Summary

Q6TFL3

Homolog: E9Q1U1.
Function: Coiled-coil domain-containing protein 171.

Statistics

Total GO Annotation: 48
Unique PROST Go: 48
Unique BLAST Go: 0

Total Homologs: 8
Unique PROST Homologs: 6
Unique BLAST Homologs: 0

Structures and Sequence Alignment

The best structural homolog that predicted by 1. PB was E9Q1U1 (Coiled-coil domain-containing protein 171) with a FATCAT P-Value: 1.51e-09 and RMSD of 17.39 angstrom. The sequence alignment identity is 87.0%.
Structural alignment shown in left. Query protein Q6TFL3 colored as red in alignment, homolog E9Q1U1 colored as blue. Query protein Q6TFL3 is also shown in right top, homolog E9Q1U1 showed in right bottom. They are colored based on secondary structures. 

  Q6TFL3 MNLNTSSN-T-GDTQRLKIASLDVKQILKNETELD-ITDNLRKKLHWAKKEKLEITTKHNAELASYESQIAKLRSEVEKGEALRQSLEYDLAVARKEAGL 97
  E9Q1U1 MSLNTSSNATPGDTQRLKNASLDVKQMLKNETESDIIAD-LRKKLHRAKKEKLEMTTKHNAELSSYESQIARLRSEVEKGEALRQRLEYDLAVARKEAGL 99

  Q6TFL3 GRRAAEERLAEAHRIQEKLCAQNSELQAKTNETEKAFQTSQQKWKEECRRFEHDLEERDNMIQNCNREYDLLMKEKSRLEKTLQEALEKHQREKNEMESH 197
  E9Q1U1 GRRAAEERLAEAQRIQERLCAQNSELQGKANEIEKTFQISQEKWREECRRFEHDLEERDNIIQNCNQEYESLMQEKTRLQKTLQEILEKHEQEKTELESR 199

  Q6TFL3 IRETALEEFRLQEEQWEAERRELQFIVQEQDTAVQNMHKKVEKLETEHMDCSDLLRRQTSELEFSTQREERLRKEFEATTLRVRKLEENIEAERAAHLES 297
  E9Q1U1 VRETALGEFRLQTEEWEAERRELQLIVQEQDSAVQSMQKKVEQLEAEHMDCSDLLRRQTSELEFSTQREERLRKEFEATTLRVRKLEENIEAERAAHLES 299

  Q6TFL3 KFNSEIIQLRIRDLEGALQVEKASQAEAVADLEIIKNEFKEVESAYEREKHNAQESFAKLNLLEKEYFSKNKKLNEDIEEQKKVIIDLSKRLQYNEKSCS 397
  E9Q1U1 KFNSEIIQLRIRDLEGALQVEKASQAEAVADLEMIKNEFKEVESAYEREKQNTQESCAKLNLLEREYFSQNKKLNEEIEDQKKVIIDLSKRLQYNEKSCG 399

  Q6TFL3 ELQEELVMAKKHQAFLVETCENNVKELESILDSFTVSGQWTSGIHKDKDKPPSFSVVLERLRRTLTDYQNKLEDASNEEKACNELDSTKQKIDSHTKNIK 497
  E9Q1U1 ELQEELVMAKKHQAFLVETCENNVRELESILGSFSVSAQWTSGVHKDKDKPPSFSVVLETLRRTLTDYQNKLEDASNEEKTSNELDSTKQKIETHIKNTK 499

  Q6TFL3 ELQDKLADVNKELSHLHTKCADREALISTLKVELQNVLHCWEKEKAQAAQSESELQKLSQAFHKDAEEKLTFLHTLYQHLVAGCVLIKQPEGMLDKFSWS 597
  E9Q1U1 ELQDKLTEVHKELSHLRAKCADREALITSLKVELQNVLHCWEKEKACAAQCESELQKLSQAFQKDSEEKLTFLHTLYQHLVAGCVLIKQPEGMLDKFSWS 599

  Q6TFL3 ELCAVLQENVDALIADLNRANEKIRHLEYICKNKSDTMRELQQTQEDTFTKVAEQIKAQESCWHRQKKELELQYSELFLEVQKRAQKFQEIAEKNMEKLN 697
  E9Q1U1 ELCAVLQENVDALIADLNRANEKISHLEYICKNKSDTMRELQQTQEDTFNKVAEQIKAQESCWQKQKKELEFQYSELLLEVQRRAQKFQEIAEKNSEKLN 699

  Q6TFL3 HIEKSHEQLVLENSHFKKLLSQTQREQMSLLAACALMAGALYPLYSRSCALSTQRDFLQEQVNTFELFKLEIRTLAQALSTVEEKKQEEAKMKKKTFKGL 797
  E9Q1U1 RIETSHEQLVRENSHFKTTLSRTQREQTCLLAACALMAGALCPLYSRSCALSTQRDFLQEQVNSLELFKLEIRTLAQALSAVDEKKQEEAKTKKKTFKGL 799

  Q6TFL3 IRIFRKGVIAVLAANRLKILGQSCASLFTWMESFKEGIGMLVCTGEPQDKHKFPKHQKEQLRCLQALSWLTSSDLLAAIISSMAELQDVIGKADPNSRIC 897
  E9Q1U1 VRVFRKGVIAILAANRLKLLGQSCAFLFTWMESCKEGIGMLVCTGEPKDKRQFPKHQREQLRCLQALAWLTSSDLLGTVISSMTELQEVISKTDPNSRIC 899

  Q6TFL3 GHLLIGAAKNSFAKLMDKISLVMECIPLHSSRSITYVEKDSLVQRLAHGLHKVNTLALKYGLRGHVPITKSTASLQKQILGFTQRLHAAEVERRSLRLEV 997
  E9Q1U1 GHLLIGAAKNSFAKLMDKLSSAMASIPLHSSRSITYVEKDSLVQRLARGLHKVNTLALKYGLCSHIPIMKSTAALQKQIFGFTQRLHAAEVERRSLRLEV 999

  Q6TFL3 TEFKRSVNEMKKELDKAQGLQMQLNEFKQSKLITHEKFESACEELNNALLREEQAQMLLNEQAQQLQELNYKLELHSSEEADKNQTLGEAVKSLSEAKME 1097
  E9Q1U1 TEYKRTVHEMKKELDKSQSLQTQLNEFKHSKLITHEKFESACEELNNALLREQQAQMLLNEQAQQLQELNYRLELHSSEEADKNQTLGEAVKSLSEAKME 1099

  Q6TFL3 LRRKDQSLRQLNRHLTQLEQDKRRLEENIHDAESALRMAAKDKECVANHMRAVENTLHKVRDQISLSWSAASRNDFTLQLPKLHLETFAMEGLKGGPEVV 1197
  E9Q1U1 LRRKDQSLRQLNRHLTQLEQDKRRLEENIRDAESALRMAAKDKECVANHMRTIENMLHKVRDQISLSRTAATRNDFTLQLPKLHLETFAMEGLQGGPEVV 1199

  Q6TFL3 ACQAMIKSFMDVYQLASTRIMTLEKEMTSHRSHIAALKSELHTACLRENASLQSIGSRDHSNLSIPSRAPLPADTTGIGDFLPLKAELDTTYTFLKETFI 1297
  E9Q1U1 ACQAMIKSFMDVYQLASARISTLEKEMTSHRSHIATLKSELHTACLRENESLQSMGSRDHSNLSVPSRAAAPMDT--VGDLLPLQAELDTTYTFLKETFV 1297

  Q6TFL3 NTVPHALTSSHSSP-V-TMSANANRPTQIGL 1326
  E9Q1U1 NTAPHSL-SSQSSPGVPT---NAKRPSQIGL 1324

Go Annotations

1. PB indicates the go terms that are found by both PROST and BLAST.
2. P indicates the go terms that are found by only PROST.
3. B indicates the go terms that are only annotated by BLAST.
Source GO Description
2. P GO:0005869 dynactin complex
2. P GO:0030286 dynein complex
2. P GO:0051010 microtubule plus-end binding
2. P GO:0031116 positive regulation of microtubule polymerization
2. P GO:0005876 spindle microtubule
2. P GO:0005874 microtubule
2. P GO:0005814 centriole
2. P GO:0007098 centrosome cycle
2. P GO:0031023 microtubule organizing center organization
2. P GO:0005819 spindle
2. P GO:0045665 negative regulation of neuron differentiation
2. P GO:0034452 dynactin binding
2. P GO:0000931 gamma-tubulin large complex
2. P GO:0000922 spindle pole
2. P GO:0090316 positive regulation of intracellular protein transport
2. P GO:0000132 establishment of mitotic spindle orientation
2. P GO:0048814 regulation of dendrite morphogenesis
2. P GO:0031122 cytoplasmic microtubule organization
2. P GO:0034451 centriolar satellite
2. P GO:0045931 positive regulation of mitotic cell cycle
2. P GO:0070840 dynein complex binding
2. P GO:0033365 protein localization to organelle
2. P GO:0005875 microtubule associated complex
2. P GO:0000086 G2/M transition of mitotic cell cycle
2. P GO:0005813 centrosome
2. P GO:0043015 gamma-tubulin binding
2. P GO:0035371 microtubule plus-end
2. P GO:0001578 microtubule bundle formation
2. P GO:0070507 regulation of microtubule cytoskeleton organization
2. P GO:0000242 pericentriolar material
2. P GO:0007099 centriole replication
2. P GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity
2. P GO:0051286 cell tip
2. P GO:0022008 neurogenesis
2. P GO:0008017 microtubule binding
2. P GO:0007020 microtubule nucleation
2. P GO:0060236 regulation of mitotic spindle organization
2. P GO:0015631 tubulin binding
2. P GO:0072393 microtubule anchoring at microtubule organizing center
2. P GO:0099738 cell cortex region
2. P GO:0046600 negative regulation of centriole replication
2. P GO:0000776 kinetochore
2. P GO:0008093 cytoskeletal anchor activity
2. P GO:0000743 nuclear migration involved in conjugation with cellular fusion
2. P GO:0097431 mitotic spindle pole
2. P GO:0005938 cell cortex
2. P GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint
2. P GO:0007097 nuclear migration

Homologs

1. PB indicates the homologs that are found by both PROST and BLAST.
2. P indicates homologs that are only found by PROST.
3. B indicates homologs that are only found by BLAST.

Source Homolog Description FATCAT p-val PROST Evalue BLAST Evalue
1. PB Q6TFL3 Coiled-coil domain-containing protein 171 0 1.13e-149 0.0
1. PB E9Q1U1 Coiled-coil domain-containing protein 171 1.51e-09 5.38e-82 0.0
2. P Q6PHN1 Coiled-coil domain-containing protein 57 6.10e-04 1.84e-04 NA
2. P P33420 Protein NIP100 2.56e-04 5.80e-04 NA
2. P Q6PCJ1 Dynactin subunit 1 2.06e-05 6.68e-03 NA
2. P V6CJ04 Protein bicaudal D homolog 8.96e-06 1.94e-04 NA
2. P Q8K389 CDK5 regulatory subunit-associated protein 2 3.08e-01 1.07e-03 NA
2. P P35458 Dynactin subunit 1 NA 7.58e-03 NA