Summary

A8MVM7

Homolog: Q2LYY4.
Function: Protein aurora borealis.

Statistics

Total GO Annotation: 88
Unique PROST Go: 88
Unique BLAST Go: 0

Total Homologs: 60
Unique PROST Homologs: 58
Unique BLAST Homologs: 0

Structures and Sequence Alignment

The best structural homolog that predicted by 2. P was Q2LYY4 (Protein aurora borealis) with a FATCAT P-Value: 0.0495 and RMSD of 4.42 angstrom. The sequence alignment identity is 23.3%.
Structural alignment shown in left. Query protein A8MVM7 colored as red in alignment, homolog Q2LYY4 colored as blue. Query protein A8MVM7 is also shown in right top, homolog Q2LYY4 showed in right bottom. They are colored based on secondary structures. 

  A8MVM7 MDKIRHTEADIFKNGSKRMIATVPLRHSIRDRKPSLHFLHSLASSSSLIY----R--NALLHKS-Y--KL-HLQKN-KSQKEKHRHS---KMKIAYKDTP 86
  Q2LYY4 ------------------------------------------------MYTDEVRTPQAL--KSRYFTNLGDL--NCRT----RRNSATGNSSVASAATP 44

  A8MVM7 RNRLSRNAKKCLED-NKLV--P-------IS---EVSL-D----PIISSNP-LLRWWA-T---SASN-DSLLEELNNRFEQITNAWV-----QV--SGD- 154
  Q2LYY4 TNGGKQNT-KCSPQMSTLVCTPPPKRFHKIRNPFEGALADRLHLPLIAS-PSLFR--ARTPQLSSTQFEWNIDEVS----QLTPADVEPHETQFHDSPDP 136

  A8MVM7 EAENCIHKKREHIENDHFK----VASPLETC-------LLELEVSPVKMLFQKKY------DLNELCTWFMQTTETQSLSL---VRKA--NARNP-LE-- 229
  Q2LYY4 ELES---KAQMAI-SAFFKESLIVPSPVD-CPLRKNRIILNADHTPIS---NKSSSGRRGRD----CS--VQ-TE---LTLPPILPKALEEALRPYLQPH 218

  A8MVM7 VI-NTRG-IKLGTKYSD-FNASPFRKHFKKFALSSPSKSAEKLHIL-HKVA-NSPLLNVKSNLAIARLKRTEFK-RLHHERWKREGKLHNHGTVDWNSKR 323
  Q2LYY4 LAGGTSGRFKSRSSGSDVFNSS-MRR--KLFDL-------HNVIVLGEKEAVQSPQM-VGSS---PQGKQTMFAGRL-SDSASGEG---SFGSL---SPI 297

  A8MVM7 RNLRFFCQNQFLNKTEGETNADIPL----QG------KSIVDNQC-----VLPPEIRGDLQQRVVMPDFKIHASFENKFKSEA-KE-NGTNCSQKDFQKG 406
  Q2LYY4 RNL---C---------G-----LPLGTPDDGNRSSKRKLLLINELEFPSPIAPPE---HLSRRLV--HSKVEASISSNEQHDTLSELTGT---------G 366

  A8MVM7 -PRLENVC---PNSWRSKTLKDCRIFLRKLNCLEHRNTFKLNTIIYSPESTDSG-NTHQTHMEESKRFT-LRSHSARQ---NSF---KKQS--KEIENAN 492
  Q2LYY4 RP----ACRFTPD--RSSS---------PMQALEH---------------SDSSIN---------QRVSRLRVNSTRQLPSQSFLETVDQALFEEVEADD 427

  A8MVM7 TNNPSADEFAD----HLGNSKLSKCVNFDKNPDSFEVLSNLNKRKRPPWKITEMSTKR-HKR-QSCNSGQMANYFSKSLVSKIFGQPNFLAPSMKLVKLG 586
  Q2LYY4 TDEPEADQESDEDEEEAEAMQLS-TISF--NCSS----SN-----------SD--TPRGHRRHRSAN--------RKNL-SQSF--------SANLEEVE 490

  A8MVM7 AAKCTSALPHLLICPGFHTNK-NIYSRDIEIIFKIYYFNNVDVIS-F-CIW-------------- 634
  Q2LYY4 AQRVKTAPP--VINP--PAQRIGLYRVD-------SGFNETSIISTFACSQDISMACCSTPSTRP 544

Go Annotations

1. PB indicates the go terms that are found by both PROST and BLAST.
2. P indicates the go terms that are found by only PROST.
3. B indicates the go terms that are only annotated by BLAST.
Source GO Description
2. P GO:0007276 gamete generation
2. P GO:0008608 attachment of spindle microtubules to kinetochore
2. P GO:0004402 histone acetyltransferase activity
2. P GO:0043505 CENP-A containing nucleosome
2. P GO:0007060 male meiosis chromosome segregation
2. P GO:0071539 protein localization to centrosome
2. P GO:0009630 gravitropism
2. P GO:1903394 protein localization to kinetochore involved in kinetochore assembly
2. P GO:0051640 organelle localization
2. P GO:0046599 regulation of centriole replication
2. P GO:0016242 negative regulation of macroautophagy
2. P GO:0007089 traversing start control point of mitotic cell cycle
2. P GO:0071962 mitotic sister chromatid cohesion, centromeric
2. P GO:0006281 DNA repair
2. P GO:0034080 CENP-A containing chromatin assembly
2. P GO:0032045 guanyl-nucleotide exchange factor complex
2. P GO:0010789 meiotic sister chromatid cohesion involved in meiosis I
2. P GO:0035307 positive regulation of protein dephosphorylation
2. P GO:0051754 meiotic sister chromatid cohesion, centromeric
2. P GO:1903170 negative regulation of calcium ion transmembrane transport
2. P GO:0006260 DNA replication
2. P GO:1901386 negative regulation of voltage-gated calcium channel activity
2. P GO:0051666 actin cortical patch localization
2. P GO:0031930 mitochondria-nucleus signaling pathway
2. P GO:0051321 meiotic cell cycle
2. P GO:0000779 condensed chromosome, centromeric region
2. P GO:0006897 endocytosis
2. P GO:1903432 regulation of TORC1 signaling
2. P GO:0043631 RNA polyadenylation
2. P GO:0005634 nucleus
2. P GO:1901098 positive regulation of autophagosome maturation
2. P GO:0017108 5'-flap endonuclease activity
2. P GO:0007099 centriole replication
2. P GO:0004860 protein kinase inhibitor activity
2. P GO:0002357 defense response to tumor cell
2. P GO:0007049 cell cycle
2. P GO:0051660 establishment of centrosome localization
2. P GO:0051177 meiotic sister chromatid cohesion
2. P GO:0090307 mitotic spindle assembly
2. P GO:0110053 regulation of actin filament organization
2. P GO:0048487 beta-tubulin binding
2. P GO:0016321 female meiosis chromosome segregation
2. P GO:0006310 DNA recombination
2. P GO:0051101 regulation of DNA binding
2. P GO:0000070 mitotic sister chromatid segregation
2. P GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle
2. P GO:0007059 chromosome segregation
2. P GO:0042393 histone binding
2. P GO:0043014 alpha-tubulin binding
2. P GO:0045132 meiotic chromosome segregation
2. P GO:0071763 nuclear membrane organization
2. P GO:0051301 cell division
2. P GO:0000775 chromosome, centromeric region
2. P GO:0043254 regulation of protein-containing complex assembly
2. P GO:0045167 asymmetric protein localization involved in cell fate determination
2. P GO:0031616 spindle pole centrosome
2. P GO:0010387 COP9 signalosome assembly
2. P GO:0090708 specification of plant organ axis polarity
2. P GO:0005814 centriole
2. P GO:0050862 positive regulation of T cell receptor signaling pathway
2. P GO:0005935 cellular bud neck
2. P GO:0019901 protein kinase binding
2. P GO:2000220 regulation of pseudohyphal growth
2. P GO:0032880 regulation of protein localization
2. P GO:0045955 negative regulation of calcium ion-dependent exocytosis
2. P GO:0016407 acetyltransferase activity
2. P GO:0072687 meiotic spindle
2. P GO:0051258 protein polymerization
2. P GO:0033089 positive regulation of T cell differentiation in thymus
2. P GO:0007566 embryo implantation
2. P GO:1905392 plant organ morphogenesis
2. P GO:0045143 homologous chromosome segregation
2. P GO:0005813 centrosome
2. P GO:2000012 regulation of auxin polar transport
2. P GO:0033557 Slx1-Slx4 complex
2. P GO:0010457 centriole-centriole cohesion
2. P GO:0007088 regulation of mitotic nuclear division
2. P GO:0044174 host cell endosome
2. P GO:0039557 suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity
2. P GO:0060236 regulation of mitotic spindle organization
2. P GO:0006469 negative regulation of protein kinase activity
2. P GO:0030479 actin cortical patch
2. P GO:0046600 negative regulation of centriole replication
2. P GO:0000776 kinetochore
2. P GO:0032147 activation of protein kinase activity
2. P GO:0033255 SAS acetyltransferase complex
2. P GO:1904776 regulation of protein localization to cell cortex
2. P GO:1902902 negative regulation of autophagosome assembly

Homologs

1. PB indicates the homologs that are found by both PROST and BLAST.
2. P indicates homologs that are only found by PROST.
3. B indicates homologs that are only found by BLAST.

Source Homolog Description FATCAT p-val PROST Evalue BLAST Evalue
1. PB Q3TNU4 Putative uncharacterized protein ENSP00000382790 homolog 6.31e-04 7.59e-16 0.0
1. PB A8MVM7 Putative uncharacterized protein ENSP00000382790 0 1.88e-145 0.0
2. P A6NN90 Uncharacterized protein C2orf81 2.62e-01 2.34e-02 NA
2. P Q6DJL7 Protein aurora borealis 1.70e-01 2.58e-03 NA
2. P Q9VVR2 Protein aurora borealis 4.94e-01 2.93e-04 NA
2. P Q08471 G1-specific transcription factors activator MSA1 3.91e-01 2.83e-03 NA
2. P A2RU30 Protein TESPA1 2.63e-01 2.79e-02 NA
2. P Q6ZUT6 Coiled-coil domain-containing protein 9B 1.94e-01 4.03e-06 NA
2. P Q5AJ77 Transcription factor IRO1 4.55e-01 3.65e-02 NA
2. P Q14B71 Cell division cycle-associated protein 2 4.36e-01 4.19e-03 NA
2. P Q5JVX7 Uncharacterized protein C1orf141 6.02e-01 9.96e-03 NA
2. P Q06604 Protein BSP1 3.19e-01 2.19e-02 NA
2. P Q5F2C3 Meiosis-specific kinetochore protein 8.56e-01 2.01e-03 NA
2. P O94378 Uncharacterized protein C1604.12 3.68e-01 1.82e-02 NA
2. P A0A2K1L2D9 Protein SOSEKI 2 3.44e-01 1.17e-02 NA
2. P Q8NCD3 Holliday junction recognition protein 2.93e-01 1.56e-02 NA
2. P A5AAW6 Structure-specific endonuclease subunit slx4 8.20e-01 2.02e-04 NA
2. P Q6FWU4 Protein DSE3 2.67e-01 8.24e-03 NA
2. P P37937 Mating-type protein A-alpha Z3 4.10e-01 6.67e-03 NA
2. P Q5RBH3 Mitotic interactor and substrate of PLK1 4.08e-01 2.03e-03 NA
2. P O94497 Uncharacterized serine-rich protein C18E5.07 4.88e-01 1.35e-04 NA
2. P Q66L44 Voltage-dependent calcium channel beta subunit-associated regulatory protein 2.42e-01 1.62e-02 NA
2. P B8MED8 Structure-specific endonuclease subunit slx4 4.79e-01 2.95e-02 NA
2. P Q5M864 Protein aurora borealis 3.82e-01 7.92e-03 NA
2. P Q2LYY4 Protein aurora borealis 4.95e-02 1.19e-02 NA
2. P P25579 Laminarase-resistance protein LRE1 1.23e-01 1.77e-04 NA
2. P Q5FBB7 Shugoshin 1 3.86e-01 2.46e-04 NA
2. P Q6PG16 Holliday junction recognition protein 1.82e-01 1.56e-02 NA
2. P Q6DF94 Spindle and centriole-associated protein 1 1.43e-01 2.82e-02 NA
2. P Q9HGK9 Inner kinetochore subunit cnp20 1.70e-01 3.13e-02 NA
2. P Q5ZMW6 Nuclear protein MDM1 1.67e-01 4.63e-02 NA
2. P B6HBG5 Structure-specific endonuclease subunit slx4 5.86e-01 4.50e-03 NA
2. P Q29RT4 Cell division cycle-associated protein 2 5.25e-01 3.13e-02 NA
2. P Q04003 Something about silencing protein 4 4.17e-01 1.40e-02 NA
2. P Q5RCJ6 Coiled-coil domain-containing protein 9B 1.88e-01 6.36e-07 NA
2. P Q2R435 Protein LAZY 1 7.68e-01 2.63e-02 NA
2. P Q2KIL1 Uncharacterized protein C1orf141 homolog 6.82e-01 2.25e-02 NA
2. P B7ZNG4 Tastin 2.95e-01 1.72e-02 NA
2. P O42928 Uncharacterized protein C16C6.04 5.02e-01 6.16e-03 NA
2. P P34072 Negative regulator of RAS-cAMP pathway 5.01e-01 1.95e-02 NA
2. P A1L253 Protein FAM149B1 1.38e-01 1.80e-02 NA
2. P Q2KHM9 Protein moonraker 6.59e-01 1.89e-03 NA
2. P Q74ZL3 Meiotic sister-chromatid recombination protein 3 3.38e-01 1.04e-02 NA
2. P F5HDE4 Protein ORF45 NA 1.47e-03 NA
2. P Q66HC8 Gametogenetin 3.22e-01 4.59e-02 NA
2. P O74504 UPF0590 protein C594.01 1.65e-01 5.03e-03 NA
2. P Q6PUR7 Guanine nucleotide exchange protein smcr8b 6.89e-01 2.19e-02 NA
2. P Q949W6 Protein KAKU4 6.22e-02 3.09e-06 NA
2. P Q9HDX7 Uncharacterized protein PB1A10.13 3.07e-01 1.07e-04 NA
2. P P40020 Factor interacting with REF2 5.26e-01 2.02e-04 NA
2. P Q03695 Uncharacterized protein YMR206W 6.20e-01 4.89e-04 NA
2. P Q676U7 Minor capsid protein L2 NA 8.16e-03 NA
2. P Q6FQG3 Protein BSP1 3.73e-01 2.46e-02 NA
2. P Q8BS90 Protein aurora borealis 3.56e-01 4.11e-05 NA
2. P P0C9Z5 Structural protein p49 NA 6.22e-03 NA
2. P Q6CK58 Meiotic sister-chromatid recombination protein 3 8.50e-02 2.79e-02 NA
2. P Q68FQ8 Deleted in lung and esophageal cancer protein 1 homolog 9.09e-02 4.29e-02 NA
2. P Q2U6E8 Structure-specific endonuclease subunit slx4 4.69e-01 7.68e-03 NA
2. P Q80W69 Uncharacterized protein C12orf71 homolog 4.98e-01 1.60e-02 NA
2. P B8NLN6 Structure-specific endonuclease subunit slx4 5.73e-01 8.49e-03 NA