Summary

Q5T1B0

Homolog: Q3UZ57.
Function: Axonemal dynein light chain domain-containing protein 1.

Statistics

Total GO Annotation: 43
Unique PROST Go: 29
Unique BLAST Go: 11

Total Homologs: 17
Unique PROST Homologs: 6
Unique BLAST Homologs: 9

Structures and Sequence Alignment

The best structural homolog that predicted by 3. B was Q3UZ57 (Axonemal dynein light chain domain-containing protein 1) with a FATCAT P-Value: 5.29e-12 and RMSD of 2.70 angstrom. The sequence alignment identity is 29.1%.
Structural alignment shown in left. Query protein Q5T1B0 colored as red in alignment, homolog Q3UZ57 colored as blue. Query protein Q5T1B0 is also shown in right top, homolog Q3UZ57 showed in right bottom. They are colored based on secondary structures. 

  Q5T1B0 MSLPKTPSTPLNSTSTSESKKLKVSVAKEGTRGLPELKEKKNMVDRSKLLPTSLQNEFIPKEVLLSLTYAANAGPCPENLLPPKKIKTPKGTLPRLVDHV 100
  Q3UZ57 ---------------------------------------------------------------------------------------------------- 0

  Q5T1B0 WHHPVRRNKFKYLIDHPVSLTGAGRDISFLYDVTYAKGQTREKAVCPPHLARSLQSHDGVIVPHKPKTLTDTLIPEEFHIVSSTGVSGLECYDDKYTTLL 200
  Q3UZ57 ---------------------------------------------------------------------------------------------------- 0

  Q5T1B0 TDSENRLLLFPSMKPNKRVEVAQLNDVMDTMLERAGVENQEYTGPTKMHKLLHILKKEQTIYNMIFHELIRQVSVDCADRGELLSKVRERYVQMLDQIAR 300
  Q3UZ57 ------------MKPNKRVEVVQLSNVMDTMLERAGIENENYVGPTKMHQLLNVLKREQSIYNTVFHELIRQVSVDCADRGELLSKIREKYVQMLDHIAQ 88

  Q5T1B0 QMIDFYKDLVTQRVMDQRILEELYNFKHVIEELTRELCLVRAHDVKLTKETEKAHKDLAQALLNAEKNAKIVEEYHDLYTLQRERMENDMKKLVAERDIW 400
  Q3UZ57 QMIEFYKDLVTQRMMDQRILQELYNFKNVIEELTRELCLVQAHDRKLTKEAEKVQKNLAEALLEAEKNAKIVEDYHDLYTMQRGRMESDIKLLMTERDIW 188

  Q5T1B0 SSATYELALKVIERNRVILARRLYLNEKGWNKYTKHFIILLSNKDTEDLALLQKLTQKWRNLVNKLKQEVEQMEESTSETLKIVKDGLIKWQEFFNE--- 497
  Q3UZ57 SSATYELAL----------------------------------KDTGDLGMVEKLTEKWKKLVNKFKQDVERTEESTKEKSEIVKAGIIKWQEFFNNNLG 254

  Q5T1B0 KDILSPNKGNIFNSVLL-DFKQWQKILNEKKEEFTGDVLLSKYDTLKIIKHLQENWADIGLGIFNRHKSLEGEMPSERQYMEEIIKNIQKLYKEYEIRIN 596
  Q3UZ57 KDVIIPSKRSPF-AVALNDFKEYEKMLEEEKEKFTGDFLLSRYDALKVIKRLQENWTDIGFGILSRHKSMDGLLPPEHEYMEDIVKIISKLYREYEIRIN 353

  Q5T1B0 GDNGYSKILPSLISSLDFCSFKLEN-LEFPDTPLEEWQEIDEKINEMKSHLDILLNLTGIVPQHIDVDSVSVLQAYIFNMIQQWLLKIGNEINNGNIELQ 695
  Q3UZ57 GDNGISKVLPNLVISLDMCVFKLENFLDYSQVPTEEWLEIDEKINEMKFHLEALLNIIDSVPEGMDMEPGA----------------------------- 424

  Q5T1B0 HHMDELHISMIQWMVNLLILMIPNFTDQDCLLKLEEESAEKHDIGVARLELDAIELTRKLYQYSSYLSSCCKGMVTAMALSKSTNSHKNATEDLYEVDKL 795
  Q3UZ57 ---------------------------------------------------------------------------------------------------- 424

  Q5T1B0 KKECYEWINTCSCLLSNIKGRKITLLTYEEIERLLEEEAVKEFIEPEIDESFKEDEEESKEDRKLQEENKERAEEQPSTSTEKEKLIRFIGEDENVHSKP 895
  Q3UZ57 ---------------------------------------------------------------------------------------------------- 424

  Q5T1B0 LFETDVLSSWRESAKQGTLAQKYLEAMAVIEHMQEKLLEVENRARQAEEKFEDAYEKLHHTLIKNKDLEELVMTSRKESKEEKENQDEREVKEEEEQQEE 995
  Q3UZ57 ---------------------------------------------------------------------------------------------------- 424

  Q5T1B0 EEVRSAENSSKSPKKGH 1012
  Q3UZ57 ----------------- 424

Go Annotations

1. PB indicates the go terms that are found by both PROST and BLAST.
2. P indicates the go terms that are found by only PROST.
3. B indicates the go terms that are only annotated by BLAST.
Source GO Description
1. PB GO:0005929 cilium
1. PB GO:0005930 axoneme
1. PB GO:0031514 motile cilium
2. P GO:0031594 neuromuscular junction
2. P GO:0005774 vacuolar membrane
2. P GO:0016010 dystrophin-associated glycoprotein complex
2. P GO:0030659 cytoplasmic vesicle membrane
2. P GO:0060170 ciliary membrane
2. P GO:0098797 plasma membrane protein complex
2. P GO:0007474 imaginal disc-derived wing vein specification
2. P GO:0051216 cartilage development
2. P GO:0070286 axonemal dynein complex assembly
2. P GO:0008307 structural constituent of muscle
2. P GO:0046716 muscle cell cellular homeostasis
2. P GO:0030010 establishment of cell polarity
2. P GO:0001501 skeletal system development
2. P GO:0003416 endochondral bone growth
2. P GO:0042383 sarcolemma
2. P GO:0015031 protein transport
2. P GO:0048172 regulation of short-term neuronal synaptic plasticity
2. P GO:0007517 muscle organ development
2. P GO:0036064 ciliary basal body
2. P GO:0007224 smoothened signaling pathway
2. P GO:0048790 maintenance of presynaptic active zone structure
2. P GO:0007274 neuromuscular synaptic transmission
2. P GO:0045880 positive regulation of smoothened signaling pathway
2. P GO:0050699 WW domain binding
2. P GO:0046928 regulation of neurotransmitter secretion
2. P GO:0005938 cell cortex
2. P GO:0008586 imaginal disc-derived wing vein morphogenesis
2. P GO:0006914 autophagy
2. P GO:0005858 axonemal dynein complex
3. B GO:0036126 sperm flagellum
3. B GO:0003341 cilium movement
3. B GO:0030286 dynein complex
3. B GO:0120293 dynein axonemal particle
3. B GO:0036156 inner dynein arm
3. B GO:0036159 inner dynein arm assembly
3. B GO:0030175 filopodium
3. B GO:0097729 9+2 motile cilium
3. B GO:0045504 dynein heavy chain binding
3. B GO:0097546 ciliary base
3. B GO:0060294 cilium movement involved in cell motility

Homologs

1. PB indicates the homologs that are found by both PROST and BLAST.
2. P indicates homologs that are only found by PROST.
3. B indicates homologs that are only found by BLAST.

Source Homolog Description FATCAT p-val PROST Evalue BLAST Evalue
1. PB Q5T1B0 Axonemal dynein light chain domain-containing protein 1 0 6.65e-168 0.0
1. PB Q95LP5 Axonemal dynein light chain domain-containing protein 1 4.82e-11 3.20e-35 0.0
2. P Q4V7B5 Coiled-coil domain-containing protein 105 2.61e-01 6.35e-03 NA
2. P Q5IF00 Autophagy-related protein 28 4.31e-03 4.88e-04 NA
2. P P0DL09 Dynein regulatory complex protein 1 5.13e-04 1.37e-02 NA
2. P P57679 Ellis-van Creveld syndrome protein 1.25e-03 1.13e-02 NA
2. P C4R159 Autophagy-related protein 28 3.28e-03 4.88e-04 NA
2. P Q9VDW3 Dystrophin, isoform B 9.58e-02 9.23e-03 NA
3. B Q4FZV3 Axonemal dynein light intermediate polypeptide 1 4.52e-03 NA 0.019
3. B Q26630 33 kDa inner dynein arm light chain, axonemal 5.25e-03 NA 0.008
3. B Q4R3K5 Axonemal dynein light intermediate polypeptide 1 9.95e-03 NA 0.017
3. B Q9VGG6 Putative inner dynein arm light chain, axonemal 1.38e-02 NA 0.010
3. B Q8BVN8 Axonemal dynein light intermediate polypeptide 1 1.30e-02 NA 0.015
3. B Q3UZ57 Axonemal dynein light chain domain-containing protein 1 5.29e-12 NA 0.0
3. B Q39604 28 kDa inner dynein arm light chain, axonemal 1.28e-02 NA 0.012
3. B O14645 Axonemal dynein light intermediate polypeptide 1 6.63e-03 NA 0.017
3. B Q6GN86 Axonemal dynein light intermediate polypeptide 1 7.98e-03 NA 0.006