Summary

A6NN90

Homolog: Q08490.
Function: Shugoshin.

Statistics

Total GO Annotation: 40
Unique PROST Go: 40
Unique BLAST Go: 0

Total Homologs: 22
Unique PROST Homologs: 18
Unique BLAST Homologs: 0

Structures and Sequence Alignment

The best structural homolog that predicted by 2. P was Q08490 (Shugoshin) with a FATCAT P-Value: 0.0441 and RMSD of 13.95 angstrom. The sequence alignment identity is 18.2%.
Structural alignment shown in left. Query protein A6NN90 colored as red in alignment, homolog Q08490 colored as blue. Query protein A6NN90 is also shown in right top, homolog Q08490 showed in right bottom. They are colored based on secondary structures. 

  A6NN90 MAHEGSRQVRDRGVTRSKAEKVRPPTVPVPQVDIVPGRLSEAEWMALTALEEGEDVVGDILADL--LARVMD-SAFKV-YLTQQCIPFTISQAREAMLQI 96
  Q08490 ----------------------------MPKRKIAPNK--ESSRRTVS-----HD---DLTPQIQEFQNLMDLESQKVENIRQ-------SYSRQNSL-- 53

  A6NN90 TEWRFLARDEGESAVAEDPTWGEDEEPSACTTDSWAQGSVPVLHASTS-------EGLEN-FQGEDPGGV----DRIPLGRSWM---GRGSQEQMESWEP 181
  Q08490 -----LAKD---NSILKIKVNSLEKKISQLVQE-----NV-TLRSKTSISEAIYRERLSNQLQVIE-NGIIQRFDEI----FYMFENVR-KNENL----P 129

  A6NN90 SPQLRVTSAPPPTSELFQEAGPGGPVEEADGQSRGLSS-AGSLS--ASFQLSVEEAPADDADPSLDP-------------YLVAS--PQASTGRGHPLGF 263
  Q08490 SSSLR-TML-KRTSSRSRSCSLSSPT-YSKSYTR-LSNHENNLSHESSFN-------KDDG-PDLEPKAKKRKSSRRQSMFVSTSLEPEDETGENEPMME 217

  A6NN90 HLSLEDLYCCMP-------QLDAAGDRL---ELRSEGVPCIASGVL-VSYPSVGGATRPSASCQQQRAGHSDVRLSAHHH--RMRRKAAVKRLDPAR-LP 349
  Q08490 NSSVE-----VPAESHESAQVEETIDALNPEEENSDSVSNFTNSIIEYSIPEE-NPTEPE---------HSSSKLEIFNDSTNM-----LSTV-PSNPLP 296

  A6NN90 CHWVRPL---AEVLVP----DSQT-RPLEAYRGRQRGEKTKARAEPQALGPGTRVSPAAFFPLRPGI-----PFRDLDSGPALLFP-TLNL-G--LSS-- 430
  Q08490 L----PLPGPSATL-PTTTSDASTVYP-SSSSSTNSHPKTKIK---HSMKP-PRI------ELKKKVIDEVMPVSNMSSNSEISFTRTRRTRGKAVDYTL 380

  A6NN90 PSLESKLPLPNSRIRFLTTHPVLP--DV---ARSR--SPKLWPSVRWPSGWEGKAELLGELWAGRTRVP--PQGLE--LADRE-GQDPGRWPRTTPPVLE 518
  Q08490 PSLRAKMRRPSEKLVDATT--VIDIHDLQVSKRNRETSHK-----R-------KS-L------SQDSIPDEPQ-LREVVVSKDYGTPKGK--KTEDEIHE 456

  A6NN90 ATSQVMW-----------KPVL---LPEALKLAPGVSMWNRS--------TQVLLSSGVPEQ-EDKEGSTFPPVEQHPIQTGAPKPR------------- 582
  Q08490 DTAHLMTTSNNNSNNKNEKKLTSNNSPK--KSSPLLDITNKSENKKKSTRTKKLFKNAIVNNLSD-ENSTTRPSKS---SKGTSNNNNNYNNFDNNNSNI 550

  A6NN90 ---------------------------------------- 582
  Q08490 NNVNNKSVSFRLNEDDLAVFDLFGNGKAVKHQPKTYRTKK 590

Go Annotations

1. PB indicates the go terms that are found by both PROST and BLAST.
2. P indicates the go terms that are found by only PROST.
3. B indicates the go terms that are only annotated by BLAST.
Source GO Description
2. P GO:0045132 meiotic chromosome segregation
2. P GO:0005768 endosome
2. P GO:0008608 attachment of spindle microtubules to kinetochore
2. P GO:0045184 establishment of protein localization
2. P GO:0007094 mitotic spindle assembly checkpoint signaling
2. P GO:0051301 cell division
2. P GO:0034454 microtubule anchoring at centrosome
2. P GO:0000775 chromosome, centromeric region
2. P GO:0007051 spindle organization
2. P GO:0043254 regulation of protein-containing complex assembly
2. P GO:0005654 nucleoplasm
2. P GO:0061512 protein localization to cilium
2. P GO:0005814 centriole
2. P GO:0090734 site of DNA damage
2. P GO:0071962 mitotic sister chromatid cohesion, centromeric
2. P GO:0034080 CENP-A containing chromatin assembly
2. P GO:0000922 spindle pole
2. P GO:0051383 kinetochore organization
2. P GO:0042393 histone binding
2. P GO:0031134 sister chromatid biorientation
2. P GO:0034096 positive regulation of maintenance of meiotic sister chromatid cohesion
2. P GO:0019900 kinase binding
2. P GO:0045143 homologous chromosome segregation
2. P GO:0005813 centrosome
2. P GO:0034508 centromere complex assembly
2. P GO:0000779 condensed chromosome, centromeric region
2. P GO:0010457 centriole-centriole cohesion
2. P GO:0008104 protein localization
2. P GO:0030426 growth cone
2. P GO:0070199 establishment of protein localization to chromosome
2. P GO:0051757 meiotic sister chromatid separation
2. P GO:0034090 maintenance of meiotic sister chromatid cohesion
2. P GO:0045144 meiotic sister chromatid segregation
2. P GO:0120103 centriolar subdistal appendage
2. P GO:0000776 kinetochore
2. P GO:0051177 meiotic sister chromatid cohesion
2. P GO:2001033 negative regulation of double-strand break repair via nonhomologous end joining
2. P GO:0051101 regulation of DNA binding
2. P GO:0000070 mitotic sister chromatid segregation
2. P GO:0007059 chromosome segregation

Homologs

1. PB indicates the homologs that are found by both PROST and BLAST.
2. P indicates homologs that are only found by PROST.
3. B indicates homologs that are only found by BLAST.

Source Homolog Description FATCAT p-val PROST Evalue BLAST Evalue
1. PB A6NN90 Uncharacterized protein C2orf81 0 1.60e-152 0.0
1. PB Q9DAQ4 Uncharacterized protein C2orf81 homolog 1.10e-03 1.57e-30 0.0
1. PB Q6AXP4 Uncharacterized protein C2orf81 homolog 9.44e-05 1.76e-33 0.0
1. PB A8NIX5 Uncharacterized protein C2orf81 homolog 2.15e-05 6.40e-19 2.07e-146
2. P Q8IYM0 Protein FAM186B 1.55e-01 1.29e-02 NA
2. P Q06813 Uncharacterized protein YPR078C 1.44e-01 2.60e-02 NA
2. P A8MVM7 Putative uncharacterized protein ENSP00000382790 2.46e-01 8.87e-03 NA
2. P Q10310 Meiotically up-regulated gene 68 protein 5.55e-01 4.27e-04 NA
2. P A1L253 Protein FAM149B1 2.86e-01 2.62e-02 NA
2. P P0CAX8 T-cell activation GTPase-activating protein 1 5.23e-02 3.26e-02 NA
2. P Q96HB5 Coiled-coil domain-containing protein 120 1.26e-01 1.97e-02 NA
2. P Q8NCD3 Holliday junction recognition protein 8.83e-02 3.63e-02 NA
2. P P16128 Uncharacterized protein At4g18490 7.46e-01 2.55e-02 NA
2. P Q08490 Shugoshin 4.41e-02 2.24e-02 NA
2. P Q69ZZ9 Uncharacterized protein KIAA0754 3.91e-01 1.61e-04 NA
2. P Q6PG16 Holliday junction recognition protein 3.65e-01 6.59e-03 NA
2. P Q5FBB7 Shugoshin 1 8.60e-02 3.61e-03 NA
2. P Q5PQL8 Primary cilium assembly protein FAM149B1 1.58e-01 7.85e-03 NA
2. P Q66H17 Spermatogenesis-associated protein 32 1.76e-01 3.63e-02 NA
2. P A2AEV7 Coiled-coil domain-containing protein 120 1.25e-01 2.86e-03 NA
2. P Q6FMT2 Shugoshin 6.02e-02 3.45e-02 NA
2. P D3ZUC4 Aurora kinase A and ninein-interacting protein 1.35e-01 9.92e-03 NA