Summary

P0DP75

Homolog: P59021.
Function: Down syndrome critical region protein 9.

Statistics

Total GO Annotation: 31
Unique PROST Go: 31
Unique BLAST Go: 0

Total Homologs: 45
Unique PROST Homologs: 44
Unique BLAST Homologs: 0

Structures and Sequence Alignment

The best structural homolog that predicted by 2. P was P59021 (Down syndrome critical region protein 9) with a FATCAT P-Value: 0.0277 and RMSD of 3.21 angstrom. The sequence alignment identity is 25.0%.
Structural alignment shown in left. Query protein P0DP75 colored as red in alignment, homolog P59021 colored as blue. Query protein P0DP75 is also shown in right top, homolog P59021 showed in right bottom. They are colored based on secondary structures. 

  P0DP75 --------MRSSSL---PGARSPRRNGSGQS--RHRLPPG--RLRT---GSRAPTAEARPHVA-RSPPTPGTGARGG-G-------RR----GWGGSRAA 69
  P59021 MGRICPVNSRARRLRARPG-R-P----SGDSLPYHQLQGGAPRLWSPDPG-R-PAAYRRAHVCDVTAPRWGSTSRQGEGAVLQRMLRRRAPPSWSRDHAY 92

  P0DP75 PQRG--SCA-SANAQKQLRQTAATYMLTAR-------GGSRSAERKGDLQRTFRQVGQTMPMVPPLDFTMNAASVE 135
  P59021 SRRGWENVALFLNRKRKQEGTENT-SICCRPESALACGGNLSPQF---LKKVI-QI-QTQELW------------- 149

Go Annotations

1. PB indicates the go terms that are found by both PROST and BLAST.
2. P indicates the go terms that are found by only PROST.
3. B indicates the go terms that are only annotated by BLAST.
Source GO Description
2. P GO:0042025 host cell nucleus
2. P GO:0090200 positive regulation of release of cytochrome c from mitochondria
2. P GO:0034974 Swi5-Swi2 complex
2. P GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
2. P GO:0033650 host cell mitochondrion
2. P GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
2. P GO:0032798 Swi5-Sfr1 complex
2. P GO:0070449 elongin complex
2. P GO:2001244 positive regulation of intrinsic apoptotic signaling pathway
2. P GO:0048863 stem cell differentiation
2. P GO:0001836 release of cytochrome c from mitochondria
2. P GO:0071479 cellular response to ionizing radiation
2. P GO:0035098 ESC/E(Z) complex
2. P GO:0140538 negative regulation of conjugation with zygote
2. P GO:0007517 muscle organ development
2. P GO:0020008 rhoptry
2. P GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
2. P GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
2. P GO:0007181 transforming growth factor beta receptor complex assembly
2. P GO:0035616 histone H2B conserved C-terminal lysine deubiquitination
2. P GO:0007183 SMAD protein complex assembly
2. P GO:0097194 execution phase of apoptosis
2. P GO:0039652 induction by virus of host NF-kappaB cascade
2. P GO:0030291 protein serine/threonine kinase inhibitor activity
2. P GO:0039592 suppression by virus of G2/M transition of host mitotic cell cycle
2. P GO:0048663 neuron fate commitment
2. P GO:0019079 viral genome replication
2. P GO:0046332 SMAD binding
2. P GO:0017015 regulation of transforming growth factor beta receptor signaling pathway
2. P GO:0006351 transcription, DNA-templated
2. P GO:0110046 signal transduction involved in cell cycle switching, mitotic to meiotic cell cycle

Homologs

1. PB indicates the homologs that are found by both PROST and BLAST.
2. P indicates homologs that are only found by PROST.
3. B indicates homologs that are only found by BLAST.

Source Homolog Description FATCAT p-val PROST Evalue BLAST Evalue
1. PB P0DP75 Putative uncharacterized protein MED14OS 0 9.45e-170 8.90e-91
2. P Q6X7S9 EP300-interacting inhibitor of differentiation 2 1.69e-01 1.80e-04 NA
2. P P20976 Protein X NA 1.66e-02 NA
2. P Q9PXA2 Protein X NA 1.59e-03 NA
2. P P0C864 Putative uncharacterized protein DANCR 4.24e-02 2.59e-03 NA
2. P Q64902 Protein X NA 8.34e-03 NA
2. P P59021 Down syndrome critical region protein 9 2.77e-02 1.50e-02 NA
2. P P0C686 Protein X NA 4.59e-02 NA
2. P P20975 Protein X NA 4.73e-04 NA
2. P Q569G3 Uncharacterized protein C5orf47 5.28e-02 3.62e-02 NA
2. P Q8IYB0 Putative uncharacterized protein MGC39545 4.24e-01 9.15e-03 NA
2. P Q8NFD4 Uncharacterized protein FLJ76381 2.34e-01 3.17e-03 NA
2. P Q8JN06 Protein X NA 2.50e-05 NA
2. P Q80IU5 Protein X NA 2.05e-02 NA
2. P A6NHQ4 Elongin BC and Polycomb repressive complex 2-associated protein 2.85e-01 2.13e-03 NA
2. P Q8JMY3 Protein X NA 3.81e-02 NA
2. P P0DMU3 FAM231A/C-like protein LOC102723383 1.45e-01 4.50e-02 NA
2. P P0C879 Putative uncharacterized protein FLJ43185 8.49e-02 3.14e-05 NA
2. P Q8N7S6 Uncharacterized protein ARIH2OS 9.54e-02 1.89e-02 NA
2. P Q67923 Protein X NA 6.10e-03 NA
2. P P08090 21 kDa protein inducing meiosis and sporulation 3.18e-02 4.74e-03 NA
2. P Q495Z4 Putative uncharacterized protein ASB16-AS1 9.15e-02 4.31e-03 NA
2. P P0C685 Protein X NA 1.58e-02 NA
2. P Q9PX75 Protein X NA 2.13e-02 NA
2. P Q71F78 Putative lung carcinoma-associated protein 10 5.54e-02 2.46e-02 NA
2. P Q9ULZ0 TP53-target gene 3 protein 8.04e-02 8.96e-03 NA
2. P Q5T4H9 Putative uncharacterized protein encoded by MIR1915-HG 6.81e-02 1.60e-05 NA
2. P Q1ZZU3 DNA repair protein SWI5 homolog 6.89e-02 4.52e-04 NA
2. P P03400 18 kDa protein NA 1.66e-02 NA
2. P Q99HR6 Protein X NA 1.82e-02 NA
2. P Q5T036 Uncharacterized protein FAM120AOS 1.61e-01 2.33e-05 NA
2. P P69713 Protein X NA 1.35e-02 NA
2. P Q8JMZ5 Protein X NA 1.26e-04 NA
2. P Q6ZUF6 Putative uncharacterized protein encoded by LINC00336 2.87e-02 4.00e-02 NA
2. P Q96PG8 Bcl-2-binding component 3, isoforms 3/4 3.82e-01 8.25e-04 NA
2. P Q91C38 Protein X NA 2.56e-02 NA
2. P Q24JP4 Uncharacterized protein C5orf47 homolog 3.78e-02 4.18e-07 NA
2. P P69714 Protein X NA 4.59e-03 NA
2. P Q8JMY5 Protein X NA 1.29e-04 NA
2. P P21959 EAMZP30-47 protein (Fragment) 1.50e-01 7.06e-03 NA
2. P P20977 Protein X NA 3.45e-03 NA
2. P P59020 Down syndrome critical region protein 9 7.48e-02 3.31e-02 NA
2. P Q9YUC9 Uncharacterized protein ORF4 NA 2.43e-03 NA
2. P A0A1B0GUV1 Uncharacterized protein C17orf114 2.64e-01 3.57e-04 NA
2. P Q63647 Proline-rich nuclear receptor coactivator 1 2.25e-01 7.55e-04 NA