Summary

H3BNL8

Homolog: Q4I624.
Function: Hsp70 nucleotide exchange factor FES1.

Statistics

Total GO Annotation: 16
Unique PROST Go: 16
Unique BLAST Go: 0

Total Homologs: 22
Unique PROST Homologs: 21
Unique BLAST Homologs: 0

Structures and Sequence Alignment

The best structural homolog that predicted by 2. P was Q4I624 (Hsp70 nucleotide exchange factor FES1) with a FATCAT P-Value: 7.34e-08 and RMSD of 3.10 angstrom. The sequence alignment identity is 19.5%.
Structural alignment shown in left. Query protein H3BNL8 colored as red in alignment, homolog Q4I624 colored as blue. Query protein H3BNL8 is also shown in right top, homolog Q4I624 showed in right bottom. They are colored based on secondary structures. 

  H3BNL8 MANSRFSCTQIWVKMYGYFAGLC-RRLQKF--WRVTVKGFFVKKKEKKIPSAETYFHEEKIVVL--GQV---LMNESLPIEKRAQAAQ-KIG--LLAFTG 89
  Q4I624 ---------------------MADPRLNELLKW--SIEQSEATKNDPDAPPAKTQLTPELMAALMGGPSDADLMKASMEIITSDNAEEVSLDDKLVAF-- 75

  H3BNL8 GPPAGNFA--AEYME---EVAHL-----LQDEELAPKIKILLLQSVACWCY---L--NPVSQKRAKSLQFIPILISFFEGRFESTIKSETNSYLLLKFWT 174
  Q4I624 ----DNFEQLIENLDNANNIANLSLWTPLLD-QL--KHEEREMRKMAAWCVGTAVQNNEKTQERLLAVGGVPMLVDL------AT-KED--EPVDVRRKA 159

  H3BNL8 CYVLSVMTCN-----NLSCVKEL--KDHSALKYH-LQMLAAE---NWSGWTENFAEVLYFLIGFHRN 230
  Q4I624 VYALSSAVRNYQPAMDLFA-DELTKKGHKTDKVDATSMEAVDEVVN--GLREKIGKA---------- 213

Go Annotations

1. PB indicates the go terms that are found by both PROST and BLAST.
2. P indicates the go terms that are found by only PROST.
3. B indicates the go terms that are only annotated by BLAST.
Source GO Description
2. P GO:0005783 endoplasmic reticulum
2. P GO:0007288 sperm axoneme assembly
2. P GO:0006366 transcription by RNA polymerase II
2. P GO:0005694 chromosome
2. P GO:0031398 positive regulation of protein ubiquitination
2. P GO:1990918 double-strand break repair involved in meiotic recombination
2. P GO:0004857 enzyme inhibitor activity
2. P GO:0031625 ubiquitin protein ligase binding
2. P GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
2. P GO:0007283 spermatogenesis
2. P GO:0005788 endoplasmic reticulum lumen
2. P GO:0044782 cilium organization
2. P GO:0000774 adenyl-nucleotide exchange factor activity
2. P GO:0007144 female meiosis I
2. P GO:0007141 male meiosis I
2. P GO:0006417 regulation of translation

Homologs

1. PB indicates the homologs that are found by both PROST and BLAST.
2. P indicates homologs that are only found by PROST.
3. B indicates homologs that are only found by BLAST.

Source Homolog Description FATCAT p-val PROST Evalue BLAST Evalue
1. PB H3BNL8 Armadillo-like helical domain-containing protein 2 0 2.76e-126 8.98e-173
2. P Q5RD03 Armadillo repeat-containing protein 6 5.58e-05 9.69e-03 NA
2. P O75031 Heat shock factor 2-binding protein 5.80e-07 4.16e-02 NA
2. P P0CN69 Hsp70 nucleotide exchange factor FES1 4.70e-05 8.48e-05 NA
2. P Q32KV6 Nucleotide exchange factor SIL1 1.61e-05 3.59e-02 NA
2. P Q9D4G2 Heat shock factor 2-binding protein 5.71e-07 2.32e-03 NA
2. P P0DOO9 Protein A47 NA 3.92e-03 NA
2. P O57248 Protein A47 NA 4.57e-02 NA
2. P Q5AYT7 Hsp70 nucleotide exchange factor fes1 1.38e-06 7.19e-03 NA
2. P P0CN68 Hsp70 nucleotide exchange factor FES1 2.32e-05 8.48e-05 NA
2. P Q2U9E2 Hsp70 nucleotide exchange factor fes1 1.55e-06 1.27e-02 NA
2. P Q6IMX7 Hsp70-binding protein 1 2.35e-07 1.14e-04 NA
2. P Q8NEN0 Armadillo repeat-containing protein 2 1.36e-04 7.03e-04 NA
2. P Q9NZL4 Hsp70-binding protein 1 2.12e-06 5.23e-05 NA
2. P Q99P31 Hsp70-binding protein 1 4.87e-07 1.09e-05 NA
2. P Q4R588 Hsp70-binding protein 1 2.36e-06 1.80e-04 NA
2. P P21067 Protein A47 NA 6.13e-04 NA
2. P Q4I624 Hsp70 nucleotide exchange factor FES1 7.34e-08 7.39e-03 NA
2. P P0DOP0 Protein A47 NA 3.92e-03 NA
2. P P26673 Protein A47 NA 8.31e-05 NA
2. P P0C6R2 Armadillo repeat-containing protein 2 1.52e-04 1.21e-02 NA
2. P Q3URY6 Armadillo repeat-containing protein 2 1.13e-04 1.28e-03 NA