Results | PROST

Summary

Q569G3

Homolog: Q80ZG6.
Function: Bcl-2-binding component 3.

Statistics

Total GO Annotation: 90
Unique PROST Go: 90
Unique BLAST Go: 0

Total Homologs: 63
Unique PROST Homologs: 61
Unique BLAST Homologs: 0

Structures and Sequence Alignment

The best structural homolog that predicted by 2. P was Q80ZG6 (Bcl-2-binding component 3) with a FATCAT P-Value: 0.00505 and RMSD of 3.30 angstrom. The sequence alignment identity is 23.4%.
Structural alignment shown in left. Query protein Q569G3 colored as red in alignment, homolog Q80ZG6 colored as blue. Query protein Q569G3 is also shown in right top, homolog Q80ZG6 showed in right bottom. They are colored based on secondary structures.

  Q569G3 MAAA---G------RGREQDSARFVYVTRF--GSHQCSGVLQLG---GRGAQGLWGQGPGAG-CRQEKPREAMAVAGVQGGSELPLG--SQLRVPTTPGV 83
  Q80ZG6 MARARQEGSSPEPVEGLARDSPRPFPLGRLMPSAVSC-GLCEPGLPAAPAAPALL---PAAYLC---APTAPPAVTAALGGPRWPGGHRSRPRGPRPDGP 93

  Q569G3 EAAAS-ASSQLRASRVQSGTRQSARAGLIQKDAAKKYDFP-IPLNEASKIMKKKKKVLVWNR-VYKVISRMLEE-NEKY-RHRLKCQRLSSESSNYTR-- 176
  Q80ZG6 QPSLSPAQQHL-ESPVPSAPE--ALAG-GPTQAA-----PGVRVEEEE-----------WAREIGAQLRRMADDLNAQYERRRQEEQH-RHRPSPW-RVM 171

  Q569G3 ---------------------- 176
  Q80ZG6 YNLFMGLLPLPRDPGAPEMEPN 193

Go Annotations

1. PB indicates the go terms that are found by both PROST and BLAST.
2. P indicates the go terms that are found by only PROST.
3. B indicates the go terms that are only annotated by BLAST.

Source	GO	Description
2. P	GO:0043243	positive regulation of protein-containing complex disassembly
2. P	GO:2000378	negative regulation of reactive oxygen species metabolic process
2. P	GO:0010940	positive regulation of necrotic cell death
2. P	GO:0043029	T cell homeostasis
2. P	GO:0090141	positive regulation of mitochondrial fission
2. P	GO:1900740	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
2. P	GO:0070449	elongin complex
2. P	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
2. P	GO:0045926	negative regulation of growth
2. P	GO:0007127	meiosis I
2. P	GO:0010637	negative regulation of mitochondrial fusion
2. P	GO:0035148	tube formation
2. P	GO:0032471	negative regulation of endoplasmic reticulum calcium ion concentration
2. P	GO:0039592	suppression by virus of G2/M transition of host mitotic cell cycle
2. P	GO:0048663	neuron fate commitment
2. P	GO:0097141	BIM-BCL-2 complex
2. P	GO:0051209	release of sequestered calcium ion into cytosol
2. P	GO:0043065	positive regulation of apoptotic process
2. P	GO:1902110	positive regulation of mitochondrial membrane permeability involved in apoptotic process
2. P	GO:0097140	BIM-BCL-xl complex
2. P	GO:0010917	negative regulation of mitochondrial membrane potential
2. P	GO:0051561	positive regulation of mitochondrial calcium ion concentration
2. P	GO:0090200	positive regulation of release of cytochrome c from mitochondria
2. P	GO:0034974	Swi5-Swi2 complex
2. P	GO:0071279	cellular response to cobalt ion
2. P	GO:0048102	autophagic cell death
2. P	GO:0043067	regulation of programmed cell death
2. P	GO:0008340	determination of adult lifespan
2. P	GO:0097190	apoptotic signaling pathway
2. P	GO:0006974	cellular response to DNA damage stimulus
2. P	GO:0043068	positive regulation of programmed cell death
2. P	GO:0002262	myeloid cell homeostasis
2. P	GO:0043525	positive regulation of neuron apoptotic process
2. P	GO:1902263	apoptotic process involved in embryonic digit morphogenesis
2. P	GO:0001776	leukocyte homeostasis
2. P	GO:0001782	B cell homeostasis
2. P	GO:0039652	induction by virus of host NF-kappaB cascade
2. P	GO:0070242	thymocyte apoptotic process
2. P	GO:0005740	mitochondrial envelope
2. P	GO:0046620	regulation of organ growth
2. P	GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator
2. P	GO:0032464	positive regulation of protein homooligomerization
2. P	GO:0005737	cytoplasm
2. P	GO:1902237	positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
2. P	GO:0033650	host cell mitochondrion
2. P	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway
2. P	GO:0032798	Swi5-Sfr1 complex
2. P	GO:0071479	cellular response to ionizing radiation
2. P	GO:1903896	positive regulation of IRE1-mediated unfolded protein response
2. P	GO:0043583	ear development
2. P	GO:0090649	response to oxygen-glucose deprivation
2. P	GO:0048066	developmental pigmentation
2. P	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
2. P	GO:0002260	lymphocyte homeostasis
2. P	GO:0048070	regulation of developmental pigmentation
2. P	GO:0051117	ATPase binding
2. P	GO:0031334	positive regulation of protein-containing complex assembly
2. P	GO:0019079	viral genome replication
2. P	GO:0035694	mitochondrial protein catabolic process
2. P	GO:0034976	response to endoplasmic reticulum stress
2. P	GO:0010659	cardiac muscle cell apoptotic process
2. P	GO:0042025	host cell nucleus
2. P	GO:0060139	positive regulation of apoptotic process by virus
2. P	GO:0006915	apoptotic process
2. P	GO:0071456	cellular response to hypoxia
2. P	GO:0097345	mitochondrial outer membrane permeabilization
2. P	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
2. P	GO:0046902	regulation of mitochondrial membrane permeability
2. P	GO:0097136	Bcl-2 family protein complex
2. P	GO:0001836	release of cytochrome c from mitochondria
2. P	GO:0035098	ESC/E(Z) complex
2. P	GO:0140507	granzyme-mediated programmed cell death signaling pathway
2. P	GO:2000271	positive regulation of fibroblast apoptotic process
2. P	GO:1901998	toxin transport
2. P	GO:1903599	positive regulation of autophagy of mitochondrion
2. P	GO:0070245	positive regulation of thymocyte apoptotic process
2. P	GO:0045837	negative regulation of membrane potential
2. P	GO:1990144	intrinsic apoptotic signaling pathway in response to hypoxia
2. P	GO:0035616	histone H2B conserved C-terminal lysine deubiquitination
2. P	GO:1903715	regulation of aerobic respiration
2. P	GO:1902109	negative regulation of mitochondrial membrane permeability involved in apoptotic process
2. P	GO:2001056	positive regulation of cysteine-type endopeptidase activity
2. P	GO:0097194	execution phase of apoptosis
2. P	GO:0048563	post-embryonic animal organ morphogenesis
2. P	GO:0010666	positive regulation of cardiac muscle cell apoptotic process
2. P	GO:0043653	mitochondrial fragmentation involved in apoptotic process
2. P	GO:0034263	positive regulation of autophagy in response to ER overload
2. P	GO:0055093	response to hyperoxia
2. P	GO:0006351	transcription, DNA-templated
2. P	GO:0097677	STAT family protein binding

Homologs

1. PB indicates the homologs that are found by both PROST and BLAST.
2. P indicates homologs that are only found by PROST.
3. B indicates homologs that are only found by BLAST.

Source	Homolog	Description	FATCAT p-val	PROST Evalue	BLAST Evalue
1. PB	Q569G3	Uncharacterized protein C5orf47	0	2.76e-147	1.34e-127
1. PB	Q24JP4	Uncharacterized protein C5orf47 homolog	3.56e-05	2.64e-15	6.22e-42
2. P	P20976	Protein X	NA	3.99e-08	NA
2. P	Q9QAX0	Protein X	NA	2.00e-07	NA
2. P	Q9PXA2	Protein X	NA	2.20e-10	NA
2. P	P0C864	Putative uncharacterized protein DANCR	7.94e-02	2.83e-06	NA
2. P	Q99ML1	Bcl-2-binding component 3	7.92e-03	3.69e-05	NA
2. P	Q64902	Protein X	NA	5.17e-06	NA
2. P	A0A1B0GUV1	Uncharacterized protein C17orf114	1.31e-01	4.02e-02	NA
2. P	P12912	Protein X	NA	2.50e-03	NA
2. P	P0C686	Protein X	NA	1.34e-08	NA
2. P	Q05499	Protein X	NA	2.34e-06	NA
2. P	P20975	Protein X	NA	1.10e-06	NA
2. P	B1ANY3	Putative protein FAM220BP	1.72e-02	2.55e-03	NA
2. P	Q9IBI5	Protein X	NA	3.70e-02	NA
2. P	Q8JN06	Protein X	NA	4.52e-09	NA
2. P	Q80IU5	Protein X	NA	1.43e-06	NA
2. P	Q8JMY3	Protein X	NA	1.29e-08	NA
2. P	A6NHQ4	Elongin BC and Polycomb repressive complex 2-associated protein	1.69e-01	6.39e-03	NA
2. P	P0C879	Putative uncharacterized protein FLJ43185	1.18e-02	2.40e-02	NA
2. P	Q67923	Protein X	NA	4.48e-08	NA
2. P	O71302	Protein X	NA	1.06e-04	NA
2. P	P87743	Protein X	NA	2.11e-08	NA
2. P	P0C685	Protein X	NA	3.06e-07	NA
2. P	Q9PX75	Protein X	NA	5.09e-08	NA
2. P	Q71F78	Putative lung carcinoma-associated protein 10	6.06e-02	1.91e-02	NA
2. P	Q41387	Photosystem II reaction center W protein, chloroplastic	3.82e-02	2.45e-02	NA
2. P	Q9J5S3	Protein X	NA	9.83e-03	NA
2. P	Q1ZZU3	DNA repair protein SWI5 homolog	1.58e-02	1.36e-06	NA
2. P	Q99HR6	Protein X	NA	3.22e-06	NA
2. P	Q80IU8	Protein X	NA	4.54e-06	NA
2. P	Q66PJ3	ADP-ribosylation factor-like protein 6-interacting protein 4	8.53e-02	3.63e-02	NA
2. P	Q9E6S8	Protein X	NA	2.03e-05	NA
2. P	P69713	Protein X	NA	2.93e-03	NA
2. P	Q8JMZ5	Protein X	NA	3.50e-09	NA
2. P	Q67877	Protein X	NA	1.91e-06	NA
2. P	Q4R1S1	Protein X	NA	1.29e-04	NA
2. P	P03165	Protein X	NA	4.68e-05	NA
2. P	Q9YZR6	Protein X	NA	1.06e-05	NA
2. P	Q69027	Protein X	NA	8.00e-09	NA
2. P	Q81163	Protein X	NA	2.19e-09	NA
2. P	O91531	Protein X	NA	2.03e-06	NA
2. P	Q69607	Protein X	NA	6.93e-06	NA
2. P	Q80ZG6	Bcl-2-binding component 3	5.05e-03	4.47e-05	NA
2. P	Q913A9	Protein X	NA	1.54e-06	NA
2. P	Q91C38	Protein X	NA	4.81e-04	NA
2. P	O93195	Protein X	NA	6.39e-05	NA
2. P	P69714	Protein X	NA	3.59e-03	NA
2. P	Q8JMY5	Protein X	NA	2.01e-08	NA
2. P	P17102	Protein X	NA	1.94e-04	NA
2. P	Q9QMI3	Protein X	NA	6.93e-06	NA
2. P	Q69604	Protein X	NA	1.72e-07	NA
2. P	O54918	Bcl-2-like protein 11	5.97e-03	2.22e-02	NA
2. P	P20977	Protein X	NA	6.64e-09	NA
2. P	P12936	Protein X	NA	2.40e-05	NA
2. P	P24026	Protein X	NA	2.93e-06	NA
2. P	P0C689	Protein X	NA	7.49e-09	NA
2. P	P0C681	Protein X	NA	2.96e-03	NA
2. P	Q3UPL5	Uncharacterized protein C11orf96 homolog	1.90e-02	8.49e-03	NA
2. P	Q12983	BCL2/adenovirus E1B 19 kDa protein-interacting protein 3	2.46e-02	2.79e-02	NA
2. P	A8MYX2	Protein FAM25E	2.73e-02	2.73e-03	NA
2. P	P0C678	Protein X	NA	5.66e-05	NA
2. P	Q9BXH1	Bcl-2-binding component 3, isoforms 1/2	8.51e-03	3.16e-05	NA