Summary

Q6ZRN7

Homolog: Q8QZZ9.
Function: Tumor suppressor ARF.

Statistics

Total GO Annotation: 77
Unique PROST Go: 77
Unique BLAST Go: 0

Total Homologs: 21
Unique PROST Homologs: 20
Unique BLAST Homologs: 0

Structures and Sequence Alignment

The best structural homolog that predicted by 2. P was Q8QZZ9 (Tumor suppressor ARF) with a FATCAT P-Value: 0.0425 and RMSD of 5.29 angstrom. The sequence alignment identity is 27.0%.
Structural alignment shown in left. Query protein Q6ZRN7 colored as red in alignment, homolog Q8QZZ9 colored as blue. Query protein Q6ZRN7 is also shown in right top, homolog Q8QZZ9 showed in right bottom. They are colored based on secondary structures. 

  Q6ZRN7 ----------MSPTKDSHPSPH-F---------PRD-SGIHAPTPPDSG--ALTLSPP--VSQGPG--VGPRTG--RGNRLCRPPGRSAARSFCL--LPG 69
  Q8QZZ9 MGRRFVVTVRIRRTGRS-PQVRVFLVQFLGSSRPRSANG----T---RGFVALVLRPERIARRGPQPHPGP--GDDDGQ---RQSGSSPALLWCRFELRG 87

  Q6ZRN7 P--PLGTGALGSPRAAQGLGFRGSGQRARHNSFTSPSPPGAHHPLGTHTRALPPPLARCPCAALLAGRECHGGPSPAAPRPLP--GTSLTWPSRA----- 160
  Q8QZZ9 PHHPLPTGA---RRSAGGL--------PRHSGSTAPG-RGA---AG--------------CA-----R-CLG--SPAA-RPGPRAGTS---RRRAVFAVS 146

  Q6ZRN7 PLPRPPPRERQGPGDRSPSPSAPSCPGVGASSPRRRKPREAAGLTPDG 208
  Q8QZZ9 TLLR---WERF-PGHRQA------------------------------ 160

Go Annotations

1. PB indicates the go terms that are found by both PROST and BLAST.
2. P indicates the go terms that are found by only PROST.
3. B indicates the go terms that are only annotated by BLAST.
Source GO Description
2. P GO:0048149 behavioral response to ethanol
2. P GO:0033088 negative regulation of immature T cell proliferation in thymus
2. P GO:0000082 G1/S transition of mitotic cell cycle
2. P GO:0090398 cellular senescence
2. P GO:0090399 replicative senescence
2. P GO:0060058 positive regulation of apoptotic process involved in mammary gland involution
2. P GO:0035986 obsolete senescence-associated heterochromatin focus assembly
2. P GO:0021549 cerebellum development
2. P GO:0007615 anesthesia-resistant memory
2. P GO:0070542 response to fatty acid
2. P GO:0097371 MDM2/MDM4 family protein binding
2. P GO:0006836 neurotransmitter transport
2. P GO:0039540 suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity
2. P GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
2. P GO:0070301 cellular response to hydrogen peroxide
2. P GO:0005184 neuropeptide hormone activity
2. P GO:0039545 suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity
2. P GO:0007265 Ras protein signal transduction
2. P GO:0055105 ubiquitin-protein transferase inhibitor activity
2. P GO:0035985 senescence-associated heterochromatin focus
2. P GO:1903051 negative regulation of proteolysis involved in cellular protein catabolic process
2. P GO:0051059 NF-kappaB binding
2. P GO:0032091 negative regulation of protein binding
2. P GO:0007611 learning or memory
2. P GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process
2. P GO:0051090 regulation of DNA-binding transcription factor activity
2. P GO:0048266 behavioral response to pain
2. P GO:0035375 zymogen binding
2. P GO:0040040 thermosensory behavior
2. P GO:0007190 activation of adenylate cyclase activity
2. P GO:0022008 neurogenesis
2. P GO:0031647 regulation of protein stability
2. P GO:0001953 negative regulation of cell-matrix adhesion
2. P GO:0008544 epidermis development
2. P GO:0097655 serpin family protein binding
2. P GO:0044220 host cell perinuclear region of cytoplasm
2. P GO:0051494 negative regulation of cytoskeleton organization
2. P GO:0032088 negative regulation of NF-kappaB transcription factor activity
2. P GO:0035019 somatic stem cell population maintenance
2. P GO:0007613 memory
2. P GO:0071333 cellular response to glucose stimulus
2. P GO:0061771 response to caloric restriction
2. P GO:2000346 negative regulation of hepatocyte proliferation
2. P GO:0070534 protein K63-linked ubiquitination
2. P GO:0010033 response to organic substance
2. P GO:0046822 regulation of nucleocytoplasmic transport
2. P GO:0045786 negative regulation of cell cycle
2. P GO:0044192 host cell mitochondrial inner membrane
2. P GO:0010243 response to organonitrogen compound
2. P GO:2000111 positive regulation of macrophage apoptotic process
2. P GO:0033600 negative regulation of mammary gland epithelial cell proliferation
2. P GO:0034393 positive regulation of smooth muscle cell apoptotic process
2. P GO:0044164 host cell cytosol
2. P GO:0019933 cAMP-mediated signaling
2. P GO:0042025 host cell nucleus
2. P GO:0005198 structural molecule activity
2. P GO:0007619 courtship behavior
2. P GO:0039526 modulation by virus of host apoptotic process
2. P GO:0047485 protein N-terminus binding
2. P GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity
2. P GO:0007616 long-term memory
2. P GO:0030889 negative regulation of B cell proliferation
2. P GO:0008049 male courtship behavior
2. P GO:0007569 cell aging
2. P GO:0042066 perineurial glial growth
2. P GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity
2. P GO:0019028 viral capsid
2. P GO:0001848 complement binding
2. P GO:0042326 negative regulation of phosphorylation
2. P GO:0008355 olfactory learning
2. P GO:0014070 response to organic cyclic compound
2. P GO:0001652 granular component
2. P GO:0048103 somatic stem cell division
2. P GO:0009303 rRNA transcription
2. P GO:0051444 negative regulation of ubiquitin-protein transferase activity
2. P GO:2000774 positive regulation of cellular senescence
2. P GO:0072375 medium-term memory

Homologs

1. PB indicates the homologs that are found by both PROST and BLAST.
2. P indicates homologs that are only found by PROST.
3. B indicates homologs that are only found by BLAST.

Source Homolog Description FATCAT p-val PROST Evalue BLAST Evalue
1. PB Q6ZRN7 Putative uncharacterized protein FLJ46214 0 1.34e-143 2.53e-136
2. P Q24049 Amnesiac neuropeptides 3.11e-01 1.47e-02 NA
2. P P0C5U7 Protein PB1-F2 NA 3.02e-02 NA
2. P A8MTZ7 Uncharacterized protein C12orf71 3.31e-01 3.61e-02 NA
2. P Q66K80 Putative uncharacterized protein RUSC1-AS1 5.55e-02 9.71e-04 NA
2. P P0C045 F protein NA 8.94e-05 NA
2. P Q8QZZ9 Tumor suppressor ARF 4.25e-02 4.50e-02 NA
2. P P58512 Uncharacterized protein encoded by LINC01547 5.24e-01 1.62e-04 NA
2. P P47188 Putative UPF0320 protein YJR162C 7.70e-01 7.13e-04 NA
2. P P0C044 F protein NA 1.08e-03 NA
2. P P0C5V4 Protein PB1-F2 NA 3.02e-02 NA
2. P P15481 Protein VP5 NA 8.40e-03 NA
2. P Q0VFX4 Putative uncharacterized protein LOC100128554 3.11e-01 4.65e-06 NA
2. P P0DPF5 Uncharacterized protein C2orf27A 1.66e-01 2.79e-03 NA
2. P P17145 Uncharacterized protein US25 NA 2.17e-06 NA
2. P Q8NI28 Putative uncharacterized protein encoded by LINC01006 7.76e-01 9.44e-05 NA
2. P P0C5V5 Protein PB1-F2 NA 3.02e-02 NA
2. P Q8N8H1 Putative protein ZNF321 6.47e-02 6.39e-03 NA
2. P P0DPF6 Putative uncharacterized protein CDRT15P3 2.16e-01 5.31e-03 NA
2. P Q9H8X3 Putative uncharacterized protein LINC00574 5.94e-01 1.02e-02 NA
2. P Q96M66 Putative uncharacterized protein FLJ32790 5.88e-02 1.74e-07 NA