Summary

Q5T6C5

Homolog: O15265.
Function: Ataxin-7.

Statistics

Total GO Annotation: 63
Unique PROST Go: 35
Unique BLAST Go: 8

Total Homologs: 21
Unique PROST Homologs: 9
Unique BLAST Homologs: 7

Structures and Sequence Alignment

The best structural homolog that predicted by 1. PB was O15265 (Ataxin-7) with a FATCAT P-Value: 0.000461 and RMSD of 11.33 angstrom. The sequence alignment identity is 31.5%.
Structural alignment shown in left. Query protein Q5T6C5 colored as red in alignment, homolog O15265 colored as blue. Query protein Q5T6C5 is also shown in right top, homolog O15265 showed in right bottom. They are colored based on secondary structures. 

  Q5T6C5 ------------------------------------------------------------------MAVRERAAAAMAAL-ERR-VPSLDDFAGQSWSSW 32
  O15265 MSERAADDVRGEPRRAAAAAGGAAAAAARQQQQQQQQQQPPPPQPQRQQHPPPPPRRTRPEDGGPGAA--STSAAAMATVGERRPLPSPEVMLGQSWNLW 98

  Q5T6C5 VERADLPAADGAELEESSKN-TKKLDAMTLIKEDMSIFGHCPAHDDFYLVVCNHCSQVVKPQAFQKHCERRHGPLSKLYGRAPP---PPPA-----PA-S 122
  O15265 VEASKLPGKDGTELDESFKEFGKNREVMGLCREDMPIFGFCPAHDDFYLVVCNDCNQVVKPQAFQSHYERRHSSSSK-----PPLAVPPTSVFSFFPSLS 193

  Q5T6C5 SQKCHVVNG-----QGPACRA-PGSTK--TSSREKGQ--G-SR-------SR---GH--QPPEKTQKDNLCQP---GGLTKDSPGKPPMAPPS-----KE 191
  O15265 KSKGGSASGSNRSSSGGVLSASSSSSKLLKSPKEKLQLRGNTRPMHPIQQSRVPHGRIMTPSVKVEK--I-HPKMDGTLLKSAVG--PTCPATVSSLVK- 287

  Q5T6C5 PPGREN---I--EIIPSEGSSHWAEG--SPP--EKEP---SGTRLPPK-THRKMARKECDLNRQCGVINPETKKICTRLLTCKIHSVHQRREVQGRAKDF 278
  O15265 -PGL-NCPSIPKPTLPSPGQILNGKGLPAPPTLEKKPEDNSNNR---KFLNKRLSEREFDPDIHCGVIDLDTKKPCTRSLTCKTHSLTQRRAVQGRRKRF 382

  Q5T6C5 DVLVAELKANSRKGESPKEKSPGRKEQVLERP-SQELPSSVQVVAAVAAPSSTFSVRAKQTYPYCALP-RSR---AS-----SESELD-DEGPC----GG 363
  O15265 DVLLAEHK-N---------KT--REKELIRHPDSQQPPQPLR--DPHPAPPRT-SQEPHQN-PHGVIPSESKPFVASKPKPHTPS-LPRPPG-CPAQQGG 464

  Q5T6C5 DG--D-PGLF--PFPMPRGGTQASSEESEEEGTSDD-------LHPPPDCHYATRPPRPQAFCTFGSRLVSPGCYVFSRRLDRF-CSALSSMLERHLSTH 450
  O15265 SAPIDPPPVHESPHP-PLPATEPASRLSSEEGEGDDKEESVEKL----DCHYSGHHPQPASFCTFGSRQIGRGYYVFDSRWNRLRC-ALNLMVEKHLNAQ 558

  Q5T6C5 MWKKIPP---AAEP-----PAHLVNS-P--------L-SAPLSPSS---TGTC--P---RLP--GPTL--RPAC-----P-ASM-----------PPTKD 503
  O15265 LWKKIPPVPSTTSPISTRIP-HRTNSVPTSQCGVSYLAAATVSTSPVLLSSTCISPNSKSVPAHGTTLNAQPAASGAMDPVCSMQSRQVSSSSSSPSTPS 657

  Q5T6C5 NL--VPSYP-AGSP-------SV--------AAACSQA--ECMGGS---QAITSPLPANTPSPSFSKLPPSKASKSSKGKDGVEVEAPS-RKRKLS---- 575
  O15265 GLSSVPSSPMSRKPQKLKSSKSLRPKESSGNSTNCQNASSSTSGGSGKKRKNSSPLLVHSSSSS------SSSSSSS---HSME----SFRKNCVAHSGP 744

  Q5T6C5 PGPTTLKRT------CIL----------EPTGKGKPSGCRGLSAKTKTALSMGLN---GT--MGPRVKRAG--PLDCRGS-PHQLPTPVKASQLENRGAA 651
  O15265 PYPSTVTSSHSIGLNCVTNKANAVNVRHDQSGRGPPTGSPAESIK-RMSV-M-VNSSDSTLSLGPFIHQSNELPVNSHGSFSHS-HTPL--DKL-----I 833

  Q5T6C5 GHPAKALPTNCLSEEEVAKKRKNLATYCRPVK-AKHCQAGAPADVACSVRRKKPG--P-ALAFEEKCSTL--KSKAH- 722
  O15265 GKKRKCSPSS--S--SI----NN--SSSKPTKVAK-----VPA-VN-NVHMKHTGTIPGAQGLMN--SSLLHQPKARP 892

Go Annotations

1. PB indicates the go terms that are found by both PROST and BLAST.
2. P indicates the go terms that are found by only PROST.
3. B indicates the go terms that are only annotated by BLAST.
Source GO Description
1. PB GO:0071819 DUBm complex
1. PB GO:0046822 regulation of nucleocytoplasmic transport
1. PB GO:0016578 histone deubiquitination
1. PB GO:0046695 SLIK (SAGA-like) complex
1. PB GO:0006406 mRNA export from nucleus
1. PB GO:0016363 nuclear matrix
1. PB GO:1905634 regulation of protein localization to chromatin
1. PB GO:0016573 histone acetylation
1. PB GO:0007026 negative regulation of microtubule depolymerization
1. PB GO:0000124 SAGA complex
1. PB GO:1904802 RITS complex assembly
1. PB GO:0008047 enzyme activator activity
1. PB GO:0045899 positive regulation of RNA polymerase II transcription preinitiation complex assembly
1. PB GO:0015630 microtubule cytoskeleton
1. PB GO:0005634 nucleus
1. PB GO:0000226 microtubule cytoskeleton organization
1. PB GO:0042326 negative regulation of phosphorylation
1. PB GO:0006997 nucleus organization
1. PB GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway
1. PB GO:0034622
2. P GO:0010233 phloem transport
2. P GO:0051015 actin filament binding
2. P GO:2000280 regulation of root development
2. P GO:0016409 palmitoyltransferase activity
2. P GO:0010088 phloem development
2. P GO:0005884 actin filament
2. P GO:0005874 microtubule
2. P GO:0018345 protein palmitoylation
2. P GO:0015629 actin cytoskeleton
2. P GO:0010588 cotyledon vascular tissue pattern formation
2. P GO:0010923 negative regulation of phosphatase activity
2. P GO:1905171 positive regulation of protein localization to phagocytic vesicle
2. P GO:2000220 regulation of pseudohyphal growth
2. P GO:0030036 actin cytoskeleton organization
2. P GO:1903078 positive regulation of protein localization to plasma membrane
2. P GO:0046330 positive regulation of JNK cascade
2. P GO:0051865 protein autoubiquitination
2. P GO:0031397 negative regulation of protein ubiquitination
2. P GO:0019902 phosphatase binding
2. P GO:0031930 mitochondria-nucleus signaling pathway
2. P GO:0010187 negative regulation of seed germination
2. P GO:0003779 actin binding
2. P GO:0051764 actin crosslink formation
2. P GO:0004864 protein phosphatase inhibitor activity
2. P GO:0022622 root system development
2. P GO:0046329 negative regulation of JNK cascade
2. P GO:0008017 microtubule binding
2. P GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
2. P GO:0008157 protein phosphatase 1 binding
2. P GO:0008093 cytoskeletal anchor activity
2. P GO:0062208 positive regulation of pattern recognition receptor signaling pathway
2. P GO:0019706 protein-cysteine S-palmitoyltransferase activity
2. P GO:0010150 leaf senescence
2. P GO:0009867 jasmonic acid mediated signaling pathway
2. P GO:0006808 regulation of nitrogen utilization
3. B GO:0003713 transcription coactivator activity
3. B GO:0010390 histone monoubiquitination
3. B GO:0006325 chromatin organization
3. B GO:0030374 nuclear receptor coactivator activity
3. B GO:0045893 positive regulation of transcription, DNA-templated
3. B GO:0006357 regulation of transcription by RNA polymerase II
3. B GO:0005730 nucleolus
3. B GO:0031048 heterochromatin assembly by small RNA

Homologs

1. PB indicates the homologs that are found by both PROST and BLAST.
2. P indicates homologs that are only found by PROST.
3. B indicates homologs that are only found by BLAST.

Source Homolog Description FATCAT p-val PROST Evalue BLAST Evalue
1. PB Q5T6C5 Ataxin-7-like protein 2 0 6.78e-141 0.0
1. PB Q8R4I1 Ataxin-7 6.74e-03 8.70e-15 2.22e-28
1. PB Q9ULK2 Ataxin-7-like protein 1 6.30e-04 1.05e-30 8.10e-45
1. PB P53165 SAGA-associated factor 73 1.49e-01 1.28e-03 1.95e-05
1. PB O15265 Ataxin-7 4.61e-04 8.80e-14 8.28e-28
2. P Q9FU27 Zinc finger CCCH domain-containing protein 2 5.94e-01 3.94e-03 NA
2. P Q9ZWA1 Zinc finger CCCH domain-containing protein 2 2.75e-01 2.32e-02 NA
2. P P34072 Negative regulator of RAS-cAMP pathway 1.88e-01 1.16e-02 NA
2. P E1BLT8 Palmitoyltransferase ZDHHC5 6.47e-02 4.63e-02 NA
2. P Q3UWW6 GAS2-like protein 3 2.69e-01 1.61e-02 NA
2. P Q9FKW2 Zinc finger CCCH domain-containing protein 61 2.29e-01 2.84e-03 NA
2. P Q9SS80 Protein OCTOPUS 1.55e-01 4.46e-02 NA
2. P Q86XJ1 GAS2-like protein 3 3.17e-01 2.55e-02 NA
2. P Q8TEC5 E3 ubiquitin-protein ligase SH3RF2 2.59e-01 4.59e-02 NA
3. B A2AWT3 Ataxin-7-like protein 3 2.11e-01 NA 0.020
3. B Q3T136 Ataxin-7-like protein 1 2.19e-01 NA 2.84e-29
3. B P0DH68 SCA7 domain-containing protein SELMODRAFT_431321 1.09e-01 NA 8.74e-05
3. B Q9CZ05 Ataxin-7-like protein 1 2.07e-01 NA 2.73e-29
3. B O94397 SAGA-associated factor 73 1.57e-01 NA 1.32e-04
3. B Q14CW9 Ataxin-7-like protein 3 4.46e-01 NA 0.021
3. B P0DH66 SCA7 domain-containing protein SELMODRAFT_439258 6.36e-02 NA 9.72e-05