Summary
Structures and Sequence Alignment
The best structural homolog that predicted by 3. B was
Q6PAX2
(ATPase family AAA domain-containing protein 3-B) with a FATCAT P-Value: 0.0128 and RMSD of 3.65 angstrom. The sequence alignment identity is 14.7%.
Structural alignment shown in left. Query protein Q0VF49 colored as red in alignment, homolog Q6PAX2 colored as blue.
Query protein Q0VF49 is also shown in right top, homolog Q6PAX2 showed in right bottom. They are colored based on secondary structures.
Q0VF49 MFTLSLLSRGHGKLGQDKQKLEVYFEPEDYLNWRSPEDYVPVSKPQDKNNASQHSWSLFLPKTFSTRKGALILYSEGFAISAWTPKERRKGPYCPRGPWR 100 Q6PAX2 ---------------------------------------------------------------------------------------------------- 0 Q0VF49 KLDLELHTLQDLKEAILAYGRQQGEQDRAWQPYLHFRSQLESQAQRQIQPGHSAKRYLRGLLRTWPPDAMYRLWCAGYIKDSVLLQDSQLNVPKKLRPQQ 200 Q6PAX2 ---------------------------------------------------------------------MS--WLFG------------LN-----RGQP 12 Q0VF49 DLSGVP--PKYHLLPVFPSFWIQQGKSFEQRQQGLDEGEAGAAGHVDQGPLAKNHGSQGTRLPPRRKQPWQE-DETQAE---------DTSIENHLCLYA 288 Q6PAX2 EPPGVPGFPE----P--PS---PPGGS------G-D-G--G-----D-----KN------R--PKDK--WSNFDPTGLERAAKAARELDQS--RH----- 66 Q0VF49 SKESYN-----EKT----QQTSRKAFGHGRIDHSWLPSDKSHITFCGGAFPNRKADLSD--KQRNV------KLHKARSSHLL--QVLPAERSLFPPVAS 369 Q6PAX2 AKEALNLAKVQEETLQMEQQAKIKEY-EAAVEQ--IKNEQIRVQ----SEEKRKT-LNEETKQHQARAQYQDKLARQRYEDQLRQQQLQNEENLRRQEES 158 Q0VF49 ATGSRIITPGEVKKKKA-PKALKLPPISEEPPRVLEPLKSQFKANEPPTELFILPVEIHYHTK-QPPKEKAH--R-----RGAPHPESEPESSE-ESTPV 459 Q6PAX2 -----------VQKQEAMRKA----TVEHE----ME-LR--HK-ND------MLRIEAEAHARAKVERENADIIREQIRLKAAEHRQTVLESIKTAGT-V 228 Q0VF49 WRPPLKHASLETPWE-LTVHLPVDASRDTLSPQGSSSLPPASLGNLTLK---GSKARH--TRVHSQGKGVWKGDDDAPP--HDVA--PPLDLLP-PIK-G 547 Q6PAX2 FGEGFR--TFISDWDKVTA---------TVA--GLTLL---AVGVYTAKNGTGVAGRYIEARL---GK---------PSLVRDTSRITVVEAIKHPIKIS 300 Q0VF49 K----KSPESQKGVD-SPRTSDHNSPPSLPNMRVPRRALPAAQEDS-SDPTLGHFLL--GPDG-EKVCL---SLPGHTQTE-ALPSGKAYESVNSNISHE 634 Q6PAX2 KRIFSKIQDALEGVILSPRLEE----------RV--RDIAIATRNTKANKGLYRNILMYGPPGTGKT-LFAKKLAMHSSMDYAIMTGG---DV-APMGR- 382 Q0VF49 EEGPSSQH--FLKANTEPRANLHMNLY--ETSP-L-TQTTEK--QGAQQSLEAAAQKTGEPQSCINK--ALICSNRKE-F-YT---R---KLHIDMTPFL 716 Q6PAX2 -EGVTAMHKVFDWAGTSKRGLL---LFVDEADAFLRKRSTEKISEDLRATLNAFLYRTGE-QS--NKFMLVLASNQPEQFDWAINDRIDEIVHFDL-P-- 472 Q0VF49 KESGNALDYQEEAGRPLRETHHNDQDPEPRSMTLDSPRASR-TEHIQTPEADIVQKVGRD-YDVHHLHRGLLGYGPE-SPERL-----SAVYTSLLPRER 808 Q6PAX2 ---G--LEERE---RLVR--LYFDK------YVL-QP-ASEGKQRLKVAQFD----YGKKCSELATLTEGM--SGREIS--KLGVAWQAAAYAS-----E 541 Q0VF49 EGKAEPRLFSQETSANISHER--DLINEAKRK-E--KPK-KDKTK--G--P-KSEREG-KVYGQAEAAIGKSKDSKAKKKLEKKTRPQRKRTQKERNLEI 896 Q6PAX2 DG----IL----TEAMI-DARVADAIRQHQQKMEWLKAEGKESTKEIGKNPLQPLLEGTPV--------------------------------------- 593 Q0VF49 AAELSGPDVSYEETEDTSNRGSFASDSFVEDPWLSPKYDAQESQVSLDGRSSPSQIATVTGNMESKEERRCEDPSKALLTKREQEKASWDRLRAERAEMR 996 Q6PAX2 ---------------------------------------------------------------------------------------------------- 593 Q0VF49 WLEVEKKRREQEEQRQLQQEQLERAKKMEEELELEQQRRTEEIRLRKQRLQEEQQRQEEEERKQQLRLKAAQERARQQQEEFRRKLRELQRKKQQEEAER 1096 Q6PAX2 ---------------------------------------------------------------------------------------------------- 593 Q0VF49 AEAEKQRQEELEMQLEEEQKHLMEMAEEERLEYQRRKQEAEEKARLEAEERRQKEEEAARLALEEATKQAQEQARYWIFGQQLP 1180 Q6PAX2 ------------------------------------------------------------------------------------ 593
Go Annotations
1. PB indicates the go terms that are found by both PROST and BLAST.2. P indicates the go terms that are found by only PROST.
3. B indicates the go terms that are only annotated by BLAST.
| Source | GO | Description |
|---|---|---|
| 3. B | GO:0003774 | cytoskeletal motor activity |
| 3. B | GO:0030286 | dynein complex |
| 3. B | GO:0048467 | gynoecium development |
| 3. B | GO:0090436 | leaf pavement cell development |
| 3. B | GO:0009826 | unidimensional cell growth |
| 3. B | GO:0005628 | prospore membrane |
| 3. B | GO:0030507 | spectrin binding |
| 3. B | GO:0005874 | microtubule |
| 3. B | GO:0045505 | dynein intermediate chain binding |
| 3. B | GO:0030048 | actin filament-based movement |
| 3. B | GO:0051646 | mitochondrion localization |
| 3. B | GO:0051011 | microtubule minus-end binding |
| 3. B | GO:0006335 | DNA replication-dependent chromatin assembly |
| 3. B | GO:0007005 | mitochondrion organization |
| 3. B | GO:0022604 | regulation of cell morphogenesis |
| 3. B | GO:0005935 | cellular bud neck |
| 3. B | GO:0005743 | mitochondrial inner membrane |
| 3. B | GO:0051959 | dynein light intermediate chain binding |
| 3. B | GO:0003743 | translation initiation factor activity |
| 3. B | GO:1990225 | rhoptry neck |
| 3. B | GO:0010154 | fruit development |
| 3. B | GO:0031113 | regulation of microtubule polymerization |
| 3. B | GO:0010090 | trichome morphogenesis |
| 3. B | GO:0051601 | exocyst localization |
| 3. B | GO:0033186 | CAF-1 complex |
| 3. B | GO:0030050 | vesicle transport along actin filament |
| 3. B | GO:0031122 | cytoplasmic microtubule organization |
| 3. B | GO:0007026 | negative regulation of microtubule depolymerization |
| 3. B | GO:0048309 | endoplasmic reticulum inheritance |
| 3. B | GO:0044647 | host-symbiont bicellular tight junction |
| 3. B | GO:0043332 | mating projection tip |
| 3. B | GO:0036449 | microtubule minus-end |
| 3. B | GO:0031175 | neuron projection development |
| 3. B | GO:0005875 | microtubule associated complex |
| 3. B | GO:0002224 | toll-like receptor signaling pathway |
| 3. B | GO:0090522 | vesicle tethering involved in exocytosis |
| 3. B | GO:0090647 | modulation of age-related behavioral decline |
| 3. B | GO:0003777 | microtubule motor activity |
| 3. B | GO:0031507 | heterochromatin assembly |
| 3. B | GO:0000145 | exocyst |
| 3. B | GO:0043596 | nuclear replication fork |
| 3. B | GO:0008569 | minus-end-directed microtubule motor activity |
| 3. B | GO:1990426 | mitotic recombination-dependent replication fork processing |
| 3. B | GO:0000226 | microtubule cytoskeleton organization |
| 3. B | GO:0000146 | microfilament motor activity |
| 3. B | GO:0009791 | post-embryonic development |
| 3. B | GO:0001927 | exocyst assembly |
| 3. B | GO:0008017 | microtubule binding |
| 3. B | GO:0042645 | mitochondrial nucleoid |
| 3. B | GO:0051645 | Golgi localization |
| 3. B | GO:0000131 | incipient cellular bud site |
| 3. B | GO:0007010 | cytoskeleton organization |
| 3. B | GO:0071108 | protein K48-linked deubiquitination |
| 3. B | GO:0005934 | cellular bud tip |
| 3. B | GO:0006893 | Golgi to plasma membrane transport |
| 3. B | GO:0005516 | calmodulin binding |
| 3. B | GO:0016459 | myosin complex |
| 3. B | GO:0060151 | peroxisome localization |
| 3. B | GO:0003924 | GTPase activity |
Homologs
1. PB indicates the homologs that are found by both PROST and BLAST.
2. P indicates homologs that are only found by PROST.
3. B indicates homologs that are only found by BLAST.
| Source | Homolog | Description | FATCAT p-val | PROST Evalue | BLAST Evalue |
|---|---|---|---|---|---|
| 1. PB | Q0VF49 | Uncharacterized protein KIAA2012 | 0 | 4.90e-145 | 0.0 |
| 1. PB | A7YY35 | Uncharacterized protein KIAA2012 homolog | 1.30e-05 | 1.72e-48 | 0.0 |
| 3. B | Q39160 | Myosin-5 | 6.82e-02 | NA | 0.049 |
| 3. B | Q8ILR9 | Protein PF14_0175 | NA | NA | 1.34e-08 |
| 3. B | Q3IJ53 | Translation initiation factor IF-2 | 1.09e-01 | NA | 0.016 |
| 3. B | P33332 | Exocyst complex component SEC3 | 5.20e-01 | NA | 7.92e-04 |
| 3. B | Q6NVR9 | ATPase family AAA domain-containing protein 3 | 7.43e-02 | NA | 0.004 |
| 3. B | Q5T5Y3 | Calmodulin-regulated spectrin-associated protein 1 | 4.18e-01 | NA | 0.015 |
| 3. B | Q5E7L5 | Translation initiation factor IF-2 | 1.15e-01 | NA | 0.001 |
| 3. B | P46504 | Uncharacterized protein F23F12.8 | 8.33e-02 | NA | 0.029 |
| 3. B | Q8IDX6 | Reticulocyte-binding protein homolog 2a | NA | NA | 0.010 |
| 3. B | Q8IID4 | Dynein heavy chain-like protein PF11_0240 | NA | NA | 0.016 |
| 3. B | B5FA79 | Translation initiation factor IF-2 | 1.33e-01 | NA | 0.002 |
| 3. B | D3Z8E6 | Calmodulin-regulated spectrin-associated protein 1 | 3.11e-01 | NA | 0.040 |
| 3. B | Q6PAX2 | ATPase family AAA domain-containing protein 3-B | 1.28e-02 | NA | 0.012 |
| 3. B | Q58E76 | ATPase family AAA domain-containing protein 3-A | 1.97e-02 | NA | 0.015 |
| 3. B | Q09237 | GYF domain-containing protein gyf-1 | 1.09e-01 | NA | 0.015 |
| 3. B | A2AUY4 | Bromodomain adjacent to zinc finger domain protein 2B | 1.73e-01 | NA | 0.005 |
| 3. B | Q1MTN9 | Chromatin assembly factor 1 subunit rlf2 | 8.73e-02 | NA | 0.006 |
| 3. B | A2AHC3 | Calmodulin-regulated spectrin-associated protein 1 | 1.73e-01 | NA | 0.040 |
| 3. B | C4L8X4 | Translation initiation factor IF-2 | 4.16e-01 | NA | 0.037 |
| 3. B | Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | 5.00e-01 | NA | 0.016 |