Summary

H7BZ55

Homolog: Q5TZA2.
Function: Rootletin.

Statistics

Total GO Annotation: 134
Unique PROST Go: 88
Unique BLAST Go: 13

Total Homologs: 38
Unique PROST Homologs: 28
Unique BLAST Homologs: 4

Structures and Sequence Alignment

The best structural homolog that predicted by 1. PB was Q5TZA2 (Rootletin) with a FATCAT P-Value: 1.47e-08 and RMSD of 9.78 angstrom. The sequence alignment identity is 34.5%.
Structural alignment shown in left. Query protein H7BZ55 colored as red in alignment, homolog Q5TZA2 colored as blue. Query protein H7BZ55 is also shown in right top, homolog Q5TZA2 showed in right bottom. They are colored based on secondary structures. 

  H7BZ55 MSSASSEPGNGDASQQPL-LGLDTVIQRLEDTILSPTASREDRALTVRGEGRQASPTPVPTRIREIVAGSLSEEPPQAGVQEP-T--ATVARVQEENELL 96
  Q5TZA2 MSL-------GLARAQEVELTLETVIQTLESSVLC-----QEKGLGARDLAQDAQITSLPALIREIVTRNLSQ--PESPVLLPATEMASLLSLQEENQLL 86

  H7BZ55 QEELTRLGDLLAQASAERDELASRCRVVSEQL-QA-R-----LETTE--------AQLRR---------------------------------------- 141
  Q5TZA2 QQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRLEPGELETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKR 186

  H7BZ55 -SEL-------------------EHSVDLEEALGRLEAAEERSTGLCQVNALLREQLEHMKKANDALGRELAGMTGSVQRLQGELELRR--WAQR--QTR 217
  Q5TZA2 CSELEQQLLERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAW-RREEESF 285

  H7BZ55 SGGLGQPRD-LLLLWRQAVVLGTD--LAELRVATERGLADLQADTARTARRLHTACLNLDSNLRLSASSTASTL-------GQ---QLRDK---AGEMLQ 301
  Q5TZA2 NAYFSNEHSRLLLLWRQ--VVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQLRDKVLREKDLAQ 383

  H7BZ55 LQGRWDAEKVALQARLSEQTLLVEKLTEQN---EQ--K---AK-----TI-----AALRT-D---LQN-L--VAQE---DARC-LELAGSSITE------ 366
  Q5TZA2 QQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEALESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGS 483

  H7BZ55 L----GE--PRRPLR-SPQRATSPHQGASPPHICS-PATLDPALQAMRAAIERRWRREQELCLQLKSSQALVASLQEQLSES---RRELWAAQKLQQERA 455
  Q5TZA2 LRGLSGQRTPSPPRRSSPGRGRSPRRGPSP--ACSDSSTL--AL--IHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRAL--EEQLQ--RL 573

  H7BZ55 REQARERE-ALRGQLEAQRLEVQQCRASCKLLGREKAALEMVVEELKGKADAADAEKQGLEAEAAEL--QRSLLLQAERREELALR---RERSCRALETS 549
  Q5TZA2 RDKT---DGAMQAHEDAQR-EVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRL--EEEQED-AVQDGARVR--RELERS 664

  H7BZ55 QGRLQQLEEKVSGLREELASVREALSTAQLQRDVVESEREGLRSALARAECSNADLELLVRRLKSEGVEQRDSLAAMAALMEGLAQDKSALNHLALQLEQ 649
  Q5TZA2 HRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEE 764

  H7BZ55 ERDQLR-EQRKTLEQERARAGEQLAQAEQQLALER-AERRGLQQACGRL---EQRQEQLEGQAALLGREKAQLQEQVGQVTCQKQALEEQLAQSLQDQEA 744
  Q5TZA2 EKSALQGRQRQA-EQEATVAREEQERLE-ELRLEQEVARQGLE---GSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQR 859

  H7BZ55 QMGTLQQALQGKDALSEERAQLLAKQEALERQGRLAAEEAADLRVERDSLESSLLEAQ-QLATKL---QEQLEEEARSAGLARQALQVEMEQL-QSDWEV 839
  Q5TZA2 QVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLA-QLEARREQLEAEGQALLLAKETLTGELAGLRQQIIAT 958

  H7BZ55 QEMKLRQDTVRLQRQVAQQEREAQRALESQALAHREALAQLQREKETLSLTLAEEKEVARCQLEQEK-ELVTKSAAEREALKGEIQSLKQERDESLLQLE 938
  Q5TZA2 QE-KASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAE 1057

  H7BZ55 HKMQQALSLKETERSLLSEELSRARRTL-------ERVQQEAQSQQEQAQATISATTEELKALQAQFEDAITAHQRETTALRESLQDLAAERGDVEREAE 1031
  Q5TZA2 SEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAE 1157

  H7BZ55 RLRAQLTV---AQEGLAALRQEL----QGVEESREG--LHR-EAQEARRALSDEAREKDVLLLFNSELRATICRAEQEKASFKRSKEEKEQKLLILEEAQ 1121
  Q5TZA2 ELRTQLRLLEDARDG---LRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEAR 1254

  H7BZ55 AALQQEASALRAHLWELEQAGGDARQELRELHRQVRTLKAENQRRSG-EAHELQAQCSQEVLELRRQAAKAEAKHE--GARKEVL-G---L--------- 1205
  Q5TZA2 TAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRL-GRELAELQGR-----LALGERAEK-ESRRETLGLRQRLLKGEASLEVMRQELQV 1347

  H7BZ55 -QRKLAEVEAAGE--AHGQRLQEHLRESRGAE-QTL---RA-ELHSVTRKLQEASGVADALQARLDQACHRIHSLEQELAQAEGARQDAEAQLGRLCSTL 1297
  Q5TZA2 AQRKLQEQE--GEFRTRERRLLGSLEEARGTEKQQLDHARGLEL-----KLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSAL 1440

  H7BZ55 RRGLGLQR-QSPWASPEQPGSPTKGSDSSQALP--GQ-QG-TSPPARPHSPLRWPSPTPGGRSS----ELMDVATVQDILRDFVQKLREAQRERDDSRIQ 1388
  Q5TZA2 RRGLGLGRAPSPAPRP-VPGSPAR--DA----PAEGSGEGLNSPSTLECSPGSQP-PSPGPATSPASPDL-DPEAVRGALREFLQELRSAQRERDELRTQ 1531

  H7BZ55 MATLSSRLSEAECRCARAQSRVGQLQKALAEAEEGQRRVEGALSSARAARALQKEALRR--------LE----LEH-L-AS---VRAA------------ 1459
  Q5TZA2 TSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKANET 1631

  H7BZ55 ---GQEKRRLQEQLE-----TLRQALEESRRHSQGLAKQGKLLEEQLTNLEHRCQKAEVSLEPL-RQM-EQE----TLKREEDVARL-GA-EKEQLDQSL 1543
  Q5TZA2 KLEG-DKRRLKEVLDASESRTVK--LELQRRSLEGELQRSRL---GLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQL--TVERLNGALAK--VEESE 1721

  H7BZ55 NSLHQEVDG---ALRQNQ-QLQAQMTEMEQAHTQRLQDLTA-QHQRDLATEAERLHGARPQATQAL-ESQEWTHQ--QQVKVLEEQVASLK----E---Q 1628
  Q5TZA2 GALRDKVRGLTEALAQSSASLNS--TRDKNLHLQKA--LTACEHDRQVL--QERLDAAR----QALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQ 1811

  H7BZ55 LDQ--EV-QWRQQAHLGQ--AFQTGHAQRD---------------------------------------------------------------------- 1653
  Q5TZA2 LQQLREVLRQRQE---GEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDR 1908

  H7BZ55 ---------------------------------------------------------------------------------------------------- 1653
  Q5TZA2 TLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKGQLQQELRRSSAPF 2008

  H7BZ55 --------- 1653
  Q5TZA2 SPPSGPPEK 2017

Go Annotations

1. PB indicates the go terms that are found by both PROST and BLAST.
2. P indicates the go terms that are found by only PROST.
3. B indicates the go terms that are only annotated by BLAST.
Source GO Description
1. PB GO:0030997 regulation of centriole-centriole cohesion
1. PB GO:0048471 perinuclear region of cytoplasm
1. PB GO:0010669 epithelial structure maintenance
1. PB GO:0051656 establishment of organelle localization
1. PB GO:0031616 spindle pole centrosome
1. PB GO:0001750 photoreceptor outer segment
1. PB GO:0015629 actin cytoskeleton
1. PB GO:0005814 centriole
1. PB GO:0005200 structural constituent of cytoskeleton
1. PB GO:0007098 centrosome cycle
1. PB GO:0032053 ciliary basal body organization
1. PB GO:0019901 protein kinase binding
1. PB GO:0008022 protein C-terminus binding
1. PB GO:0050908 detection of light stimulus involved in visual perception
1. PB GO:0000278 mitotic cell cycle
1. PB GO:0060271 cilium assembly
1. PB GO:0033365 protein localization to organelle
1. PB GO:0005813 centrosome
1. PB GO:0032991 protein-containing complex
1. PB GO:0019894 kinesin binding
1. PB GO:0010457 centriole-centriole cohesion
1. PB GO:0008104 protein localization
1. PB GO:1903566 positive regulation of protein localization to cilium
1. PB GO:0036064 ciliary basal body
1. PB GO:1905515 non-motile cilium assembly
1. PB GO:0045494 photoreceptor cell maintenance
1. PB GO:0032580 Golgi cisterna membrane
1. PB GO:0035253 ciliary rootlet
1. PB GO:0045724 positive regulation of cilium assembly
1. PB GO:0097729 9+2 motile cilium
1. PB GO:0001917 photoreceptor inner segment
1. PB GO:1904781 positive regulation of protein localization to centrosome
1. PB GO:0120219 subapical part of cell
2. P GO:0099041 vesicle tethering to Golgi
2. P GO:0097539 ciliary transition fiber
2. P GO:0050772 positive regulation of axonogenesis
2. P GO:0098831 presynaptic active zone cytoplasmic component
2. P GO:0060050 positive regulation of protein glycosylation
2. P GO:0097224 sperm connecting piece
2. P GO:0090161 Golgi ribbon formation
2. P GO:0003413 chondrocyte differentiation involved in endochondral bone morphogenesis
2. P GO:0071539 protein localization to centrosome
2. P GO:0005874 microtubule
2. P GO:0006511 ubiquitin-dependent protein catabolic process
2. P GO:0048786 presynaptic active zone
2. P GO:0031062 positive regulation of histone methylation
2. P GO:0098882 structural constituent of presynaptic active zone
2. P GO:0032091 negative regulation of protein binding
2. P GO:0030426 growth cone
2. P GO:0044877 protein-containing complex binding
2. P GO:0016574 histone ubiquitination
2. P GO:0007030 Golgi organization
2. P GO:0033523 histone H2B ubiquitination
2. P GO:0007020 microtubule nucleation
2. P GO:2001168 positive regulation of histone H2B ubiquitination
2. P GO:0048790 maintenance of presynaptic active zone structure
2. P GO:0120103 centriolar subdistal appendage
2. P GO:0051645 Golgi localization
2. P GO:0004842 ubiquitin-protein transferase activity
2. P GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport
2. P GO:0090166 Golgi disassembly
2. P GO:0003730 mRNA 3'-UTR binding
2. P GO:0098978 glutamatergic synapse
2. P GO:0005815 microtubule organizing center
2. P GO:0030336 negative regulation of cell migration
2. P GO:0008356 asymmetric cell division
2. P GO:0010507 negative regulation of autophagy
2. P GO:0033503 HULC complex
2. P GO:0007283 spermatogenesis
2. P GO:0000922 spindle pole
2. P GO:0005802 trans-Golgi network
2. P GO:0043025 neuronal cell body
2. P GO:0048167 regulation of synaptic plasticity
2. P GO:0001520 outer dense fiber
2. P GO:0030165 PDZ domain binding
2. P GO:0090306 meiotic spindle assembly
2. P GO:0002039 p53 binding
2. P GO:0061676 importin-alpha family protein binding
2. P GO:0043195 terminal bouton
2. P GO:1900364 negative regulation of mRNA polyadenylation
2. P GO:0042734 presynaptic membrane
2. P GO:0051225 spindle assembly
2. P GO:0002081 outer acrosomal membrane
2. P GO:0000151 ubiquitin ligase complex
2. P GO:0060122 inner ear receptor cell stereocilium organization
2. P GO:0020035 cytoadherence to microvasculature, mediated by symbiont protein
2. P GO:0002079 inner acrosomal membrane
2. P GO:0031625 ubiquitin protein ligase binding
2. P GO:0003713 transcription coactivator activity
2. P GO:0045162 clustering of voltage-gated sodium channels
2. P GO:0072686 mitotic spindle
2. P GO:0000209 protein polyubiquitination
2. P GO:0030134 COPII-coated ER to Golgi transport vesicle
2. P GO:0006486 protein glycosylation
2. P GO:0099518 vesicle cytoskeletal trafficking
2. P GO:0010390 histone monoubiquitination
2. P GO:0048278 vesicle docking
2. P GO:0030276 clathrin binding
2. P GO:0051660 establishment of centrosome localization
2. P GO:0090307 mitotic spindle assembly
2. P GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane
2. P GO:0003281 ventricular septum development
2. P GO:0042393 histone binding
2. P GO:0003682 chromatin binding
2. P GO:0009617 response to bacterium
2. P GO:0051289 protein homotetramerization
2. P GO:0016082 synaptic vesicle priming
2. P GO:0005798 Golgi-associated vesicle
2. P GO:0098982 GABA-ergic synapse
2. P GO:0005794 Golgi apparatus
2. P GO:0031267 small GTPase binding
2. P GO:0014069 postsynaptic density
2. P GO:0000137 Golgi cis cisterna
2. P GO:0005801 cis-Golgi network
2. P GO:0007274 neuromuscular synaptic transmission
2. P GO:0019905 syntaxin binding
2. P GO:0035773 insulin secretion involved in cellular response to glucose stimulus
2. P GO:0017080 sodium channel regulator activity
2. P GO:0042802 identical protein binding
2. P GO:0048788 cytoskeleton of presynaptic active zone
2. P GO:0071439 clathrin complex
3. B GO:0021591 ventricular system development
3. B GO:0005198 structural molecule activity
3. B GO:1904158 axonemal central apparatus assembly
3. B GO:0002064 epithelial cell development
3. B GO:0019904 protein domain specific binding
3. B GO:0090498 extrinsic component of Golgi membrane
3. B GO:1990718 axonemal central pair projection
3. B GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
3. B GO:0060438 trachea development
3. B GO:0003779 actin binding
3. B GO:0070062 extracellular exosome
3. B GO:0003341 cilium movement
3. B GO:1990716 axonemal central apparatus

Homologs

1. PB indicates the homologs that are found by both PROST and BLAST.
2. P indicates homologs that are only found by PROST.
3. B indicates homologs that are only found by BLAST.

Source Homolog Description FATCAT p-val PROST Evalue BLAST Evalue
1. PB Q9BV73 Centrosome-associated protein CEP250 3.48e-06 1.52e-03 3.06e-42
1. PB Q60952 Centrosome-associated protein CEP250 2.93e-05 6.91e-04 9.70e-42
1. PB H7BZ55 Ciliary rootlet coiled-coil protein 2 0 7.47e-141 0.0
1. PB Q5TZA2 Rootletin 1.47e-08 8.59e-11 5.26e-149
1. PB F6XLV1 Ciliary rootlet coiled-coil protein 2 1.02e-06 1.07e-24 0.0
1. PB Q8CJ40 Rootletin 1.72e-07 4.02e-10 2.20e-163
2. P P21249 Major antigen 6.70e-06 6.21e-03 NA
2. P O61308 227 kDa spindle- and centromere-associated protein 2.64e-06 1.91e-02 NA
2. P Q5T9S5 Coiled-coil domain-containing protein 18 7.16e-06 3.69e-03 NA
2. P Q8BI22 Centrosomal protein of 128 kDa 4.60e-06 3.32e-02 NA
2. P Q5ZLS3 E3 ubiquitin-protein ligase BRE1A 1.12e-03 1.84e-02 NA
2. P P75471 Cytadherence high molecular weight protein 2 1.24e-07 2.08e-02 NA
2. P Q8C9S4 Coiled-coil domain-containing protein 186 1.82e-02 3.35e-04 NA
2. P G5E861 Sodium channel and clathrin linker 1 4.28e-06 6.98e-03 NA
2. P Q5DTM8 E3 ubiquitin-protein ligase BRE1A 3.19e-05 8.31e-03 NA
2. P Q5VTR2 E3 ubiquitin-protein ligase BRE1A 1.37e-05 2.50e-03 NA
2. P A2VDP1 E3 ubiquitin-protein ligase BRE1A 2.64e-05 6.98e-03 NA
2. P Q6ZU80 Centrosomal protein of 128 kDa 6.80e-05 1.60e-02 NA
2. P Q5ZKK5 Outer dense fiber protein 2 8.11e-06 2.37e-02 NA
2. P Q8CJ99 Sodium channel and clathrin linker 1 5.23e-05 4.11e-02 NA
2. P Q8CDI7 Coiled-coil domain-containing protein 150 1.09e-03 7.50e-04 NA
2. P Q6PH08 ERC protein 2 7.42e-04 1.02e-04 NA
2. P Q96NL6 Sodium channel and clathrin linker 1 3.73e-05 4.60e-04 NA
2. P Q15643 Thyroid receptor-interacting protein 11 1.69e-06 2.10e-02 NA
2. P Q62839 Golgin subfamily A member 2 9.21e-06 1.38e-02 NA
2. P O15083 ERC protein 2 5.19e-06 1.49e-04 NA
2. P Q9Z221 Polyamine-modulated factor 1-binding protein 1 6.69e-06 2.57e-03 NA
2. P F1R4Y7 Centrosomal protein of 83 kDa 5.90e-06 3.41e-02 NA
2. P Q9WVQ0 Polyamine-modulated factor 1-binding protein 1 2.27e-03 4.80e-02 NA
2. P Q9Y592 Centrosomal protein of 83 kDa 9.69e-05 3.29e-02 NA
2. P Q32LM7 Coiled-coil domain-containing protein 152 2.47e-02 2.93e-03 NA
2. P Q8K3M6 ERC protein 2 1.19e-03 1.81e-04 NA
2. P Q921M4 Golgin subfamily A member 2 4.24e-06 3.20e-02 NA
2. P Q7Z3E2 Coiled-coil domain-containing protein 186 7.28e-05 2.45e-03 NA
3. B Q86T23 Putative ciliary rootlet coiled-coil protein-like 1 protein 3.65e-02 NA 1.34e-05
3. B Q80W93 Hydrocephalus-inducing protein NA NA 0.003
3. B Q8IVE0 Putative ciliary rootlet coiled-coil protein-like 2 protein 1.59e-02 NA 3.09e-07
3. B P55937 Golgin subfamily A member 3 1.14e-05 NA 1.96e-05