Summary
Structures and Sequence Alignment
The best structural homolog that predicted by 3. B was
Q8N328
(PiggyBac transposable element-derived protein 3) with a FATCAT P-Value: 0.0 and RMSD of 1.47 angstrom. The sequence alignment identity is 55.9%.
Structural alignment shown in left. Query protein P0DP91 colored as red in alignment, homolog Q8N328 colored as blue.
Query protein P0DP91 is also shown in right top, homolog Q8N328 showed in right bottom. They are colored based on secondary structures.
P0DP91 MPNEGIPHSSQTQEQDCLQSQPVSNNEEMAIKQESGGDGEVEEYLSFRSVGDGLSTSAVGCASAAPRRGPALLHIDRHQIQAVEPSAQALELQGLGVDVY 100 Q8N328 ---------------------------------------------------------------------------------------------------- 0 P0DP91 DQDVLEQGVLQQVDNAIHEASRASQLVDVEKEYRSVLDDLTSCTTSLRQINKIIEQLSPQAATSRDINRKLDSVKRQKYNKEQQLKKITAKQKHLQAILG 200 Q8N328 ---------------------------------------------------------------------------------------------------- 0 P0DP91 GAEVKIELDHASLEEDAEPGPSSLGSMLMPVQETAWEELIRTGQMTPFGTQIPQKQEKKPRKIMLNEASGFEKYLADQAKLSFERKKQGCNKRAARKAPA 300 Q8N328 ---------------------------------------------------------------------------------------------------- 0 P0DP91 PVTPPAPVQNKNKPNKKARVLSKKEERLKKHIKKLQKRALQFQGKVGLPKARRPWESDMRPEAEGDSEGEESEYFPTEEEEEEEDDEVEGAEADLSGDGT 400 Q8N328 ---------------------------------------------------------------------------------------------------- 0 P0DP91 DYELKPLPKGGKRQKKVPVQEIDDDFFPSSGEEAEAASVGEGGGGGRKVGRYRDDGDEDYYKQRLSPKMPRTLSLHEITDLLETDDSIEASAIVIQPPEN 500 Q8N328 --------------------------------------------------------------------MPRTLSLHEITDLLETDDSIEASAIVIQPPEN 32 P0DP91 ATAPVSDEESGDEEGGTINNLPGSLLHTAAYLIQDGSDAESDSDDPSYAPKDDSPDEVPSTFTVQQPPPSRRRKMTKILCKWKKADLTVQPVAGRVTAPP 600 Q8N328 ATAPVSDEESGDEEGGTINNLPGSLLHTAAYLIQDGSDAESDSDDPSYAPKDDSPDEVPSTFTVQQPPPSRRRKMTKILCKWKKADLTVQPVAGRVTAPP 132 P0DP91 NDFFTVMRTPTEILELFLDDEVIELIVKYSNLYACSKGVHLGLTSSEFKCFLGIIFLSGYVSVPRRRMFWEQRTDVHNVLVSAAMRRDRFETIFSNLHVA 700 Q8N328 NDFFTVMRTPTEILELFLDDEVIELIVKYSNLYACSKGVHLGLTSSEFKCFLGIIFLSGYVSVPRRRMFWEQRTDVHNVLVSAAMRRDRFETIFSNLHVA 232 P0DP91 DNANLDPVDKFSKLRPLISKLNERCMKFVPNETYFSFDEFMVPYFGRHGCKQFIRGKPIRFGYKFWCGATCLGYICWFQPYQGKNPNTKHEEYGVGASLV 800 Q8N328 DNANLDPVDKFSKLRPLISKLNERCMKFVPNETYFSFDEFMVPYFGRHGCKQFIRGKPIRFGYKFWCGATCLGYICWFQPYQGKNPNTKHEEYGVGASLV 332 P0DP91 LQFSEALTEAHPGQYHFVFNNFFTSIALLDKLSSMGHQATGTVRKDHIDRVPLESDVALKKKERGTFDYRIDGKGNIVCRWNDNSVVTVASSGAGIHPLC 900 Q8N328 LQFSEALTEAHPGQYHFVFNNFFTSIALLDKLSSMGHQATGTVRKDHIDRVPLESDVALKKKERGTFDYRIDGKGNIVCRWNDNSVVTVASSGAGIHPLC 432 P0DP91 LVSRYSQKLKKKIQVQQPNMIKVYNQFMGGVDRADENIDKYRASIRGKKWYSSPLLFCFELVLQNAWQLHKTYDEKPVDFLEFRRRVVCHYLETHGHPPE 1000 Q8N328 LVSRYSQKLKKKIQVQQPNMIKVYNQFMGGVDRADENIDKYRASIRGKKWYSSPLLFCFELVLQNAWQLHKTYDEKPVDFLEFRRRVVCHYLETHGHPPE 532 P0DP91 PGQKGRPQKRNIDSRYDGINHVIVKQGKQTRCAECHKNTTFRCEKCDVALHVKCSVEYHTE 1061 Q8N328 PGQKGRPQKRNIDSRYDGINHVIVKQGKQTRCAECHKNTTFRCEKCDVALHVKCSVEYHTE 593
Go Annotations
1. PB indicates the go terms that are found by both PROST and BLAST.2. P indicates the go terms that are found by only PROST.
3. B indicates the go terms that are only annotated by BLAST.
| Source | GO | Description |
|---|---|---|
| 1. PB | GO:0016604 | nuclear body |
| 1. PB | GO:0005044 | scavenger receptor activity |
| 1. PB | GO:0033141 | positive regulation of peptidyl-serine phosphorylation of STAT protein |
| 1. PB | GO:0010628 | positive regulation of gene expression |
| 1. PB | GO:0043565 | sequence-specific DNA binding |
| 1. PB | GO:0045739 | positive regulation of DNA repair |
| 1. PB | GO:0002230 | positive regulation of defense response to virus by host |
| 2. P | GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| 2. P | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| 3. B | GO:0006283 | transcription-coupled nucleotide-excision repair |
| 3. B | GO:0030296 | protein tyrosine kinase activator activity |
| 3. B | GO:0003682 | chromatin binding |
| 3. B | GO:0005654 | nucleoplasm |
| 3. B | GO:0004386 | helicase activity |
| 3. B | GO:0000012 | single strand break repair |
| 3. B | GO:0097680 | double-strand break repair via classical nonhomologous end joining |
| 3. B | GO:0090734 | site of DNA damage |
| 3. B | GO:0006362 | transcription elongation from RNA polymerase I promoter |
| 3. B | GO:0009411 | response to UV |
| 3. B | GO:0007254 | JNK cascade |
| 3. B | GO:0008022 | protein C-terminus binding |
| 3. B | GO:0010332 | response to gamma radiation |
| 3. B | GO:0008094 | ATP-dependent activity, acting on DNA |
| 3. B | GO:0008630 | intrinsic apoptotic signaling pathway in response to DNA damage |
| 3. B | GO:0010165 | response to X-ray |
| 3. B | GO:0070063 | RNA polymerase binding |
| 3. B | GO:0032784 | regulation of DNA-templated transcription, elongation |
| 3. B | GO:0031175 | neuron projection development |
| 3. B | GO:0009636 | response to toxic substance |
| 3. B | GO:0006290 | pyrimidine dimer repair |
| 3. B | GO:1905168 | positive regulation of double-strand break repair via homologous recombination |
| 3. B | GO:0000303 | response to superoxide |
| 3. B | GO:0044877 | protein-containing complex binding |
| 3. B | GO:0004519 | endonuclease activity |
| 3. B | GO:0098038 | non-replicative transposition, DNA-mediated |
| 3. B | GO:0047485 | protein N-terminus binding |
| 3. B | GO:0043044 | |
| 3. B | GO:0006284 | base-excision repair |
| 3. B | GO:0010224 | response to UV-B |
| 3. B | GO:0070615 | |
| 3. B | GO:0006979 | response to oxidative stress |
| 3. B | GO:0022008 | neurogenesis |
| 3. B | GO:0032508 | DNA duplex unwinding |
| 3. B | GO:0008023 | transcription elongation factor complex |
| 3. B | GO:0045494 | photoreceptor cell maintenance |
| 3. B | GO:0004803 | transposase activity |
| 3. B | GO:2001033 | negative regulation of double-strand break repair via nonhomologous end joining |
| 3. B | GO:0032786 | positive regulation of DNA-templated transcription, elongation |
| 3. B | GO:0000077 | DNA damage checkpoint signaling |
| 3. B | GO:0035264 | multicellular organism growth |
| 3. B | GO:0030182 | neuron differentiation |
| 3. B | GO:0060261 | positive regulation of transcription initiation from RNA polymerase II promoter |
Homologs
1. PB indicates the homologs that are found by both PROST and BLAST.
2. P indicates homologs that are only found by PROST.
3. B indicates homologs that are only found by BLAST.
| Source | Homolog | Description | FATCAT p-val | PROST Evalue | BLAST Evalue |
|---|---|---|---|---|---|
| 1. PB | P0DP91 | Chimeric ERCC6-PGBD3 protein | 0 | 4.09e-158 | 0.0 |
| 1. PB | Q96JS3 | PiggyBac transposable element-derived protein 1 | 3.53e-05 | 7.18e-05 | 1.28e-101 |
| 3. B | Q96DM1 | PiggyBac transposable element-derived protein 4 | 2.04e-11 | NA | 9.34e-26 |
| 3. B | Q6P3X8 | PiggyBac transposable element-derived protein 2 | 1.58e-14 | NA | 7.67e-156 |
| 3. B | Q8N328 | PiggyBac transposable element-derived protein 3 | 0.00e+00 | NA | 0.0 |
| 3. B | F8VPZ5 | DNA excision repair protein ERCC-6 | 4.68e-03 | NA | 0.0 |
| 3. B | Q8N414 | PiggyBac transposable element-derived protein 5 | 1.08e-06 | NA | 4.25e-07 |
| 3. B | D3YZI9 | PiggyBac transposable element-derived protein 5 | 1.47e-07 | NA | 1.85e-05 |
| 3. B | Q03468 | DNA excision repair protein ERCC-6 | 5.12e-02 | NA | 0.0 |