Summary

A8MYA2

Homolog: A0A096MK47.
Function: Muscular LMNA-interacting protein.

Statistics

Total GO Annotation: 38
Unique PROST Go: 38
Unique BLAST Go: 0

Total Homologs: 27
Unique PROST Homologs: 23
Unique BLAST Homologs: 0

Structures and Sequence Alignment

The best structural homolog that predicted by 2. P was A0A096MK47 (Muscular LMNA-interacting protein) with a FATCAT P-Value: 0.0389 and RMSD of 11.85 angstrom. The sequence alignment identity is 19.5%.
Structural alignment shown in left. Query protein A8MYA2 colored as red in alignment, homolog A0A096MK47 colored as blue. Query protein A8MYA2 is also shown in right top, homolog A0A096MK47 showed in right bottom. They are colored based on secondary structures. 

      A8MYA2 -----------------------MSSPDKVSV-CGAG--FD---LE-----GGKKAGSR----TASPGAPGAHSHGLDLGVPGSGD-GKSESGF-TDPEG 60
  A0A096MK47 MEFEKHEQGNALKKNEKLEERVTFEYSDHMTFSCESKEERDQRILDYPSEVSGKNS-QRKEFNTKEP-------QGMQ-----KGDLFKAEYVFIVDSDG 87

      A8MYA2 FSFESESELIEQGRVVLWGREGRPG-TPVDDQGDV------VDYSFYLADEPAAIVPPPSVQG-------HP-FPEGAAAE---GSAENWADAEVGPSGR 142
  A0A096MK47 ---EDEA-TCRQ------GEQGPPGAT-----GNIATRPKSLAISSSLASD---VV-RPKVRGVDVKVSSHPEIPHGIAPQQKHGQL-------TSPTTS 161

      A8MYA2 DVLGHSPGKWQQASAGRLHLCGPGPVRAWKNPERGSK--SRWSL-RVD----PQQPSAKGPTRLPT--HDS-----DSA-----DESSDLPLMKVG--IC 221
  A0A096MK47 EQLAHKPPAFSFVSPTNQKT--P-PVPA-K--VSGTTVLEEFHIRRLDVHGASEEETA---TYFHTTAHDSPLPAWKGASTLVFSPSAQLP----GSSLC 248

      A8MYA2 RNEGSQAKP---G-SP---KK---------RAD--TS----RQASFHC-KESYLPV--------PG-RFLTSAPRG-LTPV-AERPAVGELEDSPQKK-M 286
  A0A096MK47 ---GSNVADHTRGLAPEAQKKVSTSSALNPREDVRTSPSPASGASLRSPSASYIPVRIVMHSLSPSPKPLTSSSHGSLSTVCSQTSSSGNLSKSGLKSPV 345

      A8MYA2 QSR-----AWGK---VEVRP----SC---S-GAAAAGALPQGLSRR-KMAGG--KKSLGGASQLALGRGFPACGERLSAAPPEPA--TFPPFSGVRPQGM 365
  A0A096MK47 PSRLSLLTAILKSNPSHQRPLSPASCPTFSLNSLASSTLT--LDQKIKQTPSTPKKSLSSCS-LTTGS---TEQEQASAESHQPCHLSF--FSKTTPLSQ 437

      A8MYA2 SKKPQKPKHSSPG-------KKPAGRKTRESQAAAREDNDPNR--DEVPRAQLPTHRPGL-PRLSVRRGEFSSSDPNIRAP----QL---PGT------- 441
  A0A096MK47 AQPPSPPALASSSYAATDTEKIP-GSTLRSST------TPPQSQTDLFSLADVPSVTPGLSP-LSSSKG---RKDGDLRAPEKNRNICTRPSTLSFIPPI 526

      A8MYA2 SEPSAYSPGG-----------LVPR-------RHA-----PSGNQQPPV-------HP-------PRPER------QQQP----P--GAQGCPRCIWLQR 492
  A0A096MK47 NESTALSSSGKCFHPSPALSDLIDRSKRTCSQRHSDQRPNPSALPTPPVSRAGSASHPHLGYSILP-PESSLTQALQRSPSALHPSCGSATCPS----RT 621

      A8MYA2 EIEDLT-----QQLA--AMQF-LTDKFQDL---------------------------------------------------------------------- 514
  A0A096MK47 GMPDSTASNRSSRVSTPSLPVSLT-RTKELISPCALSMSAGPENKKPKQYKTKSSYKAFAAIPTNTLLLEQKALDEPARTESNSKASVSDLPVEHSSDSP 720

      A8MYA2 --------------------------------------------------------------------------------------- 514
  A0A096MK47 SRPSQTMLGSETIKTPTTHPRAAGRETKYANLSSSSSTTSESQLTKPGVIRPVPIKSKLFLKKEEEVYEPNPFSKYLEDSSGLFSEQ 807

Go Annotations

1. PB indicates the go terms that are found by both PROST and BLAST.
2. P indicates the go terms that are found by only PROST.
3. B indicates the go terms that are only annotated by BLAST.
Source GO Description
2. P GO:0005881 cytoplasmic microtubule
2. P GO:0009826 unidimensional cell growth
2. P GO:0006334 nucleosome assembly
2. P GO:0051513 regulation of monopolar cell growth
2. P GO:0005876 spindle microtubule
2. P GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
2. P GO:0030054 cell junction
2. P GO:0045926 negative regulation of growth
2. P GO:0005828 kinetochore microtubule
2. P GO:0005521 lamin binding
2. P GO:0036158 outer dynein arm assembly
2. P GO:0010847 regulation of chromatin assembly
2. P GO:1903243 negative regulation of cardiac muscle hypertrophy in response to stress
2. P GO:0016605 PML body
2. P GO:0048306 calcium-dependent protein binding
2. P GO:0046330 positive regulation of JNK cascade
2. P GO:0043966 histone H3 acetylation
2. P GO:0043486 histone exchange
2. P GO:0035332 positive regulation of hippo signaling
2. P GO:0072686 mitotic spindle
2. P GO:0070840 dynein complex binding
2. P GO:0042383 sarcolemma
2. P GO:0007017 microtubule-based process
2. P GO:0015630 microtubule cytoskeleton
2. P GO:0005829 cytosol
2. P GO:0010614 negative regulation of cardiac muscle hypertrophy
2. P GO:0030295 protein kinase activator activity
2. P GO:0031981 nuclear lumen
2. P GO:0004860 protein kinase inhibitor activity
2. P GO:0008017 microtubule binding
2. P GO:0120293 dynein axonemal particle
2. P GO:0071902 positive regulation of protein serine/threonine kinase activity
2. P GO:0032147 activation of protein kinase activity
2. P GO:0005912 adherens junction
2. P GO:0051233 spindle midzone
2. P GO:0005671 obsolete Ada2/Gcn5/Ada3 transcription activator complex
2. P GO:0032133 chromosome passenger complex
2. P GO:0032465 regulation of cytokinesis

Homologs

1. PB indicates the homologs that are found by both PROST and BLAST.
2. P indicates homologs that are only found by PROST.
3. B indicates homologs that are only found by BLAST.

Source Homolog Description FATCAT p-val PROST Evalue BLAST Evalue
1. PB Q9D454 Uncharacterized protein CXorf49 homolog 1.84e-03 5.41e-23 1.65e-70
1. PB Q3KR64 Uncharacterized protein CXorf49 homolog 5.05e-03 2.71e-16 5.80e-63
1. PB A5PKC7 Uncharacterized protein CXorf49 homolog 1.18e-03 1.52e-18 5.11e-87
1. PB A8MYA2 Uncharacterized protein CXorf49 0 8.00e-125 0.0
2. P Q08206 Uncharacterized protein YOL036W 6.91e-02 3.68e-04 NA
2. P Q8C5R2 Proline and serine-rich protein 2 6.00e-01 1.33e-03 NA
2. P Q9S823 Protein LONGIFOLIA 2 2.60e-01 4.80e-03 NA
2. P A0A096MK47 Muscular LMNA-interacting protein 3.89e-02 1.88e-02 NA
2. P Q95JW1 Dynein axonemal assembly factor 8 5.02e-01 3.59e-02 NA
2. P Q95JN2 Uncharacterized protein C9orf43 homolog 1.80e-01 8.36e-03 NA
2. P Q9NS73 MAP3K12-binding inhibitory protein 1 5.70e-01 1.93e-03 NA
2. P Q9D9W6 Protein FAM217A 4.73e-01 3.59e-02 NA
2. P Q8TAL5 Uncharacterized protein C9orf43 2.79e-01 1.70e-02 NA
2. P Q9NYZ3 G2 and S phase-expressed protein 1 6.29e-02 3.28e-02 NA
2. P Q8IMP6 Protein SPT2 homolog 4.96e-01 3.31e-02 NA
2. P P0CAX8 T-cell activation GTPase-activating protein 1 5.15e-01 3.36e-04 NA
2. P Q3MHH3 S100P-binding protein 8.55e-02 4.13e-02 NA
2. P O94243 Meiotically up-regulated gene 9 protein 3.97e-01 5.08e-03 NA
2. P Q9BW04 Specifically androgen-regulated gene protein 5.03e-02 1.88e-03 NA
2. P Q9SH58 Probable membrane-associated kinase regulator 2 1.69e-01 8.55e-06 NA
2. P A8DYY6 Schwannomin-interacting protein 1 homolog 4.17e-01 7.08e-06 NA
2. P Q5XHY8 Protein FAM217A 1.26e-01 7.98e-03 NA
2. P P38283 Inner centromere protein-related protein SLI15 3.37e-01 1.76e-05 NA
2. P Q55F95 Putative uncharacterized protein DDB_G0268590 1.60e-01 1.76e-04 NA
2. P Q8BI29 Specifically androgen-regulated gene protein 2.74e-01 1.88e-04 NA
2. P Q499V8 Specifically androgen-regulated gene protein 2.59e-01 4.68e-02 NA
2. P Q6AXP4 Uncharacterized protein C2orf81 homolog 5.58e-02 1.80e-05 NA