Summary

Q8N398

Homolog: Q3UR50.
Function: von Willebrand factor A domain-containing protein 5B2.

Statistics

Total GO Annotation: 27
Unique PROST Go: 10
Unique BLAST Go: 15

Total Homologs: 26
Unique PROST Homologs: 10
Unique BLAST Homologs: 7

Structures and Sequence Alignment

The best structural homolog that predicted by 1. PB was Q3UR50 (von Willebrand factor A domain-containing protein 5B2) with a FATCAT P-Value: 0.0 and RMSD of 4.01 angstrom. The sequence alignment identity is 83.8%.
Structural alignment shown in left. Query protein Q8N398 colored as red in alignment, homolog Q3UR50 colored as blue. Query protein Q8N398 is also shown in right top, homolog Q3UR50 showed in right bottom. They are colored based on secondary structures. 

  Q8N398 MPGLYCPSSWTPLPLTDSWVRACANGPCLSVRARLTYRNPQPQPVDGVFVYPLAEAEVVSGFEAEAAGRRVSFQLQSRRRSQAACCRALGPGLGTPTPRR 100
  Q3UR50 MPGLYCPTSWTPLPLTDSCVRAYAKGPCLSLRARLTYHNPQPQPVEGVFVYPLAEAEVVSGFEAEAAGRRVSFQLHSRRRSQAACCRALGPGLGTSTPRR 100

  Q8N398 CAQGHLVLDLAQARSTLVLPTGIIAAAGTMTVTLHSSRELPSRPDGVLHVALPTVLTPLAPPGPPGPPRPPGLCDDSPTSCFGVGSLQEEGLAWEE-LAA 199
  Q3UR50 CAQGHLVLNLAQARSTLVLPTGLVAAAGTMTVTLCSSRELPSRPDGVMHVALPTVFTPLAQPNLPGSPRSPGLCDDSPTSCFGVGSPEEERPTWEQPTAT 200

  Q8N398 PRDVFSGPARCPAPYTFSFEMLVTGPCLLAGLESPSHALRADAPPHASSAATICVTLAEGHHCDRALEILLHPSEPHQPHLMLEGGSLSSAEYEARVRAR 299
  Q3UR50 P-DVFSGPARCPAPYTFSFEMLVTGPCLLAGLESPSHALRADALPHASSAATIRVTLAEGHQCDRALEILLHPSEPHQPHLMLETGSLSSAEYEAQVRAR 299

  Q8N398 RDFQRLQRRDSDGDRQVWFLQRRFHKDILLNPVLALSFCPDLSSKPGHLGTATRELLFLLDSSSVAHKDAIVLAVKSLPPQTLINLAVFGTLVQPLFPES 399
  Q3UR50 HDFQRLQQRDSGGERQVWFLQRRFHKDILLNPVLVLNFCPDLSSKPGHLNAATRELLFLLDGSGAGHKDAIVLAVKSLPAQTLVNLAIFGTLVQPLFPES 399

  Q8N398 RPCSDDAVQLICESIETLQVPSGPPDVLAALDWAVGQPQHRAYPRQLFLLTAASPMAATTHRTLELMRWHRGTARCFSFGLGPTCHQLLQGLSALSRGQA 499
  Q3UR50 RPCSDDTVQLICESIETLQTVNGPPDMLAVLDWALGQPQHRAYPRQMFLITAASPTAATTHQALEFMRWHRGAARCFSFALAPACRQLLHDLSVLSRGQA 499

  Q8N398 YFLRPGQRLQPMLVQALRKALEPALSDISVDWFVPDTVEALLTPREIPALYPGDQLLGYCSLFRVDGFRSRPPGGQEPGWQSSGGSVFPSPEEAPSAASP 599
  Q3UR50 YFLRPGERLQPKLVQALRKALEPALSDISVDWFVPDAVEALLTPREIPALYPGDQLLGYCSLFRVDGFRSHALGGQEPGWQSLAGSVFPSPEEVLSATSP 599

  Q8N398 GTEPTGTSEPLGTGTVSAELSSPWAARDSEQSTDALTDPVTDPGPNP-SDTAIWRRIFQSSYIREQYVLTHCSASPEPGPGSTGSSESPGSQGPGSPEGS 698
  Q3UR50 GTEPTHTTEPLGTGTVSAELSSPWAVGDSEQSMEALTDPVMDPGPNPSSDTAIWRRIFQSSYIREQYVLTHCSASPEPGPGSTCSSESPGSQGPGSPSGS 699

  Q8N398 APLEPPSQQGCRSLAWGEPAGSRSCPLPAPTPAPFKVGALSTEVLGRQHRAALAGRSLSSPPGRANQVPGRPRKPSLGAILDGPSPEPGQQLGQGLDDSG 798
  Q3UR50 RPLDPPSQQGCRSLAWVEPAGSRSCPLPVPPPSPFKVGAMSAEVLGRRQRAALAGRSLSSPSGRANPVPGRARHPSLDAIPDGLGPEPGQQLGQGLDDSG 799

  Q8N398 NLLSPAPMDWDMLMEPPFLFTAVPPSGELAPPA--VPPQAPRCHVVIRGLCGEQPMCWEVGVGLETLWGPGDGSQPPSPPVREAAWDQALHRLTAASVVR 896
  Q3UR50 NLLSPAPLDWDMLMEPSFLFKPVPSSAESAPPAECLPPQAPRCHVVIRALCGEQPMCWEVGVGLEELWGPGDGSQPESLPMREAAWDQALHRLTAASVVQ 899

  Q8N398 DNEQLALRGGAETTADRGHARRCWLRALQTSKVSSAPSCFTCPVAVDATTREVLPGALQVCSSEPAEPPGTPPASHSHLDAAPLPTVVYSKGLQRGSPAG 996
  Q3UR50 DNEQLALRGRAETRAEQGRVRRSWLRAIQTSKVSSAPSCFTCPVAVDATTREVLPGALQVWSSDPAELSGM-SASQDQLAAAPLSTAVHSKGHQGGCSAG 998

  Q8N398 AWDSDQNGNSKRALGDPATPTEGPRRP-PPRPPC--RLSMGRRHKLCSPDPGQ--ANNSEGSDHDYLPLVRLQEAPGSFRLDAPFCAAVRISQERLCRAS 1091
  Q3UR50 AWDLDLNDNSKSALGEPISPT-GDHHGLPHQPPASSRLSLGRHRRLCSSNKGQTHENSNDGSNHDYLPLVRLQEAPGSFRLDEPFCAAVCIPQERLCRAS 1097

  Q8N398 PFAVHRASLSPTSASLPWALLGPGVGQGDSATASCSPSPSSGSEGPGQVDSGRGSDTEASEGAEGLGGTDLRGRTWATAVALAWLEHRCAAAFDEWELTA 1191
  Q3UR50 PFAAHRASLSPTSASSPWAFLSPGIGQGDSATASCSQSPSSGSEGPGQVDSGRGSDTEASEGMERQDSSDLRGRTWATAVALAWLEHRCAAAFGEWELTA 1197

  Q8N398 AKADCWLRAQHLPDGLDLAALKAAARGLFLLLRHWDQNLQLHLLCYSPANV 1242
  Q3UR50 SKADCWLRAQHLPDGLDLTALKAAARGLFLLLRHWDQNLQLHLLCYSPSNV 1248

Go Annotations

1. PB indicates the go terms that are found by both PROST and BLAST.
2. P indicates the go terms that are found by only PROST.
3. B indicates the go terms that are only annotated by BLAST.
Source GO Description
1. PB GO:0062023 collagen-containing extracellular matrix
1. PB GO:0005654 nucleoplasm
2. P GO:0030198 extracellular matrix organization
2. P GO:0072562 blood microparticle
2. P GO:0005576 extracellular region
2. P GO:0004867 serine-type endopeptidase inhibitor activity
2. P GO:0031012 extracellular matrix
2. P GO:0030212 hyaluronan metabolic process
2. P GO:0004866 endopeptidase inhibitor activity
2. P GO:0034097 response to cytokine
2. P GO:0006953 acute-phase response
2. P GO:0031089 platelet dense granule lumen
3. B GO:0006954 inflammatory response
3. B GO:0016192 vesicle-mediated transport
3. B GO:1990904 ribonucleoprotein complex
3. B GO:1990404 protein ADP-ribosylase activity
3. B GO:0016020 membrane
3. B GO:0006471 protein ADP-ribosylation
3. B GO:0005876 spindle microtubule
3. B GO:0005819 spindle
3. B GO:0006464 cellular protein modification process
3. B GO:0051972 regulation of telomerase activity
3. B GO:0042493
3. B GO:0140289 protein mono-ADP-ribosylation
3. B GO:0003950 NAD+ ADP-ribosyltransferase activity
3. B GO:0008219 cell death
3. B GO:0019899 enzyme binding

Homologs

1. PB indicates the homologs that are found by both PROST and BLAST.
2. P indicates homologs that are only found by PROST.
3. B indicates homologs that are only found by BLAST.

Source Homolog Description FATCAT p-val PROST Evalue BLAST Evalue
1. PB Q8N398 von Willebrand factor A domain-containing protein 5B2 0 5.34e-159 0.0
1. PB Q54DV3 von Willebrand factor A domain-containing protein DDB_G0292016 6.69e-05 2.19e-06 5.97e-17
1. PB Q3UR50 von Willebrand factor A domain-containing protein 5B2 0.00e+00 1.63e-91 0.0
1. PB Q5TIE3 von Willebrand factor A domain-containing protein 5B1 6.83e-09 7.74e-56 6.44e-119
1. PB Q75WE7 von Willebrand factor A domain-containing protein 5A 1.71e-03 1.51e-04 1.47e-34
1. PB A9Z1V5 von Willebrand factor A domain-containing protein 5B1 7.44e-07 9.12e-55 1.31e-116
1. PB Q99KC8 von Willebrand factor A domain-containing protein 5A 9.91e-04 3.65e-03 1.50e-32
1. PB C7G046 von Willebrand factor A domain-containing protein DDB_G0286969 1.17e-02 6.66e-03 2.79e-11
1. PB O00534 von Willebrand factor A domain-containing protein 5A 3.61e-03 4.56e-02 3.04e-34
2. P P79263 Inter-alpha-trypsin inhibitor heavy chain H4 4.32e-03 7.05e-06 NA
2. P Q61702 Inter-alpha-trypsin inhibitor heavy chain H1 8.60e-04 1.85e-02 NA
2. P Q14624 Inter-alpha-trypsin inhibitor heavy chain H4 3.01e-03 7.75e-04 NA
2. P Q5RER0 Inter-alpha-trypsin inhibitor heavy chain H5 2.53e-02 2.73e-03 NA
2. P Q3T052 Inter-alpha-trypsin inhibitor heavy chain H4 9.98e-03 1.73e-05 NA
2. P A2VE29 Inter-alpha-trypsin inhibitor heavy chain H5 9.19e-03 4.75e-02 NA
2. P Q502W6 von Willebrand factor A domain-containing protein 3B 3.80e-01 3.76e-03 NA
2. P A6X935 Inter alpha-trypsin inhibitor, heavy chain 4 3.87e-03 7.98e-06 NA
2. P Q29052 Inter-alpha-trypsin inhibitor heavy chain H1 1.09e-03 1.83e-03 NA
2. P Q6UXX5 Inter-alpha-trypsin inhibitor heavy chain H6 1.21e-03 2.78e-14 NA
3. B Q55G98 von Willebrand factor A domain-containing protein DDB_G0267758 4.56e-06 NA 7.81e-12
3. B Q54MG1 von Willebrand factor A domain-containing protein DDB_G0285981 5.83e-09 NA 7.67e-14
3. B Q54MG4 von Willebrand factor A domain-containing protein DDB_G0285975 6.06e-05 NA 3.09e-14
3. B Q54CQ8 von Willebrand factor A domain-containing protein DDB_G0292740 4.43e-04 NA 1.46e-14
3. B Q54DU5 von Willebrand factor A domain-containing protein DDB_G0292028 4.50e-03 NA 8.28e-15
3. B E9PYK3 Protein mono-ADP-ribosyltransferase PARP4 2.50e-02 NA 3.97e-06
3. B Q9UKK3 Protein mono-ADP-ribosyltransferase PARP4 1.93e-03 NA 0.001