Summary
Structures and Sequence Alignment
The best structural homolog that predicted by 3. B was
Q7SX85
(SEC14 domain and spectrin repeat-containing protein 1) with a FATCAT P-Value: 1.05e-09 and RMSD of 3.28 angstrom. The sequence alignment identity is 13.8%.
Structural alignment shown in left. Query protein Q5JYT7 colored as red in alignment, homolog Q7SX85 colored as blue.
Query protein Q5JYT7 is also shown in right top, homolog Q7SX85 showed in right bottom. They are colored based on secondary structures.
Q5JYT7 MDPPSLDTAIQHALAGLYPPFEATAPTVLGQVFRLLDSGFQGDGLSFLLDFLIPAKRLCEQVREAACAPYSHCLFLHEGWPLCLRDEVVVHLAPLNPLLL 100 Q7SX85 ---------------------------------------------------------------------------------------------------- 0 Q5JYT7 RQGDFYLQVEPQEEQSVCIMIKCLSLDLCTVDKKPVPEPAYPILFTQEWLEAINSDFEGNPLHNCLVASENGIAPVPWTKITSPEFVDDRPQVVNALCQA 200 Q7SX85 ---------------------------------------------------------------------------------------------------- 0 Q5JYT7 WGPLPLEALDLSSPQELHQASSPDNQVLPAQSLAKGKGRTYGSKYPGLIKVEQARCGEVAFRMDEVVSQDFEGDYVALLGFSQESRGESPSREAGTSSGC 300 Q7SX85 ---------------------------------------------------------------------------------------------------- 0 Q5JYT7 TSGALEEIAGTKETPLFQKILPLSEANEGPSLGNRACTKPESSEERPYNLGFRRKVNLKAPTHNSERPPQGSYMNVLEDALDCASGLRAGVSQEPAASKM 400 Q7SX85 ---------------------------------------------------------------------------------------------------- 0 Q5JYT7 QGPLGNPENMVQLRPGPRQASSPRLSPASPAAAASETKIEVKTKERNGRLPKPMPCPSRNTSSPEPPTPGLKFSFLRGQRQPSVTPEKASLQHNGPWKVL 500 Q7SX85 ---------------------------------------------------------------------------------------------------- 0 Q5JYT7 CSLYSPKPNRAKSLGKAGTTQTKTSGPATAPSPLTEEKAALPEASAGSPERGPTLEEEPPGPEPRIGALGVKVFRSRIACLPGGRD-RAGRPLLLVSTTE 599 Q7SX85 ---------------------------------------------------------------MEASCI-LPVLKKKLAFLSGGKDRRSG--LIL--T-- 30 Q5JYT7 GAWEAPWCT----VSEVTKLLSYLCTIPRPEDKAKGLAVLIDARRQPPQPGLV-SALQATQAQVPA--SIRAIL----FLGEKEAALQLQTLPD-VQVEV 687 Q7SX85 ----IPLCTEQTSMEELSTTLDYLLGIPSEKCKARGFTVIVDGRKS--QWNIVKTVVLMLQNVIPAEVSLVCVVKPDEFWDKKVTHFCFWKEKDRLGFEV 124 Q5JYT7 -LTSLKALSHHVDPSQLPAVLEGPFPYCHTEWVHFFQKL--DPFLADLHQASSLLQA--SIEEFEKADPPGGMQEATRCLSKSKELMEAVLRDP------ 776 Q7SX85 ILVSANKLTRYIEPCQLTDEFGGSLLYDHLDWVN--KRLVFEKFTKE---STSLLDELIVINENEK----GSQAEKDRS-SESN-ILPSF--DPETVLQT 211 Q5JYT7 G--LLG-L-QRE--------GGATLARLQHDASRLDFSP-DVRSHLAAATALYSLVDEQLHVLVTASNSLLGKLELRVRLGRLEAAIHQVSDWMEQEGRR 863 Q7SX85 GHELLSELQQRRFNGSEGGGGGGT-A----------WSPMD--DELLAQPQVMKLLD-SLREQYTKYQEVCRQRSKRSQLEEIQTKVMQVVNWLEGPGTD 297 Q5JYT7 CLQSLTPKDG---SL---ETVEKAHAEFEN----FFLQAAAQYRRGLELSKQAAQLGATARGAGEAERAEFPELAAFASTQRAFQAELTHF-YMAAERQR 952 Q7SX85 QLR--T-QWGIGDSIRASQALQQKHEEIESQHSEWF----AVY---VELNQQIAAL----LSAGDEE--DLMEL-------KGLQQQLSDVCY----RQA 370 Q5JYT7 TDLE---TLLHLHRFCKRMTW-FHMDCQDLMAQL-----RL--DKTSRVSPGD----QRRLHRYL-QRLAS-EFPAEKLAAVG--L--QVASLSRAGLGQ 1031 Q7SX85 SQLEFRQNVL-------QSAYEFHMTAQDLSQQLDGLLGMLCAD----VAPADGAAIQQTL-KHLEEKLKSVESALQTLREKGQALLDQMSNQTSFSYGK 458 Q5JYT7 ELWEE--ARIRHEEIRMLLEK-ALTHSSCPEAPAAHSARPERRGVAAKG-QGVSVEVTSKGRWD-QPPLDSLG--MDHLPKSYWPPGPPRGEQNRTFQAG 1124 Q7SX85 EVGVENKENIDH--IHSVMEDMQLRKQRCED------MVDVRR---LKMLQMVQL---FKCEEDASQAVEWLGELLDALLKTH-------------IRLG 531 Q5JYT7 SPPQEAGQAAEAEDGKGSH-KLPDPAR---EH---LL-ATTFFRQQ---PPRQS--QVPRL--TGGSF--SSEGTDSQTSLE--DSPQT--------SP- 1196 Q7SX85 DDSQETKVLLE----K--HKKFVDVAQSTYDYGRQLLQATVVLCQSLRCTTRSSGDTLPRLNRVWKQFTVTSD--ERQHRLEMASAFHTAAEKIVRESPE 623 Q5JYT7 LASL--------------------------------------------------------------------------------------- 1200 Q7SX85 LAELLVDVEAYEEVETLGKGLLDRLTVPVIFPDGSEQFFGSPGDMASSAESIRERMKLVEEKRFLQEEAEQRLEEEEEEEEAALEVEPRES 714
Go Annotations
1. PB indicates the go terms that are found by both PROST and BLAST.2. P indicates the go terms that are found by only PROST.
3. B indicates the go terms that are only annotated by BLAST.
| Source | GO | Description |
|---|---|---|
| 3. B | GO:0007411 | axon guidance |
| 3. B | GO:0098978 | glutamatergic synapse |
| 3. B | GO:0098885 | modification of postsynaptic actin cytoskeleton |
| 3. B | GO:0007185 | transmembrane receptor protein tyrosine phosphatase signaling pathway |
| 3. B | GO:0043005 | neuron projection |
| 3. B | GO:0070273 | phosphatidylinositol-4-phosphate binding |
| 3. B | GO:0045111 | intermediate filament cytoskeleton |
| 3. B | GO:0061003 | positive regulation of dendritic spine morphogenesis |
| 3. B | GO:0016358 | dendrite development |
| 3. B | GO:0080025 | phosphatidylinositol-3,5-bisphosphate binding |
| 3. B | GO:0048812 | neuron projection morphogenesis |
| 3. B | GO:0060137 | maternal process involved in parturition |
| 3. B | GO:0042995 | cell projection |
| 3. B | GO:0048013 | ephrin receptor signaling pathway |
| 3. B | GO:0005085 | guanyl-nucleotide exchange factor activity |
| 3. B | GO:0035176 | social behavior |
| 3. B | GO:0046959 | habituation |
| 3. B | GO:0099645 | neurotransmitter receptor localization to postsynaptic specialization membrane |
| 3. B | GO:0007399 | nervous system development |
| 3. B | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding |
| 3. B | GO:0007417 | central nervous system development |
| 3. B | GO:0035091 | phosphatidylinositol binding |
| 3. B | GO:0098793 | presynapse |
| 3. B | GO:0043025 | neuronal cell body |
| 3. B | GO:0007409 | axonogenesis |
| 3. B | GO:0070300 | phosphatidic acid binding |
| 3. B | GO:0030027 | lamellipodium |
| 3. B | GO:0098989 | NMDA selective glutamate receptor signaling pathway |
| 3. B | GO:0050773 | regulation of dendrite development |
| 3. B | GO:1904878 | negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel |
| 3. B | GO:0042711 | maternal behavior |
| 3. B | GO:0019898 | extrinsic component of membrane |
| 3. B | GO:0012505 | endomembrane system |
| 3. B | GO:0048514 | blood vessel morphogenesis |
| 3. B | GO:0005829 | cytosol |
| 3. B | GO:0051056 | regulation of small GTPase mediated signal transduction |
| 3. B | GO:0106311 | |
| 3. B | GO:0060125 | negative regulation of growth hormone secretion |
| 3. B | GO:0034704 | calcium channel complex |
| 3. B | GO:0014069 | postsynaptic density |
| 3. B | GO:0106310 | protein serine kinase activity |
| 3. B | GO:1905274 | regulation of modification of postsynaptic actin cytoskeleton |
| 3. B | GO:0045599 | negative regulation of fat cell differentiation |
| 3. B | GO:0007528 | neuromuscular junction development |
| 3. B | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane |
| 3. B | GO:0005545 | 1-phosphatidylinositol binding |
| 3. B | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding |
| 3. B | GO:0005856 | cytoskeleton |
| 3. B | GO:0008344 | adult locomotory behavior |
| 3. B | GO:0035025 | positive regulation of Rho protein signal transduction |
| 3. B | GO:0035556 | intracellular signal transduction |
| 3. B | GO:0050771 | negative regulation of axonogenesis |
| 3. B | GO:0032266 | phosphatidylinositol-3-phosphate binding |
| 3. B | GO:0007266 | Rho protein signal transduction |
| 3. B | GO:0007595 | lactation |
| 3. B | GO:0007613 | memory |
| 3. B | GO:0010314 | phosphatidylinositol-5-phosphate binding |
| 3. B | GO:0098696 | regulation of neurotransmitter receptor localization to postsynaptic specialization membrane |
| 3. B | GO:0043547 | positive regulation of GTPase activity |
| 3. B | GO:0019899 | enzyme binding |
Homologs
1. PB indicates the homologs that are found by both PROST and BLAST.
2. P indicates homologs that are only found by PROST.
3. B indicates homologs that are only found by BLAST.
| Source | Homolog | Description | FATCAT p-val | PROST Evalue | BLAST Evalue |
|---|---|---|---|---|---|
| 1. PB | Q5JYT7 | Uncharacterized protein KIAA1755 | 0 | 8.42e-138 | 0.0 |
| 1. PB | Q8BWG4 | Uncharacterized protein KIAA1755 homolog | 1.12e-11 | 2.74e-73 | 0.0 |
| 3. B | Q63406 | Guanine nucleotide exchange factor DBS | 2.93e-04 | NA | 1.92e-12 |
| 3. B | Q3UPH7 | Rho guanine nucleotide exchange factor 40 | 9.84e-07 | NA | 6.14e-48 |
| 3. B | Q58EX7 | Puratrophin-1 | 9.97e-04 | NA | 3.47e-43 |
| 3. B | A2CG49 | Kalirin | NA | NA | 5.98e-10 |
| 3. B | F1M0Z1 | Triple functional domain protein | NA | NA | 2.24e-10 |
| 3. B | O75962 | Triple functional domain protein | NA | NA | 1.79e-10 |
| 3. B | Q96PX9 | Pleckstrin homology domain-containing family G member 4B | 1.22e-02 | NA | 5.07e-45 |
| 3. B | P97924 | Kalirin | NA | NA | 8.23e-09 |
| 3. B | Q6GNM9 | SEC14 domain and spectrin repeat-containing protein 1-B | 8.45e-06 | NA | 1.11e-05 |
| 3. B | Q5M7P4 | SEC14 domain and spectrin repeat-containing protein 1 | 2.44e-05 | NA | 1.04e-05 |
| 3. B | Q86YR7 | Probable guanine nucleotide exchange factor MCF2L2 | 1.16e-04 | NA | 6.65e-07 |
| 3. B | Q7SX85 | SEC14 domain and spectrin repeat-containing protein 1 | 1.05e-09 | NA | 4.00e-06 |
| 3. B | Q86VW0 | SEC14 domain and spectrin repeat-containing protein 1 | 7.64e-06 | NA | 1.48e-05 |
| 3. B | Q1LUA6 | Triple functional domain protein | NA | NA | 9.54e-11 |
| 3. B | Q8TER5 | Rho guanine nucleotide exchange factor 40 | 1.71e-06 | NA | 2.79e-47 |
| 3. B | O60229 | Kalirin | NA | NA | 7.97e-10 |
| 3. B | O15068 | Guanine nucleotide exchange factor DBS | 6.30e-06 | NA | 3.39e-13 |
| 3. B | Q80UK0 | SEC14 domain and spectrin repeat-containing protein 1 | 5.95e-06 | NA | 1.37e-05 |
| 3. B | Q0KL02 | Triple functional domain protein | NA | NA | 2.36e-10 |
| 3. B | Q6GPX2 | SEC14 domain and spectrin repeat-containing protein 1-A | 1.09e-05 | NA | 4.49e-06 |
| 3. B | P10911 | Proto-oncogene DBL | 3.12e-04 | NA | 0.007 |
| 3. B | Q64096 | Guanine nucleotide exchange factor DBS | 2.42e-05 | NA | 5.30e-13 |