Summary

Q6ZW13

Homolog: A6NGY1.
Function: Protein FRG2-like-2.

Statistics

Total GO Annotation: 66
Unique PROST Go: 66
Unique BLAST Go: 0

Total Homologs: 31
Unique PROST Homologs: 27
Unique BLAST Homologs: 1

Structures and Sequence Alignment

The best structural homolog that predicted by 2. P was A6NGY1 (Protein FRG2-like-2) with a FATCAT P-Value: 0.015 and RMSD of 3.55 angstrom. The sequence alignment identity is 24.0%.
Structural alignment shown in left. Query protein Q6ZW13 colored as red in alignment, homolog A6NGY1 colored as blue. Query protein Q6ZW13 is also shown in right top, homolog A6NGY1 showed in right bottom. They are colored based on secondary structures. 

  Q6ZW13 MASAGAERRPGVQEATVVGQGQLTEEPG-SAQTSECPVAGDQFLVPAHEARGTQ--SEDQRP-AG----A---ASESELQ-EEG--P---KLGEERPKPH 83
  A6NGY1 -----------------MGKGN--EDPDLHCSSIQC--STDQ--PPFQQISFTEKGSDEKKPFKGKGKTAFSHSSEKHTQRQAGSDPNPNKENSEETKLK 77

  Q6ZW13 AG---ALEERGPRPVVSIVRP--RHGPKRKPVKSLSLPGLRAHLKAEAELPPKLPLQEEEPEDS---QSEPSPSAKQHKKAKKRKSLGAPVLH---AVAS 172
  A6NGY1 AGNSTA----GSEPESSSYQENCR---KRK-ISSKDICQDRAGNCPEEEC--NLTLNKKSRSSTAVHNSEIQETCDAHHRGSSRACTGRSKRHRSRALE- 166

  Q6ZW13 MVSAPLETLRLERKA--QRLRPLYQYVNYCNPELNQAGKGDGEAEVEAEAEL-APVPEEGGVEQLQALLPLAGEL-GPGLALPCPSPLVT----PTHA-- 262
  A6NGY1 -VQTP--SL---RKSLVTSVRAMSEAV-Y--QDL---------AQVWAQ-QIHSPLT----CEQL-TLLT---RLRGP-L---C-AQVQTLYSMATQAAY 234

  Q6ZW13 LAPLGEEAGEEPGGLPSLGVS--DHKA------EVDKSTQ-VD-ID--KMLSVCTAPLVPPLSPQYK 317
  A6NGY1 VFP--AESWLVPATLPGPGDSALDREAHPFPGQEI---TEPVSGSDEAK-LG---AP---------- 282

Go Annotations

1. PB indicates the go terms that are found by both PROST and BLAST.
2. P indicates the go terms that are found by only PROST.
3. B indicates the go terms that are only annotated by BLAST.
Source GO Description
2. P GO:0007015 actin filament organization
2. P GO:0030474 spindle pole body duplication
2. P GO:0031110 regulation of microtubule polymerization or depolymerization
2. P GO:0001786 phosphatidylserine binding
2. P GO:0009630 gravitropism
2. P GO:0032059 bleb
2. P GO:0061003 positive regulation of dendritic spine morphogenesis
2. P GO:0005080 protein kinase C binding
2. P GO:0006281 DNA repair
2. P GO:0008285 negative regulation of cell population proliferation
2. P GO:0060918 auxin transport
2. P GO:0031589 cell-substrate adhesion
2. P GO:0005639 integral component of nuclear inner membrane
2. P GO:0005634 nucleus
2. P GO:0099626 voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels
2. P GO:0051764 actin crosslink formation
2. P GO:0070631 spindle pole body localization
2. P GO:0008021 synaptic vesicle
2. P GO:0031584 activation of phospholipase D activity
2. P GO:0009987 cellular process
2. P GO:0005516 calmodulin binding
2. P GO:0032056 positive regulation of translation in response to stress
2. P GO:0007019 microtubule depolymerization
2. P GO:0030332 cyclin binding
2. P GO:0051015 actin filament binding
2. P GO:0099025 anchored component of postsynaptic membrane
2. P GO:1900020 positive regulation of protein kinase C activity
2. P GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA
2. P GO:0051301 cell division
2. P GO:0099571 postsynaptic cytoskeleton
2. P GO:0017124 SH3 domain binding
2. P GO:0044307 dendritic branch
2. P GO:0071208 histone pre-mRNA DCP binding
2. P GO:0004869 cysteine-type endopeptidase inhibitor activity
2. P GO:0099523 presynaptic cytosol
2. P GO:0046628 positive regulation of insulin receptor signaling pathway
2. P GO:0042585 germinal vesicle
2. P GO:0003229 ventricular cardiac muscle tissue development
2. P GO:0007417 central nervous system development
2. P GO:0080113 regulation of seed growth
2. P GO:0005823 central plaque of spindle pole body
2. P GO:0032432 actin filament bundle
2. P GO:0008284 positive regulation of cell population proliferation
2. P GO:2000816 negative regulation of mitotic sister chromatid separation
2. P GO:0051276 chromosome organization
2. P GO:0045143 homologous chromosome segregation
2. P GO:0051017 actin filament bundle assembly
2. P GO:0005813 centrosome
2. P GO:0010929 positive regulation of auxin mediated signaling pathway
2. P GO:0001520 outer dense fiber
2. P GO:2001235 positive regulation of apoptotic signaling pathway
2. P GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity
2. P GO:0099026 anchored component of presynaptic membrane
2. P GO:1905274 regulation of modification of postsynaptic actin cytoskeleton
2. P GO:0007064 mitotic sister chromatid cohesion
2. P GO:0033391 chromatoid body
2. P GO:0005816 spindle pole body
2. P GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity
2. P GO:0009733 response to auxin
2. P GO:0005856 cytoskeleton
2. P GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage
2. P GO:0071207 histone pre-mRNA stem-loop binding
2. P GO:0042802 identical protein binding
2. P GO:0005938 cell cortex
2. P GO:0009734 auxin-activated signaling pathway
2. P GO:0071204 histone pre-mRNA 3'end processing complex

Homologs

1. PB indicates the homologs that are found by both PROST and BLAST.
2. P indicates homologs that are only found by PROST.
3. B indicates homologs that are only found by BLAST.

Source Homolog Description FATCAT p-val PROST Evalue BLAST Evalue
1. PB Q9D4A5 Uncharacterized protein C16orf86 homolog 1.83e-02 7.11e-27 1.88e-87
1. PB D3ZAQ5 Uncharacterized protein C16orf86 homolog 1.06e-02 9.04e-25 1.69e-100
1. PB Q6ZW13 Uncharacterized protein C16orf86 0 8.91e-142 0.0
2. P A6NGY1 Protein FRG2-like-2 1.50e-02 2.31e-03 NA
2. P P26645 Myristoylated alanine-rich C-kinase substrate 7.89e-02 2.95e-03 NA
2. P Q9M2B3 Protein BIG GRAIN 1-like C 5.65e-01 1.67e-02 NA
2. P Q64ET8 Protein FRG2 2.37e-02 2.79e-02 NA
2. P Q9EPH2 MARCKS-related protein 2.32e-01 7.90e-04 NA
2. P Q3SZY3 Securin 1.86e-01 2.73e-04 NA
2. P Q6PKN7 Protein INCA1 4.94e-01 3.24e-04 NA
2. P P30009 Myristoylated alanine-rich C-kinase substrate 7.61e-02 2.85e-02 NA
2. P A1YF19 Securin 5.11e-01 1.11e-05 NA
2. P P28667 MARCKS-related protein 7.22e-01 6.62e-03 NA
2. P Q6P3A1 Stathmin domain-containing protein 1 2.79e-01 7.24e-03 NA
2. P A2T767 Securin NA 3.11e-06 NA
2. P Q10R09 Protein BIG GRAIN 1 4.01e-01 1.55e-02 NA
2. P Q96QU4 Protein FRG2-like-1 7.80e-02 9.62e-03 NA
2. P C5DF10 Altered inheritance of mitochondria protein 44 7.07e-01 5.60e-03 NA
2. P Q0VBZ9 MARCKS-related protein 4.07e-01 6.82e-03 NA
2. P Q14493 Histone RNA hairpin-binding protein 5.26e-01 2.62e-02 NA
2. P P35566 MARCKS-related protein 3.58e-01 5.64e-04 NA
2. P Q9CQJ7 Securin 4.03e-01 6.40e-04 NA
2. P B8APC7 Protein BIG GRAIN 1 2.39e-01 3.31e-02 NA
2. P O95997 Securin 4.69e-01 6.68e-04 NA
2. P P40023 Enhancer of mRNA-decapping protein 2 5.21e-01 3.11e-04 NA
2. P Q96B23 Uncharacterized protein C18orf25 9.78e-02 3.50e-04 NA
2. P P52919 NAP1-binding protein 8.85e-01 1.32e-03 NA
2. P Q9NZH5 Securin-2 2.34e-01 2.23e-02 NA
2. P P16527 Myristoylated alanine-rich C-kinase substrate 9.13e-02 5.27e-03 NA
2. P Q5XKK7 Protein FAM219B 5.32e-01 4.77e-03 NA
3. B Q9GKT8 Uncharacterized protein C16orf86 homolog (Fragment) 7.94e-01 NA 1.60e-39