Summary

Q8IV32

Homolog: Q2HJ91.
Function: Coiled-coil domain-containing protein 71.

Statistics

Total GO Annotation: 16
Unique PROST Go: 14
Unique BLAST Go: 2

Total Homologs: 17
Unique PROST Homologs: 12
Unique BLAST Homologs: 1

Structures and Sequence Alignment

The best structural homolog that predicted by 1. PB was Q2HJ91 (Coiled-coil domain-containing protein 71) with a FATCAT P-Value: 2.4e-05 and RMSD of 6.79 angstrom. The sequence alignment identity is 80.0%.
Structural alignment shown in left. Query protein Q8IV32 colored as red in alignment, homolog Q2HJ91 colored as blue. Query protein Q8IV32 is also shown in right top, homolog Q2HJ91 showed in right bottom. They are colored based on secondary structures. 

  Q8IV32 MSVVVQHVEEKAVHSWSRISTAGKKALEEALLVFNPMSQDLSATEAQLVAFLQGLRDDGFQPTILRSGDVYGYSSCTANPPSQTKLQARAPNPTATSPPA 100
  Q2HJ91 MSVVVQHVEEKAVHSWSRISTAGKKALEEALLVFNPMSQDLSATEAQLVAFLQGLRDDGFQPTILRSGDVYGYSSCTANPPSQTKLQARAPTPAATSPPA 100

  Q8IV32 SAPRTAMRLPAGRATLLPMPLSGRLAKASTPALAKHATTNLLLSSLKQSSASHARGAAVGFPTHLYPGVYPAMRLSVVLEALVPLKTPMPCLGAKHKAQS 200
  Q2HJ91 SAPQTAVRLPAGRATLLPMPLSGRLAKASTPGLAKHATTNLLLSSLKQSSAGRAQGAAVGFPTHLYPGVYPAMRLSVVLEALVPIKTPVACLGAKPKAQS 200

  Q8IV32 LQLSLADSPLKLRKSSGKGPGNPRPKAPRKTTSKGPKCLTRKGPGAGPRRGSGHQSKTNRATGS---PSVRRMKGGSALGTKTAQAKVARTLAKAARAQA 297
  Q2HJ91 LQLSLGDSPLKVRKGPGKRLGNAQLKAPRKATSKGSKCLAQRGPRSGPRQGAGLQSKTCKVTGSLGGP---RVKDGGALGTKAAQ-------AKAACAQA 290

  Q8IV32 KVARTQAKAAKARAKAKAAQVKAKAKAKAAQVKAKAKVMAAWAKAKAKAKAVRAKAKVARTQPRGRGRPKGSAKARTTRKGQKNRPETVGQKRKRAEEAK 397
  Q2HJ91 KVAQTQATATQARAKAKA--VRARAKAKAARIKARE------VRARAKAKAVQAKAKVARTQPRGRGRPKGSIQGRTARRSRKSRPETVGQKRKRTEEAK 382

  Q8IV32 DLPPKKRTRLGPRSPKAWLGPGTAKLLKFRAIKVDRRSSDDEVRQRAQRILRVNLSPVIRLQPLLPYSAV 467
  Q2HJ91 DLSPRKRTRLGPRSPKVQLGPGTARLLKFRAIKVDRLASDDEVRQQAQRILRVNLSPVIRLQPLPPHSAP 452

Go Annotations

1. PB indicates the go terms that are found by both PROST and BLAST.
2. P indicates the go terms that are found by only PROST.
3. B indicates the go terms that are only annotated by BLAST.
Source GO Description
2. P GO:0042025 host cell nucleus
2. P GO:0039693 viral DNA genome replication
2. P GO:1902465 negative regulation of histone H3-K27 trimethylation
2. P GO:0003700 DNA-binding transcription factor activity
2. P GO:0006275 regulation of DNA replication
2. P GO:0000166 nucleotide binding
2. P GO:0048599 oocyte development
2. P GO:0033150 cytoskeletal calyx
2. P GO:0019079 viral genome replication
2. P GO:0030430 host cell cytoplasm
2. P GO:0006351 transcription, DNA-templated
2. P GO:0005200 structural constituent of cytoskeleton
2. P GO:0006260 DNA replication
2. P GO:0003677 DNA binding
3. B GO:0044255 cellular lipid metabolic process
3. B GO:0045600 positive regulation of fat cell differentiation

Homologs

1. PB indicates the homologs that are found by both PROST and BLAST.
2. P indicates homologs that are only found by PROST.
3. B indicates homologs that are only found by BLAST.

Source Homolog Description FATCAT p-val PROST Evalue BLAST Evalue
1. PB Q4V7C4 Coiled-coil domain-containing protein 71 2.37e-03 3.39e-30 0.0
1. PB Q8IV32 Coiled-coil domain-containing protein 71 0 1.07e-151 0.0
1. PB Q2HJ91 Coiled-coil domain-containing protein 71 2.40e-05 3.00e-42 7.07e-153
1. PB Q8VEG0 Coiled-coil domain-containing protein 71 4.75e-04 8.36e-39 0.0
2. P Q80903 Regulatory protein E2 NA 3.47e-02 NA
2. P B1B0V2 EZH inhibitory protein 7.32e-01 4.93e-03 NA
2. P P36783 Regulatory protein E2 NA 2.02e-02 NA
2. P P50772 Regulatory protein E2 NA 3.31e-03 NA
2. P Q14093 Cylicin-2 1.29e-01 7.24e-03 NA
2. P Q5SRN2 Testis-expressed basic protein 1 1.68e-01 3.20e-02 NA
2. P P36785 Regulatory protein E2 NA 4.05e-02 NA
2. P P36780 Regulatory protein E2 NA 2.79e-02 NA
2. P P11202 Non-structural protein 5 NA 3.00e-02 NA
2. P P36782 Regulatory protein E2 NA 7.53e-03 NA
2. P Q80910 Regulatory protein E2 NA 9.37e-03 NA
2. P A2T3Q9 Non-structural protein 5 NA 3.00e-02 NA
3. B Q8N9Z2 Coiled-coil domain-containing protein 71L 8.23e-02 NA 6.08e-10