Summary

Q4W4Y0

Homolog: Q9UUD6.
Function: Ubiquitin carboxyl-terminal hydrolase 11.

Statistics

Total GO Annotation: 91
Unique PROST Go: 91
Unique BLAST Go: 0

Total Homologs: 71
Unique PROST Homologs: 68
Unique BLAST Homologs: 0

Structures and Sequence Alignment

The best structural homolog that predicted by 2. P was Q9UUD6 (Ubiquitin carboxyl-terminal hydrolase 11) with a FATCAT P-Value: 1.63e-05 and RMSD of 3.06 angstrom. The sequence alignment identity is 21.2%.
Structural alignment shown in left. Query protein Q4W4Y0 colored as red in alignment, homolog Q9UUD6 colored as blue. Query protein Q4W4Y0 is also shown in right top, homolog Q9UUD6 showed in right bottom. They are colored based on secondary structures. 

  Q4W4Y0 --------------------------------------MKTLFEEIK-ASIKNNYN---QDRSF--CRPVLPWGGVFTIKAGRKAVSCTPLYVEIRLKNT 56
  Q9UUD6 MSTTPLSISRAKKYKTVFKGAAILTTFAALYIVTSPSTGKRL---VKNASIKGLYNVSGND-CFLNC--VLQ-----SL-ASQESL------LEI-LKLR 81

  Q4W4Y0 CTIDGFLMLLYVILNE-NENFP-RELSLHFGREFVDCFLYLMDTYSFTTVKLLW-IWDKMEKQQYKSEV-HKASLI--IDLFGNEHD-NFTKNL----EN 145
  Q9UUD6 CSSSTLYATLYELLQKLNSG-PGNPITP--GS-FLNS-LEI-----ATNKKLVRSI--QQDAQEF---LQH---LVETLEL-QKPHTYKWSKVLSFPVDS 162

  Q4W4Y0 -LMSTI-QESYCSNWRC-PTRVQEDQQRTININ-PPQEIPHGN----LIRL--A-----VNELFCSKIELC----EEH---GCGGLR--EFSQRIFCHGA 221
  Q9UUD6 PFIGTMEQKVQCCQ--CLAISISYSTATSIQLCLPPEY--SGNSNVSLLSLMEADREQHISDYKCDS---CFKSSPKHSKTSC--IRTVDWKN------- 246

  Q4W4Y0 PPFVVLNMQHWKSEDLAYVPYYL---DLS---DHKYLLEGATLFNKEEHHY---SAAFQIG----GHWMHY---DGL---RNVNLIL---LNKPPEFL-- 297
  Q9UUD6 PP-TILQIQ---LERTSYTCQGLTRNNVSISFPSK-LI----LKNK--HHYILRSLITHSGSVTYGHYLCYRLQDDIWWKANDSLITKSSLN---EALSQ 332

  Q4W4Y0 LLSS--LVYIRATEK----- 310
  Q9UUD6 TRSACLLFY--EMESPLALD 350

Go Annotations

1. PB indicates the go terms that are found by both PROST and BLAST.
2. P indicates the go terms that are found by only PROST.
3. B indicates the go terms that are only annotated by BLAST.
Source GO Description
2. P GO:0048149 behavioral response to ethanol
2. P GO:0071819 DUBm complex
2. P GO:0030374 nuclear receptor coactivator activity
2. P GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process
2. P GO:0000425 pexophagy
2. P GO:0000422 autophagy of mitochondrion
2. P GO:0007610 behavior
2. P GO:0000245 spliceosomal complex assembly
2. P GO:0016578 histone deubiquitination
2. P GO:0006511 ubiquitin-dependent protein catabolic process
2. P GO:0043197 dendritic spine
2. P GO:0006325 chromatin organization
2. P GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
2. P GO:0035871 protein K11-linked deubiquitination
2. P GO:0007265 Ras protein signal transduction
2. P GO:0090326 positive regulation of locomotion involved in locomotory behavior
2. P GO:0061578 Lys63-specific deubiquitinase activity
2. P GO:0004197 cysteine-type endopeptidase activity
2. P GO:1900227 positive regulation of NLRP3 inflammasome complex assembly
2. P GO:0000502 proteasome complex
2. P GO:0016574 histone ubiquitination
2. P GO:1903070 negative regulation of ER-associated ubiquitin-dependent protein catabolic process
2. P GO:0030496 midbody
2. P GO:0005634 nucleus
2. P GO:0035521 monoubiquitinated histone deubiquitination
2. P GO:0008053 mitochondrial fusion
2. P GO:0034729 histone H3-K79 methylation
2. P GO:0031647 regulation of protein stability
2. P GO:0019897 extrinsic component of plasma membrane
2. P GO:0007032 endosome organization
2. P GO:0045494 photoreceptor cell maintenance
2. P GO:0090543 Flemming body
2. P GO:0031313 extrinsic component of endosome membrane
2. P GO:0031410 cytoplasmic vesicle
2. P GO:0060628 regulation of ER to Golgi vesicle-mediated transport
2. P GO:0050920 regulation of chemotaxis
2. P GO:0019783 ubiquitin-like protein-specific protease activity
2. P GO:0071629 cytoplasm protein quality control by the ubiquitin-proteasome system
2. P GO:0032228 regulation of synaptic transmission, GABAergic
2. P GO:0070628 proteasome binding
2. P GO:0019899 enzyme binding
2. P GO:0005737 cytoplasm
2. P GO:0098978 glutamatergic synapse
2. P GO:0032731 positive regulation of interleukin-1 beta production
2. P GO:0032741 positive regulation of interleukin-18 production
2. P GO:0008270 zinc ion binding
2. P GO:0099149 regulation of postsynaptic neurotransmitter receptor internalization
2. P GO:0001662 behavioral fear response
2. P GO:1905538 polysome binding
2. P GO:0005838 proteasome regulatory particle
2. P GO:0044313 protein K6-linked deubiquitination
2. P GO:0050862 positive regulation of T cell receptor signaling pathway
2. P GO:0004843 thiol-dependent deubiquitinase
2. P GO:0016579 protein deubiquitination
2. P GO:0046695 SLIK (SAGA-like) complex
2. P GO:2000311 regulation of AMPA receptor activity
2. P GO:0035634 response to stilbenoid
2. P GO:0008343 adult feeding behavior
2. P GO:0060339 negative regulation of type I interferon-mediated signaling pathway
2. P GO:0004866 endopeptidase inhibitor activity
2. P GO:0000124 SAGA complex
2. P GO:0045931 positive regulation of mitotic cell cycle
2. P GO:0008595 anterior/posterior axis specification, embryo
2. P GO:0019785 ISG15-specific protease activity
2. P GO:0061136 regulation of proteasomal protein catabolic process
2. P GO:0043967 histone H4 acetylation
2. P GO:0003407 neural retina development
2. P GO:0005829 cytosol
2. P GO:0036464 cytoplasmic ribonucleoprotein granule
2. P GO:0045202 synapse
2. P GO:1990841 promoter-specific chromatin binding
2. P GO:0045087 innate immune response
2. P GO:0039557 suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity
2. P GO:0010485 H4 histone acetyltransferase activity
2. P GO:1990380 Lys48-specific deubiquitinase activity
2. P GO:0072671 mitochondria-associated ubiquitin-dependent protein catabolic process
2. P GO:1901525 negative regulation of mitophagy
2. P GO:1901562 response to paraquat
2. P GO:1901799 negative regulation of proteasomal protein catabolic process
2. P GO:0101005 deubiquitinase activity
2. P GO:0050727 regulation of inflammatory response
2. P GO:2001056 positive regulation of cysteine-type endopeptidase activity
2. P GO:0071108 protein K48-linked deubiquitination
2. P GO:0070536 protein K63-linked deubiquitination
2. P GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process
2. P GO:0035520 monoubiquitinated protein deubiquitination
2. P GO:0035063 nuclear speck organization
2. P GO:0005741 mitochondrial outer membrane
2. P GO:0070911 global genome nucleotide-excision repair
2. P GO:0001917 photoreceptor inner segment
2. P GO:0060013 righting reflex

Homologs

1. PB indicates the homologs that are found by both PROST and BLAST.
2. P indicates homologs that are only found by PROST.
3. B indicates homologs that are only found by BLAST.

Source Homolog Description FATCAT p-val PROST Evalue BLAST Evalue
1. PB Q2KIN3 Uncharacterized protein C14orf28 homolog 4.00e-06 1.17e-71 0.0
1. PB Q4KL13 Uncharacterized protein C14orf28 homolog 0.00e+00 2.95e-113 0.0
1. PB Q4W4Y0 Uncharacterized protein C14orf28 0 6.38e-143 0.0
2. P O94269 Probable ubiquitin carboxyl-terminal hydrolase 3 1.30e-02 4.02e-05 NA
2. P P06440 Major core protein 4b NA 1.95e-03 NA
2. P P39967 Ubiquitin carboxyl-terminal hydrolase 9 1.08e-01 9.91e-03 NA
2. P Q6P8X6 Putative ubiquitin carboxyl-terminal hydrolase 50 8.41e-03 2.90e-11 NA
2. P Q9D9M2 Ubiquitin carboxyl-terminal hydrolase 12 1.43e-03 8.96e-14 NA
2. P Q9UPT9 Ubiquitin carboxyl-terminal hydrolase 22 8.85e-04 1.37e-04 NA
2. P Q9W462 Ubiquitin carboxyl-terminal hydrolase 30 homolog 1.41e-01 3.58e-07 NA
2. P P43593 Ubiquitin carboxyl-terminal hydrolase 6 2.44e-02 1.62e-08 NA
2. P A5D9H7 Ubiquitin carboxyl-terminal hydrolase 12 1.49e-03 1.24e-13 NA
2. P Q9WTV6 Ubl carboxyl-terminal hydrolase 18 2.28e-04 3.44e-19 NA
2. P A2BGT0 Ubiquitin carboxyl-terminal hydrolase 30 2.21e-01 7.63e-09 NA
2. P P62069 Ubiquitin carboxyl-terminal hydrolase 46 2.21e-04 3.39e-14 NA
2. P A4FUN7 Ubiquitin carboxyl-terminal hydrolase 12A 1.17e-03 1.07e-14 NA
2. P Q9UMW8 Ubl carboxyl-terminal hydrolase 18 9.38e-04 4.99e-18 NA
2. P C0HB46 Ubiquitin carboxyl-terminal hydrolase 12 1.53e-03 3.55e-14 NA
2. P Q6DCJ1 Ubiquitin carboxyl-terminal hydrolase 22-B 6.06e-03 6.67e-03 NA
2. P Q3UN04 Ubiquitin carboxyl-terminal hydrolase 30 3.58e-02 1.18e-05 NA
2. P O96612 Ubiquitin hydrolase B 1.03e-02 2.18e-15 NA
2. P P54578 Ubiquitin carboxyl-terminal hydrolase 14 1.69e-02 2.45e-09 NA
2. P Q5UPW7 Putative ubiquitin carboxyl-terminal hydrolase L293 NA 1.45e-07 NA
2. P Q84WC6 Ubiquitin carboxyl-terminal hydrolase 7 2.31e-02 1.45e-06 NA
2. P Q8CEG8 Ubiquitin carboxyl-terminal hydrolase 27 3.99e-04 4.33e-12 NA
2. P A4QNN3 Ubiquitin carboxyl-terminal hydrolase 30 4.45e-02 3.75e-09 NA
2. P Q8LAM0 Ubiquitin carboxyl-terminal hydrolase 4 5.47e-03 9.47e-13 NA
2. P Q70EL2 Ubiquitin carboxyl-terminal hydrolase 45 3.69e-01 2.34e-03 NA
2. P Q4R6D3 Putative ubiquitin carboxyl-terminal hydrolase 50 2.61e-04 2.68e-13 NA
2. P Q9Y6I4 Ubiquitin carboxyl-terminal hydrolase 3 3.80e-02 1.88e-02 NA
2. P Q02863 Ubiquitin carboxyl-terminal hydrolase 16 5.95e-02 1.11e-07 NA
2. P Q5UQR3 Probable ubiquitin carboxyl-terminal hydrolase R319 NA 6.79e-12 NA
2. P Q9JMA1 Ubiquitin carboxyl-terminal hydrolase 14 1.96e-02 1.76e-09 NA
2. P A6NNY8 Ubiquitin carboxyl-terminal hydrolase 27 7.92e-03 4.98e-13 NA
2. P Q91W36 Ubiquitin carboxyl-terminal hydrolase 3 4.17e-03 2.46e-02 NA
2. P Q9USR2 Probable mRNA-splicing protein ubp10 2.74e-02 1.75e-03 NA
2. P Q5M981 Ubiquitin carboxyl-terminal hydrolase 12-B 2.32e-04 1.63e-13 NA
2. P Q9UUD6 Ubiquitin carboxyl-terminal hydrolase 11 1.63e-05 6.00e-20 NA
2. P Q70CQ3 Ubiquitin carboxyl-terminal hydrolase 30 2.53e-02 4.62e-07 NA
2. P Q9FPS0 Ubiquitin carboxyl-terminal hydrolase 27 1.41e-02 3.63e-13 NA
2. P A5WWB0 Ubiquitin carboxyl-terminal hydrolase 46 9.22e-04 1.07e-14 NA
2. P P43589 Pre-mRNA-splicing factor SAD1 9.36e-03 1.30e-06 NA
2. P P62068 Ubiquitin carboxyl-terminal hydrolase 46 1.78e-03 3.39e-14 NA
2. P Q86194 Non-structural protein 1 NA 1.69e-02 NA
2. P P50102 Ubiquitin carboxyl-terminal hydrolase 8 9.02e-03 3.63e-03 NA
2. P Q70EL3 Inactive ubiquitin carboxyl-terminal hydrolase 50 4.96e-03 3.72e-14 NA
2. P Q0IIF7 Ubiquitin carboxyl-terminal hydrolase 14 1.98e-02 2.45e-09 NA
2. P Q3LFD5 Putative ubiquitin carboxyl-terminal hydrolase 41 3.23e-04 7.55e-15 NA
2. P Q6GNI6 Ubiquitin carboxyl-terminal hydrolase 22-A 6.14e-03 9.35e-03 NA
2. P Q09738 Probable ubiquitin carboxyl-terminal hydrolase 8 8.68e-03 1.15e-04 NA
2. P O75317 Ubiquitin carboxyl-terminal hydrolase 12 2.30e-03 1.37e-13 NA
2. P Q6QN14 Ubiquitin carboxyl-terminal hydrolase 17-like protein 6 4.40e-03 2.71e-06 NA
2. P Q52KZ6 Ubiquitin carboxyl-terminal hydrolase 12-A 2.35e-04 1.31e-13 NA
2. P O74442 Probable ubiquitin carboxyl-terminal hydrolase 16 4.48e-03 2.10e-03 NA
2. P P60051 Ubiquitin carboxyl-terminal hydrolase 14 1.68e-02 2.59e-09 NA
2. P Q17361 Ubiquitin carboxyl-terminal hydrolase 14 8.00e-03 6.28e-04 NA
2. P Q29RP1 Ubiquitin carboxyl-terminal hydrolase 1 2.38e-01 3.74e-03 NA
2. P P0C8Z3 Ubiquitin carboxyl-terminal hydrolase 22 5.12e-03 4.96e-05 NA
2. P P40826 Ubiquitin carboxyl-terminal hydrolase 14 1.87e-02 2.23e-09 NA
2. P Q92353 Ubiquitin carboxyl-terminal hydrolase 6 2.96e-02 9.68e-05 NA
2. P Q5DU02 Ubiquitin carboxyl-terminal hydrolase 22 6.27e-03 1.20e-04 NA
2. P Q5RBQ4 Ubiquitin carboxyl-terminal hydrolase 46 3.02e-04 3.39e-14 NA
2. P O24454 Ubiquitin carboxyl-terminal hydrolase 3 6.64e-03 2.78e-11 NA
2. P Q5RE63 Ubl carboxyl-terminal hydrolase 18 3.50e-04 1.27e-17 NA
2. P D3ZPG5 Ubiquitin carboxyl-terminal hydrolase 30 4.37e-02 2.00e-06 NA
2. P O57429 Ubiquitin carboxyl-terminal hydrolase 2 2.28e-03 3.90e-06 NA
2. P Q949Y0 Ubiquitin carboxyl-terminal hydrolase 6 2.39e-02 7.30e-06 NA
2. P A6H8I0 Ubiquitin carboxyl-terminal hydrolase 22 7.64e-04 6.22e-04 NA
2. P F1M625 Ubiquitin carboxyl-terminal hydrolase 46 2.02e-04 2.30e-14 NA
2. P P34547 Ubiquitin carboxyl-terminal hydrolase 46 6.79e-03 6.41e-11 NA
2. P Q8K387 Ubiquitin carboxyl-terminal hydrolase 45 1.66e-01 4.66e-02 NA