Summary

F5H4B4

Homolog: Q6AXP3.
Function: Protein FAM227B.

Statistics

Total GO Annotation: 4
Unique PROST Go: 4
Unique BLAST Go: 0

Total Homologs: 6
Unique PROST Homologs: 1
Unique BLAST Homologs: 4

Structures and Sequence Alignment

The best structural homolog that predicted by 3. B was Q6AXP3 (Protein FAM227B) with a FATCAT P-Value: 6.73e-07 and RMSD of 3.51 angstrom. The sequence alignment identity is 23.8%.
Structural alignment shown in left. Query protein F5H4B4 colored as red in alignment, homolog Q6AXP3 colored as blue. Query protein F5H4B4 is also shown in right top, homolog Q6AXP3 showed in right bottom. They are colored based on secondary structures. 

  F5H4B4 ---------------MNHFRKMEVINLTTLPMIPVDEHLAVSLVARNTMVK--------TVRKELENNPPSC--LIGSMHQVNQKIAD-INLRTEPSANS 74
  Q6AXP3 MELPTPQKVQEPPKSFEEFLKSQ--N---WDYWPRDVHIRDGDIWENTLRKLEEAVSYNSVYSYLWTNVPRLYEIVDSME---SKLKECSHL-LQQHASR 91

  F5H4B4 LAIERFELEKKALREKTRS-SPEDKVKRQRKSQYSCKGSELRHARSSVI---KRKTADKNL-----LAELYQYSNFNSSKPNKLPNGVDFCDMVGNVVRA 165
  Q6AXP3 L----FESDR--LISKKRTYTNLDRYKAFLKEHY-------R--RKKIVLSDQMET-EKNIEGCTFL--LKQ--N----ELTQLPRHLDAKQIYLYVLRT 167

  F5H4B4 ERDCLSGKHFCSGRELEK--FLSSSSPRAIWL-DSFWWIF-HERYQPNKELQNNLFDRIAQHYALLLFRVPKSHSEEALLKRLPSLLSKAVYTSFCCCFP 261
  Q6AXP3 HN--LEEKVF----KVWKTHILSDCS-IAL-LHDCFWWWFLH-KFKPDKRDQDWLFDRIAESYVTLFMRIP-LRRKDIFFQMYPDWLAQAVYTTFQESFP 257

  F5H4B4 QSW--F-DTHEFKSDICNTMSLWISGTYPSPQSYDSWDYSELDPERFRREELMLYRRRLTKGREFSLFAGKRAFSQKPAQSRKFYHPQSSSANSPSEKTS 358
  Q6AXP3 ESCSLFNDN--FKEDLGNTIFLWLSGLKPAP-GF--WTHWKL-------QDL------CT-----TTIHGCR---RVPVKLRR-------GIMSSQEHTS 324

  F5H4B4 SAKQNSEKSLRMQNTAKEHHCQTLVLKKPTQEVKRISEARECENMFPKKSCAACKS--PELTSNLFNIYGKSPLIVYFLQNYA----SL--QQHG-KNVL 449
  Q6AXP3 AT-----VGLKIED----------ILKNP-RALPVLKEESAASKVTTK---SHYRSLGPEFYKVLFDFGGQSPLILYYLKMHELGGISVTYNPKGSKFTK 405

  F5H4B4 IVRREKTTSTPDCTPTYTDVISET---LCSMK---KR-----KDNLNQLYQHHWTEWNYFDKHLKELQDNFSR---EMKN----------IDPK------ 519
  Q6AXP3 ILRE------PPPAPTYCEIIKDAKRKFADNKKDFKRVKQRIKDDIKFLKEQQ--E--QIDKELDRLQAKASKNLQEVKNDFENFLHKLRVEAKLKEEYR 495

  F5H4B4 --AADTKKANHMFIPPSAVNEESP----DKKTKEGKGGEGKRRETEVEHFFPL-TSKP---------------------------- 570
  Q6AXP3 GSASPSESLQSLQSPNSSLS--SPAMSEDFNSVE-EGG---LKEARSDHY--LRTTHSSFSSINLIGGECTTKSTFCCSSLKSSHQ 573

Go Annotations

1. PB indicates the go terms that are found by both PROST and BLAST.
2. P indicates the go terms that are found by only PROST.
3. B indicates the go terms that are only annotated by BLAST.
Source GO Description
2. P GO:0042025 host cell nucleus
2. P GO:0006355 regulation of transcription, DNA-templated
2. P GO:0019033 viral tegument
2. P GO:0030430 host cell cytoplasm

Homologs

1. PB indicates the homologs that are found by both PROST and BLAST.
2. P indicates homologs that are only found by PROST.
3. B indicates homologs that are only found by BLAST.

Source Homolog Description FATCAT p-val PROST Evalue BLAST Evalue
1. PB F5H4B4 Protein FAM227A 0 9.46e-140 0.0
2. P P52355 mRNA export factor ICP27 homolog NA 3.83e-02 NA
3. B Q9D518 Protein FAM227B 5.83e-05 NA 1.19e-15
3. B Q6AXP3 Protein FAM227B 6.73e-07 NA 7.38e-16
3. B Q96M60 Protein FAM227B 4.72e-06 NA 2.90e-19
3. B Q4R7D5 Protein FAM227B 2.14e-05 NA 3.01e-16