Summary

A6NE01

Homolog: A6NEY3.
Function: Putative golgin subfamily A member 6-like protein 3.

Statistics

Total GO Annotation: 97
Unique PROST Go: 82
Unique BLAST Go: 12

Total Homologs: 82
Unique PROST Homologs: 71
Unique BLAST Homologs: 9

Structures and Sequence Alignment

The best structural homolog that predicted by 2. P was A6NEY3 (Putative golgin subfamily A member 6-like protein 3) with a FATCAT P-Value: 0.0289 and RMSD of 3.52 angstrom. The sequence alignment identity is 6.9%.
Structural alignment shown in left. Query protein A6NE01 colored as red in alignment, homolog A6NEY3 colored as blue. Query protein A6NE01 is also shown in right top, homolog A6NEY3 showed in right bottom. They are colored based on secondary structures. 

  A6NE01 MFFKMKNEIDNDPESEKCIKDSTIMRREPQNILSPLMLPNLEIPFSVKDIISRIERAQLHRAREDIDMQLSEIMNNVHRIMTRYTLVFNSSSERNVSLTE 100
  A6NEY3 ---------------------------------------------------------------------------------------------------- 0

  A6NE01 HKKKQRTNFLEKMATYAKTIEIREKTLANILAWLEEWNDVLSEMTLMDVDEHHHWIAQMELLPDTLKAIENNVKILSRFSTSFLDEKKKQKKKILSRGTL 200
  A6NEY3 ---------------------------------------------------------------------------------------------------- 0

  A6NE01 WKSWKERVIKRPSTARALRPDQMISDQLATNTKVSEIQGMLQELIGTTMFSTLENNAIKYISSTIVNLSTALSMLNDELKCVNFQSSTVYAHETSEAEKE 300
  A6NEY3 ---------------------------------------------------------------------------------------------------- 0

  A6NE01 LSLKIIRDLSNENEMLQQKLQDAEEKCEQLIRSKIVIEQLYAKLSTSSTLKVLPGPSPQSSRAIIKVGDTEDNMDNILDKELENIVDEVQRKETKDSGIK 400
  A6NEY3 ---------------------------------------------------------------------------------------------------- 0

  A6NE01 WDSTISYTAQAERTPDLTELRQQPVASEDISEDSTKDNVSLKKGDFYQEDETDEYQSWKRSHKKATYVYETSGPNLSDNKSGQKVSEAKPSQYYELQVLK 500
  A6NEY3 -------------------------------------------------------------------MWPQ--PRLPPHPA---MSE-K-TQQGKLAAAK 26

  A6NE01 KKRKEMKSFSEDKSKS-PTEAKR-KHL--SLTETKSQGGKSGTSMMMLEQFRKVKRESPFDKRPTA--AEIKVEPTTESLDKEGKGEIRSLVEPLSMIQF 594
  A6NEY3 KK---LKAYWQRKSPGIPAGANRKKKINGSSPDTATSGG-----------YH-----SPGD-SATGIYGEGRASSTT--LE-----DLESQYQELA-VAL 98

  A6NE01 DDTAEPQKGKIKGKKHHISSGTITSKEEKTEEKEELTKQVKSHQLVKSLSR-VAK---ETSESTRVL--ESPDGKSEQSNLEEFQEAIMAFLKQKIDNIG 688
  A6NEY3 DSSSAI----ISQLTENINSLVRTSKEEK---KHEI------H-LVQKLGRSLFKLKNQTAEP---LAPEPPAG---PSKVEQLQDE-TNHLRKELESVG 177

  A6NE01 KAFDKKTVPKEEELLKRAEAEK---LGIIKAKMEEYFQKVAETVTKILRKYKDTKKEEQVGEKPIKQKKVVSFMPGLHFQKSPISAKSESSTLLSYESTD 785
  A6NEY3 R-----------QL--QAEVENNQMLSLLNRRQEERLREQEER----LR-----EQEERLRE---QEERLCE-------QEERLREQEER--LREQEER- 242

  A6NE01 PVINNLIQMILAEIESERDIPTVSTVQKDHKEK--EKQRQEQYLQEGQEQMSGMSLKQQLLGERNLLKEHYEKISENWEEKKAWLQMKEGK-QEQQSQKQ 882
  A6NEY3 ----------LCEQE-ER-L-------REHEERLCE---QEERLCE-QEE----RLREQ--EER--LHEQEERLCEQ-EER---LREQEERLCEQEERLR 307

  A6NE01 WQEEEMWKEEQKQATPKQAEQ-EEKQKQRGQEE--EELPKSSLQRLE-EGTQKMKTQGLLLEKENGQMRQIQKEAKHLGPHRRREKGKEKQKPERGLEDL 978
  A6NEY3 EQEERLCEQEER--LREQEERLCEQEKLPGQERLLEEVEK--L--LEQE--RRQEEQERLLERE----RLLEEVEKLLEQERRQE---EQ---ER-L--L 386

  A6NE01 ERQIKTKDQMQMKETQPKELEKMVIQTPMTLSPR-WKS-VLKDVQRSYEGKEFQRNLKTL--ENLPDEKEPISITPPPSLQYSLPGALPISG-QPLTKCI 1073
  A6NEY3 ERE-ELLDEVE--EL----LEQERLRQQ---DERLWQQETLQELERL---RELERMLE-LGWEALYEQR-----------------AEPRSGFEELVRC- 454

  A6NE01 HLTPQQAQEVGITLTPQQAQAQGITLTLQQAQELGIPLTPQQAQALEILFTPQQAQALGIPLTPQQTQVQGITLTPQQDQAPGISLTTQQAQKLGIPLTP 1173
  A6NEY3 ---PTWG---GCPL-P------------------------------------------------------------------------------------ 463

  A6NE01 QQAQALGIPLTPQQAQELGIPLTPQQAQALRVSLTPQQAQELGIPLTPQQAQALGITLTLQQAQQLGIPLTPQQAQALGITLTPKQVQELGIPLTPQQAQ 1273
  A6NEY3 ---------------------------------------------------------------------------------------------------- 463

  A6NE01 ALGITLTPKQAQELGIPLNPQQAQTLGIPLTPKQAQALGIPFTPQQAQALGIPLTPQQAQTQEITLTPQQAQALGMPLTTQQAQELGIPLTPQHAQALGM 1373
  A6NEY3 ---------------------------------------------------------------------------------------------------- 463

  A6NE01 PLTTQQAQELGIPLTPQQAQALGMPLTTQQAQELGIPLTPQQAQELGIPFTPQQAQAQEITLTPQQAQALGMPLTAQQAQELGITLTPQQAQELGIPLTP 1473
  A6NEY3 ---------------------------------------------------------------------------------------------------- 463

  A6NE01 QQAQALGIPLIPPQAQELGIPLTPQQAQALGILLIPPQAQELGIPLTPQQAQALGIPLIPPQAQELGIPLTPQQVQALGIPLIPPQAQELEIPLTPQQAQ 1573
  A6NEY3 ---------------------------------------------------------------------------------------------------- 463

  A6NE01 ALGIPLTPQQAQELGIPLTPQQAQELGIPLTPQQAQAQGIPLTPQQAQALGISLTPQQAQAQGITLTPQQAQALGVPITPVNAWVSAVTLTSEQTHALES 1673
  A6NEY3 ---------------------------------------------------------------------------------------------------- 463

  A6NE01 PMNLEQAQEQLLKLGVPLTLDKAHTLGSPLTLKQVQWSHRPFQKSKASLPTGQSIISRLSPSLRLSLASSAPTAEKSSIFGVSSTPLQISRVPLNQGPFA 1773
  A6NEY3 ---------------------------------------------------------------------------------------------------- 463

  A6NE01 PGKPLEMGILSEPGKLGAPQTLRSSGQTLVYGGQSTSAQFPAPQAPPSPGQLPISRAPPTPGQPFIAGVPPTSGQIPSLWAPLSPGQPLVPEASSIPGDL 1873
  A6NEY3 ---------------------------------------------------------------------------------------------------- 463

  A6NE01 LESGPLTFSEQLQEFQPPATAEQSPYLQAPSTPGQHLATWTLPGRASSLWIPPTSRHPPTLWPSPAPGKPQKSWSPSVAKKRLAIISSLKSKSVLIHPSA 1973
  A6NEY3 ---------------------------------------------------------------------------------------------------- 463

  A6NE01 PDFKVAQVPFTTKKFQMSEVSDTSEETQILRDTFAIESFRTFQSHFTKYRTPVYQTPYTDERALLTLMKPTTSPSSLTTLLRTSQISPLEWYQKSRFPPI 2073
  A6NEY3 ---------------------------------------------------------------------------------------------------- 463

  A6NE01 DKPWILSSVSDTKKPKVMVPPSSPQELEEKRYFVDVEAQKKNLILLNQAIKTCGLPSQLHTMARTLIIEILHMDTVQLGYLFRKYIAYRLIQHARNNIMK 2173
  A6NEY3 ---------------------------------------------------------------------------------------------------- 463

  A6NE01 RLKAIQNTGKGYEARNLHMMLSRLDDYGKKVMQVWTEKQKSLGQKRNQCLKKMIHVFNQLKKIHELNLSQPIPLIIEEKQIPASTTFVQKPFLKLLMEED 2273
  A6NEY3 ---------------------------------------------------------------------------------------------------- 463

  A6NE01 RTSDICKKFRQQEDQTEAIWNVDLSTSSYPIAEKTSMHSLWAQLGGYPDIPRLLQLEVQSTFRKSLASLQSRVKKIPK 2351
  A6NEY3 ------------------------------------------------------------------------------ 463

Go Annotations

1. PB indicates the go terms that are found by both PROST and BLAST.
2. P indicates the go terms that are found by only PROST.
3. B indicates the go terms that are only annotated by BLAST.
Source GO Description
1. PB GO:0046914 transition metal ion binding
1. PB GO:0010339 external side of cell wall
1. PB GO:0001533 cornified envelope
2. P GO:0005213 structural constituent of egg chorion
2. P GO:0044853 plasma membrane raft
2. P GO:2000781 positive regulation of double-strand break repair
2. P GO:0051656 establishment of organelle localization
2. P GO:0008275 gamma-tubulin small complex
2. P GO:0019226 transmission of nerve impulse
2. P GO:0030216 keratinocyte differentiation
2. P GO:0005874 microtubule
2. P GO:0043202 lysosomal lumen
2. P GO:0005654 nucleoplasm
2. P GO:0016358 dendrite development
2. P GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress
2. P GO:0045095 keratin filament
2. P GO:0005796 Golgi lumen
2. P GO:0000923 equatorial microtubule organizing center
2. P GO:1900006 positive regulation of dendrite development
2. P GO:0061436 establishment of skin barrier
2. P GO:0033172 gas vesicle shell
2. P GO:0031297 replication fork processing
2. P GO:0000128 flocculation
2. P GO:0034237 protein kinase A regulatory subunit binding
2. P GO:0007306 eggshell chorion assembly
2. P GO:0005540 hyaluronic acid binding
2. P GO:0045179 apical cortex
2. P GO:0007304 chorion-containing eggshell formation
2. P GO:0000226 microtubule cytoskeleton organization
2. P GO:0050902 leukocyte adhesive activation
2. P GO:0007020 microtubule nucleation
2. P GO:0008544 epidermis development
2. P GO:1902465 negative regulation of histone H3-K27 trimethylation
2. P GO:0031114 regulation of microtubule depolymerization
2. P GO:0008582 regulation of synaptic assembly at neuromuscular junction
2. P GO:0009986 cell surface
2. P GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation
2. P GO:0050900 leukocyte migration
2. P GO:0050769 positive regulation of neurogenesis
2. P GO:0031412 gas vesicle organization
2. P GO:0060106 cortical layer of collagen and cuticulin-based cuticle extracellular matrix
2. P GO:0042600 egg chorion
2. P GO:0110148 biomineralization
2. P GO:0050825 ice binding
2. P GO:0043014 alpha-tubulin binding
2. P GO:0035686 sperm fibrous sheath
2. P GO:0018149 peptide cross-linking
2. P GO:0048730 epidermis morphogenesis
2. P GO:0050901 leukocyte tethering or rolling
2. P GO:0070062 extracellular exosome
2. P GO:0033234 negative regulation of protein sumoylation
2. P GO:0000931 gamma-tubulin large complex
2. P GO:0048599 oocyte development
2. P GO:0000922 spindle pole
2. P GO:0051258 protein polymerization
2. P GO:0031424 keratinization
2. P GO:0106333 subcortical maternal complex
2. P GO:0032290 peripheral nervous system myelin formation
2. P GO:0042302 structural constituent of cuticle
2. P GO:0018153 isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine
2. P GO:0007288 sperm axoneme assembly
2. P GO:1905168 positive regulation of double-strand break repair via homologous recombination
2. P GO:0000930 gamma-tubulin complex
2. P GO:0005813 centrosome
2. P GO:0043015 gamma-tubulin binding
2. P GO:0036457 keratohyalin granule
2. P GO:0043484 regulation of RNA splicing
2. P GO:0007088 regulation of mitotic nuclear division
2. P GO:0097228 sperm principal piece
2. P GO:0110143 magnetosome
2. P GO:0005829 cytosol
2. P GO:0032287 peripheral nervous system myelin maintenance
2. P GO:0030280 structural constituent of skin epidermis
2. P GO:0040019 positive regulation of embryonic development
2. P GO:0010224 response to UV-B
2. P GO:0001931 uropod
2. P GO:0071933 Arp2/3 complex binding
2. P GO:0008088 axo-dendritic transport
2. P GO:0039644 suppression by virus of host NF-kappaB cascade
2. P GO:0005577 fibrinogen complex
2. P GO:0060052 neurofilament cytoskeleton organization
2. P GO:1990393 3M complex
2. P GO:0008355 olfactory learning
2. P GO:0005938 cell cortex
2. P GO:0060491 regulation of cell projection assembly
3. B GO:0052795 exo-alpha-(2->6)-sialidase activity
3. B GO:0008152 metabolic process
3. B GO:0048471 perinuclear region of cytoplasm
3. B GO:0098631 cell adhesion mediator activity
3. B GO:0052794 exo-alpha-(2->3)-sialidase activity
3. B GO:0052026 modulation by symbiont of host transcription
3. B GO:0052796 exo-alpha-(2->8)-sialidase activity
3. B GO:0030425 dendrite
3. B GO:0031225 anchored component of membrane
3. B GO:0045211 postsynaptic membrane
3. B GO:0034053 modulation by symbiont of host defense-related programmed cell death
3. B GO:0031362 anchored component of external side of plasma membrane

Homologs

1. PB indicates the homologs that are found by both PROST and BLAST.
2. P indicates homologs that are only found by PROST.
3. B indicates homologs that are only found by BLAST.

Source Homolog Description FATCAT p-val PROST Evalue BLAST Evalue
1. PB Q9D9R9 Protein FAM186A 4.62e-02 4.33e-06 6.34e-91
1. PB A6NE01 Protein FAM186A 0 1.18e-172 0.0
2. P P18170 Defective chorion-1 protein, FC106 isoform 3.46e-01 1.69e-02 NA
2. P P60411 Keratin-associated protein 10-9 9.68e-01 3.27e-02 NA
2. P Q08696 Axoneme-associated protein mst101(2) 2.17e-01 9.44e-04 NA
2. P Q62170 P-selectin glycoprotein ligand 1 8.74e-01 1.01e-02 NA
2. P Q09550 Uncharacterized protein F26C11.3 9.32e-01 2.01e-02 NA
2. P Q9QR71 Protein LANA1 NA 1.55e-05 NA
2. P Q2W8Q7 Magnetosome-associated protein MamJ 9.94e-01 7.26e-03 NA
2. P P26371 Keratin-associated protein 5-9 1.00e+00 4.83e-02 NA
2. P O88492 Perilipin-4 5.80e-01 2.53e-04 NA
2. P Q5UQP8 Uncharacterized protein L454 NA 1.01e-07 NA
2. P Q9UBC9 Small proline-rich protein 3 9.70e-01 4.55e-02 NA
2. P Q6XPR3 Repetin 9.62e-01 2.86e-05 NA
2. P P26694 Circumsporozoite protein 9.55e-01 1.38e-03 NA
2. P Q5XPK0 Scar-like domain-containing protein WAVE 5 7.96e-01 9.06e-03 NA
2. P D3YZV8 Coiled-coil domain-containing protein 8 homolog 9.66e-01 9.81e-05 NA
2. P P17941 Involucrin 1.42e-01 3.73e-05 NA
2. P A0A0J9YWL9 Putative testis-expressed protein 13C 8.05e-01 6.32e-05 NA
2. P P07476 Involucrin 5.00e-01 1.14e-02 NA
2. P Q5TM68 Mediator of DNA damage checkpoint protein 1 9.50e-01 1.54e-02 NA
2. P Q86MA7 Protein PRQFV-amide 9.69e-01 1.57e-02 NA
2. P Q8VE94 Protein FAM110C 8.67e-01 7.05e-04 NA
2. P Q47879 Ice nucleation protein InaU 9.99e-01 4.74e-02 NA
2. P A6NEY3 Putative golgin subfamily A member 6-like protein 3 2.89e-02 5.70e-07 NA
2. P Q62267 Cornifin-B 9.81e-01 2.52e-03 NA
2. P Q96RT7 Gamma-tubulin complex component 6 3.02e-01 4.96e-03 NA
2. P P14591 Involucrin 2.54e-01 2.13e-05 NA
2. P P21733 Uncharacterized 29.1 kDa protein in cryB1 5'region 1.00e+00 5.17e-03 NA
2. P P09413 Gas vesicle protein C 2.36e-01 1.91e-02 NA
2. P Q7T2B3 Protein SLX4IP 8.24e-01 5.12e-03 NA
2. P O55103 Periaxin 8.35e-01 2.25e-02 NA
2. P A1EGX6 Fibrous sheath CABYR-binding protein 7.25e-01 1.62e-03 NA
2. P P24709 Involucrin 2.29e-01 1.91e-04 NA
2. P E5RHQ5 Nuclear pore complex-interacting protein family member B11 4.17e-01 7.66e-03 NA
2. P P10387 Glutenin, high molecular weight subunit DY10 4.51e-01 1.29e-02 NA
2. P P34682 Cuticlin 2 9.99e-01 3.73e-02 NA
2. P Q63532 Cornifin-A 9.74e-01 1.71e-02 NA
2. P Q9URU4 Putative cell agglutination protein pfl5 9.94e-01 2.00e-05 NA
2. P P02893 Circumsporozoite protein 9.69e-01 1.35e-02 NA
2. P A6NEF3 Golgin subfamily A member 6-like protein 4 6.51e-02 8.59e-03 NA
2. P Q0II65 Coiled-coil domain-containing protein 70 4.74e-01 7.19e-03 NA
2. P P60412 Keratin-associated protein 10-11 9.95e-01 3.92e-03 NA
2. P P24712 Involucrin 2.41e-01 5.56e-04 NA
2. P P02674 Fibrinogen alpha-1 chain (Fragment) 6.26e-01 9.44e-03 NA
2. P Q6IC83 Uncharacterized protein C22orf42 8.87e-01 8.92e-04 NA
2. P D3ZVV1 KH domain-containing protein 3 9.80e-01 2.93e-03 NA
2. P A6NJU9 Nuclear pore complex-interacting protein family member B13 5.93e-01 2.32e-02 NA
2. P F8W0I5 Nuclear pore complex-interacting protein family member B12 4.69e-01 9.44e-03 NA
2. P P16112 Aggrecan core protein 9.68e-01 2.41e-02 NA
2. P B1B0V2 EZH inhibitory protein 8.52e-01 6.87e-05 NA
2. P E5AW45 Burkholderia TALE-like protein 2 8.84e-01 1.91e-02 NA
2. P Q8X482 Secreted effector protein EspF(U) NA 3.58e-02 NA
2. P Q8TAX7 Mucin-7 8.76e-01 1.14e-02 NA
2. P P05691 Circumsporozoite protein (Fragment) 9.75e-01 8.73e-04 NA
2. P P60410 Keratin-associated protein 10-8 9.96e-01 6.96e-03 NA
2. P P21138 Serine-rich 25 kDa antigen protein 9.39e-01 3.75e-03 NA
2. P Q874R4 Putative cell agglutination protein pfl3 9.98e-01 2.07e-03 NA
2. P P08672 Circumsporozoite protein 9.82e-01 4.50e-03 NA
2. P Q4UL00 Putative ankyrin repeat protein RF_0922 9.95e-01 8.07e-03 NA
2. P Q28658 Small proline-rich protein 3 9.99e-01 1.47e-03 NA
2. P P62521 Coiled-coil domain-containing protein 8 9.52e-01 1.67e-07 NA
2. P Q92617 Nuclear pore complex-interacting protein family member B3 4.81e-01 1.12e-02 NA
2. P Q27905 Probable antibacterial peptide polyprotein 9.90e-01 2.14e-03 NA
2. P P13814 Circumsporozoite protein 9.49e-01 2.59e-02 NA
2. P A0A1B0GV03 Golgin subfamily A member 6-like protein 7 8.08e-01 1.79e-06 NA
2. P A0A0U1RQI7 Kruppel-like factor 18 9.95e-01 1.18e-02 NA
2. P Q9W596 Microtubule-associated protein futsch NA 1.16e-02 NA
2. P Q54G05 Putative leucine-rich repeat-containing protein DDB_G0290503 1.59e-01 2.35e-05 NA
2. P O33479 Ice nucleation protein 9.97e-01 2.44e-03 NA
2. P Q2VIS4 Filaggrin-2 9.09e-01 1.64e-03 NA
2. P C9JG80 Nuclear pore complex-interacting protein family member B4 5.30e-01 2.78e-02 NA
2. P Q8IVF2 Protein AHNAK2 NA 2.18e-02 NA
3. B Q8IYM0 Protein FAM186B 3.18e-02 NA 1.09e-36
3. B P23253 Sialidase 9.99e-01 NA 1.21e-58
3. B Q96WV6 Uncharacterized threonine-rich GPI-anchored glycoprotein PJ4664.02 NA NA 1.83e-07
3. B Q9BE18 Melanoma-associated antigen E1 4.44e-01 NA 3.32e-09
3. B P14727 Avirulence protein AvrBs3 8.61e-01 NA 0.001
3. B P97347 Repetin 7.69e-01 NA 0.048
3. B Q9HCI5 Melanoma-associated antigen E1 5.84e-01 NA 3.21e-06
3. B P13813 110 kDa antigen (Fragment) 7.72e-01 NA 0.002
3. B P02894 Circumsporozoite protein 9.88e-01 NA 0.007