Summary

Q6ZRC1

Homolog: Q8BGY3.
Function: Leucine zipper protein 2.

Statistics

Total GO Annotation: 157
Unique PROST Go: 157
Unique BLAST Go: 0

Total Homologs: 91
Unique PROST Homologs: 90
Unique BLAST Homologs: 0

Structures and Sequence Alignment

The best structural homolog that predicted by 2. P was Q8BGY3 (Leucine zipper protein 2) with a FATCAT P-Value: 7.66e-06 and RMSD of 2.46 angstrom. The sequence alignment identity is 21.6%.
Structural alignment shown in left. Query protein Q6ZRC1 colored as red in alignment, homolog Q8BGY3 colored as blue. Query protein Q6ZRC1 is also shown in right top, homolog Q8BGY3 showed in right bottom. They are colored based on secondary structures. 

  Q6ZRC1 ----------------------------------------MLRDSEAEVT----EEDP-RLRAQQL---HHRVLT-LQCQLRDQGAAHQASLDEATRLQE 51
  Q8BGY3 MKFNAAHYLLPLLPALVLSTRQDYEELEKQLKEVFKERSTVLR----QLTKTSRELDGIKVNLQSLKNDEQSSKTDVQ-KLLELG---QRQREEMKSLQE 92

  Q6ZRC1 ELQAKLEELQKK--QHEAKLAV--TPL--KAK-IASLVRKCRE-RNRLIT-------HL---------LQELHRHGLGNLLLSELAQNMLNDVA--LAEY 125
  Q8BGY3 ALQNQLKETSEKAEKHQATINFLKTEVERKSKMIRDLQNENKSLKNKLLSGSKLCGIHAEESKKIQAQLKEL-RYGKKDLLFK--AQQ-LTELEQKLA-- 186

  Q6ZRC1 TATFLAPGVPETSHHLDVKSEM-----TAAL------RAQ---TYLL--NP-EMDSVLQ--SSLSSESWPIPE------PEWPA-----QTAQLDSLK-- 193
  Q8BGY3 ----VAKNELEKA-ALDRESQMKAMKETVQLCLSSVFRDQPPPLSLMPSNPTQM---LHPPRTVASR---IPEARTKSKPQ-PSSPGHHDSSQVQATKEE 274

  Q6ZRC1 --LPLSLVSTLDPG-TCL--------AAVTVEPGLPAQRLQEKGGMP-C-----------PALQVDNVPAPSE-LLSPARILAFHQELRQSICSNSQVHK 269
  Q8BGY3 SRRP-SVCGPQDEGSSCLVKHEEGPQSNSTAESELTTQKLQ----MPICSECEEKKGPENPSASFDGTPAREEKLL------------------------ 345

  Q6ZRC1 SPLELEM 276
  Q8BGY3 ------- 345

Go Annotations

1. PB indicates the go terms that are found by both PROST and BLAST.
2. P indicates the go terms that are found by only PROST.
3. B indicates the go terms that are only annotated by BLAST.
Source GO Description
2. P GO:0050772 positive regulation of axonogenesis
2. P GO:0008090 retrograde axonal transport
2. P GO:0051081 nuclear membrane disassembly
2. P GO:0030374 nuclear receptor coactivator activity
2. P GO:0032922 circadian regulation of gene expression
2. P GO:0043296 apical junction complex
2. P GO:0005874 microtubule
2. P GO:0048469 cell maturation
2. P GO:0048311 mitochondrion distribution
2. P GO:0051898 negative regulation of protein kinase B signaling
2. P GO:0005080 protein kinase C binding
2. P GO:0008286 insulin receptor signaling pathway
2. P GO:0047496 vesicle transport along microtubule
2. P GO:0043011 myeloid dendritic cell differentiation
2. P GO:0006338 chromatin remodeling
2. P GO:1903251 multi-ciliated epithelial cell differentiation
2. P GO:0045121 membrane raft
2. P GO:0007399 nervous system development
2. P GO:0008156 negative regulation of DNA replication
2. P GO:0000132 establishment of mitotic spindle orientation
2. P GO:0001819 positive regulation of cytokine production
2. P GO:0045109 intermediate filament organization
2. P GO:0031032 actomyosin structure organization
2. P GO:0019894 kinesin binding
2. P GO:0044877 protein-containing complex binding
2. P GO:0007030 Golgi organization
2. P GO:0007517 muscle organ development
2. P GO:0008017 microtubule binding
2. P GO:0005929 cilium
2. P GO:0007020 microtubule nucleation
2. P GO:0098972 anterograde dendritic transport of mitochondrion
2. P GO:0008021 synaptic vesicle
2. P GO:0007405 neuroblast proliferation
2. P GO:1900029 positive regulation of ruffle assembly
2. P GO:0098535 de novo centriole assembly involved in multi-ciliated epithelial cell differentiation
2. P GO:0048487 beta-tubulin binding
2. P GO:0042110 T cell activation
2. P GO:0070012 oligopeptidase activity
2. P GO:0007059 chromosome segregation
2. P GO:0090630 activation of GTPase activity
2. P GO:0006363 termination of RNA polymerase I transcription
2. P GO:0005815 microtubule organizing center
2. P GO:0005212 structural constituent of eye lens
2. P GO:0060053 neurofilament cytoskeleton
2. P GO:0032839 dendrite cytoplasm
2. P GO:0051642 centrosome localization
2. P GO:0031616 spindle pole centrosome
2. P GO:0045786 negative regulation of cell cycle
2. P GO:0001833 inner cell mass cell proliferation
2. P GO:0033157 regulation of intracellular protein transport
2. P GO:0031023 microtubule organizing center organization
2. P GO:0033551 monopolin complex
2. P GO:0055003 cardiac myofibril assembly
2. P GO:0043231 intracellular membrane-bounded organelle
2. P GO:0044565 dendritic cell proliferation
2. P GO:0048309 endoplasmic reticulum inheritance
2. P GO:0050811 GABA receptor binding
2. P GO:0098957 anterograde axonal transport of mitochondrion
2. P GO:0031252 cell leading edge
2. P GO:0042383 sarcolemma
2. P GO:0070847 core mediator complex
2. P GO:0048813 dendrite morphogenesis
2. P GO:0010975 regulation of neuron projection development
2. P GO:0051298 centrosome duplication
2. P GO:0042832 defense response to protozoan
2. P GO:0008333 endosome to lysosome transport
2. P GO:0016592 mediator complex
2. P GO:0044297 cell body
2. P GO:0005912 adherens junction
2. P GO:0032580 Golgi cisterna membrane
2. P GO:0050771 negative regulation of axonogenesis
2. P GO:0032154 cleavage furrow
2. P GO:0006493 protein O-linked glycosylation
2. P GO:0043547 positive regulation of GTPase activity
2. P GO:0034763 negative regulation of transmembrane transport
2. P GO:0006605 protein targeting
2. P GO:0016477 cell migration
2. P GO:0007100 mitotic centrosome separation
2. P GO:1990138 neuron projection extension
2. P GO:0097320 plasma membrane tubulation
2. P GO:0001786 phosphatidylserine binding
2. P GO:0021955 central nervous system neuron axonogenesis
2. P GO:0019896 axonal transport of mitochondrion
2. P GO:0005819 spindle
2. P GO:0035023 regulation of Rho protein signal transduction
2. P GO:0034503 protein localization to nucleolar rDNA repeats
2. P GO:0044295 axonal growth cone
2. P GO:0021799 cerebral cortex radially oriented cell migration
2. P GO:0030331 estrogen receptor binding
2. P GO:0005102 signaling receptor binding
2. P GO:0007249 I-kappaB kinase/NF-kappaB signaling
2. P GO:0042641 actomyosin
2. P GO:0048680 positive regulation of axon regeneration
2. P GO:0051721 protein phosphatase 2A binding
2. P GO:0006270 DNA replication initiation
2. P GO:0071392 cellular response to estradiol stimulus
2. P GO:0071931 positive regulation of transcription involved in G1/S transition of mitotic cell cycle
2. P GO:0030027 lamellipodium
2. P GO:0070374 positive regulation of ERK1 and ERK2 cascade
2. P GO:0030425 dendrite
2. P GO:1901003 negative regulation of fermentation
2. P GO:0001835 blastocyst hatching
2. P GO:0036064 ciliary basal body
2. P GO:0022008 neurogenesis
2. P GO:0045494 photoreceptor cell maintenance
2. P GO:0005930 axoneme
2. P GO:0043203 axon hillock
2. P GO:0060303 regulation of nucleosome density
2. P GO:0031410 cytoplasmic vesicle
2. P GO:0005901 caveola
2. P GO:0042134 rRNA primary transcript binding
2. P GO:0043014 alpha-tubulin binding
2. P GO:0051303 establishment of chromosome localization
2. P GO:0001764 neuron migration
2. P GO:0090724 central region of growth cone
2. P GO:0000775 chromosome, centromeric region
2. P GO:0006357 regulation of transcription by RNA polymerase II
2. P GO:0097028 dendritic cell differentiation
2. P GO:0098536 deuterosome
2. P GO:0005814 centriole
2. P GO:0005769 early endosome
2. P GO:0051455 monopolar spindle attachment to meiosis I kinetochore
2. P GO:2000574 obsolete regulation of microtubule motor activity
2. P GO:0070550 rDNA condensation
2. P GO:0005871 kinesin complex
2. P GO:0000278 mitotic cell cycle
2. P GO:1904115 axon cytoplasm
2. P GO:0032391 photoreceptor connecting cilium
2. P GO:0021987 cerebral cortex development
2. P GO:0005875 microtubule associated complex
2. P GO:0030866 cortical actin cytoskeleton organization
2. P GO:0032418 lysosome localization
2. P GO:0098939 dendritic transport of mitochondrion
2. P GO:0005813 centrosome
2. P GO:0032991 protein-containing complex
2. P GO:0045143 homologous chromosome segregation
2. P GO:0042073 intraciliary transport
2. P GO:0005923 bicellular tight junction
2. P GO:0003712 transcription coregulator activity
2. P GO:0031011 Ino80 complex
2. P GO:0017022 myosin binding
2. P GO:0000137 Golgi cis cisterna
2. P GO:0030911 TPR domain binding
2. P GO:0005882 intermediate filament
2. P GO:0005801 cis-Golgi network
2. P GO:0006361 transcription initiation from RNA polymerase I promoter
2. P GO:0000776 kinetochore
2. P GO:0030900 forebrain development
2. P GO:0032410 negative regulation of transporter activity
2. P GO:0060052 neurofilament cytoskeleton organization
2. P GO:0070307 lens fiber cell development
2. P GO:1903097 regulation of CENP-A containing nucleosome assembly
2. P GO:0042802 identical protein binding
2. P GO:0005938 cell cortex
2. P GO:0045773 positive regulation of axon extension
2. P GO:0005635 nuclear envelope
2. P GO:0005654 nucleoplasm

Homologs

1. PB indicates the homologs that are found by both PROST and BLAST.
2. P indicates homologs that are only found by PROST.
3. B indicates homologs that are only found by BLAST.

Source Homolog Description FATCAT p-val PROST Evalue BLAST Evalue
1. PB Q6ZRC1 Uncharacterized protein C4orf50 0 1.11e-129 0.0
2. P Q8BGY3 Leucine zipper protein 2 7.66e-06 3.90e-03 NA
2. P Q66IZ7 Nuclear distribution protein nudE-like 1-B 1.01e-05 8.74e-05 NA
2. P D3YN49 Geminin coiled-coil domain-containing protein 1 5.35e-03 2.67e-03 NA
2. P A4FV37 Caveolae-associated protein 3 3.79e-05 9.05e-06 NA
2. P Q9P2B4 CTTNBP2 N-terminal-like protein 1.57e-03 4.58e-03 NA
2. P F7DP49 Deuterosome assembly protein 1 2.50e-04 1.10e-03 NA
2. P Q53HC0 Coiled-coil domain-containing protein 92 5.26e-05 4.37e-03 NA
2. P Q5ZMC9 Nuclear distribution protein nudE homolog 1 2.07e-05 4.47e-02 NA
2. P A2AMM0 Caveolae-associated protein 4 6.32e-03 8.06e-03 NA
2. P B1PRL5 Caveolae-associated protein 4 2.65e-04 8.14e-04 NA
2. P Q66H98 Caveolae-associated protein 2 1.02e-04 2.29e-03 NA
2. P Q86T90 Protein hinderin 6.39e-03 2.50e-02 NA
2. P Q6NZI2 Caveolae-associated protein 1 1.39e-04 3.65e-02 NA
2. P Q28CJ6 Nuclear distribution protein nudE-like 1 1.39e-05 7.24e-04 NA
2. P Q177A7 Mediator of RNA polymerase II transcription subunit 4 1.11e-03 4.15e-04 NA
2. P Q86TE4 Leucine zipper protein 2 9.22e-05 1.29e-02 NA
2. P Q9GZM8 Nuclear distribution protein nudE-like 1 2.11e-05 6.34e-03 NA
2. P Q8CCX5 Keratin-like protein KRT222 1.11e-05 2.78e-02 NA
2. P Q91VJ2 Caveolae-associated protein 3 1.24e-04 7.22e-03 NA
2. P Q7QH62 Mediator of RNA polymerase II transcription subunit 4 1.23e-03 1.72e-04 NA
2. P Q0D2H9 Putative golgin subfamily A member 8D 8.22e-04 2.33e-07 NA
2. P Q5NB83 Probable protein ABIL3 2.80e-04 6.96e-03 NA
2. P O46480 Nuclear distribution protein nudE-like 1 2.13e-05 7.75e-04 NA
2. P Q9DCD5 Tight junction-associated protein 1 1.55e-03 6.31e-09 NA
2. P Q6ZUS6 Coiled-coil domain-containing protein 149 1.91e-03 8.55e-04 NA
2. P Q8N1L9 Basic leucine zipper transcriptional factor ATF-like 2 2.09e-03 1.54e-02 NA
2. P Q9ES39 Nuclear distribution protein nudE homolog 1 8.16e-05 2.05e-02 NA
2. P Q02435 Filensin (Fragment) 3.95e-03 2.45e-03 NA
2. P Q12934 Filensin 6.43e-02 2.60e-03 NA
2. P E9Q6B2 Coiled-coil domain-containing protein 85C 5.38e-04 2.29e-03 NA
2. P Q08AF8 Putative golgin subfamily A member 8F/8G 3.16e-04 3.14e-06 NA
2. P O94704 INO80 complex subunit 3 6.15e-04 3.40e-05 NA
2. P Q8TDR4 T-complex protein 10A homolog 1 2.01e-03 2.21e-02 NA
2. P Q86XG9 Putative neuroblastoma breakpoint family member 5 1.09e-04 8.05e-05 NA
2. P Q6DH86 Coiled-coil domain-containing protein 149-B 1.72e-03 7.45e-04 NA
2. P Q4R4S6 Nuclear distribution protein nudE-like 1 1.55e-04 1.41e-03 NA
2. P Q0P485 Coiled-coil domain-containing protein 85C-A 1.81e-03 3.82e-02 NA
2. P Q18412 Shugoshin 2.15e-04 2.16e-04 NA
2. P Q60ZS1 Shugoshin 2.35e-03 4.03e-04 NA
2. P Q5RDH2 CTTNBP2 N-terminal-like protein 7.98e-04 9.60e-03 NA
2. P Q5JKN2 Putative protein ABIL2 3.69e-04 1.69e-04 NA
2. P Q23523 Mediator of RNA polymerase II transcription subunit 4 4.17e-03 1.66e-02 NA
2. P Q6DK98 Nuclear distribution protein nudE-like 1-A 1.14e-04 2.39e-04 NA
2. P E9PVD1 Coiled-coil domain-containing protein 62 3.02e-03 9.34e-04 NA
2. P Q8R2H7 Trafficking kinesin-binding protein 2 1.54e-02 8.21e-03 NA
2. P Q86VQ0 Lebercilin 7.26e-04 9.60e-03 NA
2. P Q5R8Y4 Leucine zipper protein 2 2.45e-05 5.12e-03 NA
2. P Q9D6I9 Leucine rich adaptor protein 1 3.05e-02 6.69e-04 NA
2. P Q3URY2 Geminin coiled-coil domain-containing protein 1 7.60e-03 4.79e-06 NA
2. P Q8NBZ0 INO80 complex subunit E 9.00e-03 6.69e-04 NA
2. P Q5JTD0 Tight junction-associated protein 1 1.61e-03 3.39e-07 NA
2. P Q99LJ0 CTTNBP2 N-terminal-like protein 6.90e-04 5.36e-03 NA
2. P O74689 Nuclear distribution protein nudE 1.29e-03 2.55e-03 NA
2. P A3LXM3 SWI5-dependent HO expression protein 3 6.42e-04 2.61e-02 NA
2. P Q9QYP6 5-azacytidine-induced protein 2 4.10e-04 4.38e-06 NA
2. P Q3SYW5 5-azacytidine-induced protein 2 1.30e-03 1.78e-04 NA
2. P Q6AYH2 INO80 complex subunit E 4.56e-03 6.30e-04 NA
2. P Q969G5 Caveolae-associated protein 3 2.15e-05 4.63e-06 NA
2. P A1L260 Caveolae-associated protein 4a 1.29e-04 1.08e-02 NA
2. P Q4KMA0 5-azacytidine-induced protein 2 6.17e-04 5.07e-04 NA
2. P Q8N1A0 Keratin-like protein KRT222 2.57e-04 2.27e-03 NA
2. P Q6R6L0 Brain-enriched guanylate kinase-associated protein 3.12e-02 1.26e-06 NA
2. P Q5R8T7 Nuclear distribution protein nudE-like 1 2.48e-05 1.98e-02 NA
2. P Q6P9F0 Coiled-coil domain-containing protein 62 3.18e-03 6.89e-10 NA
2. P D4A8G3 Leucine rich adaptor protein 1 1.41e-02 1.12e-03 NA
2. P Q29RS4 INO80 complex subunit E 6.36e-03 6.52e-06 NA
2. P Q9ERR1 Nuclear distribution protein nudE-like 1 2.38e-05 1.25e-03 NA
2. P Q5U2Y9 Lebercilin 1.71e-03 3.26e-03 NA
2. P O02761 Proto-oncogene c-Fos (Fragment) 4.58e-03 2.04e-02 NA
2. P Q8VDN4 Coiled-coil domain-containing protein 92 1.65e-05 1.57e-05 NA
2. P Q2KI75 Keratin-like protein KRT222 3.82e-05 3.01e-04 NA
2. P Q68US1 T-complex protein 10A homolog 1 2.27e-03 2.97e-03 NA
2. P Q4V872 Coiled-coil domain-containing protein 85C 1.65e-04 2.39e-02 NA
2. P Q6NRH3 Coiled-coil domain-containing protein 149 6.54e-03 7.60e-06 NA
2. P Q04087 Monopolin complex subunit LRS4 4.32e-02 3.31e-07 NA
2. P Q6PD31 Trafficking kinesin-binding protein 1 1.06e-02 6.34e-03 NA
2. P Q8R1H8 Basic leucine zipper transcriptional factor ATF-like 2 1.51e-03 5.17e-06 NA
2. P Q6DHL7 Coiled-coil domain-containing protein 85C-B 3.12e-03 8.56e-05 NA
2. P O60296 Trafficking kinesin-binding protein 2 8.70e-03 1.13e-02 NA
2. P Q9UPV9 Trafficking kinesin-binding protein 1 1.81e-02 2.05e-02 NA
2. P Q9CZA6 Nuclear distribution protein nudE homolog 1 2.29e-05 7.99e-03 NA
2. P Q80ST9 Lebercilin 1.87e-03 4.84e-06 NA
2. P Q9Z1H9 Caveolae-associated protein 3 6.58e-05 1.93e-03 NA
2. P Q63918 Caveolae-associated protein 2 4.05e-04 5.36e-03 NA
2. P Q4X1V0 Nuclear distribution protein nudE homolog 1 1.72e-03 7.63e-03 NA
2. P Q4R3X1 5-azacytidine-induced protein 2 2.05e-04 4.17e-02 NA
2. P Q78PB6 Nuclear distribution protein nudE-like 1 2.31e-05 1.25e-03 NA
2. P Q5ZKH4 Nuclear distribution protein nudE-like 1 1.27e-05 2.83e-02 NA
2. P A6NCL1 Geminin coiled-coil domain-containing protein 1 3.61e-03 2.35e-06 NA
2. P Q803Q2 Nuclear distribution protein nudE-like 1-B 8.38e-06 1.84e-02 NA