Summary

Q6NSI8

Homolog: Q68FF0.
Function: SANT and BTB domain regulator of class switch recombination.

Statistics

Total GO Annotation: 28
Unique PROST Go: 28
Unique BLAST Go: 0

Total Homologs: 9
Unique PROST Homologs: 5
Unique BLAST Homologs: 0

Structures and Sequence Alignment

The best structural homolog that predicted by 1. PB was Q68FF0 (SANT and BTB domain regulator of class switch recombination) with a FATCAT P-Value: 2.55e-13 and RMSD of 2.96 angstrom. The sequence alignment identity is 88.6%.
Structural alignment shown in left. Query protein Q6NSI8 colored as red in alignment, homolog Q68FF0 colored as blue. Query protein Q6NSI8 is also shown in right top, homolog Q68FF0 showed in right bottom. They are colored based on secondary structures. 

  Q6NSI8 MSRGYSENNNFLNNNNQMVLDMILYPLIGIPQTINWETIARLVPGLTPKECAKRFDELKSSGSSPVDNQYNSLMAAGESPVETLATYIKSSLLDIHGEFQ 100
  Q68FF0 MSRGYPENNNFLNNNNQMVLDMILYPLIGIPQTINWETVARLVPGLTPKECVKRFDELKSCGSSPVDNQYNPLMATGEGPVETLATYIKSSLLDTQGDFQ 100

  Q6NSI8 ETPVGHDAVSKTGRHSIASTRNCSSESENCTTHNGGEMTEESEGPNMVIHVCDEAKNLKEDFTCPRDLLISEMKYFAEYLSMDAQRWEEVDISVHCDVHI 200
  Q68FF0 ETPVDQDTVSKAGRHSIATTRNCSSESENCTARNAGEETGESEGPNMVIHVCDEAKSLKEDFICPRDLLISEMKYFAEYLSMDAQRWEEVDISVHCDVHI 200

  Q6NSI8 FNWLIKYIKRNTKENKDCEMPTLEPGNVISILISSEFLKMDSLVEQCIQYCHKNMNAIVATPCNMNCINANLLTRIADLFSHNEVDDLKDKKDKFKSKLF 300
  Q68FF0 FNWLIKYVKRNTKESKDCEIPALEPGNVISILISSEFLKMDSLVEQCIQYCHKNMNAIVAAPCNMNCINANLLTRIADLFTHNEIDDLKDKKDKFRSKLF 300

  Q6NSI8 CKKIERLFDPEYLNPDSRSNAATLYRCCLCKKLLTKETERRIPCIPGKINVDRRGNIVYIHIRDKTWDVHEYLNSLFEELKSWRDVYWRLWGTINWLTCS 400
  Q68FF0 CKKIERLFDPEYSNPDSRNNAATLYRCCLCKKLLTRETERRIPCIPGKINVDRHGNIIYIHIRDKTWDVHEYLNSLFEELKSWRDVYWRLWGTVNWLTCS 400

  Q6NSI8 RCYQAFLCIEFSHCQYHSETVVYPTAASSLNTVGTGIYPCCNQKVLRFDPTQLTKGCKVRDHMVTLRDQGEGGDLPSCPTARMLDDLHKYRDVIVVPFSK 500
  Q68FF0 RCYQAFLCIEFSHCQYHSEVVVYSSTVNSLNTVGTGIYPCCNQKVLRFDPTQLTKGCKVRDHMVVLHDQGENDDSPSCPPAKILDDLHKHKDVIAVPFLK 500

  Q6NSI8 DTVSDVGVGLCDEKGIECDVLLEPNTPWGPKTGELNAFLSLKNWTLQLKQQSLFSEEEEYTTGSEVTEDEVGDEEEVSKKQRKKEKPKKFTRQPKKQVSS 600
  Q68FF0 DAVSDPGVGSCDEKGLEYEILLEPNTPWGSKTGELNAFLSLKNWTLQLKQQSLFSEEEEYTTGSEVTEDEVGDEEEIAKKQRKKEKPKKFTKPPKKQLSS 600

  Q6NSI8 PCAQRKEKALEKSASRDVSPFVMSMQKNKWDATRSLRFNQDAQREDDQRRMTEITGHLIKMRLGDLDRVKSKEAKEFAGGIYSRLEAQIKASVPVSARQS 700
  Q68FF0 PCSQKKEKTLEKSTSRDVSPFVVSMQKNKWDASRSLRFNQDAQREDDQRRMSEITGHLIKMRLGDLDRVKAKESKEFAGGIYSRLEAQVRASVPVTARQN 700

  Q6NSI8 SSEKNTRSKSRFGQGRPA 718
  Q68FF0 SSDKNQRSKSRFGQGRPA 718

Go Annotations

1. PB indicates the go terms that are found by both PROST and BLAST.
2. P indicates the go terms that are found by only PROST.
3. B indicates the go terms that are only annotated by BLAST.
Source GO Description
2. P GO:0009751 response to salicylic acid
2. P GO:0016567 protein ubiquitination
2. P GO:0007281 germ cell development
2. P GO:0007278 pole cell fate determination
2. P GO:0042542 response to hydrogen peroxide
2. P GO:0010200 response to chitin
2. P GO:0009555 pollen development
2. P GO:0031463 Cul3-RING ubiquitin ligase complex
2. P GO:0007279 pole cell formation
2. P GO:0005643 nuclear pore
2. P GO:0005814 centriole
2. P GO:0009733 response to auxin
2. P GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
2. P GO:0006355 regulation of transcription, DNA-templated
2. P GO:0009409 response to cold
2. P GO:0009553 embryo sac development
2. P GO:0061138 morphogenesis of a branching epithelium
2. P GO:0060693 regulation of branching involved in salivary gland morphogenesis
2. P GO:0034399 nuclear periphery
2. P GO:0007315 pole plasm assembly
2. P GO:0120177 negative regulation of torso signaling pathway
2. P GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
2. P GO:1990756 ubiquitin ligase-substrate adaptor activity
2. P GO:0005516 calmodulin binding
2. P GO:0005938 cell cortex
2. P GO:0016480 negative regulation of transcription by RNA polymerase III
2. P GO:0005635 nuclear envelope
2. P GO:0000209 protein polyubiquitination

Homologs

1. PB indicates the homologs that are found by both PROST and BLAST.
2. P indicates homologs that are only found by PROST.
3. B indicates homologs that are only found by BLAST.

Source Homolog Description FATCAT p-val PROST Evalue BLAST Evalue
1. PB Q08AX9 SANT and BTB domain regulator of class switch recombination 2.67e-10 5.76e-86 0.0
1. PB Q68FF0 SANT and BTB domain regulator of class switch recombination 2.55e-13 7.60e-106 0.0
1. PB Q6NSI8 SANT and BTB domain regulator of class switch recombination 0 6.52e-149 0.0
1. PB A1A5R8 SANT and BTB domain regulator of class switch recombination 5.63e-11 7.78e-90 0.0
2. P Q6EJ98 BTB/POZ and TAZ domain-containing protein 5 7.49e-02 1.69e-03 NA
2. P Q01820 Protein germ cell-less 2.15e-01 3.93e-05 NA
2. P Q9P203 BTB/POZ domain-containing protein 7 4.49e-01 2.04e-02 NA
2. P Q9FMK7 BTB/POZ and TAZ domain-containing protein 1 7.34e-02 2.33e-02 NA
2. P A0A2K3DDJ2 Proteome of basal body protein 15 1.16e-01 7.94e-03 NA