Summary

Q3ZCV2

Homolog: A2AVQ5.
Function: Lymphocyte expansion molecule.

Statistics

Total GO Annotation: 35
Unique PROST Go: 31
Unique BLAST Go: 1

Total Homologs: 20
Unique PROST Homologs: 17
Unique BLAST Homologs: 0

Structures and Sequence Alignment

The best structural homolog that predicted by 1. PB was A2AVQ5 (Lymphocyte expansion molecule) with a FATCAT P-Value: 1.22e-05 and RMSD of 7.63 angstrom. The sequence alignment identity is 70.6%.
Structural alignment shown in left. Query protein Q3ZCV2 colored as red in alignment, homolog A2AVQ5 colored as blue. Query protein Q3ZCV2 is also shown in right top, homolog A2AVQ5 showed in right bottom. They are colored based on secondary structures. 

  Q3ZCV2 MRESQDAAGAHGWNRVGSTATKWFTGAPFGVQSHRFDISAVYPNWKKFSTFTEAPYSTRYSTQVSHIGPGTYSSKETCFSKKKLMKEVDTGWAKAQEATR 100
  A2AVQ5 MRPRTH--GAPPRN-IMSTIPKWFKGAPFGVQSHRFDVSAVYPNQKKFSTFTEAPYSRHHSVELSHIGPGTYNSKDTCFSKKFLEQKLGSGWSQAHEATR 97

  Q3ZCV2 LTQLPHFQYQAIMKEKRLKEQKLGPGSYNLKDFLEQLREKPCSTRGLLSSGEVRFRGLTGNYYPGPGNYGEKGNPYTKLEENAWNRSHSEGLMCRMSNKP 200
  A2AVQ5 LTQLPHFHYQAIKKEKEQQVHKRGPGSYNIKDFITELQKKPQSKRGLLSSGETRFRGFIGNYYPGPGNYGEKGNPYTQLEEKAWNRSHSDGLMCRVSNKP 197

  Q3ZCV2 HPRPHQGSGLGPGTYFFKSDLETYVARSVGTRGPYDTFSGDRSKPLPYGHYSMQKKKPRELMNFKSFVEELNSHHNKKHGVFSKLPRNPKTPTERIYWAN 300
  A2AVQ5 -PLFHQGSGLGPGTYTIKSDLETFVKKSTGNRGPYDIFSGERSSPLPYGHYSVQKMKPKELTDYKSFLDEMNSQHKKKQGVFSKYPRDPKHPTERIFWTT 296

  Q3ZCV2 LSQCPRTLATSGPSFWLPQEKKCKPVNQPPFLLTSKGSGAKACQMIMGSWNPVGVGRYLNTWLMETKDRRQRYRSLFLSGSKRYLSDLARDMLMQERITP 400
  A2AVQ5 LSQCPKNMDIAGPGSWLPHETEQKHVNRPPFLLASKRCGLKAYQMILGTWNPVGVGRYLNTTLMESIDRRQRYRSLYMSEPKRYLQDLTRDRLMQKRITP 396

  Q3ZCV2 FTKGKCPPTVDYNSDPTP 418
  A2AVQ5 ITKGKCRPTVDYNSDPTP 414

Go Annotations

1. PB indicates the go terms that are found by both PROST and BLAST.
2. P indicates the go terms that are found by only PROST.
3. B indicates the go terms that are only annotated by BLAST.
Source GO Description
1. PB GO:0097177 mitochondrial ribosome binding
1. PB GO:1903862 positive regulation of oxidative phosphorylation
1. PB GO:0005739 mitochondrion
2. P GO:0036126 sperm flagellum
2. P GO:0003682 chromatin binding
2. P GO:1901537 positive regulation of DNA demethylation
2. P GO:0060971 embryonic heart tube left/right pattern formation
2. P GO:0005814 centriole
2. P GO:0042585 germinal vesicle
2. P GO:0031344 regulation of cell projection organization
2. P GO:0030036 actin cytoskeleton organization
2. P GO:0008307 structural constituent of muscle
2. P GO:0090116 C-5 methylation of cytosine
2. P GO:0005879 axonemal microtubule
2. P GO:0043065 positive regulation of apoptotic process
2. P GO:0001940 male pronucleus
2. P GO:1902110 positive regulation of mitochondrial membrane permeability involved in apoptotic process
2. P GO:0001939 female pronucleus
2. P GO:0043015 gamma-tubulin binding
2. P GO:0019894 kinesin binding
2. P GO:0005634 nucleus
2. P GO:0060537 muscle tissue development
2. P GO:0007517 muscle organ development
2. P GO:0036064 ciliary basal body
2. P GO:0005856 cytoskeleton
2. P GO:0008092 cytoskeletal protein binding
2. P GO:0045214 sarcomere organization
2. P GO:0033674 positive regulation of kinase activity
2. P GO:0030018 Z disc
2. P GO:0044782 cilium organization
2. P GO:0034453 microtubule anchoring
2. P GO:0048487 beta-tubulin binding
2. P GO:0044727 DNA demethylation of male pronucleus
2. P GO:0042393 histone binding
3. B GO:0008284 positive regulation of cell population proliferation

Homologs

1. PB indicates the homologs that are found by both PROST and BLAST.
2. P indicates homologs that are only found by PROST.
3. B indicates homologs that are only found by BLAST.

Source Homolog Description FATCAT p-val PROST Evalue BLAST Evalue
1. PB Q3ZCV2 Lymphocyte expansion molecule 0 4.27e-155 0.0
1. PB A2AVQ5 Lymphocyte expansion molecule 1.22e-05 6.83e-50 0.0
1. PB B1H283 Lymphocyte expansion molecule 2.32e-05 2.95e-43 0.0
2. P Q4KLY8 O(6)-methylguanine-induced apoptosis 2 7.74e-01 1.29e-07 NA
2. P Q5TH74 O(6)-methylguanine-induced apoptosis 2 7.84e-01 4.72e-08 NA
2. P Q3KQ80 O(6)-methylguanine-induced apoptosis 2 9.07e-01 3.91e-07 NA
2. P Q8TCI5 Protein pitchfork 8.38e-01 2.38e-03 NA
2. P Q8N412 Sperm-tail PG-rich repeat-containing protein 2 8.00e-01 1.07e-02 NA
2. P A6QQ60 O(6)-methylguanine-induced apoptosis 2 7.53e-01 6.41e-06 NA
2. P Q9DAG5 Protein STPG4 9.13e-01 8.03e-03 NA
2. P Q08BC4 Sperm-tail PG-rich repeat-containing protein 2 7.36e-01 1.28e-07 NA
2. P Q8N7X2 Protein STPG3 7.95e-01 1.32e-03 NA
2. P Q8C8J0 Sperm-tail PG-rich repeat-containing protein 2 8.65e-01 7.42e-09 NA
2. P Q8IXM7 Outer dense fiber protein 3-like protein 1 7.93e-01 3.28e-02 NA
2. P Q9D2F5 O(6)-methylguanine-induced apoptosis 2 8.29e-01 2.55e-04 NA
2. P A5WUY6 O(6)-methylguanine-induced apoptosis 2 9.24e-01 1.10e-09 NA
2. P Q24400 Muscle LIM protein Mlp84B 9.14e-01 4.48e-02 NA
2. P Q810P2 Outer dense fiber protein 3-like protein 1 8.59e-01 9.28e-04 NA
2. P Q8BQB6 Stabilizer of axonemal microtubules 2 7.58e-01 2.55e-04 NA
2. P A1A5R9 Sperm-tail PG-rich repeat-containing protein 2 9.20e-01 4.90e-06 NA