Summary
Structures and Sequence Alignment
The best structural homolog that predicted by 1. PB was
Q8CGI1
(Protein FAM193A) with a FATCAT P-Value: 5.12e-05 and RMSD of 19.14 angstrom. The sequence alignment identity is 85.4%.
Structural alignment shown in left. Query protein P78312 colored as red in alignment, homolog Q8CGI1 colored as blue.
Query protein P78312 is also shown in right top, homolog Q8CGI1 showed in right bottom. They are colored based on secondary structures.
P78312 MKVRLLRQLSAAAKVKAPSGLQGPPQAHQFISLLLEEYGALCQAARSISTFLGTLENEHLKKFQVTWELHNKHLFENLVFSEPLLQSNLPALVSQIRLGT 100 Q8CGI1 MKVRLLRQLSAAAKAKAPSGLQGPPQAHHFVSLLLEEYAALCQAARSISTFLGTLENEHLKKFQVTWELHNKHLFENLVFSEPLLQSNLPALVSQIRLGT 100 P78312 TTHDTCSEDTYSTLLQRYQRSEEELRRVAEEWLECQKRIDAYVDEQMTMKTKQRMLTEDWELFKQRRFIEEQLTNKKAVTGENNFTDTMRHMLSSRLSMP 200 Q8CGI1 TTHDTCTEDMYSTLLQRYQRSEEELRKVAEEWLECQKRIDAYVDEQMTMKTKQRMLTEDWEIFKQRRLIEEQLTNKKVVTGENNFTDTRRHMLSSRLSMP 200 P78312 DCPNCNYRRRCACDDCSLSHILTCGIMDPPVTDDIHIHQLPLQVDPAPDYLAERSPPSVSSASSGSGSSSPITIQQHPRLILTDSGSAPTFCSDDEDVAP 300 Q8CGI1 DCPNCNYRRRCACDDCSLSHILTCGIMDTPVTDDIHIHQLPLQVDSAPDYLSEMRPPSVSSASSGSGSSSPITIQQHPRLILTDNGSAPTFCSDDEDVAP 300 P78312 LSAKFADIYPLSNYDDTEVVANMNGIHSELNGGGENMALKDESPQISSTSSSSSEADDEEADGESSGEPPGAPKEDGVLGSRSPRTEESKADSPPPSYPT 400 Q8CGI1 LSAKFADIYPLTNYDDTNVVANMNGIHSELNGGGENMALKDESPQVSSTSRSSSEADDEDADGESSGEPPGAPKQEEAIGNGNPKTEESNVNTPPPSYPA 400 P78312 QQAEQAPNTCECHVCKQEASGLTPSAMTAGALPPGHQFLSPEKPTHPALHLYPHIHGHVPLHTVPHLPRPLIHPTLYATPPFTHSKALPPAPVQNHTNKH 500 Q8CGI1 QQAEQTPNTCECHVCKQEASGLPASAMTAGALPPGHQFLSPEKPTHPALHLYPHIHGHVPLHTVPHLPRPLIHPTLYPAPPFTHSKALPPAPVQSHTNKP 500 P78312 QVFNASLQDHIYPSCFGNTPEWNSSKFISLWGSEVMNDKNWNPGTFLPDTISGSEILGPTLSETRPEALPPPSSNETPAVSDSKEKKNAAKKKCLYNFQD 600 Q8CGI1 QAFNASLQDHIYPSCFGNTPDWNSSKFISLWESEMMNDKNWNPGTFLPDTISGNDILGPVLSETRPEALPPPPSNEAPAVSDIKEKKNAAKKKCLYNFQD 600 P78312 AFMEANK------VVMATSSATSSVSCTATTVQSSNSQFRVSSKRPPSVGDVFHGISKEDHRHSAPAAPRNSPTGLAPLPALSPAALSPAALSPASTPHL 694 Q8CGI1 AFMEANEVAMANTVAMATSSATSSVSCTATTVQSSSSQFKVSSRRPPSIGDVFHGLNKEDHRHSAPAAPRNSPTGLAPLP-----ALSPSALSPASTPHL 695 P78312 ANLAAPSFPKTATTTPGFVDTRKSFCPAPL--PPA-TDGSISAPPSVCSDPDCEGHRCENGVYDPQQDDGDESADEDSCSEHSSSTSTSTNQKEGKYCDC 791 Q8CGI1 PNLAAPSFPKTATTAPGFVDTRKSFCPTPVAPPPSTTDGSISAPPSVCSDPDCEGHRCENGVYDPQQDDGDESADEDSCSEHSSSTSTSTNQKEGKYCDC 795 P78312 CYCEFFGHGGPPAAPTSRNYAEMREKLRLRLTKRKEEQPKKMDQISERESVVDHRRVEDLLQFINSSETKPVSSTRAAKRARHKQRKLEEKARLEAEARA 891 Q8CGI1 CYCEFFGHGGPPAAPTSRNYAEMREKLRLRLTKRKEEQPKKMEQISEREGVVDHRRVEDLLQFINSSEAKPVSSSRAAKRARHKQRKLEEKARLEAEARA 895 P78312 REHLHLQEEQRRREEEEDEEEEED--RFKEEFQRLQELQKLRAVKKKKKERPSKDCPKLDMLTRNFQAATESVPNSGNIHNGSLEQTEEPETSSHSPSRH 989 Q8CGI1 REHLHHQEEQKQREEEEDEEEEDEEQHFKEEFQRLQELQKLRAAKKKKKDRPSKDCSKLDMLARNFQAATESISNSENIHNGSLEQTEEPETSSHSPSRH 995 P78312 MNHSEPRPGLGADGDAADPVDTRD-SKFLLPKEVNGKQHEPLSFFFDIMQHHKEGNGKQKLRQTSKASSEPARRPTEPPKATEGQSKPRAQTESKAKVVD 1088 Q8CGI1 MNHSEPRPGPGANGDATDPVDPRDPSKLLLPKEVNGKQHEPLAFLLDMMHHHKEGNSKQKLKQTSKTSNEPARKPTEPPKTTEVQLKPRAQPELKPKVVD 1095 P78312 LMSITEQKREERKVNSNNNNKKQLNHIKDEK-SNPTPMEPTSPGEHQQNSKLVLAESPQPKGKNKKNKKKKGDRVNNSIDGVSLLLPSLGYNGAILAHCN 1187 Q8CGI1 LALLTEQKREERKTNSNNNNKKQLSHIKEEKLSTVTP-EPPSPSQLLQNGRLILASSPQPKGKNKKNKKKKGDRTSSSL--------------------- 1173 P78312 LRLPGSSDCAASASQVVGITDDVFLPKDIDLDSVDMDETEREVEYFKRFCLDSARQTRQRLSINWSNFSLKKATFAAH 1265 Q8CGI1 --------------------DDVFLPKDIDLDSVDMDETEREVEYFKRFCLDSARQNRQRLSINWSNFSLKKATFAAH 1231
Go Annotations
1. PB indicates the go terms that are found by both PROST and BLAST.2. P indicates the go terms that are found by only PROST.
3. B indicates the go terms that are only annotated by BLAST.
| Source | GO | Description |
|---|---|---|
| 2. P | GO:0016572 | histone phosphorylation |
| 2. P | GO:0010032 | meiotic chromosome condensation |
| 2. P | GO:0051257 | meiotic spindle midzone assembly |
| 2. P | GO:0043539 | protein serine/threonine kinase activator activity |
| 2. P | GO:0051781 | positive regulation of cell division |
| 2. P | GO:0051310 | metaphase plate congression |
| 2. P | GO:0000940 | outer kinetochore |
| 2. P | GO:0005813 | centrosome |
| 2. P | GO:0000793 | condensed chromosome |
| 2. P | GO:0000775 | chromosome, centromeric region |
| 2. P | GO:0032467 | positive regulation of cytokinesis |
| 2. P | GO:0005876 | spindle microtubule |
| 2. P | GO:0030496 | midbody |
| 2. P | GO:0030154 | cell differentiation |
| 2. P | GO:0031110 | regulation of microtubule polymerization or depolymerization |
| 2. P | GO:0005874 | microtubule |
| 2. P | GO:1990385 | meiotic spindle midzone |
| 2. P | GO:0000281 | mitotic cytokinesis |
| 2. P | GO:0005721 | pericentric heterochromatin |
| 2. P | GO:0005819 | spindle |
| 2. P | GO:0071902 | positive regulation of protein serine/threonine kinase activity |
| 2. P | GO:0071203 | WASH complex |
| 2. P | GO:0000776 | kinetochore |
| 2. P | GO:0000922 | spindle pole |
| 2. P | GO:0140591 | nuclear envelope budding |
| 2. P | GO:0000278 | mitotic cell cycle |
| 2. P | GO:0032133 | chromosome passenger complex |
| 2. P | GO:1902412 | regulation of mitotic cytokinesis |
| 2. P | GO:0045785 | positive regulation of cell adhesion |
| 2. P | GO:0000070 | mitotic sister chromatid segregation |
| 2. P | GO:0007059 | chromosome segregation |
| 3. B | GO:0031594 | neuromuscular junction |
| 3. B | GO:0050687 | negative regulation of defense response to virus |
| 3. B | GO:0045236 | CXCR chemokine receptor binding |
| 3. B | GO:0043021 | ribonucleoprotein complex binding |
| 3. B | GO:0070534 | protein K63-linked ubiquitination |
| 3. B | GO:0044389 | ubiquitin-like protein ligase binding |
| 3. B | GO:0031083 | BLOC-1 complex |
| 3. B | GO:0021549 | cerebellum development |
| 3. B | GO:0005935 | cellular bud neck |
| 3. B | GO:0046548 | retinal rod cell development |
| 3. B | GO:0004674 | protein serine/threonine kinase activity |
| 3. B | GO:0031870 | thromboxane A2 receptor binding |
| 3. B | GO:0021532 | neural tube patterning |
| 3. B | GO:2001020 | regulation of response to DNA damage stimulus |
| 3. B | GO:0070936 | protein K48-linked ubiquitination |
| 3. B | GO:0021670 | lateral ventricle development |
| 3. B | GO:0001889 | liver development |
| 3. B | GO:0051865 | protein autoubiquitination |
| 3. B | GO:0008589 | regulation of smoothened signaling pathway |
| 3. B | GO:2000646 | positive regulation of receptor catabolic process |
| 3. B | GO:0001650 | fibrillar center |
| 3. B | GO:0021772 | olfactory bulb development |
| 3. B | GO:0032391 | photoreceptor connecting cilium |
| 3. B | GO:0005879 | axonemal microtubule |
| 3. B | GO:0035116 | embryonic hindlimb morphogenesis |
| 3. B | GO:1902036 | regulation of hematopoietic stem cell differentiation |
| 3. B | GO:0001736 | establishment of planar polarity |
| 3. B | GO:0097014 | ciliary plasm |
| 3. B | GO:0090085 | regulation of protein deubiquitination |
| 3. B | GO:0019787 | ubiquitin-like protein transferase activity |
| 3. B | GO:0007368 | determination of left/right symmetry |
| 3. B | GO:0006468 | protein phosphorylation |
| 3. B | GO:0046642 | negative regulation of alpha-beta T cell proliferation |
| 3. B | GO:0035115 | embryonic forelimb morphogenesis |
| 3. B | GO:0005634 | nucleus |
| 3. B | GO:0090102 | cochlea development |
| 3. B | GO:0045744 | negative regulation of G protein-coupled receptor signaling pathway |
| 3. B | GO:0036064 | ciliary basal body |
| 3. B | GO:0016607 | nuclear speck |
| 3. B | GO:0046329 | negative regulation of JNK cascade |
| 3. B | GO:1905515 | non-motile cilium assembly |
| 3. B | GO:0035519 | protein K29-linked ubiquitination |
| 3. B | GO:0045732 | positive regulation of protein catabolic process |
| 3. B | GO:0032480 | negative regulation of type I interferon production |
| 3. B | GO:0043584 | nose development |
| 3. B | GO:1990763 | arrestin family protein binding |
| 3. B | GO:0035253 | ciliary rootlet |
| 3. B | GO:0035869 | ciliary transition zone |
| 3. B | GO:0032088 | negative regulation of NF-kappaB transcription factor activity |
| 3. B | GO:0002669 | positive regulation of T cell anergy |
| 3. B | GO:0022038 | corpus callosum development |
| 3. B | GO:0001558 | regulation of cell growth |
| 3. B | GO:0007163 | establishment or maintenance of cell polarity |
| 3. B | GO:0070423 | nucleotide-binding oligomerization domain containing signaling pathway |
| 3. B | GO:2000772 | regulation of cellular senescence |
| 3. B | GO:0060039 | pericardium development |
| 3. B | GO:0005654 | nucleoplasm |
Homologs
1. PB indicates the homologs that are found by both PROST and BLAST.
2. P indicates homologs that are only found by PROST.
3. B indicates homologs that are only found by BLAST.
| Source | Homolog | Description | FATCAT p-val | PROST Evalue | BLAST Evalue |
|---|---|---|---|---|---|
| 1. PB | P78312 | Protein FAM193A | 0 | 1.25e-167 | 0.0 |
| 1. PB | Q8CGI1 | Protein FAM193A | 5.12e-05 | 6.14e-70 | 0.0 |
| 2. P | A1ZBW7 | WASH complex subunit 2 | 1.77e-01 | 4.50e-03 | NA |
| 2. P | P53352 | Inner centromere protein | 1.30e-01 | 9.58e-03 | NA |
| 2. P | B1H1S4 | Spindle and kinetochore-associated protein 3 | 3.27e-01 | 1.70e-02 | NA |
| 2. P | B2RX88 | Centrosome and spindle pole associated protein 1 | 3.89e-01 | 4.64e-05 | NA |
| 2. P | B0BM16 | Spindle and kinetochore-associated protein 3 | 2.80e-01 | 1.78e-02 | NA |
| 2. P | Q5HYW2 | NHS-like protein 2 | 2.09e-01 | 3.02e-04 | NA |
| 2. P | B1AXH1 | NHS-like protein 2 | 1.64e-01 | 4.13e-02 | NA |
| 2. P | Q1MSJ5 | Centrosome and spindle pole-associated protein 1 | 4.57e-01 | 1.75e-02 | NA |
| 3. B | Q68CZ1 | Protein fantom | 6.04e-01 | NA | 2.40e-05 |
| 3. B | P51957 | Serine/threonine-protein kinase Nek4 | 2.86e-01 | NA | 0.003 |
| 3. B | Q96MD7 | Uncharacterized protein C9orf85 | 8.69e-01 | NA | 0.004 |
| 3. B | A6NIU2 | Putative uncharacterized protein encoded by LINC01549 | 6.10e-01 | NA | 0.029 |
| 3. B | Q8N9N2 | Activating signal cointegrator 1 complex subunit 1 | 6.20e-01 | NA | 1.56e-06 |
| 3. B | Q09FC8 | Zinc finger protein 415 | 9.53e-01 | NA | 3.72e-04 |
| 3. B | Q8TDM0 | Breast carcinoma-amplified sequence 4 | 3.97e-01 | NA | 0.001 |
| 3. B | Q96PV7 | Protein FAM193B | 3.64e-02 | NA | 1.86e-34 |
| 3. B | A7MB40 | Protein FAM193B | 1.50e-01 | NA | 4.41e-19 |
| 3. B | Q5H9K5 | Zinc finger matrin-type protein 1 | 1.44e-01 | NA | 4.37e-04 |
| 3. B | Q8WTZ3 | Zinc finger protein ENSP00000375192 | 9.58e-01 | NA | 0.001 |
| 3. B | Q96J02 | E3 ubiquitin-protein ligase Itchy homolog | 7.33e-01 | NA | 1.53e-04 |
| 3. B | Q3U2K0 | Protein FAM193B | 1.79e-01 | NA | 6.06e-29 |
| 3. B | Q5AG71 | Serine/threonine-protein kinase HSL1 | 3.52e-01 | NA | 0.017 |
| 3. B | Q9BUA6 | Myosin regulatory light chain 10 | 8.55e-01 | NA | 0.026 |