Summary

B1AJZ9

Homolog: A6PWD2.
Function: Forkhead-associated domain-containing protein 1.

Statistics

Total GO Annotation: 30
Unique PROST Go: 11
Unique BLAST Go: 14

Total Homologs: 23
Unique PROST Homologs: 5
Unique BLAST Homologs: 11

Structures and Sequence Alignment

The best structural homolog that predicted by 1. PB was A6PWD2 (Forkhead-associated domain-containing protein 1) with a FATCAT P-Value: 7.12e-06 and RMSD of 20.09 angstrom. The sequence alignment identity is 65.3%.
Structural alignment shown in left. Query protein B1AJZ9 colored as red in alignment, homolog A6PWD2 colored as blue. Query protein B1AJZ9 is also shown in right top, homolog A6PWD2 showed in right bottom. They are colored based on secondary structures. 

  B1AJZ9 MKAYLKSAEGFFVLNKSTTIGRHENSDLVLQSPDIDNHHALIEYNEAECSFVLQDFNSRNGTFVNECHIQNVAVKLIPGDILRFGSAGLTYELVIENPPP 100
  A6PWD2 MKAYLKSADGFFVLNKSTTIGKHADSDLVLQSADIDNHHALIEFNEAEGTFVLQDFNSRNGTFVNECHIQNVAVKLIPGDILRFGSAGMTYELVIENPSP 100

  B1AJZ9 VSFPWMRGPAPWPGPQPPRATQQPNQAPPPSHIPFHQGVQPAPMQRSWSQAFPRPTVVLPASHRRPVSANKEMFSFVVDDARKPPVIKQVWTNAMKLSEK 200
  A6PWD2 VSCPWVRGPAPWPSPQPHLSS-----SPP--DMPFHHGIQPATVQRSWSQGCPRPTMVPPAPHQRPMSASGKMFSFVMDP--KSPVINQVWANAMDMSEQ 191

  B1AJZ9 SVAEGIPGAVPPAEIYVEEDLAQQDKDEIILLLGKEVSRLSDYEIESKYKDVIIANLQNEVAELSQKVSET---TTSRQNEKEISQKC----QVLDE-DI 292
  A6PWD2 CMMDGLSGTIPPTEIFMDHDLSQQDKDEIILLLGREVNRLSDFEMESKYKDALIMNLQAEVADLSQRLSETAAVAAARQ-----SNRCDPKLQGVDEGD- 285

  B1AJZ9 DAKQKEIQSLKSQISALQKGYSKVLCQTLSERNSEITSLKNEGENLKRDNAITSGMVSSLQKDILAKDEQVQQLKEEVSHLKSQNKDKDHQLEALGSRCS 392
  A6PWD2 DLRQKEIESMKSQINALQKGYSQVLSQTLAERNTEIESLKNEGENLKRDHAITSGMVTSLQKDMSARNEQVQQLQEEVNRLRIENREKEYQLEALSSRCS 385

  B1AJZ9 VLKEELKQEDAHRELREAQEKELKLCKTQIQDMEKEMKKLRAELRKSCTEQSVISRTLREKSKVEEKLQEDSRRKLLQLQEMGNRESVIKINLERAVGQL 492
  A6PWD2 VMKEELRKEEAQKDRREAQEKELKLCRSQMQDMEKEVRKLREELKKNYMGQNIISKTLREKNKVEEKLQEDSRRKLLQLQEMGNRENLIKINLERAVGQL 485

  B1AJZ9 EHFRSQVIKATYGRAKPFRDKPVTDQQLIEKITQVTEDNINFQQKKWTLQKETQLSNSKQEETTENIEKLRTSLDSCQACMKISCCSHDLKKEVDLLQHL 592
  A6PWD2 ENFRNQVIKATFGKTKPFRDKPITDQQLIEKIIQVTEDNLSFQQRKWTLQRETHL-HPKQEETMHSVEKLRVLLDKCQACMRDSCSSIDLKKEVELLQHL 584

  B1AJZ9 QVSPPVSGLQKVVLDVLRHALSWLEEVEQLLRDLGI-LPSSPNKDQVQQFSGNS--AVFTAGKAAGASGREGEAERGEARARGEAQSQNQATDGREGGKA 689
  A6PWD2 PLSPLVSGLQKTVVNILRVSLSWLEETEQLLGDLDIELSDS---DK-----GFSLCLIYLL-----------EHYKKIMSQSQDLQAQMNAS--RETQKS 663

  B1AJZ9 L-EEYITQERNRAKETLEEERKRMQELESLLAQQKKALAKSITQEKNRVKEALEEEQTRVQELEERLARQKEVLESSIAHEKRKAKEALESEKRKVQDLE 788
  A6PWD2 LRQEHLA-EKEKLAEKLEQEEKLKAKIQQ-LTEEKAALEESIGQEKSRSEEALEKAQARVRELENHLASQKEALENSVAQEKRKMREMLEAERRKAQDLE 761

  B1AJZ9 NHLTQQKEISESNIAYEKRKAKEAMEKEKKKVQDLENRLTKQKEELELKEQKEDVLNNKLSDALAMVEETQKTKATESLKAESLALKLNETLAELETTKT 888
  A6PWD2 NQLTQQKEISENN-TYEKLKMRDTLEKEKRKIQDLENRLTKQKEEIELKEQKENVLNNKLKDALVMVEDAQQMKTTESQRAETLALKLKETLAELETTKT 860

  B1AJZ9 KMIMVEERLILQQKMVKALQDEQESQRHGFEEEIMEYKEQIKQHAQTIVSLEEKLQKVTQHHKKIEGEIATLKDNDPAPKEERPQDPLVA-PMTESSAKD 987
  A6PWD2 KMILTDDRLKLQQQSMKALQDERESQKHGFEEEISEYKEQIKQHSQTIVSLEERLCQVTQYYQKIEGEITTLKNNDTGPKEEASQD-LTAGPPLDSGDKE 959

  B1AJZ9 MAYEHLIDDLLAAQKEILSQQEVIMKLRKDLTEAHSRMSDLRGELNEKQKMELEQNVVLVQQQSKELSVLKEKMAQMSSLVEKKDRELKALEEALRASQE 1087
  A6PWD2 IACDHLIDDLLMAQKEILSQQEIIMKLRTDLGEAHSRMSDLRGELSEKQKMELERQVALVRQQSGELSMLKAKVAQTTGLMEKKDRELKVLREALRASQE 1059

  B1AJZ9 KHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQEQQSFSDLGVRCKGSRHEEVIQRQKKALSELRARIKELEKARSPDHKDHQNESFLDLKNLR 1187
  A6PWD2 KPRPHLST--EQKPRTLSQKCDISLQIEPAHPDSFSSFQEEQSFSDLGVKCKGSRHEETIQRQRKALSELRTRVRELEKANSCNHKDHVNESFLELRTLR 1157

  B1AJZ9 MENNVQKILLDAKPDLPTLSRIEILAPQNGLCNARFGS--AMEKSGKMDVAEALELSEKLYLDMSKTLGSLMNIKNMSGHVSMKYLSRQEREKVNQLRQR 1285
  A6PWD2 MEKNVQKILLDAKPDLTTLARVEIRPPQNSPFNS--GSTLVMEKSVKTDAGEALELSEKLYTDMIKTLGSLMNIKDMSSHTSLKHLSPKEREKVNHLRQK 1255

  B1AJZ9 DLDLVFDKITQLKNQLGRKEELLRGYEKDVEQLRRSKVSIEMYQSQVAKLEDDIYKEAEEKALLKEALERMEHQLCQEKRINRAIRQQK----------- 1374
  A6PWD2 DLDLVFDKITQLKTRLQRKEELLKGYEQELEQLRHSKVSVQMYQTQVAKLEDDVHKEAEEKALLKEALERTEQQLSQERRFNRVFKQQKDRGEDPEQRNM 1355

  B1AJZ9 -----------------------------VGTRKASLKMDQEREMLRKETSSKSSQSLLHSKPSGKY 1412
  A6PWD2 SYSPFKDNEKQRRLFVEMVKSKMQNSSVQAGAKKATLKTGQERE-TKKE-AYKSTQSLSFVKPGGKN 1420

Go Annotations

1. PB indicates the go terms that are found by both PROST and BLAST.
2. P indicates the go terms that are found by only PROST.
3. B indicates the go terms that are only annotated by BLAST.
Source GO Description
1. PB GO:0120103 centriolar subdistal appendage
1. PB GO:0005813 centrosome
1. PB GO:0005874 microtubule
1. PB GO:0072686 mitotic spindle
1. PB GO:0005814 centriole
2. P GO:0042383 sarcolemma
2. P GO:0005815 microtubule organizing center
2. P GO:0031430 M band
2. P GO:0030018 Z disc
2. P GO:0006936 muscle contraction
2. P GO:0005615 extracellular space
2. P GO:1902305 regulation of sodium ion transmembrane transport
2. P GO:0005790 smooth endoplasmic reticulum
2. P GO:1905150 regulation of voltage-gated sodium channel activity
2. P GO:0072659 protein localization to plasma membrane
2. P GO:1900825 regulation of membrane depolarization during cardiac muscle cell action potential
3. B GO:0002224 toll-like receptor signaling pathway
3. B GO:0003677 DNA binding
3. B GO:0000160 phosphorelay signal transduction system
3. B GO:0051321 meiotic cell cycle
3. B GO:0090443 FAR/SIN/STRIPAK complex
3. B GO:0016887 ATP hydrolysis activity
3. B GO:0061509 asymmetric protein localization to old mitotic spindle pole body
3. B GO:0009555 pollen development
3. B GO:0031030 negative regulation of septation initiation signaling
3. B GO:0032153 cell division site
3. B GO:0044732 mitotic spindle pole body
3. B GO:0006355 regulation of transcription, DNA-templated
3. B GO:0051286 cell tip
3. B GO:0004888 transmembrane signaling receptor activity

Homologs

1. PB indicates the homologs that are found by both PROST and BLAST.
2. P indicates homologs that are only found by PROST.
3. B indicates homologs that are only found by BLAST.

Source Homolog Description FATCAT p-val PROST Evalue BLAST Evalue
1. PB Q498L0 Centrosomal protein of 170 kDa protein B 8.12e-01 2.05e-03 1.57e-04
1. PB Q80U49 Centrosomal protein of 170 kDa protein B 7.67e-01 2.66e-03 2.80e-05
1. PB A6PWD2 Forkhead-associated domain-containing protein 1 7.12e-06 1.46e-40 0.0
1. PB Q9Y4F5 Centrosomal protein of 170 kDa protein B 7.36e-01 3.27e-04 2.37e-05
1. PB Q6A065 Centrosomal protein of 170 kDa 7.53e-01 3.17e-02 2.47e-04
1. PB Q5SW79 Centrosomal protein of 170 kDa 7.74e-01 3.48e-03 1.26e-04
1. PB B1AJZ9 Forkhead-associated domain-containing protein 1 0 1.75e-153 0.0
2. P Q28623 Sarcolemmal membrane-associated protein 8.80e-05 3.86e-03 NA
2. P Q9ULE4 Protein FAM184B 1.87e-04 3.49e-02 NA
2. P P0C219 Sarcolemmal membrane-associated protein 1.23e-05 4.85e-04 NA
2. P Q14BN4 Sarcolemmal membrane-associated protein 3.90e-05 1.07e-04 NA
2. P Q3URD3 Sarcolemmal membrane-associated protein 1.37e-05 9.25e-06 NA
3. B P9WGJ9 Transcriptional regulatory protein EmbR 6.04e-01 NA 0.002
3. B O74388 Uncharacterized protein C3H7.13 4.64e-02 NA 0.005
3. B Q8ILR9 Protein PF14_0175 NA NA 0.025
3. B Q8FTJ5 Oxoglutarate dehydrogenase inhibitor 4.21e-02 NA 0.039
3. B Q2M243 Coiled-coil domain-containing protein 27 1.26e-02 NA 0.003
3. B P66800 Transcriptional regulatory protein EmbR 7.19e-01 NA 0.002
3. B B7SY83 FHA domain-containing protein PS1 6.58e-01 NA 0.048
3. B A0JM08 Centrosomal protein of 170 kDa protein B 7.22e-01 NA 3.68e-05
3. B P9WGJ8 Transcriptional regulatory protein EmbR 4.81e-01 NA 0.002
3. B Q9BWU0 Kanadaptin 1.98e-01 NA 2.77e-04
3. B Q6NHD4 Oxoglutarate dehydrogenase inhibitor 4.05e-02 NA 0.028