Summary

D6RIA3

Homolog: M0RD54.
Function: Cardiac-enriched FHL2-interacting protein.

Statistics

Total GO Annotation: 28
Unique PROST Go: 25
Unique BLAST Go: 3

Total Homologs: 10
Unique PROST Homologs: 4
Unique BLAST Homologs: 4

Structures and Sequence Alignment

The best structural homolog that predicted by 3. B was M0RD54 (Cardiac-enriched FHL2-interacting protein) with a FATCAT P-Value: 0.047 and RMSD of 24.59 angstrom. The sequence alignment identity is 21.2%.
Structural alignment shown in left. Query protein D6RIA3 colored as red in alignment, homolog M0RD54 colored as blue. Query protein D6RIA3 is also shown in right top, homolog M0RD54 showed in right bottom. They are colored based on secondary structures. 

  D6RIA3 MLSFHFWKSRGQPTDAASSVADGIQTPRCCRRCQANNWTGQLSYRTLATVSAGAAAPQPQTTSTASSRSLPTSLRLAAAPPQGLKNWEVVAAVAAVPTAL 100
  M0RD54 ---------------------------------------------------------------------------------------------------- 0

  D6RIA3 GPVQIRGTLLRATLQPLRGQRRTQDFPSDHHCLFLSLKPGQGLIMEAAPPELNSKARQAEVGDGVSSAQDSQELKQQLWPLPKPSASSQREAKYVDMCAS 200
  M0RD54 ---------------------------------------------------------------------------------------------------- 0

  D6RIA3 AEVQRESPQTMKLTLGHCPGGQRASRSPKEKAQDEPSSKTPSPQNNPASSQLSRSQHSASEEGGNFSSSSSSSPMNKAEEDGLSKMEDSTTSTGALATSS 300
  M0RD54 ---------------------------------------------------------------------------------------------------- 0

  D6RIA3 SSLGFESESGESEGCQAVGGEGEKISGGGGGGKGGGGGGAGDGTECRDIIAKSQGSRDPPKVEEAHYITTHEI-QLSEVEQDMDFDVGLASRWD--FEDN 397
  M0RD54 ---------------------------------MQGNKKCADG--FSD--TSSIGS----VLDEAD----REVSNLT----DRAF-RSLCISEDTSFHDS 50

  D6RIA3 NVIYSFVDYAS-FGGS--DET-------PGDITSLTEEDDDNSCYLST---TPS---------TNTTRTPSPTSSDLARPNAG-RSG-----------RD 463
  M0RD54 DLALS-PEITSQVSGTFHQETVSHANRKSGIWSQLPSQGTEHSGWAATFQQQPKYVQGEEKYPKNSP-LPTPVQRRLEVPISGLRSSSKPISKVSSLIRS 148

  D6RIA3 TSSTEVGSGPSDSGPTPPPTGPGTAPLTEPLPETPEAA----SGAAAAAASSCGSAASQILLSIKPASRAINEPSNVRAKQNIIYAAKHE-----GDMSL 554
  M0RD54 FDRTE--AQPCDS--RPPPSKP---P---ALKNTPKFAHPPESG-----VNFCFDSA---FLTVR---RV---PAGVSSTHQ----SSHQPCRAPGE--P 218

  D6RIA3 RVSTAAE---HNSSSLKQNPAAAVAQDHAKKF--IAV-PARLQTRCGAIRAKELVDYSSGA--SSAVSELD--DAD----KEVRNLT-----SRA---FR 632
  M0RD54 EPPTNPEIACHSSDSLLRAP-DRVAGSCEPRFPSPSLKPPKAET--G--RGKEWI--SRGTFLHSENSAFESWDAHQPKLRERKDITETTPESKAPKHYE 311

  D6RIA3 S---LAYPY-FEA-L-------NISSRESSTTLSEVGF----GRWSTFLDLKCG-------GVGARVEQSLLRSSAA--SVAAGLRKG--SGAR-ATADQ 704
  M0RD54 DMPLLKEPYPAESKLSPCQGRANCAQEENR---SPSGIQSTSGAWGA-RD--SGSQVFPVEGNASQIDPQVKRNQAPWRKPKTG--KGGTDGPHDASEDK 403

  D6RIA3 LYIQSKKSQTKALEFVVSKV--EGEI-------------KHVETPLCFQKQVQTGSRVVT-LLEPLNV--RSESK-ASSAPGPGRATKGPGKGPGSAYTD 785
  M0RD54 -----KQPNRKGLP-LYSKLNPQGQLPENGVLDLPEESSDHYSSP--F--NI---SKLLTPIISTKHVLETSDTQPVETSPSP------PGQLNG--YQE 482

  D6RIA3 DGSETSEGSKPTSRADGPQKSKFASSLLKNV--ISKKMQREH-EFKMERGEVMD--TSHHLSGTSKETEG-ARGSERQRERGLQRQSSRHSEAGSEYTVV 879
  M0RD54 --KESSEAQ---SR-DS-YKSK-APSLLFNLKDVRKRVKSTYSPLPLLKG--FDEKTRGKLDG--KQ-EPLSNG--VTLPNGLEENPPT-AELVKE-TL- 564

  D6RIA3 SMSDAGGEGSVAGSKSP-VFKASTPRERNAGPGR-NFTDGH-TEVCEIKKSASETVKGIFLRSQN--SAFRSWKEKEAEKRE-EQAPIGKLKLPKGGDWR 973
  M0RD54 --DDA-----------PSVLHSSTQKD-PAMDSRESFADSHPT-----FSSPSASSKTHF--SINGEAAERNSHEKEEANGESEQ---G---LSEGG-WH 636

  D6RIA3 ADLGEISASKNTIMSRLFVPNI-----QQTPKDKQPR---K-------QAT---------KYPAAQATSTAVIRPKAPEIKIRLGSVQQPSSDFNIAKLL 1049
  M0RD54 PDSRENLPRKH--LS-LKLCNRDSETGQATEKMK-PRQLEKRLSRSISQETEPEREMGFQNLPVSQKFSPGPLSPEEEDV---FYSDSQ--SDFTPC-VQ 726

  D6RIA3 T-PKLAGGSASNLFKTIEDNSRAQQKL-F-RG---DNLEKVPHFQVRD-IRD-K----SKAQGP----LHQ-VRDVRKLIKGSGDSSDKGSVTPEQGLTG 1132
  M0RD54 TKAKFSTSSSDQSFASFED----QQKMWFTEGPREDG--K-SHVSLGDNQKDEKETEVEKEE-PQQCALHNGVEEHRQ--K---ETQRK-----AQGVLG 808

  D6RIA3 PKPRQLSA---AAGGS--GSLSPMVITCQAVVNQREDSMDREP-RESMGKGGGSRVLNSSSP--EGTVLVHRASGRLPVATIAPNKPEQGSYLPVLKIVS 1224
  M0RD54 GRPRKASAEEVSVRGSWTGADKD---T--ALSHAKDPT----PLPASTNK---HRLF----PIKDNTL---RAT---PV--I---KP---IILPLLRTVS 878

  D6RIA3 KASTQKTPEKL----KEEEV------KEEG----KATKPARNALEKLTAAVRSMEE---LYSFNRNEWKRKSDPLPMMMDSHVLSLIASEE-----REG- 1301
  M0RD54 ------SEDSLSGGHKENELPRQPWGEDAGGLGASESQEMRNT--PLSNSTPSTEQKCVVYE-GVEE-----DPV------HT---AAQDETSQQTRKGS 955

  D6RIA3 ---V-VVADGDH-----DKLSKRLGEVEERG--TGNKAGVVLRGAPIERLQRRNSNPSAESVSARAAAFENLARERPRSLYIPPVH--------K----D 1378
  M0RD54 FSFLPLVEEGGKTKPPPDTADERLAHEKSRSADSG-K----LE-AP-QHI------P---TIALHS---DDL-EDSPPSL---PQHTCWEEQGFKSHFLS 1032

  D6RIA3 VERTQP--LQPLP------PLPSN-RNVFTVS--ASSI-QKTGGVAGKF-----PQGPSP-ESPSAAKGIKSQGL-RSLKISPATRAPPDEVTNRKSGS- 1458
  M0RD54 APRAGPSGRRPVPSEAATSPNPSSLGGSSTCSPAASSIWEDASQAAGEHWQRQEPPGPGPWASPGPS-G--PTGLTRR---EDMTRG----LTWEAEGSD 1122

  D6RIA3 -NLEKSNSDCENYLTI-P----LKGSSAAGE---LLSRPGASREG-PPNSSAATLCSLPP-----LSARS-QVPS-SSKGSQVSGTSRPAWRTK--PDNP 1539
  M0RD54 PHLERL-AD---FRTLSPRGIFLTGAAEKPEPSSLLEK--AA--GKPP--------AVPPKTEKALR-RAKKLASKRRKSDQMSEKHTEAWEGKSFTEDA 1205

  D6RIA3 RETVAAP--P--GPQSPEHPPT-TIYHQPPLPFTLQGAQPQVLCFSPPSMPAPAPAAS-APVPTDPFQQAQPQQTQRKMLLDVTTGQYYLVDTPVQPMTR 1633
  M0RD54 QGTEQRPVSPGKGPR-PRFPEVRSL---PP-P-T---HRHSVSCGWEPAGRRPWGSQSLIPLP--PY----P-ATQ-KVLQDPQSGQYFVFDMPLQVKIK 1288

  D6RIA3 RLFDPETGQY--VDVPMTSQQQAVAPMSISVPPL--ALSPGAYGPTYMIYPGFLPTVLPTNALQPTPIARAPRGSELSPMVAEPSSKEAAATFTEAPYFM 1729
  M0RD54 TFYDPETGKYVKVSVP-SSEED---P---SEPPLQDALT----AP-YLLYPGFQP--VPVTSLMP---LRC--SSQLA-----------------APTFL 1352

  D6RIA3 ASGQS--PASSTSS--APAATSQLLGAKAFAQLHGKPVISITSQPLGPRIIAPPSFDGT---TMSFV----VEHR------ 1793
  M0RD54 RQGSSHRPQSSQGARLQP--PPERLGES--AQ-H----VSSAQRPRGPP-LSPEE-EGAEAPSLSIISTDDLEDFATEGVS 1422

Go Annotations

1. PB indicates the go terms that are found by both PROST and BLAST.
2. P indicates the go terms that are found by only PROST.
3. B indicates the go terms that are only annotated by BLAST.
Source GO Description
2. P GO:0005704 polytene chromosome band
2. P GO:0005844 polysome
2. P GO:0006342
2. P GO:0010603 regulation of cytoplasmic mRNA processing body assembly
2. P GO:0034063 stress granule assembly
2. P GO:0005154 epidermal growth factor receptor binding
2. P GO:0036353 histone H2A-K119 monoubiquitination
2. P GO:1990904 ribonucleoprotein complex
2. P GO:0010494 cytoplasmic stress granule
2. P GO:0002091 negative regulation of receptor internalization
2. P GO:1990841 promoter-specific chromatin binding
2. P GO:0016070 RNA metabolic process
2. P GO:0010629 negative regulation of gene expression
2. P GO:0007419 ventral cord development
2. P GO:0060612 adipose tissue development
2. P GO:0006338 chromatin remodeling
2. P GO:0003713 transcription coactivator activity
2. P GO:0050658 RNA transport
2. P GO:0008022 protein C-terminus binding
2. P GO:0035102 PRC1 complex
2. P GO:0005802 trans-Golgi network
2. P GO:0033962 P-body assembly
2. P GO:0051091 positive regulation of DNA-binding transcription factor activity
2. P GO:0031519 PcG protein complex
2. P GO:0035186 syncytial blastoderm mitotic cell cycle
3. B GO:0030018 Z disc
3. B GO:0070886 positive regulation of calcineurin-NFAT signaling cascade
3. B GO:0005654 nucleoplasm

Homologs

1. PB indicates the homologs that are found by both PROST and BLAST.
2. P indicates homologs that are only found by PROST.
3. B indicates homologs that are only found by BLAST.

Source Homolog Description FATCAT p-val PROST Evalue BLAST Evalue
1. PB D6RIA3 Uncharacterized protein C4orf54 0 1.20e-133 0.0
1. PB E0CYV9 Uncharacterized protein C4orf54 homolog 5.00e-04 1.12e-50 0.0
2. P E1BLP6 AT-rich interactive domain-containing protein 5B 4.39e-01 3.10e-02 NA
2. P Q99700 Ataxin-2 2.28e-01 6.31e-03 NA
2. P P35820 Polycomb group protein Psc 1.66e-01 5.24e-03 NA
2. P Q0UJJ7 Stress response protein NST1 8.82e-01 1.89e-02 NA
3. B D3Z1D3 Cardiac-enriched FHL2-interacting protein 1.36e-01 NA 1.24e-07
3. B Q711Q0 Cardiac-enriched FHL2-interacting protein 1.17e-01 NA 2.42e-05
3. B E7EW31 Proline-rich basic protein 1 1.72e-01 NA 2.52e-07
3. B M0RD54 Cardiac-enriched FHL2-interacting protein 4.70e-02 NA 3.01e-07