Summary

Q6ZSR6

Homolog: Q1E7S5.
Function: Mediator of RNA polymerase II transcription subunit 7.

Statistics

Total GO Annotation: 24
Unique PROST Go: 15
Unique BLAST Go: 9

Total Homologs: 16
Unique PROST Homologs: 13
Unique BLAST Homologs: 2

Structures and Sequence Alignment

The best structural homolog that predicted by 2. P was Q1E7S5 (Mediator of RNA polymerase II transcription subunit 7) with a FATCAT P-Value: 0.00214 and RMSD of 2.25 angstrom. The sequence alignment identity is 17.1%.
Structural alignment shown in left. Query protein Q6ZSR6 colored as red in alignment, homolog Q1E7S5 colored as blue. Query protein Q6ZSR6 is also shown in right top, homolog Q1E7S5 showed in right bottom. They are colored based on secondary structures. 

  Q6ZSR6 MLVETGFCRVG-QAGLELLSSSDKAAGLDLPKCWDYRHEPPRLAPL--LIFNPHPSTVLSCNCEYNSFFEFCDSLQQIVIPERVLGTPRHIFP--LP--- 92
  Q1E7S5 M--EEG----GQQKGI-------TAAFPPPPPFWK-KFTPENLERLEKAKREAEPQ-ALS--RKWSP--EALHALK--LAPE--L---RYLVPPELPKEG 74

  Q6ZSR6 --LLF--SHFLWSKLKEAPACLL--QGSSEHTEIICDLISSSKQFIKKFLSNKPSALHGGDADENDFLQLITRLQK-LLFKSLSMYVCVHIHQHTHACPQ 185
  Q1E7S5 SYSLFGEAQSLSTQL---PS--LEEQG-------IEQLYPSS-------LTNE-TA--GPSPDHAYYL-L--KISKSLLLNFLELVGILSINPEQYE-PK 148

  Q6ZSR6 LSCLHQNQD-EELFYCQN---------------------------------------------------------------------------------- 202
  Q1E7S5 I------EDIRNLFI--NAHHLLNLYRPHQSRESLITMMEEQLEQAKEEIREMEQTKERVEIYLRELEAEGRNVSPNDEPVQTPESGPHNTKTQTSESQA 240

  Q6ZSR6 ---------------- 202
  Q1E7S5 NGEQVLWKLLDKVEES 256

Go Annotations

1. PB indicates the go terms that are found by both PROST and BLAST.
2. P indicates the go terms that are found by only PROST.
3. B indicates the go terms that are only annotated by BLAST.
Source GO Description
2. P GO:0039689 negative stranded viral RNA replication
2. P GO:0039580 suppression by virus of host PKR signaling
2. P GO:0032588 trans-Golgi network membrane
2. P GO:0016592 mediator complex
2. P GO:0039502 suppression by virus of host type I interferon-mediated signaling pathway
2. P GO:0070847 core mediator complex
2. P GO:0046907 intracellular transport
2. P GO:0039501 suppression by virus of host type I interferon production
2. P GO:0003712 transcription coregulator activity
2. P GO:0039653 suppression by virus of host transcription
2. P GO:0039602 suppression by virus of host transcription initiation from RNA polymerase II promoter
2. P GO:0006357 regulation of transcription by RNA polymerase II
2. P GO:0039657 suppression by virus of host gene expression
2. P GO:0030121 AP-1 adaptor complex
2. P GO:0030276 clathrin binding
3. B GO:0051087 chaperone binding
3. B GO:0032991 protein-containing complex
3. B GO:0000776 kinetochore
3. B GO:0000151 ubiquitin ligase complex
3. B GO:0043947 obsolete positive regulation by host of symbiont catalytic activity
3. B GO:0050821 protein stabilization
3. B GO:0005634 nucleus
3. B GO:0000278 mitotic cell cycle
3. B GO:0031647 regulation of protein stability

Homologs

1. PB indicates the homologs that are found by both PROST and BLAST.
2. P indicates homologs that are only found by PROST.
3. B indicates homologs that are only found by BLAST.

Source Homolog Description FATCAT p-val PROST Evalue BLAST Evalue
1. PB Q6ZSR6 Putative uncharacterized protein FLJ45256 0 4.33e-154 4.71e-149
2. P Q8BHN9 Uncharacterized protein CLBA1 2.27e-01 1.18e-02 NA
2. P A1CT75 Mediator of RNA polymerase II transcription subunit 7 2.74e-03 5.25e-03 NA
2. P Q08278 Mediator of RNA polymerase II transcription subunit 7 2.40e-03 1.89e-02 NA
2. P Q7Z6I5 Spermatogenesis-associated protein 12 3.66e-01 1.30e-02 NA
2. P A2QWI7 Mediator of RNA polymerase II transcription subunit 7 3.86e-03 3.19e-04 NA
2. P Q5BBF7 Mediator of RNA polymerase II transcription subunit 7 2.48e-03 1.17e-03 NA
2. P Q2UHU3 Mediator of RNA polymerase II transcription subunit 7 3.76e-03 2.99e-03 NA
2. P Q4WMG1 Mediator of RNA polymerase II transcription subunit 7 2.81e-03 8.78e-03 NA
2. P A1DN59 Mediator of RNA polymerase II transcription subunit 7 3.64e-03 2.75e-03 NA
2. P Q1E7S5 Mediator of RNA polymerase II transcription subunit 7 2.14e-03 2.58e-03 NA
2. P P38752 Uncharacterized protein YHL005C 9.60e-01 6.59e-03 NA
2. P P21698 Non-structural protein S NA 4.41e-02 NA
2. P Q0CK31 Mediator of RNA polymerase II transcription subunit 7 3.47e-03 4.45e-02 NA
3. B Q8WTZ3 Zinc finger protein ENSP00000375192 3.39e-01 NA 4.49e-07
3. B Q9Y2Z0 Protein SGT1 homolog 3.21e-02 NA 0.049