Summary

A6NJI1

Homolog: Q3T020.
Function: Transcription elongation factor A protein-like 8.

Statistics

Total GO Annotation: 33
Unique PROST Go: 33
Unique BLAST Go: 0

Total Homologs: 11
Unique PROST Homologs: 8
Unique BLAST Homologs: 0

Structures and Sequence Alignment

The best structural homolog that predicted by 2. P was Q3T020 (Transcription elongation factor A protein-like 8) with a FATCAT P-Value: 0.000585 and RMSD of 3.28 angstrom. The sequence alignment identity is 27.5%.
Structural alignment shown in left. Query protein A6NJI1 colored as red in alignment, homolog Q3T020 colored as blue. Query protein A6NJI1 is also shown in right top, homolog Q3T020 showed in right bottom. They are colored based on secondary structures. 

  A6NJI1 M----GTGLRS-QSL---REPRPSYGKLQEPWGRPQ---EGQLRRAL--SLRQGQEKSRSQGL-ERGTEG--PDATAQERVPGSLGDTEQLIQAQRRGS- 83
  Q3T020 MQKSCGENERKPQNMPKAEEDRPLEAVPQEAEGNPQPSEEG-VSQEAEGNLR-G-------GLTQPG-QGYKEDSPV--R---HL-DPEEMI----RGAD 80

  A6NJI1 ---RWWLRRYQQVRRRWESFVAIF--PSVTLSQPASP----- 115
  Q3T020 ELER--LR--EEIRRVRNKFVMMHWKQRHSRSRP-YPVCFRP 117

Go Annotations

1. PB indicates the go terms that are found by both PROST and BLAST.
2. P indicates the go terms that are found by only PROST.
3. B indicates the go terms that are only annotated by BLAST.
Source GO Description
2. P GO:2001244 positive regulation of intrinsic apoptotic signaling pathway
2. P GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
2. P GO:0007420 brain development
2. P GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
2. P GO:0071479 cellular response to ionizing radiation
2. P GO:0045926 negative regulation of growth
2. P GO:0030308 negative regulation of cell growth
2. P GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
2. P GO:0032471 negative regulation of endoplasmic reticulum calcium ion concentration
2. P GO:0051117 ATPase binding
2. P GO:0031334 positive regulation of protein-containing complex assembly
2. P GO:0034976 response to endoplasmic reticulum stress
2. P GO:0051209 release of sequestered calcium ion into cytosol
2. P GO:0043065 positive regulation of apoptotic process
2. P GO:0006915 apoptotic process
2. P GO:0071456 cellular response to hypoxia
2. P GO:0090200 positive regulation of release of cytochrome c from mitochondria
2. P GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
2. P GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
2. P GO:0008340 determination of adult lifespan
2. P GO:0001836 release of cytochrome c from mitochondria
2. P GO:0000932 P-body
2. P GO:0097190 apoptotic signaling pathway
2. P GO:1901998 toxin transport
2. P GO:0006974 cellular response to DNA damage stimulus
2. P GO:0070245 positive regulation of thymocyte apoptotic process
2. P GO:0043525 positive regulation of neuron apoptotic process
2. P GO:2001056 positive regulation of cysteine-type endopeptidase activity
2. P GO:0097194 execution phase of apoptosis
2. P GO:0005740 mitochondrial envelope
2. P GO:0050699 WW domain binding
2. P GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator
2. P GO:0032464 positive regulation of protein homooligomerization

Homologs

1. PB indicates the homologs that are found by both PROST and BLAST.
2. P indicates homologs that are only found by PROST.
3. B indicates homologs that are only found by BLAST.

Source Homolog Description FATCAT p-val PROST Evalue BLAST Evalue
1. PB Q2KIL8 Uncharacterized protein C11orf86 homolog 7.25e-06 1.23e-17 7.34e-48
1. PB A6NJI1 Uncharacterized protein C11orf86 0 5.99e-127 1.32e-75
1. PB Q8VC23 Uncharacterized protein C11orf86 homolog 1.11e-04 1.28e-11 2.89e-45
2. P Q99ML1 Bcl-2-binding component 3 5.33e-03 1.67e-02 NA
2. P Q3T020 Transcription elongation factor A protein-like 8 5.85e-04 2.02e-02 NA
2. P Q969H9 Disrupted in renal carcinoma protein 1 4.57e-03 3.68e-02 NA
2. P B5X392 Proline-rich nuclear receptor coactivator 2 1.19e-01 3.00e-02 NA
2. P Q80ZG6 Bcl-2-binding component 3 1.32e-02 1.26e-02 NA
2. P O83168 Uncharacterized protein TP_0132 5.07e-02 1.01e-03 NA
2. P A5J277 Putative uncharacterized protein ycf15 4.32e-02 1.84e-02 NA
2. P Q9H8W2 Putative uncharacterized protein encoded by LINC00472 7.25e-02 7.00e-03 NA