Summary

Q8N412

Homolog: Q8C8J0.
Function: Sperm-tail PG-rich repeat-containing protein 2.

Statistics

Total GO Annotation: 18
Unique PROST Go: 13
Unique BLAST Go: 2

Total Homologs: 15
Unique PROST Homologs: 6
Unique BLAST Homologs: 4

Structures and Sequence Alignment

The best structural homolog that predicted by 1. PB was Q8C8J0 (Sperm-tail PG-rich repeat-containing protein 2) with a FATCAT P-Value: 9.01e-05 and RMSD of 6.62 angstrom. The sequence alignment identity is 48.8%.
Structural alignment shown in left. Query protein Q8N412 colored as red in alignment, homolog Q8C8J0 colored as blue. Query protein Q8N412 is also shown in right top, homolog Q8C8J0 showed in right bottom. They are colored based on secondary structures. 

  Q8N412 MYDRAPRLLKLAEGGSTEAHVGPGSYQVPFLKQQATGSNAPFLSLTARESTFTIASSIEKAVPGPGHYNVSEAQ-------------K-----IS----- 77
  Q8C8J0 MYDRAPRWLDCANRGSTEEHVGPGTYQVPFPKQQATGCYAPFLSLSSKTSACVVSSDAGQAVPGPAHYNVSQAQYNIRGGRSLQNREKRFKKLISDGPGP 100

  Q8N412 --------------------RSPTLTRSVDVPSIPSCGKSYGYHINDDGSIIKCFPPACDSTLGPAYYKPQFDVSNATLKYKGIHFGNSSGRQELPKKSG 157
  Q8C8J0 GSYNWPYLGTLCITTRQKTPRTPAVSRNIDIPSIPSSGKSHGYHLNDDDTIMRRTPPPSDNTIGPAYYNPQFDYPKASLKYKGVNFGNATGRQEFLKYSG 200

  Q8N412 PGPGQYDIVQKKTSYYENVNIKRDQQQNYCSFIPRLYEIIVLQEKKK------------------------------------RFLPMKSITPAPGTYNE 221
  Q8C8J0 PGPGQYDIIQKRKLHCENINIKREQEHNYYTYVPRLYEAIILQEEKKGVPGPGKYNIKSEFDMIKSMSALVNSPSFIFFSETERFEPIKSCTPAPGTYNE 300

  Q8N412 PRTALKSLKKTSGLKNIPFGQSAVRFTQDIRTEEMPGPGFYNVLNNTIIASVRNICSKKQKKSAFGSSVPRTFFSVQKEACATPGPADYQEFWHSQGV-G 320
  Q8C8J0 IRTAFKCPKKRFGL-SLPFNQSAARFTEDSKAQKLPGPGFYDISTNIVKAQVKKPCLKKQPKTGFGSSVPRTLFTAQKKAFRGPGPSDYQ-------VRG 392

  Q8N412 ISDELPNLTNKYAAFLSRAKRTMKVPDMVIPAPGSYDVHKSYEMSQVKHKYMPPRSLVAKRKHASFLSATPRCLEKVTDGPGPAAYNPVLRKSCPIPLFV 420
  Q8C8J0 THDELPNL-NKSAAFLSRAEKTPPVRKMRLPAPGRYDVQKSYDMSQVKHKYMPPRTSVAKKRHSSFLSAAPRCLGKIADGPGPATYSPVLMKSGAIISFV 491

  Q8N412 KASKRFEE-SKEITPGPATYEIS---QE---KKKGNLIGEMAADIM-------------------------- 459
  Q8C8J0 KGPKRFQEFHGEFSPGPTTYELSPFLRHSLLKRTYNVT--LPCSSSPNRENTGCPSQKATQKFQREKLQYFN 561

Go Annotations

1. PB indicates the go terms that are found by both PROST and BLAST.
2. P indicates the go terms that are found by only PROST.
3. B indicates the go terms that are only annotated by BLAST.
Source GO Description
1. PB GO:1902110 positive regulation of mitochondrial membrane permeability involved in apoptotic process
1. PB GO:0043065 positive regulation of apoptotic process
1. PB GO:0005739 mitochondrion
2. P GO:0097177 mitochondrial ribosome binding
2. P GO:0001939 female pronucleus
2. P GO:0003682 chromatin binding
2. P GO:1901537 positive regulation of DNA demethylation
2. P GO:1903862 positive regulation of oxidative phosphorylation
2. P GO:0044727 DNA demethylation of male pronucleus
2. P GO:0042585 germinal vesicle
2. P GO:0009055 electron transfer activity
2. P GO:0005506 iron ion binding
2. P GO:0042393 histone binding
2. P GO:0008284 positive regulation of cell population proliferation
2. P GO:0051539 4 iron, 4 sulfur cluster binding
2. P GO:0001940 male pronucleus
3. B GO:0005634 nucleus
3. B GO:0006915 apoptotic process

Homologs

1. PB indicates the homologs that are found by both PROST and BLAST.
2. P indicates homologs that are only found by PROST.
3. B indicates homologs that are only found by BLAST.

Source Homolog Description FATCAT p-val PROST Evalue BLAST Evalue
1. PB Q4KLY8 O(6)-methylguanine-induced apoptosis 2 5.94e-01 1.39e-02 0.006
1. PB Q8C8J0 Sperm-tail PG-rich repeat-containing protein 2 9.01e-05 4.83e-22 4.50e-179
1. PB Q8N412 Sperm-tail PG-rich repeat-containing protein 2 0 9.38e-151 0.0
1. PB A1A5R9 Sperm-tail PG-rich repeat-containing protein 2 1.22e-02 1.22e-16 7.30e-180
1. PB Q08BC4 Sperm-tail PG-rich repeat-containing protein 2 2.08e-02 5.22e-16 2.37e-80
2. P B1H283 Lymphocyte expansion molecule 6.92e-01 2.98e-07 NA
2. P Q50784 Polyferredoxin protein MvhB 9.86e-01 1.40e-02 NA
2. P A5WUY6 O(6)-methylguanine-induced apoptosis 2 7.09e-01 6.74e-03 NA
2. P Q3ZCV2 Lymphocyte expansion molecule 7.65e-01 1.05e-03 NA
2. P P60232 Polyferredoxin protein MvhB 9.80e-01 3.89e-02 NA
2. P A2AVQ5 Lymphocyte expansion molecule 6.36e-01 6.63e-06 NA
3. B Q3KQ80 O(6)-methylguanine-induced apoptosis 2 7.18e-01 NA 5.71e-06
3. B Q5TH74 O(6)-methylguanine-induced apoptosis 2 6.12e-01 NA 0.003
3. B A6QQ60 O(6)-methylguanine-induced apoptosis 2 5.95e-01 NA 3.15e-04
3. B Q9D2F5 O(6)-methylguanine-induced apoptosis 2 6.37e-01 NA 0.036