Summary

A6NGY3

Homolog: A5A777.
Function: Biogenesis of lysosome-related organelles complex 1 subunit 5.

Statistics

Total GO Annotation: 48
Unique PROST Go: 48
Unique BLAST Go: 0

Total Homologs: 22
Unique PROST Homologs: 20
Unique BLAST Homologs: 0

Structures and Sequence Alignment

The best structural homolog that predicted by 2. P was A5A777 (Biogenesis of lysosome-related organelles complex 1 subunit 5) with a FATCAT P-Value: 1.33e-05 and RMSD of 1.51 angstrom. The sequence alignment identity is 23.7%.
Structural alignment shown in left. Query protein A6NGY3 colored as red in alignment, homolog A5A777 colored as blue. Query protein A6NGY3 is also shown in right top, homolog A5A777 showed in right bottom. They are colored based on secondary structures. 

  A6NGY3 M----TQPTRPSVT-CD--QGSSTIGGTA--AQATTSSSA----TS-GSNYQRDRLGRRPEIGVGGQPQIC---FPRPRSAQQ-PVLFSLMNSSEAAMKK 82
  A5A777 MSGGGTE-T-P--TGCEAPSGGGGGGGRKRDSLGTTSSPAHLIIKDLGEIHSR-LLDHRP-V-IQGETRYFVKEFEEKRGLREMRALENLKNMIHETNEH 93

  A6NGY3 TLP------KSHLSRVIIHDNRI---TQRIYEMEVSALEKTKKKISHYYEHL---KKK-------FMTEQ------L----RK-LGRWREESVNSNRYL- 151
  A5A777 TLPTCTETMEDSLSHVL---QRLQAATASVCRLQQREQE--RKKV-H-NDHLIASEKQHIMQWEDFMKEQHSKQADVDEEHRKAMEKLKEQYAEMEKDLA 186

  A6NGY3 ---TFGIPPPV 159
  A5A777 KFSTF------ 191

Go Annotations

1. PB indicates the go terms that are found by both PROST and BLAST.
2. P indicates the go terms that are found by only PROST.
3. B indicates the go terms that are only annotated by BLAST.
Source GO Description
2. P GO:0043014 alpha-tubulin binding
2. P GO:0035082 axoneme assembly
2. P GO:0033650 host cell mitochondrion
2. P GO:0060349 bone morphogenesis
2. P GO:0000722 telomere maintenance via recombination
2. P GO:0008089 anterograde axonal transport
2. P GO:0031083 BLOC-1 complex
2. P GO:0005874 microtubule
2. P GO:0140538 negative regulation of conjugation with zygote
2. P GO:0030430 host cell cytoplasm
2. P GO:2000134 negative regulation of G1/S transition of mitotic cell cycle
2. P GO:0007283 spermatogenesis
2. P GO:0030291 protein serine/threonine kinase inhibitor activity
2. P GO:0009880 embryonic pattern specification
2. P GO:0039592 suppression by virus of G2/M transition of host mitotic cell cycle
2. P GO:0007219 Notch signaling pathway
2. P GO:0019079 viral genome replication
2. P GO:1904115 axon cytoplasm
2. P GO:0050942 positive regulation of pigment cell differentiation
2. P GO:0060271 cilium assembly
2. P GO:0030317 flagellated sperm motility
2. P GO:0008233 peptidase activity
2. P GO:0016567 protein ubiquitination
2. P GO:0001756 somitogenesis
2. P GO:0001503 ossification
2. P GO:0032402 melanosome transport
2. P GO:0007368 determination of left/right symmetry
2. P GO:0031011 Ino80 complex
2. P GO:0006348
2. P GO:0070507 regulation of microtubule cytoskeleton organization
2. P GO:0036342 post-anal tail morphogenesis
2. P GO:0005634 nucleus
2. P GO:0035646 endosome to melanosome transport
2. P GO:0005680 anaphase-promoting complex
2. P GO:0030133 transport vesicle
2. P GO:0005929 cilium
2. P GO:0032525 somite rostral/caudal axis specification
2. P GO:0048666 neuron development
2. P GO:0042766 nucleosome mobilization
2. P GO:0048490 anterograde synaptic vesicle transport
2. P GO:0039652 induction by virus of host NF-kappaB cascade
2. P GO:0000776 kinetochore
2. P GO:2000035 regulation of stem cell division
2. P GO:1904428 negative regulation of tubulin deacetylation
2. P GO:0000723 telomere maintenance
2. P GO:0030516 regulation of axon extension
2. P GO:0019069 viral capsid assembly
2. P GO:0110046 signal transduction involved in cell cycle switching, mitotic to meiotic cell cycle

Homologs

1. PB indicates the homologs that are found by both PROST and BLAST.
2. P indicates homologs that are only found by PROST.
3. B indicates homologs that are only found by BLAST.

Source Homolog Description FATCAT p-val PROST Evalue BLAST Evalue
1. PB A6NGY3 Uncharacterized protein C5orf52 0 3.01e-148 1.43e-117
1. PB Q9CR34 Uncharacterized protein C5orf52 homolog 7.21e-09 1.22e-07 5.43e-50
2. P A5E748 Ribosome biogenesis protein ALB1 3.35e-02 5.11e-05 NA
2. P Q8JMZ5 Protein X NA 1.93e-02 NA
2. P Q5TAB7 Protein ripply2 2.13e-01 2.91e-02 NA
2. P Q6GQ63 Anaphase-promoting complex subunit 16 1.67e-02 2.15e-03 NA
2. P Q32P68 Cilia- and flagella-associated protein HOATZ 2.74e-03 1.31e-04 NA
2. P Q80Y73 Cilia- and flagella-associated protein HOATZ 6.37e-04 9.58e-03 NA
2. P O75956 Cyclin-dependent kinase 2-associated protein 2 3.11e-03 2.44e-03 NA
2. P G5EC89 Homeobox protein ceh-17 1.56e-02 1.68e-02 NA
2. P Q38036 Internal scaffolding protein B NA 4.15e-02 NA
2. P Q5R590 Protein BEX4 4.40e-02 2.66e-02 NA
2. P Q58CN7 Cyclin-dependent kinase 2-associated protein 2 6.28e-04 2.11e-03 NA
2. P Q9CPY4 Cyclin-dependent kinase 2-associated protein 2 1.52e-03 1.26e-03 NA
2. P P0CT25 Uncharacterized protein UM12046 1.00e-01 1.27e-02 NA
2. P P08090 21 kDa protein inducing meiosis and sporulation 1.29e-01 1.60e-02 NA
2. P Q6PI97 Cilia- and flagella-associated protein HOATZ 3.09e-03 3.76e-04 NA
2. P A5A777 Biogenesis of lysosome-related organelles complex 1 subunit 5 1.33e-05 2.06e-02 NA
2. P Q6DJQ9 Anaphase-promoting complex subunit 16 1.65e-03 4.11e-02 NA
2. P P31278 Internal scaffolding protein B NA 1.95e-02 NA
2. P Q12345 Ino eighty subunit 3 1.44e-02 1.95e-03 NA
2. P Q8VCS6 Mediator of RNA polymerase II transcription subunit 9 2.36e-03 4.50e-02 NA