B1 | 7.09e-02 | NA | 7.02e-28 |
| 3. B | A0JNF3 | Primary cilium assembly protein FAM149B1 | 9.36e-02 | NA | 4.43e-30 |
| 3. B | Q6NSV7 | Primary cilium assembly protein FAM149B1 | 1.54e-02 | NA | 1.75e-34 |