Summary
Structures and Sequence Alignment
The best structural homolog that predicted by 3. B was
Q3V2A7
(Glutamine-rich protein 2) with a FATCAT P-Value: 0.0136 and RMSD of 5.36 angstrom. The sequence alignment identity is 14.6%.
Structural alignment shown in left. Query protein A6NNT2 colored as red in alignment, homolog Q3V2A7 colored as blue.
Query protein A6NNT2 is also shown in right top, homolog Q3V2A7 showed in right bottom. They are colored based on secondary structures.
A6NNT2 MSFSLTFTELANIAIPQCGVLNFKALHLLLHGILEHIHMAELKKVLSGDEDFLQTSQVVIMPREGDAQPILNPMKRLSNVFDHVVSRLDKLENQLALLQD 100 Q3V2A7 ---------------------------------------------------------------------------------------------------- 0 A6NNT2 LPSTAQLLEASQGTARPVQDLWHLIKLRKMVEGHDEVMAKSMQTLQDLLTDLHALQVTITALRKEVDMLKNMLDKVHPERMDIFAEDFKIQNWKMVALQR 200 Q3V2A7 ---------------------------------------------------------------------------------------------------- 0 A6NNT2 EVASLQNKFKTIPKTEDMVLWSGLHDAMFTSEIGSSPLDLWQSVEQLPEAALAQTTKYLEATRAIQVSEPVQNPQLLQTVWHYEVPELLPEGSSAQAVSL 300 Q3V2A7 ---------------------------------------------------------------------------------------------------- 0 A6NNT2 SRAQEPAQPPALTPESAPGCTTEFAPGPAPGTEPVPGLELGLELEPVPALGPVPGPSVTPGSLPAPWPVLGPVPAPGAQPPPLGDWPALPRRWPLPQGWP 400 Q3V2A7 ---------------------------------------------------------------------------------------------------- 0 A6NNT2 RVGSWPLWDLGVLRPTQPQPSRAPPPATEFGSLWPRPLQPYQSRQGEALQLAAVQVKGEENDVPSLRGLRERARKDGAPKDRTRKDGVPKDRGGKDVDPK 500 Q3V2A7 ---------------------------------------------------------------------------------------------------- 0 A6NNT2 DRAHKDDVPKDRGGKDVDPKDRAHKDDVPKDRGGKDGDPKDRVGKDGAPKEAQPKAPQSALHRLKTTAAIAAAAAAAYAAATSSAAQAAKVAAKFVKDAP 600 Q3V2A7 ---------------------------------------------------------------------------------------------------- 0 A6NNT2 ATKMAAIATDTAAAGPLGVFADVLGAGPSRGATESQILGDDSEIYEI-LSPSYSAASIGP---DPALSQAMVATKQAMSPEDKKRAVKYSMSHIAQIPVK 696 Q3V2A7 ---ME----NSVSEASLYL-QDQL--DKLRTIIES-MLGSSSTLLSMSITPHKSTACLVPGQIDPE------AT----CP-----ACSLDVSH--QVSL- 71 A6NNT2 HDSLKEEFAQLSCNLNQRLSYLANMGGPS---SL-GTTVDILQKKIGSLQKSRLKEE-ELERIWGNQIEMMKDRYITLDKAVENLQIRMDEFKTLQAQIK 791 Q3V2A7 ---LVQRYEQ----LQDMVSGLA-ASRPSKKAKLQGQDEELL----GHVQSAILQVQGDCEKL--N---------ITTSNLIEDHRQKQKDIEVLYQGIE 148 A6NNT2 RLEMNKVNKSTMEEELREKADRSALAGKASRVDLETVALELNEMIQGILFKVTIHEDSWKKAMEELSKDVNTKLVHSDLDPLKKEMEEVWKIVRKLLIEG 891 Q3V2A7 RLDKEKANREHLEMEIDEKADKSALASKVSRIQFDATTEQLNHMMQELVAKMSGQEQDWQKLLDKLLAEMDSKLDRLELDPLKQMLEDRWKSLRQQLKE- 247 A6NNT2 LR--L-DPDSAAGFRRKLFKRVKCISCDRPVE-MMTGPQLITIRKAHLLS-----R-LRPASANSCEYLQRQ----------------QM-REQQWL--- 961 Q3V2A7 -RPPLYQADEAAAMRRQLLAHFHCLSCDRPLETTVTG-QVISV--TPIISSMPGHRSVRPYTVFELEQIRQQSRNLKLGSSFPRVDMSQMERSVGRLHSM 343 A6NNT2 ---QLQDL-------G---------IQE---------DCQQ---DWGDGPQNATSLKCKSCNLLTLYPY--GDP-HV--ID-------YDSAEVDILGVD 1018 Q3V2A7 HSRMLMDMEKVQVHFGGSVKASSQMIRELLHTQCLSHPCYKRGADTADYSYSTVSRRCGGSHTLT-YPYRRNRPQHLSPLEEIQIAMKHD--EVDILGLD 440 A6NNT2 GILYKGRVNSQR-----GAQ-PLAVAK-------------ELAAVKAPSPPSQSLYDRVHS---SALFG-AICPPLCPRSS---ACSAA--SGPHLTMPA 1090 Q3V2A7 GHIYKGRMDT-RLPGILGKDAP-GVTKHNKAKLQQLQQLQQLQQLQQLQQLQQAQHARPHAHRQPSL-GNMISPPSRPQSAQMIADSKAVPSGQK---KD 534 A6NNT2 RPPSLPPLLL--------LPPLIPSLRDPQQAPGSTRLSRAPHIESRVGRKPP----EEPA-NP------ 1141 Q3V2A7 RPVSSEGRLLQSNVSHSSIPTDIASLQGSQQ--G---LNM--HID--V---PPGEGLEEPTRGPRSTAAH 592
Go Annotations
1. PB indicates the go terms that are found by both PROST and BLAST.2. P indicates the go terms that are found by only PROST.
3. B indicates the go terms that are only annotated by BLAST.
| Source | GO | Description |
|---|---|---|
| 3. B | GO:0036126 | sperm flagellum |
| 3. B | GO:0071222 | cellular response to lipopolysaccharide |
| 3. B | GO:2000059 | negative regulation of ubiquitin-dependent protein catabolic process |
| 3. B | GO:0030031 | cell projection assembly |
| 3. B | GO:0017128 | phospholipid scramblase activity |
| 3. B | GO:0042609 | CD4 receptor binding |
| 3. B | GO:0031965 | nuclear membrane |
| 3. B | GO:0017121 | plasma membrane phospholipid scrambling |
| 3. B | GO:0030317 | flagellated sperm motility |
| 3. B | GO:0019899 | enzyme binding |
Homologs
1. PB indicates the homologs that are found by both PROST and BLAST.
2. P indicates homologs that are only found by PROST.
3. B indicates homologs that are only found by BLAST.
| Source | Homolog | Description | FATCAT p-val | PROST Evalue | BLAST Evalue |
|---|---|---|---|---|---|
| 1. PB | A6NNT2 | Uncharacterized protein C16orf96 | 0 | 9.52e-149 | 0.0 |
| 1. PB | E9QMW4 | Uncharacterized protein C16orf96 homolog | 4.48e-06 | 2.65e-31 | 0.0 |
| 3. B | P58196 | Phospholipid scramblase 4 | 9.73e-01 | NA | 0.048 |
| 3. B | Q3V2A7 | Glutamine-rich protein 2 | 1.36e-02 | NA | 5.06e-25 |
| 3. B | Q568R1 | Nuclear speckle splicing regulatory protein 1 | 1.45e-01 | NA | 0.015 |
| 3. B | D4APE0 | Uncharacterized secreted protein ARB_06108 | 7.46e-01 | NA | 1.25e-04 |
| 3. B | Q9H0J4 | Glutamine-rich protein 2 | 1.06e-01 | NA | 5.80e-23 |