Summary

L0R6Q1

Homolog: A2AJB2.
Function: Transmembrane protein 141.

Statistics

Total GO Annotation: 51
Unique PROST Go: 43
Unique BLAST Go: 6

Total Homologs: 56
Unique PROST Homologs: 52
Unique BLAST Homologs: 3

Structures and Sequence Alignment

The best structural homolog that predicted by 2. P was A2AJB2 (Transmembrane protein 141) with a FATCAT P-Value: 3.29e-07 and RMSD of 1.95 angstrom. The sequence alignment identity is 22.0%.
Structural alignment shown in left. Query protein L0R6Q1 colored as red in alignment, homolog A2AJB2 colored as blue. Query protein L0R6Q1 is also shown in right top, homolog A2AJB2 showed in right bottom. They are colored based on secondary structures. 

  L0R6Q1 MADDKDSLPKLKDLAFLKNQLESLQRRVEDEV---NSGVGQDGSLLSSPFLKG---FLAG---------YVVAKLRASAVLGFAVGTCTGIYAAQAYAVP 85
  A2AJB2 ----------------MVN-L-GL-SRVDDAVAARHPGLEEFAACQSHAFMKGVFTFVTGTGATFGLLMFIKRKFPYPVQWSFLVSAIAGSVA--SYRVT 79

  L0R6Q1 NVE--K--TLRDYLQLLRKG--P-D------- 103
  A2AJB2 SMECQKCSNL--WL-FLETGQLPKDISTDPHD 108

Go Annotations

1. PB indicates the go terms that are found by both PROST and BLAST.
2. P indicates the go terms that are found by only PROST.
3. B indicates the go terms that are only annotated by BLAST.
Source GO Description
1. PB GO:0032056 positive regulation of translation in response to stress
1. PB GO:0016021 integral component of membrane
2. P GO:0008535 respiratory chain complex IV assembly
2. P GO:0005768 endosome
2. P GO:0009617 response to bacterium
2. P GO:0031307 integral component of mitochondrial outer membrane
2. P GO:1902884 positive regulation of response to oxidative stress
2. P GO:0005747 mitochondrial respiratory chain complex I
2. P GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT
2. P GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o)
2. P GO:0009877 nodulation
2. P GO:0006730 one-carbon metabolic process
2. P GO:0007007 inner mitochondrial membrane organization
2. P GO:0005743 mitochondrial inner membrane
2. P GO:0042407 cristae formation
2. P GO:0070131 positive regulation of mitochondrial translation
2. P GO:0070096 mitochondrial outer membrane translocase complex assembly
2. P GO:0045273 respiratory chain complex II
2. P GO:0061024 membrane organization
2. P GO:0044284 mitochondrial crista junction
2. P GO:0001401 SAM complex
2. P GO:0019867 outer membrane
2. P GO:0032259 methylation
2. P GO:0019386 methanogenesis, from carbon dioxide
2. P GO:0043069 negative regulation of programmed cell death
2. P GO:0005739 mitochondrion
2. P GO:0030269 tetrahydromethanopterin S-methyltransferase activity
2. P GO:0097250 mitochondrial respirasome assembly
2. P GO:0140275 MIB complex
2. P GO:0033617 mitochondrial cytochrome c oxidase assembly
2. P GO:0042717 plasma membrane-derived chromatophore membrane
2. P GO:0006979 response to oxidative stress
2. P GO:0012507 ER to Golgi transport vesicle membrane
2. P GO:0031305 integral component of mitochondrial inner membrane
2. P GO:0061484 hematopoietic stem cell homeostasis
2. P GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly
2. P GO:0005749 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)
2. P GO:0005789 endoplasmic reticulum membrane
2. P GO:0043495 protein-membrane adaptor activity
2. P GO:0006811 ion transport
2. P GO:0045040 protein insertion into mitochondrial outer membrane
2. P GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane
2. P GO:0032981 mitochondrial respiratory chain complex I assembly
2. P GO:0043066 negative regulation of apoptotic process
2. P GO:0061617 MICOS complex
3. B GO:0005746 mitochondrial respirasome
3. B GO:0032731 positive regulation of interleukin-1 beta production
3. B GO:1900227 positive regulation of NLRP3 inflammasome complex assembly
3. B GO:0005758 mitochondrial intermembrane space
3. B GO:0005741 mitochondrial outer membrane
3. B GO:0045087 innate immune response

Homologs

1. PB indicates the homologs that are found by both PROST and BLAST.
2. P indicates homologs that are only found by PROST.
3. B indicates homologs that are only found by BLAST.

Source Homolog Description FATCAT p-val PROST Evalue BLAST Evalue
1. PB L0R6Q1 SLC35A4 upstream open reading frame protein 0 7.73e-129 4.70e-70
2. P Q9HFF0 MICOS complex subunit mic10 7.15e-04 1.46e-04 NA
2. P A8KB87 Cytochrome c oxidase assembly factor 3 homolog, mitochondrial 1.44e-04 2.44e-04 NA
2. P Q6GZQ6 Transmembrane protein 069R NA 1.01e-02 NA
2. P Q96I45 Transmembrane protein 141 4.82e-07 1.69e-02 NA
2. P Q9AIS6 Sulfur-rich protein 6.64e-05 2.22e-02 NA
2. P Q50774 Tetrahydromethanopterin S-methyltransferase subunit G 6.55e-06 2.82e-02 NA
2. P Q3SYY7 OCIA domain-containing protein 2 1.13e-04 2.58e-02 NA
2. P O27225 Tetrahydromethanopterin S-methyltransferase subunit G 6.72e-06 3.39e-02 NA
2. P Q0UV26 Vacuolar ATPase assembly integral membrane protein VMA21 4.48e-05 3.51e-02 NA
2. P Q5B905 Vacuolar ATPase assembly integral membrane protein vma21 2.84e-05 4.52e-02 NA
2. P P24022 Bacteriocin lactacin-F subunit LafA 4.83e-03 4.26e-02 NA
2. P Q58263 Tetrahydromethanopterin S-methyltransferase subunit G 8.84e-07 7.42e-04 NA
2. P Q7RYI0 MICOS complex subunit mic10 7.47e-06 2.00e-15 NA
2. P Q6ZCC4 Succinate dehydrogenase subunit 6, mitochondrial 2.69e-04 1.66e-13 NA
2. P A2AJB2 Transmembrane protein 141 3.29e-07 2.00e-04 NA
2. P P0DJZ1 Uncharacterized protein X NA 1.72e-02 NA
2. P A7F5K4 Vacuolar ATPase assembly integral membrane protein vma21 6.63e-05 6.53e-04 NA
2. P Q941A6 Succinate dehydrogenase subunit 6, mitochondrial 2.13e-05 3.75e-07 NA
2. P Q7S158 Vacuolar ATPase assembly integral membrane protein vma-21 4.14e-07 2.70e-02 NA
2. P Q9BW72 HIG1 domain family member 2A, mitochondrial 6.25e-04 3.56e-03 NA
2. P Q56VL3 OCIA domain-containing protein 2 4.27e-05 5.57e-03 NA
2. P O05329 ATP synthase protein I 2.40e-06 7.43e-08 NA
2. P B2RYW8 MICOS complex subunit Mic10 9.05e-05 1.63e-06 NA
2. P Q9CQC7 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 8.13e-04 3.11e-02 NA
2. P Q96VH5 MICOS complex subunit MIC10 6.64e-05 9.17e-12 NA
2. P Q9D8W7 OCIA domain-containing protein 2 2.51e-05 2.82e-02 NA
2. P Q21154 MICOS complex subunit MIC27 4.38e-05 1.01e-02 NA
2. P Q9CN31 Uncharacterized protein PM0614 9.17e-05 7.94e-04 NA
2. P Q7TNS2 MICOS complex subunit Mic10 5.51e-05 4.84e-06 NA
2. P Q75D23 Cytochrome c oxidase assembly protein COX20, mitochondrial 6.55e-04 6.75e-03 NA
2. P B6K2Z6 Respiratory supercomplex factor 1, mitochondrial 9.68e-04 6.10e-04 NA
2. P P0DKM0 Cytochrome c oxidase assembly factor 3, mitochondrial 6.15e-05 4.45e-04 NA
2. P P48305 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 5.27e-04 7.27e-04 NA
2. P Q751T2 MICOS complex subunit MIC10 4.45e-05 2.24e-10 NA
2. P Q9CQ00 Distal membrane-arm assembly complex protein 1 1.59e-04 7.20e-04 NA
2. P P62512 Mitochondrial import protein 1 1.22e-02 4.80e-02 NA
2. P Q9CQJ1 HIG1 domain family member 2A 6.61e-05 2.68e-02 NA
2. P G2TRP9 Cytochrome c oxidase assembly protein cox20, mitochondrial 1.18e-04 2.71e-03 NA
2. P O74992 Uncharacterized membrane protein C338.18 2.33e-05 9.82e-03 NA
2. P Q02921 Early nodulin-93 1.60e-06 5.58e-08 NA
2. P A4R0J5 Vacuolar ATPase assembly integral membrane protein VMA21 4.30e-05 1.90e-04 NA
2. P Q47710 Uncharacterized protein YqjK 3.05e-06 1.43e-05 NA
2. P Q58911 Uncharacterized protein MJ1516 3.62e-03 1.10e-03 NA
2. P Q2HDV5 Vacuolar ATPase assembly integral membrane protein VMA21 1.23e-04 7.94e-04 NA
2. P P15011 ATP synthase protein I 1.44e-04 3.73e-05 NA
2. P Q5TGZ0 MICOS complex subunit MIC10 3.96e-05 5.54e-05 NA
2. P Q0CXF5 Vacuolar ATPase assembly integral membrane protein vma21 5.97e-05 2.65e-02 NA
2. P B2WDD8 Vacuolar ATPase assembly integral membrane protein vma21 2.99e-05 2.28e-02 NA
2. P Q9ZEC0 Uncharacterized protein RP024 3.05e-04 3.53e-05 NA
2. P Q3SZU9 Transmembrane protein 141 9.65e-07 1.56e-02 NA
2. P Q9UTB1 HIG1 domain-containing protein C25B8.07c, mitochondrial 3.12e-03 2.90e-03 NA
2. P Q0MQD0 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 2.09e-02 6.94e-03 NA
3. B P0DP99 Short transmembrane mitochondrial protein 1 1.91e-03 NA 0.010
3. B E0CX11 Short transmembrane mitochondrial protein 1 8.92e-04 NA 0.011
3. B B3DFW5 Short transmembrane mitochondrial protein 1 7.39e-04 NA 0.002