Summary

P84996

Homolog: Q9Z213.
Function: Protein ALEX.

Statistics

Total GO Annotation: 67
Unique PROST Go: 0
Unique BLAST Go: 2

Total Homologs: 12
Unique PROST Homologs: 6
Unique BLAST Homologs: 3

Structures and Sequence Alignment

The best structural homolog that predicted by 1. PB was Q9Z213 (Protein ALEX) with a FATCAT P-Value: 0.0106 and RMSD of 6.63 angstrom. The sequence alignment identity is 41.1%.
Structural alignment shown in left. Query protein P84996 colored as red in alignment, homolog Q9Z213 colored as blue. Query protein P84996 is also shown in right top, homolog Q9Z213 showed in right bottom. They are colored based on secondary structures. 

  P84996 -------MMARPVDPQRSPDPTFRSSTRHSGKLEPMEATAHLLRKQCPSRLNSPAWEASGLHWSSLD--SPVGSMQALRPS---AQ-----H----SWSP 79
  Q9Z213 MSPSPTRLTVRSVDPLKTPNLTSRAPVRPSRKSKWAETTAHLQRKPCHSRSNSPAWEISGPPWSSLDHLDPI-RHQSLQPSDFGARTPTGAHPGLGAYSP 99

  P84996 EP-SVVP----DQAWEDTALHQKKLC--PLSLTSL-P--REAAVNFSYRSQTLLQEAQVL----QGSPELLPRSPKPSGLQRLAPEEATALPLRRLCHLS 165
  Q9Z213 PPEEAMPFEFNEPAQEDR-------CQPPLQVPDLAPGGPEA-----WVSRALPAEPGNLGFENTGFRE--DYSP-P-------PEE--SVPFQ------ 169

  P84996 LMEKDLGTTAHPRGFPE-LSHKSTAAASSRQSR---PRV-RSASL---PPRTRLPSGSQAPSAAHPKRLSDLLLTSRAAAPGWRSPDPRSRLAAPPLGST 257
  Q9Z213 LDGEEFGGDSPP---PDSASH-----ATNRHWRFEFPTVAVPSTLCLRPARTRLPSGSRAPLADH-ARLSD-LLTSHTTFPQWRSPDPCLRLAEPPLGST 259

  P84996 TLP-STWTAPQSRLTARPSRSPEPQIRESEQRDPQLRRKQQRWKE------PLM------PRREEKYP-------------LRG---T------------ 316
  Q9Z213 TTPLSIWTAPQSQVMARPSKSREPQLRASTQRDPHLSDKQPR-QETALSAAPLQRRQKSPPSSEEKDPPPNLKQCISSQLLLRSPERTLPKPIRTQLHTQ 358

  P84996 ------------DPLPP-------------------GQPQRIPL------------------PGQPL-QP--QPILTPGQ-PQKIP----TPGQHQPILT 359
  Q9Z213 FFRSVLRKSEESQPCPPIFRLLLKMRAQMSGQNQTEGQPQP-PLPSPKTTENQPPPPPPSQPPSQPLSQPPSQP---PSQPPSQLPRQSLTP---KPSLP 451

  P84996 PGHSQPIPTPGQ-PLPPQPIP-----TPGRPLTPQPI--PTPGRPLTPQPIQMPG------R--PLRL--PP---PLRLLRPGQPMSPQLRQTQG---LP 435
  Q9Z213 PGQS---PTPKRSPQPRQPLPRRRSLPPGQP--PSPLRSPLPGLSLLPEPIQPPGLSLEPQRCQPL-LGQPPLEQPMQVLWSGEPGHSRLLQPLGHPSLP 545

  P84996 ---LP--QPLLPPGQ--PKSAGRPLQPLPP--GPDARSISDPPAPRSRLPIRLLRGLL-ARLPGGASPRAAAAAACTTMKGWPA-ATMTPAETSPTM--- 521
  Q9Z213 AQQLPPEQPLL-PAQSLP--AG---QPLPPQAGP----ILDPPARRSRLLTRLLRGLLRGRVPGLTNTNVAEAAA--GMRLRPASARSSP----PAMSRK 629

  P84996 -GPPDASAGFSIGEIAAAESPSATY-----SATFSCKPSGAASVDLRVPSPKPRALSRSRRYPWRRSADRCAKKPWRSGPRSAQRRNAVSSSTNNSRTKR 615
  Q9Z213 KGPLAASSGFC-GETAALASPGATQSGATRSATSSPEPSEAASVYLSVPDHDPSAPGRP-RILWKRGANRCAKKPWRCESRSAQIRNAASSSTSNWRRRR 727

  P84996 WATCVRTACCF 626
  Q9Z213 WTTCVHTACCF 738

Go Annotations

1. PB indicates the go terms that are found by both PROST and BLAST.
2. P indicates the go terms that are found by only PROST.
3. B indicates the go terms that are only annotated by BLAST.
Source GO Description
1. PB GO:0043014 alpha-tubulin binding
1. PB GO:0005768 endosome
1. PB GO:0048701 embryonic cranial skeleton morphogenesis
1. PB GO:0005159 insulin-like growth factor receptor binding
1. PB GO:0120162 positive regulation of cold-induced thermogenesis
1. PB GO:0060789 hair follicle placode formation
1. PB GO:0070527 platelet aggregation
1. PB GO:0045669 positive regulation of osteoblast differentiation
1. PB GO:0031224 intrinsic component of membrane
1. PB GO:0045672 positive regulation of osteoclast differentiation
1. PB GO:0031748 D1 dopamine receptor binding
1. PB GO:0019904 protein domain specific binding
1. PB GO:0071514 genomic imprinting
1. PB GO:0051430 corticotropin-releasing hormone receptor 1 binding
1. PB GO:0001958 endochondral ossification
1. PB GO:0051216 cartilage development
1. PB GO:0001934 positive regulation of protein phosphorylation
1. PB GO:0010765 positive regulation of sodium ion transport
1. PB GO:0030142 COPI-coated Golgi to ER transport vesicle
1. PB GO:0007606 sensory perception of chemical stimulus
1. PB GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway
1. PB GO:0055074 calcium ion homeostasis
1. PB GO:0045121 membrane raft
1. PB GO:0009966 regulation of signal transduction
1. PB GO:0071870 cellular response to catecholamine stimulus
1. PB GO:0045776 negative regulation of blood pressure
1. PB GO:0042493
1. PB GO:0055037 recycling endosome
1. PB GO:0071107 response to parathyroid hormone
1. PB GO:0001501 skeletal system development
1. PB GO:0043025 neuronal cell body
1. PB GO:0035116 embryonic hindlimb morphogenesis
1. PB GO:0008284 positive regulation of cell population proliferation
1. PB GO:0035255 ionotropic glutamate receptor binding
1. PB GO:2000828 regulation of parathyroid hormone secretion
1. PB GO:0005834 heterotrimeric G-protein complex
1. PB GO:0001664 G protein-coupled receptor binding
1. PB GO:0071380 cellular response to prostaglandin E stimulus
1. PB GO:0035814 negative regulation of renal sodium excretion
1. PB GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway
1. PB GO:0060348 bone development
1. PB GO:0050890 cognition
1. PB GO:0043950 positive regulation of cAMP-mediated signaling
1. PB GO:0048589 developmental growth
1. PB GO:0040015 negative regulation of multicellular organism growth
1. PB GO:0007186 G protein-coupled receptor signaling pathway
1. PB GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway
1. PB GO:0030425 dendrite
1. PB GO:0006306 DNA methylation
1. PB GO:0010856 adenylate cyclase activator activity
1. PB GO:0009791 post-embryonic development
1. PB GO:0031852 mu-type opioid receptor binding
1. PB GO:0001894 tissue homeostasis
1. PB GO:0006112 energy reserve metabolic process
1. PB GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity
1. PB GO:0001965 G-protein alpha-subunit binding
1. PB GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
1. PB GO:0031683 G-protein beta/gamma-subunit complex binding
1. PB GO:0032588 trans-Golgi network membrane
1. PB GO:0031681 G-protein beta-subunit binding
1. PB GO:0031698 beta-2 adrenergic receptor binding
1. PB GO:0040032 post-embryonic body morphogenesis
1. PB GO:0043588 skin development
1. PB GO:0035264 multicellular organism growth
1. PB GO:0001726 ruffle
3. B GO:0030115 S-layer
3. B GO:0048471 perinuclear region of cytoplasm

Homologs

1. PB indicates the homologs that are found by both PROST and BLAST.
2. P indicates homologs that are only found by PROST.
3. B indicates homologs that are only found by BLAST.

Source Homolog Description FATCAT p-val PROST Evalue BLAST Evalue
1. PB Q6R0H6 Protein ALEX 1.70e-02 1.70e-28 3.09e-122
1. PB P84996 Protein ALEX 0 6.95e-150 0.0
1. PB Q9Z213 Protein ALEX 1.06e-02 2.10e-19 4.60e-34
2. P Q8N8H1 Putative protein ZNF321 4.26e-01 8.69e-04 NA
2. P Q5JRC9 Protein FAM47A 4.44e-01 8.21e-03 NA
2. P Q3E765 Uncharacterized protein YKL183C-A NA 1.33e-02 NA
2. P Q12528 Uncharacterized protein YLR111W 9.85e-01 3.77e-02 NA
2. P Q2KI51 Protein phosphatase 1 regulatory subunit 15A 1.18e-01 7.05e-05 NA
2. P Q45977 Holdfast attachment protein D 9.91e-01 2.32e-02 NA
3. B Q06852 Cell surface glycoprotein 1 9.67e-01 NA 0.044
3. B A6NE01 Protein FAM186A 7.17e-01 NA 7.71e-05
3. B P12255 Filamentous hemagglutinin NA NA 6.76e-05