Summary

Q8N4P6

Homolog: Q9D3W5.
Function: Leucine-rich repeat-containing protein 71.

Statistics

Total GO Annotation: 196
Unique PROST Go: 32
Unique BLAST Go: 160

Total Homologs: 68
Unique PROST Homologs: 16
Unique BLAST Homologs: 34

Structures and Sequence Alignment

The best structural homolog that predicted by 1. PB was Q9D3W5 (Leucine-rich repeat-containing protein 71) with a FATCAT P-Value: 1.53e-13 and RMSD of 4.88 angstrom. The sequence alignment identity is 80.7%.
Structural alignment shown in left. Query protein Q8N4P6 colored as red in alignment, homolog Q9D3W5 colored as blue. Query protein Q8N4P6 is also shown in right top, homolog Q9D3W5 showed in right bottom. They are colored based on secondary structures.

  Q8N4P6 MSSEQSAPGASPRAPRPGTQKSSGAVTKKGERAAKEKPATVLPPVGEEEPKSPEEYQCSGVLETDFAELCTRWGYTDFPKVVNRPRPHPPFVPSASLSEK 100
  Q9D3W5 MSSEPSTTGTSPRTPRPGAQKSSGAVTKKGDRAAKDKTASTLPPVGEDEPKNPEEYQCTGVLETDFAELCTRSGYVDFPKVVTRPRVQQSSVPSASTSEK 100

  Q8N4P6 ATLDDPRLSGSCSLNSLESKYVFFRPTIQVELEQEDSKSVKEIYIRGWKVEERILGVFSKCLPPLTQLQAINLWKVGLTDKTLTTFIELLPLCSSTLRKV 200
  Q9D3W5 PVLDDQRPSASCSQSSLESKYVFFRPTIQVELEQEDSKAVKEIYIRGWKVEDRILGIFSKCLPSLSQLQAINLWKVGLTDKTLTTFIALLPLCSSTLRKV 200

  Q8N4P6 SLEGNPLPEQSYHKLMALDSTIAHLSLRNNNIDDRGAQLLGQALSTLHSCNRTLVSLNLGFNHIGDEGAGYIADGLRLNRSLLWLSLAHNRIQDKGALKL 300
  Q9D3W5 SLEGNPIPEQSFSKLMGLDSTIVHLSLRNNNINDHGAQLLGQALSTLQNSNRTLVSLNLAFNHIGDVGAGYIADGLRLNRSLLWLSLAHNHIQDKGALKL 300

  Q8N4P6 AEVLRAFELTHTEVVERRRLLLEKGTQERSRSPSSSRHGDSKTDREKSQMVGISNSALVDKTDKTQTMKTPKGLGKKKEKSWELAKKEEKLGSGQSPTQG 400
  Q9D3W5 AEVLRPFELTHREVVERRRLLLVKGTQERSRSPSSSRYGDSKAEREKSQTLGISNVTLVDKQEKMQSLKAPKTISKKKEKTGEVVKKEEKLGSGQSPTQG 400

  Q8N4P6 TPKKEDATKAGKGKVTIPEQKPSRAKGIKIGSREKRSILLESE-LVVEATEVVNPLLEPVEHRDGKVFMPGNKVLLHLNLIRNRITEVGLEGFLATVQYQ 499
  Q9D3W5 TPKKEDAAKAGKGKVTIPEQKMSKGKATKMGAKEKRSILLESEQLVVEATEMVNPLLEPVEHRDGKVFLPGNKVLLHLNLLRNQITEVGLEGFLTAVQYQ 500

  Q8N4P6 MQFSKAKSASKGPVGLLWLSLAKNCFAPQCPAYAIIQELMLPRDPIKAKLREDEAMAFFP 559
  Q9D3W5 VQVSKPKTSPKAPLGLLWLSLAKNCFDPQCPTHVMIQELMLPRDPVKAKAREEEAAAT-- 558

Go Annotations

1. PB indicates the go terms that are found by both PROST and BLAST.
2. P indicates the go terms that are found by only PROST.
3. B indicates the go terms that are only annotated by BLAST.
Source GO Description
1. PB GO:0030154 cell differentiation
1. PB GO:0004864 protein phosphatase inhibitor activity
1. PB GO:0007015 actin filament organization
1. PB GO:0005730 nucleolus
2. P GO:0005096 GTPase activator activity
2. P GO:0060170 ciliary membrane
2. P GO:0030239 myofibril assembly
2. P GO:0009504 cell plate
2. P GO:0006941 striated muscle contraction
2. P GO:0005819 spindle
2. P GO:0009524 phragmoplast
2. P GO:0019005 SCF ubiquitin ligase complex
2. P GO:0030016 myofibril
2. P GO:0048741 skeletal muscle fiber development
2. P GO:0043231 intracellular membrane-bounded organelle
2. P GO:0031965 nuclear membrane
2. P GO:0045010 actin nucleation
2. P GO:0005523 tropomyosin binding
2. P GO:0031514 motile cilium
2. P GO:0048743 positive regulation of skeletal muscle fiber development
2. P GO:0005865 striated muscle thin filament
2. P GO:0051694 pointed-end actin filament capping
2. P GO:0031430 M band
2. P GO:0006936 muscle contraction
2. P GO:0030030 cell projection organization
2. P GO:0006913 nucleocytoplasmic transport
2. P GO:0006606 protein import into nucleus
2. P GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
2. P GO:0031672 A band
2. P GO:0005930 axoneme
2. P GO:0030240 skeletal muscle thin filament assembly
2. P GO:0000911 cytokinesis by cell plate formation
2. P GO:0007165 signal transduction
2. P GO:0005635 nuclear envelope
2. P GO:0004722 protein serine/threonine phosphatase activity
2. P GO:0003785 actin monomer binding
3. B GO:0036336 dendritic cell migration
3. B GO:0050680 negative regulation of epithelial cell proliferation
3. B GO:0051656 establishment of organelle localization
3. B GO:0044319 wound healing, spreading of cells
3. B GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding
3. B GO:0045591 positive regulation of regulatory T cell differentiation
3. B GO:0032701 negative regulation of interleukin-18 production
3. B GO:0009595 detection of biotic stimulus
3. B GO:0032720 negative regulation of tumor necrosis factor production
3. B GO:0032755 positive regulation of interleukin-6 production
3. B GO:0051639 actin filament network formation
3. B GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin
3. B GO:0010942 positive regulation of cell death
3. B GO:0031953 negative regulation of protein autophosphorylation
3. B GO:0072558 NLRP1 inflammasome complex
3. B GO:0043549 regulation of kinase activity
3. B GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
3. B GO:0048147 negative regulation of fibroblast proliferation
3. B GO:0034451 centriolar satellite
3. B GO:0048872 homeostasis of number of cells
3. B GO:0060471 cortical granule exocytosis
3. B GO:0032733 positive regulation of interleukin-10 production
3. B GO:0060340 positive regulation of type I interferon-mediated signaling pathway
3. B GO:0032879 regulation of localization
3. B GO:0002710 negative regulation of T cell mediated immunity
3. B GO:0032498 detection of muramyl dipeptide
3. B GO:0071224 cellular response to peptidoglycan
3. B GO:0044877 protein-containing complex binding
3. B GO:1904417 positive regulation of xenophagy
3. B GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
3. B GO:0042834 peptidoglycan binding
3. B GO:0045751 negative regulation of Toll signaling pathway
3. B GO:0002732 positive regulation of dendritic cell cytokine production
3. B GO:1900016 negative regulation of cytokine production involved in inflammatory response
3. B GO:0045179 apical cortex
3. B GO:0002830 positive regulation of type 2 immune response
3. B GO:0061851 leading edge of lamellipodium
3. B GO:0140608 cysteine-type endopeptidase activator activity
3. B GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
3. B GO:1900029 positive regulation of ruffle assembly
3. B GO:0009986 cell surface
3. B GO:0042110 T cell activation
3. B GO:0090091 positive regulation of extracellular matrix disassembly
3. B GO:0050871 positive regulation of B cell activation
3. B GO:2000363 positive regulation of prostaglandin-E synthase activity
3. B GO:0006954 inflammatory response
3. B GO:0046645 positive regulation of gamma-delta T cell activation
3. B GO:0051293 establishment of spindle localization
3. B GO:0032494 response to peptidoglycan
3. B GO:0002227 innate immune response in mucosa
3. B GO:0050766 positive regulation of phagocytosis
3. B GO:1901223 negative regulation of NIK/NF-kappaB signaling
3. B GO:0030011 maintenance of cell polarity
3. B GO:0016323 basolateral plasma membrane
3. B GO:0030277 maintenance of gastrointestinal epithelium
3. B GO:0019901 protein kinase binding
3. B GO:0030544 Hsp70 protein binding
3. B GO:0002862 negative regulation of inflammatory response to antigenic stimulus
3. B GO:0050700 CARD domain binding
3. B GO:0060339 negative regulation of type I interferon-mediated signaling pathway
3. B GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process
3. B GO:0045345 positive regulation of MHC class I biosynthetic process
3. B GO:0045089 positive regulation of innate immune response
3. B GO:0031252 cell leading edge
3. B GO:0051092 positive regulation of NF-kappaB transcription factor activity
3. B GO:0045087 innate immune response
3. B GO:0051353 positive regulation of oxidoreductase activity
3. B GO:0005856 cytoskeleton
3. B GO:0045824 negative regulation of innate immune response
3. B GO:0061339 establishment or maintenance of monopolar cell polarity
3. B GO:0071222 cellular response to lipopolysaccharide
3. B GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation
3. B GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
3. B GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process
3. B GO:0039536 negative regulation of RIG-I signaling pathway
3. B GO:0061702 inflammasome complex
3. B GO:0036126 sperm flagellum
3. B GO:0071225 cellular response to muramyl dipeptide
3. B GO:0060473 cortical granule
3. B GO:0032760 positive regulation of tumor necrosis factor production
3. B GO:0002606 positive regulation of dendritic cell antigen processing and presentation
3. B GO:0038187 pattern recognition receptor activity
3. B GO:0007249 I-kappaB kinase/NF-kappaB signaling
3. B GO:0002720 positive regulation of cytokine production involved in immune response
3. B GO:0046330 positive regulation of JNK cascade
3. B GO:0050728 negative regulation of inflammatory response
3. B GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process
3. B GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling
3. B GO:0032735 positive regulation of interleukin-12 production
3. B GO:0046597 negative regulation of viral entry into host cell
3. B GO:0070374 positive regulation of ERK1 and ERK2 cascade
3. B GO:0034136 negative regulation of toll-like receptor 2 signaling pathway
3. B GO:0032715 negative regulation of interleukin-6 production
3. B GO:0050679 positive regulation of epithelial cell proliferation
3. B GO:0032692 negative regulation of interleukin-1 production
3. B GO:0071257 cellular response to electrical stimulus
3. B GO:0006887 exocytosis
3. B GO:0071639 positive regulation of monocyte chemotactic protein-1 production
3. B GO:0032757 positive regulation of interleukin-8 production
3. B GO:0032687 negative regulation of interferon-alpha production
3. B GO:0032088 negative regulation of NF-kappaB transcription factor activity
3. B GO:0045348 positive regulation of MHC class II biosynthetic process
3. B GO:0051879 Hsp90 protein binding
3. B GO:0060335 positive regulation of interferon-gamma-mediated signaling pathway
3. B GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
3. B GO:0051000 positive regulation of nitric-oxide synthase activity
3. B GO:0019899 enzyme binding
3. B GO:0002253 activation of immune response
3. B GO:0032731 positive regulation of interleukin-1 beta production
3. B GO:1902523 positive regulation of protein K63-linked ubiquitination
3. B GO:0032689 negative regulation of interferon-gamma production
3. B GO:0002221 pattern recognition receptor signaling pathway
3. B GO:0032703 negative regulation of interleukin-2 production
3. B GO:0032695 negative regulation of interleukin-12 production
3. B GO:2000813 negative regulation of barbed-end actin filament capping
3. B GO:0007584 response to nutrient
3. B GO:1900017 positive regulation of cytokine production involved in inflammatory response
3. B GO:2000110 negative regulation of macrophage apoptotic process
3. B GO:0017024 myosin I binding
3. B GO:0043330 response to exogenous dsRNA
3. B GO:0090022 regulation of neutrophil chemotaxis
3. B GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
3. B GO:0042585 germinal vesicle
3. B GO:0043487 regulation of RNA stability
3. B GO:0005794 Golgi apparatus
3. B GO:0106333 subcortical maternal complex
3. B GO:1902745 positive regulation of lamellipodium organization
3. B GO:0042981 regulation of apoptotic process
3. B GO:0030317 flagellated sperm motility
3. B GO:0051302 regulation of cell division
3. B GO:0045747 positive regulation of Notch signaling pathway
3. B GO:0070685 macropinocytic cup
3. B GO:0032991 protein-containing complex
3. B GO:0097300 programmed necrotic cell death
3. B GO:0032495 response to muramyl dipeptide
3. B GO:0006963 positive regulation of antibacterial peptide biosynthetic process
3. B GO:0032740 positive regulation of interleukin-17 production
3. B GO:0043406 positive regulation of MAP kinase activity
3. B GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway
3. B GO:0040019 positive regulation of embryonic development
3. B GO:0032688 negative regulation of interferon-beta production
3. B GO:0031982 vesicle
3. B GO:0060585 positive regulation of prostaglandin-endoperoxide synthase activity
3. B GO:0035556 intracellular signal transduction
3. B GO:0015631 tubulin binding
3. B GO:0050727 regulation of inflammatory response
3. B GO:0046658 anchored component of plasma membrane
3. B GO:0032874 positive regulation of stress-activated MAPK cascade
3. B GO:0071407 cellular response to organic cyclic compound
3. B GO:0045944 positive regulation of transcription by RNA polymerase II
3. B GO:0016045 detection of bacterium
3. B GO:0042742 defense response to bacterium
3. B GO:0045335 phagocytic vesicle
3. B GO:0006965 positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria
3. B GO:0044354 macropinosome
3. B GO:0005938 cell cortex
3. B GO:0050830 defense response to Gram-positive bacterium
3. B GO:0032500 muramyl dipeptide binding
3. B GO:1900226 negative regulation of NLRP3 inflammasome complex assembly
3. B GO:1901224 positive regulation of NIK/NF-kappaB signaling

Homologs

1. PB indicates the homologs that are found by both PROST and BLAST.
2. P indicates homologs that are only found by PROST.
3. B indicates homologs that are only found by BLAST.

Source Homolog Description FATCAT p-val PROST Evalue BLAST Evalue
1. PB Q8BKR5 Protein phosphatase 1 regulatory subunit 37 4.83e-03 6.90e-05 1.21e-05
1. PB Q19857 Protein phosphatase 1 regulatory subunit 37 homolog 2.43e-03 2.76e-09 0.022
1. PB Q9DAM1 Leucine-rich repeat-containing protein 34 1.16e-04 3.51e-05 0.005
1. PB A8HMZ4 Dynein regulatory complex subunit 5 1.29e-04 1.68e-05 5.32e-04
1. PB O75864 Protein phosphatase 1 regulatory subunit 37 4.00e-03 2.82e-04 8.19e-06
1. PB Q0VAA2 Leucine-rich repeat-containing protein 74A 4.58e-04 9.69e-07 8.57e-06
1. PB Q9M651 RAN GTPase-activating protein 2 6.96e-03 2.26e-02 0.021
1. PB A8Y3R9 Protein phosphatase 1 regulatory subunit 37 homolog 1.05e-02 2.72e-08 8.09e-04
1. PB Q9D3W5 Leucine-rich repeat-containing protein 71 1.53e-13 2.16e-93 0.0
1. PB Q14BP6 Leucine-rich repeat-containing protein 74B 8.77e-04 1.40e-08 1.04e-04
1. PB A0JPI9 Leucine-rich repeat-containing protein 74A 8.25e-05 1.27e-09 9.51e-07
1. PB Q8IZ02 Leucine-rich repeat-containing protein 34 6.53e-05 4.78e-08 8.75e-04
1. PB Q6ZQY2 Leucine-rich repeat-containing protein 74B 4.91e-04 8.04e-08 6.34e-06
1. PB B2RYF1 Protein phosphatase 1 regulatory subunit 37 2.06e-02 3.12e-04 9.66e-06
1. PB Q1L994 Protein phosphatase 1 regulatory subunit 37 2.31e-03 1.31e-03 8.77e-06
1. PB Q8N4P6 Leucine-rich repeat-containing protein 71 0 2.00e-153 0.0
1. PB Q4V8D9 Leucine-rich repeat-containing protein 34 8.97e-05 3.94e-03 0.004
1. PB A7Z026 Protein phosphatase 1 regulatory subunit 37 2.76e-03 6.66e-05 5.53e-07
2. P Q4KLV2 Leucine-rich repeat-containing protein 42 8.06e-02 1.63e-02 NA
2. P Q0P4D1 Protein AMN1 homolog 2.45e-02 3.07e-02 NA
2. P Q6PEZ8 Podocan-like protein 1 1.95e-02 2.73e-03 NA
2. P Q6UY01 Leucine-rich repeat-containing protein 31 1.08e-02 1.99e-04 NA
2. P Q8R2U7 Leucine-rich repeat-containing protein 42 2.64e-02 3.03e-06 NA
2. P Q9Y546 Leucine-rich repeat-containing protein 42 7.93e-02 1.58e-08 NA
2. P E9QA62 Leiomodin-3 1.12e-02 4.37e-03 NA
2. P Q3UV48 Leucine-rich repeat-containing protein 30 9.06e-02 3.52e-02 NA
2. P A6NM36 Leucine-rich repeat-containing protein 30 9.59e-02 7.95e-03 NA
2. P Q9LE82 RAN GTPase-activating protein 1 2.10e-03 8.78e-05 NA
2. P Q2HJ90 Leucine-rich repeat-containing protein 42 1.11e-01 1.60e-07 NA
2. P Q4KM95 Leucine-rich repeat-containing protein 42 4.89e-02 4.72e-06 NA
2. P Q5U201 Protein AMN1 homolog 2.73e-03 1.99e-02 NA
2. P Q387Y5 Leucine-rich repeat-containing protein 56 homolog 3.68e-02 3.84e-02 NA
2. P Q0V9Y8 Leucine-rich repeat-containing protein 42 3.17e-02 1.20e-06 NA
2. P A6NHZ5 Leucine-rich repeat-containing protein 14B 9.70e-03 3.78e-03 NA
3. B Q66X19 NACHT, LRR and PYD domains-containing protein 4E 3.65e-02 NA 8.73e-05
3. B P10775 Ribonuclease inhibitor 1.07e-03 NA 0.018
3. B A6H639 Dynein regulatory complex subunit 5 8.83e-04 NA 2.07e-06
3. B Q86WI3 Protein NLRC5 1.18e-01 NA 0.007
3. B Q7RTR2 NLR family CARD domain-containing protein 3 1.51e-02 NA 1.17e-09
3. B Q4R642 Dynein regulatory complex subunit 5 1.28e-03 NA 1.68e-04
3. B Q3TL44 NLR family member X1 3.23e-02 NA 0.009
3. B Q9Y239 Nucleotide-binding oligomerization domain-containing protein 1 1.62e-02 NA 0.001
3. B Q3TKR3 NACHT, LRR and PYD domains-containing protein 4C 3.19e-02 NA 4.38e-04
3. B Q3V3V9 Capping protein, Arp2/3 and myosin-I linker protein 2 7.54e-02 NA 0.043
3. B Q2LKU9 NACHT, LRR and PYD domains-containing protein 1a 7.91e-02 NA 0.030
3. B Q96CN5 Leucine-rich repeat-containing protein 45 1.83e-03 NA 0.009
3. B E9Q5R7 NACHT, LRR and PYD domains-containing protein 12 1.64e-02 NA 0.003
3. B Q5DU56 Protein NLRC3 1.91e-02 NA 9.94e-09
3. B Q5JU00 Dynein regulatory complex subunit 5 2.94e-04 NA 1.73e-04
3. B Q5ZI11 Leucine-rich repeat-containing protein 45 1.11e-03 NA 0.002
3. B Q53B88 Nucleotide-binding oligomerization domain-containing protein 2 1.82e-02 NA 1.34e-09
3. B Q1ZXD6 Probable serine/threonine-protein kinase roco5 NA NA 1.31e-06
3. B Q647I9 NACHT, LRR and PYD domains-containing protein 5 2.82e-02 NA 0.002
3. B Q6B966 NACHT, LRR and PYD domains-containing protein 14 4.56e-02 NA 0.026
3. B Q9R1M5 NACHT, LRR and PYD domains-containing protein 5 9.07e-02 NA 0.005
3. B Q95VZ3 Protein CARMIL 3.49e-02 NA 0.001
3. B Q6E804 Nucleotide-binding oligomerization domain-containing protein 2 1.03e-02 NA 1.18e-04
3. B Q8K3Z0 Nucleotide-binding oligomerization domain-containing protein 2 1.37e-02 NA 8.41e-06
3. B Q86W25 NACHT, LRR and PYD domains-containing protein 13 3.08e-02 NA 6.51e-04
3. B P59047 NACHT, LRR and PYD domains-containing protein 5 1.08e-01 NA 7.09e-06
3. B Q8CIM1 Leucine-rich repeat-containing protein 45 1.78e-03 NA 7.02e-04
3. B Q8BHB0 Nucleotide-binding oligomerization domain-containing protein 1 1.64e-02 NA 2.23e-04
3. B Q53B87 Nucleotide-binding oligomerization domain-containing protein 2 2.50e-02 NA 3.58e-10
3. B P79621 MHC class II transactivator 8.98e-02 NA 1.25e-05
3. B Q86W24 NACHT, LRR and PYD domains-containing protein 14 3.98e-02 NA 3.40e-04
3. B Q8BU40 NACHT, LRR and PYD domains-containing protein 4A 2.37e-02 NA 0.002
3. B Q9HC29 Nucleotide-binding oligomerization domain-containing protein 2 2.36e-02 NA 1.01e-09
3. B Q96MN2 NACHT, LRR and PYD domains-containing protein 4 1.79e-02 NA 2.83e-04