Summary

Q8IXQ3

Homolog: Q99966.
Function: Cbp/p300-interacting transactivator 1.

Statistics

Total GO Annotation: 81
Unique PROST Go: 76
Unique BLAST Go: 4

Total Homologs: 24
Unique PROST Homologs: 20
Unique BLAST Homologs: 1

Structures and Sequence Alignment

The best structural homolog that predicted by 2. P was Q99966 (Cbp/p300-interacting transactivator 1) with a FATCAT P-Value: 0.0461 and RMSD of 3.40 angstrom. The sequence alignment identity is 21.6%.
Structural alignment shown in left. Query protein Q8IXQ3 colored as red in alignment, homolog Q99966 colored as blue. Query protein Q8IXQ3 is also shown in right top, homolog Q99966 showed in right bottom. They are colored based on secondary structures. 

  Q8IXQ3 ----------------MAKRRAAEPVTFHVPWKRLLLCDFAEQPPPPPLWIRPPGVAHAGQLLGVPEQHRKRKIDAGTMAEPSASPSKRRDSGDNSAPSG 84
  Q99966 MPTTSRPALDVKGGTSPAKEDANQEMS-SVAYSNLAVKDRKAV----AI-LHYPGVA-----------------SNGTKA--SGAPT--SSSG---SPIG 70

  Q8IXQ3 QEREDHGLETGDPPLPPPPV-L-PGPGEELPGARL-------PG-GGGDDG-AGRAGPPRGDWGVASRQHNEEFWQYNTFQYWRNPL----PPID---LA 166
  Q99966 S-------PTTTPPTKPPSFNLHPAP-HLLASMHLQKLNSQYQGMAAATPGQPGEAGPLQ-NWDFGAQAGGAE--SLSPSAGAQSPAIIDSDPVDEEVLM 159

  Q8IXQ3 D-IEDLSEDT---LTEATLQGRNEGAE--VDMES-- 194
  Q99966 SLVVELGLDRANELPELWL-GQNE-FDFTADFPSSC 193

Go Annotations

1. PB indicates the go terms that are found by both PROST and BLAST.
2. P indicates the go terms that are found by only PROST.
3. B indicates the go terms that are only annotated by BLAST.
Source GO Description
1. PB GO:0045893 positive regulation of transcription, DNA-templated
2. P GO:0001570 vasculogenesis
2. P GO:0070670 response to interleukin-4
2. P GO:0009637 response to blue light
2. P GO:0060711 labyrinthine layer development
2. P GO:0007080 mitotic metaphase plate congression
2. P GO:0070741 response to interleukin-6
2. P GO:0051591 response to cAMP
2. P GO:0045892 negative regulation of transcription, DNA-templated
2. P GO:1902462 positive regulation of mesenchymal stem cell proliferation
2. P GO:0000578 embryonic axis specification
2. P GO:0070669 response to interleukin-2
2. P GO:0045668 negative regulation of osteoblast differentiation
2. P GO:0003713 transcription coactivator activity
2. P GO:0061608 nuclear import signal receptor activity
2. P GO:0051510 regulation of unidimensional cell growth
2. P GO:0071559 response to transforming growth factor beta
2. P GO:0007076 mitotic chromosome condensation
2. P GO:0032868 response to insulin
2. P GO:0034451 centriolar satellite
2. P GO:0030991 intraciliary transport particle A
2. P GO:0010218 response to far red light
2. P GO:0051457 maintenance of protein location in nucleus
2. P GO:0006302 double-strand break repair
2. P GO:0050693 LBD domain binding
2. P GO:0005634 nucleus
2. P GO:0031536 positive regulation of exit from mitosis
2. P GO:0060395 SMAD protein signal transduction
2. P GO:0005929 cilium
2. P GO:0001890 placenta development
2. P GO:0071104 response to interleukin-9
2. P GO:0009987 cellular process
2. P GO:0001558 regulation of cell growth
2. P GO:0031048 heterochromatin assembly by small RNA
2. P GO:0000785 chromatin
2. P GO:0010018 far-red light signaling pathway
2. P GO:0060712 spongiotrophoblast layer development
2. P GO:0042803 protein homodimerization activity
2. P GO:0070410 co-SMAD binding
2. P GO:0042438 melanin biosynthetic process
2. P GO:0071105 response to interleukin-11
2. P GO:0043473 pigmentation
2. P GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
2. P GO:0003682 chromatin binding
2. P GO:0043622 cortical microtubule organization
2. P GO:0009639 response to red or far red light
2. P GO:0009646 response to absence of light
2. P GO:0070555 response to interleukin-1
2. P GO:0071922 regulation of cohesin loading
2. P GO:0030318 melanocyte differentiation
2. P GO:0004869 cysteine-type endopeptidase inhibitor activity
2. P GO:0030178 negative regulation of Wnt signaling pathway
2. P GO:0034341 response to interferon-gamma
2. P GO:0060231 mesenchymal to epithelial transition
2. P GO:1901000 regulation of response to salt stress
2. P GO:0035721 intraciliary retrograde transport
2. P GO:0001658 branching involved in ureteric bud morphogenesis
2. P GO:0071107 response to parathyroid hormone
2. P GO:0060271 cilium assembly
2. P GO:2000816 negative regulation of mitotic sister chromatid separation
2. P GO:0006915 apoptotic process
2. P GO:0003340 negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
2. P GO:0045143 homologous chromosome segregation
2. P GO:0015630 microtubule cytoskeleton
2. P GO:0006913 nucleocytoplasmic transport
2. P GO:0007064 mitotic sister chromatid cohesion
2. P GO:0034097 response to cytokine
2. P GO:0009640 photomorphogenesis
2. P GO:0005856 cytoskeleton
2. P GO:0043524 negative regulation of neuron apoptotic process
2. P GO:0097542 ciliary tip
2. P GO:0001656 metanephros development
2. P GO:0010029 regulation of seed germination
2. P GO:0010780 meiotic DNA double-strand break formation involved in reciprocal meiotic recombination
2. P GO:0010114 response to red light
2. P GO:0043627 response to estrogen
2. P GO:0009416 response to light stimulus
3. B GO:0005815 microtubule organizing center
3. B GO:0051901 positive regulation of mitochondrial depolarization
3. B GO:0097190 apoptotic signaling pathway
3. B GO:0090200 positive regulation of release of cytochrome c from mitochondria

Homologs

1. PB indicates the homologs that are found by both PROST and BLAST.
2. P indicates homologs that are only found by PROST.
3. B indicates homologs that are only found by BLAST.

Source Homolog Description FATCAT p-val PROST Evalue BLAST Evalue
1. PB Q66H24 Uncharacterized protein C9orf40 homolog 1.03e-04 7.31e-26 3.90e-52
1. PB Q8VCE4 Uncharacterized protein C9orf40 homolog 7.52e-04 3.23e-22 5.49e-43
1. PB Q8IXQ3 Uncharacterized protein C9orf40 0 1.57e-138 1.26e-138
2. P Q9LZW2 Transcription repressor OFP1 1.25e-01 4.03e-02 NA
2. P A8MR65 Protein FAR-RED-ELONGATED HYPOCOTYL 1-LIKE 1.18e-01 9.58e-04 NA
2. P Q3KQW6 UPF0688 protein C1orf174 homolog 4.04e-02 8.84e-04 NA
2. P Q8S4Q6 Protein FAR-RED ELONGATED HYPOCOTYL 1 2.60e-01 7.98e-06 NA
2. P Q32PF7 UPF0688 protein C1orf174 homolog 6.87e-02 1.18e-03 NA
2. P E2QSX5 Intraflagellar transport protein 43 homolog 1.41e-01 2.06e-02 NA
2. P P87309 Mei4-dependent protein 2 1.60e-01 4.10e-02 NA
2. P Q96FF9 Sororin 1.90e-01 2.23e-02 NA
2. P Q1L9C7 UPF0688 protein C1orf174 homolog 4.92e-02 1.74e-02 NA
2. P Q2TBN9 Intraflagellar transport protein 43 homolog 2.60e-01 2.96e-03 NA
2. P Q96FT9 Intraflagellar transport protein 43 homolog 1.08e-01 2.73e-02 NA
2. P Q9D9U4 Testis-expressed protein 22 1.66e-01 1.15e-02 NA
2. P Q9CQJ7 Securin 1.15e-01 6.21e-03 NA
2. P A0JM83 UPF0688 protein C1orf174 homolog 2.58e-02 2.98e-05 NA
2. P Q5XG21 Sororin-B 1.06e-01 3.88e-03 NA
2. P Q9DA69 Intraflagellar transport protein 43 homolog 2.32e-01 1.01e-02 NA
2. P Q99966 Cbp/p300-interacting transactivator 1 4.61e-02 1.88e-03 NA
2. P E7F555 Intraflagellar transport protein 43 homolog 1.70e-01 3.36e-03 NA
2. P Q9BDI3 Cbp/p300-interacting transactivator 1 8.24e-02 2.78e-02 NA
2. P B5G1P1 Intraflagellar transport protein 43 homolog 7.95e-02 5.22e-07 NA
3. B A3KQS5 Protein AF1q 2.87e-01 NA 0.024