Summary

Q5VYM1

Homolog: A6QP92.
Function: Trichohyalin-like protein 1.

Statistics

Total GO Annotation: 41
Unique PROST Go: 35
Unique BLAST Go: 6

Total Homologs: 24
Unique PROST Homologs: 19
Unique BLAST Homologs: 3

Structures and Sequence Alignment

The best structural homolog that predicted by 2. P was A6QP92 (Trichohyalin-like protein 1) with a FATCAT P-Value: 0.0494 and RMSD of 19.52 angstrom. The sequence alignment identity is 22.4%.
Structural alignment shown in left. Query protein Q5VYM1 colored as red in alignment, homolog A6QP92 colored as blue. Query protein Q5VYM1 is also shown in right top, homolog A6QP92 showed in right bottom. They are colored based on secondary structures. 

  Q5VYM1 MEWLLEDLLGAKGDMGLLWGQLTHALACRHCGS-SCFQSPGNLV-TLF--LF---VVWQIQRWWQLGRLRQLHPWCSGNMVQGKELPLLHRVAFLDHLC- 92
  A6QP92 MPQLLRDIL------CVI--ETFHKYAREDAATLTCTELK-QLIQSEFEDIFQPCAIHAVER--NL-NLLNID--SNG-AISFDEF-VLAIFSFL-NVCY 83

  Q5VYM1 -KQKSEVEEEGEE--EEEG-EDEASLDPLKPCSPTKEAPTGEQATPAPPQ-------PSCGSEGLLKAIGIPEQTV-MQPVSP-----SRSFPIFQILTS 175
  A6QP92 LDTQSLLNSEPRQVSKPEGMPHDMGLQ-V-----TNE--T-DQWTEGTSQTQDKVVLPS-GTAS-STHLSLEERAVEHNRVDPQGHTTAHKLP---VETS 169

  Q5VYM1 FPVRHKIASGNRQQQRKSQLFWGLPSLHSESLEAIFLSSGGPSPLKWSVCSSVFFNKLAFLPRSNLLLPQYHSSAQFSTH--G-AHTMEDLE-GMAPDPQ 271
  A6QP92 ---EH---SDSKNQHLK-----G--DEQSQKVDQ-DVSATGDS--RTQRETS----K----PMA--------GSEQISSHTKGEGQNKEILQKG---D-- 232

  Q5VYM1 LLPPPSSPSVS---------SL-LLH--L-----RP--FPVD-----HKGVLSGAEAP-TQSP---GTS-P----LEVLPGY-------ETHLETTGHKK 331
  A6QP92 ILARKQSGTETGGRFGEQEGSLGILHSPLEETTQRPGGSSEDQEVAGEKGV-KG--HPKSQEPSVQGKDEPSSEHVD-LPKQAAARKPSQTQ-KSAAAKD 327

  Q5VYM1 MPQAFEPPMPPPCQSPA----SLS---EPRKVS--PEGGLAI-SKDFWG-----TVGYREKPQASESSMPVPCPPLDSLP-ELQRESSLEDPSRYKPQWE 415
  A6QP92 ESRTAETP-EPPIQEKEYETRDLSVQGENRNVSETPM--VRVERKGVRGPEVHQTVG--QK-QIEEKTQP---PALEE-PTEDKKYHELQESSKEK---- 413

  Q5VYM1 CRENSGNLWAFESPVLDLNPELSGTSPECVPPASE---TPWKGMQSRENIWVPADPVSPPSL---PSVPLLESLVMGPQGVLSESKALWE--TM----GQ 503
  A6QP92 ---NAGE----DSETHELNSE-GG---EQKDSESEGAISP--GEEARH-----AEEGTAEALVNSKNAPEAE----GTPGT-RER--IWELTTLENQSGE 488

  Q5VYM1 KENLWASDSPDPVHSTPPTTLM-EPHRINPGECLATSE--ATWKDTEHSRNSSASRSPSLALSPPPALAPELLRVRSMGVLSDSEARCGDIQKTKNSWAS 600
  A6QP92 KNKMTTK-----IHD----KLVKEDDGYQ-GE---GSEPVATQND-E--------RSP----ETPNSLTAE-----------D-----GD----SNSETS 542

  Q5VYM1 KHPACNLPQDLHGASPLGVLSDSQSIVGEMEQKENCVPVFPG--RGSSPSSNSVSKSHVSEPIADQSNYKPDGEAVEQRKNHWATELPAPSSLSTPLPEP 698
  A6QP92 ---------DLF------VQGDSQS------QT-N--P-FRGSVQGSD-SNNPETQKHLA--LSE-----------EKRVQE-AAVL----AVR---GE- 594

  Q5VYM1 HIDLELVWRNVQQRE----VPQGPSPLAVDPL-HPVPQPPTLAEAVKIERT---HPGLPKGVTCP--GV-KAEAPLSQRWTVPELLTHPGIHAWQWSREL 787
  A6QP92 --DEQVTEEHAQEHEGQGSATTGRGP-AVEPRGH----SDTQVFIVRDENTKSLEPGIP-G--APNAGITK---QLSVR-QLP---TKKD------SR-- 669

  Q5VYM1 KLRLKKLRQSPASR--APGPSQSFCSSPILSSTIPDFWGLPSCPPQQIYPPNPCPHSSSCHPQEVQRTVPQPV---QS-SHCHHFQSSSQLQPQESGRAE 881
  A6QP92 K-ELKD--QSPSTKKEEDG---------ALEAQ-EDL--VKSLDENNAVSQKTCP--ATLE-EETES--PQQLAGEQSLSTKEHDPSVS-----ESGLEE 744

  Q5VYM1 QGSQRGEKMKGKMVSQVPSQGPCVHMEAGVDYLSPGPGEPSNSKVL----VS-GKRKDKASASSSAKKREHPRKPKAGDHRRGTARLGLSTVTGKNHPAQ 976
  A6QP92 R-MQRDQEL-------------CL-VERGAEHSSP-LYEALQEKMLQQTNVTQGEHQNQAQTASVAS----P------EIRRNQSS---ASLT--NDSSD 813

  Q5VYM1 A------RSLVEAPVSTF-PQRSQHRGQSSQHTALPQLLLPKASG-PQ-DQPEAGRRASDILTPRHCKHCPWAHMEKYLSFPTLKASLTRGLQKVLAKCL 1067
  A6QP92 GLVFFIDRQALQKYIREFLPDEDP-TG--AQQISAPQALEDK-QGRPQREELEPQKEAS---APKQ---------------------------------- 872

  Q5VYM1 DNHRPLPTKSSQ 1079
  A6QP92 ------------ 872

Go Annotations

1. PB indicates the go terms that are found by both PROST and BLAST.
2. P indicates the go terms that are found by only PROST.
3. B indicates the go terms that are only annotated by BLAST.
Source GO Description
2. P GO:0007018 microtubule-based movement
2. P GO:1903099 positive regulation of CENP-A containing nucleosome assembly
2. P GO:0045860 positive regulation of protein kinase activity
2. P GO:0010369 chromocenter
2. P GO:0005815 microtubule organizing center
2. P GO:0000775 chromosome, centromeric region
2. P GO:0007080 mitotic metaphase plate congression
2. P GO:0035458 cellular response to interferon-beta
2. P GO:0051315 attachment of mitotic spindle microtubules to kinetochore
2. P GO:0005654 nucleoplasm
2. P GO:0005828 kinetochore microtubule
2. P GO:0099607 lateral attachment of mitotic spindle microtubules to kinetochore
2. P GO:0007079 mitotic chromosome movement towards spindle pole
2. P GO:0030036 actin cytoskeleton organization
2. P GO:0000278 mitotic cell cycle
2. P GO:0030071 regulation of mitotic metaphase/anaphase transition
2. P GO:0005854 nascent polypeptide-associated complex
2. P GO:0043515 kinetochore binding
2. P GO:0051310 metaphase plate congression
2. P GO:0000779 condensed chromosome, centromeric region
2. P GO:0008574 plus-end-directed microtubule motor activity
2. P GO:0003777 microtubule motor activity
2. P GO:0015630 microtubule cytoskeleton
2. P GO:0006612 protein targeting to membrane
2. P GO:0030496 midbody
2. P GO:0002218 activation of innate immune response
2. P GO:0007052 mitotic spindle organization
2. P GO:0051382 kinetochore assembly
2. P GO:0099606 microtubule plus-end directed mitotic chromosome migration
2. P GO:0000776 kinetochore
2. P GO:1990023 mitotic spindle midzone
2. P GO:0051233 spindle midzone
2. P GO:0005730 nucleolus
2. P GO:0031941 filamentous actin
2. P GO:0046914 transition metal ion binding
3. B GO:0001669 acrosomal vesicle
3. B GO:0030154 cell differentiation
3. B GO:0003779 actin binding
3. B GO:0043160 acrosomal lumen
3. B GO:0002080 acrosomal membrane
3. B GO:0007283 spermatogenesis

Homologs

1. PB indicates the homologs that are found by both PROST and BLAST.
2. P indicates homologs that are only found by PROST.
3. B indicates homologs that are only found by BLAST.

Source Homolog Description FATCAT p-val PROST Evalue BLAST Evalue
1. PB Q5VYM1 Uncharacterized protein C9orf131 0 3.10e-184 0.0
1. PB Q3V0E1 Uncharacterized protein C9orf131 homolog 5.64e-03 9.18e-18 2.77e-167
2. P F4KCE9 Kinetochore-associated protein KNL-2 homolog 5.84e-01 2.23e-03 NA
2. P Q5SWP3 NAC-alpha domain-containing protein 1 1.13e-01 4.00e-06 NA
2. P A6QP92 Trichohyalin-like protein 1 4.94e-02 4.36e-03 NA
2. P Q96M43 Neuroblastoma breakpoint family member 4 1.70e-01 1.89e-02 NA
2. P A0A1B0GUW6 Uncharacterized protein SPEM3 6.24e-02 1.56e-02 NA
2. P P69281 Protein W NA 8.91e-04 NA
2. P Q8N3D4 EH domain-binding protein 1-like protein 1 1.06e-01 2.03e-02 NA
2. P Q02224 Centromere-associated protein E NA 3.62e-02 NA
2. P Q5SS00 DBF4-type zinc finger-containing protein 2 homolog 4.59e-01 2.82e-02 NA
2. P Q3V3Q4 Pyrin domain-containing protein 3 4.02e-01 4.41e-02 NA
2. P P18593 Protein VirD3 2.94e-01 7.90e-03 NA
2. P A8NIX5 Uncharacterized protein C2orf81 homolog 4.02e-01 8.63e-07 NA
2. P A5PL33 Protein KRBA1 1.60e-01 3.95e-06 NA
2. P Q5VWK0 Neuroblastoma breakpoint family member 6 2.59e-01 1.73e-02 NA
2. P P69288 Protein W NA 4.06e-02 NA
2. P P69286 Protein W NA 2.85e-02 NA
2. P P69285 Protein W NA 1.70e-04 NA
2. P P69283 Protein W NA 8.21e-04 NA
2. P P13463 Protein VirD3 3.05e-01 7.81e-03 NA
3. B B6VQA5 Spermatogenesis-associated protein 31 1.53e-01 NA 0.045
3. B Q6ZU69 Protein FAM205A 1.32e-01 NA 0.005
3. B Q63HN1 Putative protein FAM205B 8.34e-01 NA 0.007