Summary

Q5VT03

Homolog: A1L443.
Function: NUT family member 2F.

Statistics

Total GO Annotation: 40
Unique PROST Go: 39
Unique BLAST Go: 1

Total Homologs: 11
Unique PROST Homologs: 2
Unique BLAST Homologs: 2

Structures and Sequence Alignment

The best structural homolog that predicted by 1. PB was A1L443 (NUT family member 2F) with a FATCAT P-Value: 1.52e-05 and RMSD of 14.81 angstrom. The sequence alignment identity is 78.6%.
Structural alignment shown in left. Query protein Q5VT03 colored as red in alignment, homolog A1L443 colored as blue. Query protein Q5VT03 is also shown in right top, homolog A1L443 showed in right bottom. They are colored based on secondary structures. 

  Q5VT03 MFQEPVYFQIFLFQLDSGASGEPGHSLGLTLGFSHCGNCQTAVVSAQPEGMASNGAYPALGPGVTANPGTSLSVFTALPFTTPAPGPAHGPLLVTAGAPP 100
  A1L443 --------------------------------------------------MASNGAYPVLGPGVTVNPGTSLSVFTALPFATPAPGPAHRPPLVTAVVPP 50

  Q5VT03 GGPLVLSNFPSTPLVTEQDGCGPSGAGASNVFVQMRTEVGPVKAAQAQTLVLTQTPLVWQAPGALCGGVVCPPPLLLAAAPVVPVMAAQVVGGTQACEGG 200
  A1L443 AGPLVLSAFPSTPLVAGQDGRGPSGAGASNVFVQMRTEVGPVKPPQAQTLILTQAPLVWQAPGTLCGGVMCPPPLLLAAAPGVPVTSAQVVGGTQACEGG 150

  Q5VT03 WSQGLPLPPPPPPAAQLPPIVSQGNAGPWPQGAHGEGSLASSQAKAPPDDSCNPRSVYENFRLWQHYKPLARRHLPQSPDTEALSCFLIPVLRSLARRKP 300
  A1L443 WSHGLPL-PPPPPAAQVAPIVSPGNARPWPQGAHGEGSLAPSQAKARPDDSCKPKSVYENFRLWQHYKPLARRHLPQSPDTEALSCFLIPVLRSLARRKP 249

  Q5VT03 TMTLEEGLWRAMREWQHTSNFDRMIFYEMAEKFLEFEAEEEMQIQKSQWMKGPQCLPPPATPRLEPRGPPAPEVVKQPVYLPSKAGPKAPTACLPPPRPQ 400
  A1L443 TMTLEEGLWQAMREWQHTSNFDRMIFYEMAEKFLEFEAEEEMQIQKSQWMKGPQSLPPPAPPRLEPRGPPAPEVVKQPVYLPSKDGPKAPTACLPPPRPQ 349

  Q5VT03 RPV-TKARRPPPRPHRRAETKARLPPPRPQRPAETKVPEEIPPEVVQEYVDIMEELLG--PSLGATGEPEKQREEGEVKQPQEEDWTPPDPGLLSYTDKL 497
  A1L443 RPAETKAHLPPPRPQRPAETNAHLPPPRPQRPAETKVPEEIPPEVVQEYVDIMEELLGSHP--GDTGEPEGQREKGKVEQPQEEDGITSDPGLLSYIDKL 447

  Q5VT03 CSQKDFVTKVEAVIHPQFLEELLSPDPQMDFLALSQELEQEEGLTLAQLVEKRLLPLKEKQHARAAPSRGTARLDSSSSKFAAGQGAERDVPDPQQGVGM 597
  A1L443 CSQEDFVTKVEAVIHPRFLEELLSPDPQMDFLALSQELEQEEGLTLAQLVEKRLLSLKEKGCGRAAPRHGTARLDSSPSEFAAGQEAAREVPDPQQRVSV 547

  Q5VT03 ETCPPQTTARDSQGRGRAHTGMARSKDSVVLLGCQDSPGLRAARPTSPPQDHRPTCPGVGTKDALDLPGGSPVRESHGLAQGSSEEEELPSLAFLLGSQH 697
  A1L443 ETSPPQTAAQDPQGQGRVRTGMARSEDPAVLLGCQDSPRLKAVRPTSPPQDHRPTCPGLGTKDALGLPGESPVKESHGLAKGSSEETELPGMVYVVGSHH 647

  Q5VT03 KLLPWWLPQSPVPASGLLSPEKWGPQGTHQSPSAERRGLNLAPSPANKAKKRPLFGSLSPAEKTPHPGPGLRVSGEQSLTWGLGGPSQSQKRKGDPLVSR 797
  A1L443 RLRPWRLSQSPVPSSGLLSPGGRGPQGALQSPSAQKRGLSPSPSPASKSKKRPLFGSPSPAEKTPHPGPGLRVSGEQSLAWGLGGPSQSQKRKGDPLASR 747

  Q5VT03 KEKKQRCSQ 806
  A1L443 RKKKRHCSQ 756

Go Annotations

1. PB indicates the go terms that are found by both PROST and BLAST.
2. P indicates the go terms that are found by only PROST.
3. B indicates the go terms that are only annotated by BLAST.
Source GO Description
2. P GO:0034613 cellular protein localization
2. P GO:0045666 positive regulation of neuron differentiation
2. P GO:0016580 Sin3 complex
2. P GO:0021895 cerebral cortex neuron differentiation
2. P GO:0002244 hematopoietic progenitor cell differentiation
2. P GO:0003682 chromatin binding
2. P GO:0031937 obsolete positive regulation of chromatin silencing
2. P GO:0000122 negative regulation of transcription by RNA polymerase II
2. P GO:0045892 negative regulation of transcription, DNA-templated
2. P GO:0002230 positive regulation of defense response to virus by host
2. P GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress
2. P GO:0051595 response to methylglyoxal
2. P GO:0010817 regulation of hormone levels
2. P GO:0010243 response to organonitrogen compound
2. P GO:0003713 transcription coactivator activity
2. P GO:0048511 rhythmic process
2. P GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding
2. P GO:2000678 negative regulation of transcription regulatory region DNA binding
2. P GO:0017053 transcription repressor complex
2. P GO:0006476 protein deacetylation
2. P GO:0001701 in utero embryonic development
2. P GO:0140416 transcription regulator inhibitor activity
2. P GO:0042754 negative regulation of circadian rhythm
2. P GO:0003714 transcription corepressor activity
2. P GO:1901675 negative regulation of histone H3-K27 acetylation
2. P GO:0016575 histone deacetylation
2. P GO:1903351 cellular response to dopamine
2. P GO:0044877 protein-containing complex binding
2. P GO:0002218 activation of innate immune response
2. P GO:1900181 negative regulation of protein localization to nucleus
2. P GO:0000118 histone deacetylase complex
2. P GO:0045944 positive regulation of transcription by RNA polymerase II
2. P GO:0007568 aging
2. P GO:0000776 kinetochore
2. P GO:0000785 chromatin
2. P GO:0030516 regulation of axon extension
2. P GO:0043066 negative regulation of apoptotic process
2. P GO:0010971 positive regulation of G2/M transition of mitotic cell cycle
2. P GO:0071333 cellular response to glucose stimulus
3. B GO:0005634 nucleus

Homologs

1. PB indicates the homologs that are found by both PROST and BLAST.
2. P indicates homologs that are only found by PROST.
3. B indicates homologs that are only found by BLAST.

Source Homolog Description FATCAT p-val PROST Evalue BLAST Evalue
1. PB Q5VZR2 NUT family member 2G 3.20e-03 2.72e-55 0.0
1. PB Q3V0C3 NUT family member 2 9.87e-04 4.88e-37 1.82e-139
1. PB Q5VT03 NUT family member 2D 0 4.46e-138 0.0
1. PB A1L443 NUT family member 2F 1.52e-05 7.52e-55 0.0
1. PB Q8IVF1 NUT family member 2A 2.56e-05 9.64e-40 0.0
1. PB A6NNL0 NUT family member 2B 5.20e-05 6.03e-42 0.0
1. PB B1AL46 NUT family member 2E 3.75e-05 1.07e-41 0.0
2. P Q60520 Paired amphipathic helix protein Sin3a 5.40e-01 2.67e-02 NA
2. P Q96ST3 Paired amphipathic helix protein Sin3a 3.84e-01 4.77e-02 NA
3. B Q86Y26 NUT family member 1 9.41e-03 NA 3.72e-124
3. B Q8BHP2 NUT family member 1 1.73e-02 NA 2.21e-108