Summary

Q86WR6

Homolog: Q5F416.
Function: TIMELESS-interacting protein.

Statistics

Total GO Annotation: 86
Unique PROST Go: 59
Unique BLAST Go: 24

Total Homologs: 61
Unique PROST Homologs: 51
Unique BLAST Homologs: 7

Structures and Sequence Alignment

The best structural homolog that predicted by 2. P was Q5F416 (TIMELESS-interacting protein) with a FATCAT P-Value: 0.0023 and RMSD of 3.45 angstrom. The sequence alignment identity is 21.9%.
Structural alignment shown in left. Query protein Q86WR6 colored as red in alignment, homolog Q5F416 colored as blue. Query protein Q86WR6 is also shown in right top, homolog Q5F416 showed in right bottom. They are colored based on secondary structures. 

  Q86WR6 MEASDGQGGEGDKPLEQVTNVSCL--------ET----SSSASPAR-DSLMRHAKGLDQD---TFKTCKEY---LR-PLKKFLRKL---HL--PRDLPQK 75
  Q5F416 MAMID--------PLEN--NLFDLPDYENTEDETFPPLPPPTSPGRGDAEWAQANG-DPDGNQQSET-KDSSSAARKAVKRSIPKLDANRLVSERGLP-- 86

  Q86WR6 KKLKYMKQSLVVLG-----DHINTFLQHYCQAWEIKHWRKMLWRFISL-FSE-LEAKQLRRLYKYTKSSQPAKFLVTFCAS----DAPERSLLADREDSL 164
  Q5F416 -ALRHMFDNVKFKGKGHEAEDLKTLLRH------MEHWAHRL--FPKLQFDDFID--RVESL--GNK-----KEVQT-CLKRIRLDLP---IL--HEDFT 162

  Q86WR6 PKLCHAWGLHSNISG--M-KERLSNMQTPGQ-G--SPLPG---QPRSQDHVKKDSLRELSQKPKLKRKRIK----------E-APETPETE---P----- 236
  Q5F416 AN--EGGGGESN--GLDMATEEVHSFS--GNVGELDSLPGTTLTEEQQQRIKRN--RQLA----LERRQAKMQCNSQSQHDELSPSYPEEELNIPVARDL 250

  Q86WR6 --------------------------------- 236
  Q5F416 TGALEDTQVTATNVAVTETEDRERELQCASEKQ 283

Go Annotations

1. PB indicates the go terms that are found by both PROST and BLAST.
2. P indicates the go terms that are found by only PROST.
3. B indicates the go terms that are only annotated by BLAST.
Source GO Description
1. PB GO:0005634 nucleus
1. PB GO:0006357 regulation of transcription by RNA polymerase II
1. PB GO:0003677 DNA binding
2. P GO:0046966 thyroid hormone receptor binding
2. P GO:0090698 post-embryonic plant morphogenesis
2. P GO:0032202 telomere assembly
2. P GO:0046718 viral entry into host cell
2. P GO:0000151 ubiquitin ligase complex
2. P GO:0031396 regulation of protein ubiquitination
2. P GO:0031298 replication fork protection complex
2. P GO:0045475 locomotor rhythm
2. P GO:0030430 host cell cytoplasm
2. P GO:0071280 cellular response to copper ion
2. P GO:0075732 viral penetration into host nucleus
2. P GO:0005667 transcription regulator complex
2. P GO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter
2. P GO:0016602 CCAAT-binding factor complex
2. P GO:0005819 spindle
2. P GO:0003713 transcription coactivator activity
2. P GO:0005758 mitochondrial intermembrane space
2. P GO:0000003 reproduction
2. P GO:0072738 cellular response to diamide
2. P GO:0016605 PML body
2. P GO:0000076 DNA replication checkpoint signaling
2. P GO:0019827 stem cell population maintenance
2. P GO:0000444 MIS12/MIND type complex
2. P GO:0016233 telomere capping
2. P GO:0048478 replication fork protection
2. P GO:0031965 nuclear membrane
2. P GO:0043111 replication fork arrest
2. P GO:1903936 cellular response to sodium arsenite
2. P GO:0051457 maintenance of protein location in nucleus
2. P GO:0005198 structural molecule activity
2. P GO:0032211 negative regulation of telomere maintenance via telomerase
2. P GO:1902426 deactivation of mitotic spindle assembly checkpoint
2. P GO:0070847 core mediator complex
2. P GO:0005813 centrosome
2. P GO:0009792 embryo development ending in birth or egg hatching
2. P GO:0003712 transcription coregulator activity
2. P GO:0030496 midbody
2. P GO:0070198 protein localization to chromosome, telomeric region
2. P GO:0075521 microtubule-dependent intracellular transport of viral material towards nucleus
2. P GO:0019033 viral tegument
2. P GO:0000783 nuclear telomere cap complex
2. P GO:0009299 mRNA transcription
2. P GO:0016604 nuclear body
2. P GO:0003723 RNA binding
2. P GO:0005929 cilium
2. P GO:0070187 shelterin complex
2. P GO:0016592 mediator complex
2. P GO:1904356 regulation of telomere maintenance via telomere lengthening
2. P GO:0010836 negative regulation of protein ADP-ribosylation
2. P GO:0044770 cell cycle phase transition
2. P GO:0010370 perinucleolar chromocenter
2. P GO:0031573 mitotic intra-S DNA damage checkpoint signaling
2. P GO:0030695 GTPase regulator activity
2. P GO:0000785 chromatin
2. P GO:0044177 host cell Golgi apparatus
2. P GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
2. P GO:0007096 regulation of exit from mitosis
2. P GO:0032205 negative regulation of telomere maintenance
2. P GO:0039619 T=4 icosahedral viral capsid
3. B GO:0060218 hematopoietic stem cell differentiation
3. B GO:0005705 polytene chromosome interband
3. B GO:0035042 fertilization, exchange of chromosomal proteins
3. B GO:0003682 chromatin binding
3. B GO:0000775 chromosome, centromeric region
3. B GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
3. B GO:0006974 cellular response to DNA damage stimulus
3. B GO:0043044
3. B GO:0007517 muscle organ development
3. B GO:0004386 helicase activity
3. B GO:0070615
3. B GO:0006333 chromatin assembly or disassembly
3. B GO:0043923 positive regulation by host of viral transcription
3. B GO:0006338 chromatin remodeling
3. B GO:0007476 imaginal disc-derived wing morphogenesis
3. B GO:0006325 chromatin organization
3. B GO:0048477 oogenesis
3. B GO:0035064 methylated histone binding
3. B GO:0016569 obsolete covalent chromatin modification
3. B GO:0140603 obsolete ATP hydrolysis activity
3. B GO:0005703 polytene chromosome puff
3. B GO:0043486 histone exchange
3. B GO:0003678 DNA helicase activity
3. B GO:0042393 histone binding

Homologs

1. PB indicates the homologs that are found by both PROST and BLAST.
2. P indicates homologs that are only found by PROST.
3. B indicates homologs that are only found by BLAST.

Source Homolog Description FATCAT p-val PROST Evalue BLAST Evalue
1. PB Q9D979 Uncharacterized protein C17orf64 homolog 1.54e-11 3.67e-56 2.08e-114
1. PB Q32KP7 Uncharacterized protein C17orf64 homolog 5.41e-10 7.63e-46 1.19e-121
1. PB Q86WR6 Uncharacterized protein C17orf64 0 4.41e-132 4.30e-176
2. P Q4R930 ADP-ribosylation factor-like protein 2-binding protein 1.71e-02 1.51e-02 NA
2. P P03148 Capsid protein NA 3.29e-03 NA
2. P Q32PC9 ADP-ribosylation factor-like protein 2-binding protein 1.65e-02 1.55e-03 NA
2. P P0C6I4 Capsid protein NA 2.25e-03 NA
2. P Q9UU95 Meiotically up-regulated gene 128 protein 7.44e-03 8.02e-03 NA
2. P Q9QAB9 Capsid protein NA 1.19e-02 NA
2. P Q76R61 Capsid protein NA 1.83e-02 NA
2. P Q5R9K8 ADP-ribosylation factor-like protein 2-binding protein 5.09e-02 4.05e-02 NA
2. P Q5F416 TIMELESS-interacting protein 2.30e-03 2.67e-04 NA
2. P P12901 Capsid protein NA 9.63e-03 NA
2. P Q3T123 Mediator of RNA polymerase II transcription subunit 7 3.03e-02 1.86e-03 NA
2. P P0C6I9 Capsid protein NA 4.01e-02 NA
2. P P0C6I8 Capsid protein NA 1.95e-02 NA
2. P Q9DCX1 MAD2L1-binding protein 1.08e-01 1.46e-02 NA
2. P Q4JQW8 Tegument protein UL51 homolog NA 9.86e-04 NA
2. P Q60V43 Mediator of RNA polymerase II transcription subunit 7 NA 1.45e-05 NA
2. P P0C680 Capsid protein NA 3.35e-03 NA
2. P O43513 Mediator of RNA polymerase II transcription subunit 7 2.98e-02 1.17e-04 NA
2. P Q9QXG9 TERF1-interacting nuclear factor 2 4.58e-02 5.32e-04 NA
2. P B8AH02 Protein G1-like3 3.62e-02 3.05e-03 NA
2. P Q6GPM0 Regulator of G-protein signaling 7-binding protein 9.38e-03 4.34e-02 NA
2. P P69706 Capsid protein NA 1.83e-02 NA
2. P Q81102 Capsid protein NA 2.15e-02 NA
2. P P0C677 Capsid protein NA 3.31e-02 NA
2. P O10346 Uncharacterized 29.4 kDa protein NA 4.91e-04 NA
2. P Q96IY1 Kinetochore-associated protein NSL1 homolog 4.73e-02 3.91e-04 NA
2. P P17392 Capsid protein NA 6.43e-03 NA
2. P Q3TQ03 Circadian-associated transcriptional repressor 1.19e-01 7.80e-03 NA
2. P Q9D385 ADP-ribosylation factor-like protein 2-binding protein 2.09e-02 2.66e-02 NA
2. P Q5BJ48 Mediator of RNA polymerase II transcription subunit 7 2.24e-02 1.30e-02 NA
2. P Q7ZV35 Mediator of RNA polymerase II transcription subunit 7 1.65e-02 8.17e-03 NA
2. P Q9CZB6 Mediator of RNA polymerase II transcription subunit 7 3.17e-02 2.81e-04 NA
2. P Q8IUE0 Homeobox protein TGIF2LY 1.68e-02 4.30e-02 NA
2. P Q2F7Z4 Mediator of RNA polymerase II transcription subunit 7 2.84e-02 2.25e-04 NA
2. P Q84W66 Nuclear transcription factor Y subunit B-6 5.42e-02 1.49e-02 NA
2. P P0C6I6 Capsid protein NA 1.58e-03 NA
2. P Q3ZCC4 TIMELESS-interacting protein 5.15e-03 5.76e-03 NA
2. P Q9E6S6 Capsid protein NA 1.67e-02 NA
2. P Q9UUD2 Pre-mRNA-splicing factor 38 1.23e-01 8.25e-03 NA
2. P Q95Q17 Mediator of RNA polymerase II transcription subunit 7 8.95e-02 2.55e-03 NA
2. P Q69608 Capsid protein NA 6.80e-03 NA
2. P Q2YDF2 Mediator of RNA polymerase II transcription subunit 30 1.13e-01 1.74e-03 NA
2. P Q0DZF3 Protein G1-like3 4.63e-02 3.05e-03 NA
2. P O18805 Death domain-associated protein 6 1.52e-01 3.06e-02 NA
2. P Q15013 MAD2L1-binding protein 1.40e-01 8.32e-03 NA
2. P O71303 Capsid protein NA 8.60e-04 NA
2. P P0C6H6 Capsid protein NA 2.13e-03 NA
2. P P69707 Capsid protein NA 1.83e-02 NA
2. P P0C6H4 Capsid protein NA 1.89e-02 NA
2. P P69708 Capsid protein NA 1.83e-02 NA
2. P P09271 Tegument protein UL51 homolog NA 9.86e-04 NA
3. B O14646 Chromodomain-helicase-DNA-binding protein 1 1.38e-01 NA 2.87e-18
3. B O14647 Chromodomain-helicase-DNA-binding protein 2 3.58e-01 NA 7.84e-13
3. B Q7KU24 Chromodomain-helicase-DNA-binding protein 1 2.70e-01 NA 3.34e-12
3. B A9X4T1 Chromodomain-helicase-DNA-binding protein 1 3.36e-01 NA 2.12e-10
3. B E9PZM4 Chromodomain-helicase-DNA-binding protein 2 3.55e-01 NA 6.25e-13
3. B P40201 Chromodomain-helicase-DNA-binding protein 1 4.91e-01 NA 5.86e-19
3. B B6ZLK2 Chromodomain-helicase-DNA-binding protein 1 2.67e-01 NA 1.77e-18