Summary

Q8N7Z2

Homolog: A8MZA4.
Function: Golgin subfamily A member 6-like protein 6.

Statistics

Total GO Annotation: 212
Unique PROST Go: 50
Unique BLAST Go: 133

Total Homologs: 79
Unique PROST Homologs: 30
Unique BLAST Homologs: 36

Structures and Sequence Alignment

The best structural homolog that predicted by 1. PB was A8MZA4 (Golgin subfamily A member 6-like protein 6) with a FATCAT P-Value: 0.0 and RMSD of 5.61 angstrom. The sequence alignment identity is 85.1%.
Structural alignment shown in left. Query protein Q8N7Z2 colored as red in alignment, homolog A8MZA4 colored as blue. Query protein Q8N7Z2 is also shown in right top, homolog A8MZA4 showed in right bottom. They are colored based on secondary structures.

  Q8N7Z2 MLMWPQPHLPTHPHLPTHPHLPTHPHLPTHPHLPTHPHLPTHPHLPTHPMMSKETRQSKLAEAKEQLTDHHPQTNPSVGTAASDTKKKKINNGTNPETTT 100
  A8MZA4 MLMWPQ------------PHLPTHPHLPTHPHLPTHPHLPTHPHLPTHPMMSKETRQSKLAEAKEQLTDHHPQTNPSVGTAASDTKKKKINNGTNPETTT 88

  Q8N7Z2 SGGCHSPEDEQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTK 200
  A8MZA4 SGGCHSPEDEQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTK 188

  Q8N7Z2 ERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEE 300
  A8MZA4 ERDALSLELYRNTITDEELKEKNAELQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEE 288

  Q8N7Z2 KMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQ 400
  A8MZA4 KMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQ 388

  Q8N7Z2 EEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQ-EKIRKQEEKVWR 499
  A8MZA4 EEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEEKIRKQEEKVWR 488

  Q8N7Z2 QEEKMHDQEEKIREQEEKMWRQEEKIRE--------------------------------QEEKIRE-------QEEKIREQEEMMQEQEEKMGEQEEKM 560
  A8MZA4 QEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKI 588

  Q8N7Z2 QEQ-EKMRRQEEKIREQEEKIREQ---------K--------------------------EKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCE 624
  A8MZA4 REQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCE 688

  Q8N7Z2 QEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEAAI 668
  A8MZA4 QEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEH-------- 724

Go Annotations

1. PB indicates the go terms that are found by both PROST and BLAST.
2. P indicates the go terms that are found by only PROST.
3. B indicates the go terms that are only annotated by BLAST.
Source GO Description
1. PB GO:0050772 positive regulation of axonogenesis
1. PB GO:0060050 positive regulation of protein glycosylation
1. PB GO:0051289 protein homotetramerization
1. PB GO:0090161 Golgi ribbon formation
1. PB GO:0008356 asymmetric cell division
1. PB GO:0010507 negative regulation of autophagy
1. PB GO:0007098 centrosome cycle
1. PB GO:0000922 spindle pole
1. PB GO:0005794 Golgi apparatus
1. PB GO:0072686 mitotic spindle
1. PB GO:0030134 COPII-coated ER to Golgi transport vesicle
1. PB GO:0006486 protein glycosylation
1. PB GO:0020016 ciliary pocket
1. PB GO:0032091 negative regulation of protein binding
1. PB GO:0090306 meiotic spindle assembly
1. PB GO:0007030 Golgi organization
1. PB GO:0000137 Golgi cis cisterna
1. PB GO:0005801 cis-Golgi network
1. PB GO:0008017 microtubule binding
1. PB GO:0061676 importin-alpha family protein binding
1. PB GO:0007020 microtubule nucleation
1. PB GO:0051645 Golgi localization
1. PB GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport
1. PB GO:0032580 Golgi cisterna membrane
1. PB GO:0090307 mitotic spindle assembly
1. PB GO:0019905 syntaxin binding
1. PB GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane
1. PB GO:0090166 Golgi disassembly
1. PB GO:0051225 spindle assembly
2. P GO:0048471 perinuclear region of cytoplasm
2. P GO:0003682 chromatin binding
2. P GO:0010445 nuclear dicing body
2. P GO:0030336 negative regulation of cell migration
2. P GO:0007420 brain development
2. P GO:0000151 ubiquitin ligase complex
2. P GO:0035279 miRNA-mediated gene silencing by mRNA destabilization
2. P GO:0031492 nucleosomal DNA binding
2. P GO:0005654 nucleoplasm
2. P GO:0006511 ubiquitin-dependent protein catabolic process
2. P GO:0005796 Golgi lumen
2. P GO:0031625 ubiquitin protein ligase binding
2. P GO:0010008 endosome membrane
2. P GO:0033503 HULC complex
2. P GO:0010589 leaf proximal/distal pattern formation
2. P GO:0043588 skin development
2. P GO:0006325 chromatin organization
2. P GO:0003713 transcription coactivator activity
2. P GO:0035198 miRNA binding
2. P GO:0030016 myofibril
2. P GO:0098792 xenophagy
2. P GO:0031062 positive regulation of histone methylation
2. P GO:0045109 intermediate filament organization
2. P GO:0000209 protein polyubiquitination
2. P GO:0035196 production of miRNAs involved in gene silencing by miRNA
2. P GO:0010305 leaf vascular tissue pattern formation
2. P GO:0010390 histone monoubiquitination
2. P GO:0009735 response to cytokinin
2. P GO:0016574 histone ubiquitination
2. P GO:0030422 production of siRNA involved in RNA interference
2. P GO:0005634 nucleus
2. P GO:0010267 primary ta-siRNA processing
2. P GO:1901098 positive regulation of autophagosome maturation
2. P GO:0002039 p53 binding
2. P GO:0033523 histone H2B ubiquitination
2. P GO:0000139 Golgi membrane
2. P GO:2001168 positive regulation of histone H2B ubiquitination
2. P GO:0032982 myosin filament
2. P GO:0004842 ubiquitin-protein transferase activity
2. P GO:0031054 pre-miRNA processing
2. P GO:1900364 negative regulation of mRNA polyadenylation
2. P GO:0045893 positive regulation of transcription, DNA-templated
2. P GO:0070307 lens fiber cell development
2. P GO:0005730 nucleolus
2. P GO:0042802 identical protein binding
2. P GO:0016459 myosin complex
2. P GO:0042255 ribosome assembly
2. P GO:0031053 primary miRNA processing
2. P GO:0003730 mRNA 3'-UTR binding
2. P GO:0042393 histone binding
3. B GO:1990535 neuron projection maintenance
3. B GO:0071711 basement membrane organization
3. B GO:1990414 replication-born double-strand break repair via sister chromatid exchange
3. B GO:0010737 protein kinase A signaling
3. B GO:0046007 negative regulation of activated T cell proliferation
3. B GO:0045886 negative regulation of synaptic assembly at neuromuscular junction
3. B GO:0007414 axonal defasciculation
3. B GO:0005874 microtubule
3. B GO:0009888 tissue development
3. B GO:0005608 laminin-3 complex
3. B GO:1901588 dendritic microtubule
3. B GO:0071169 establishment of protein localization to chromatin
3. B GO:0005201 extracellular matrix structural constituent
3. B GO:0002011 morphogenesis of an epithelial sheet
3. B GO:0044409 entry into host
3. B GO:0035118 embryonic pectoral fin morphogenesis
3. B GO:1903136 cuprous ion binding
3. B GO:1900449 regulation of glutamate receptor signaling pathway
3. B GO:0043083 synaptic cleft
3. B GO:0008307 structural constituent of muscle
3. B GO:0050860 negative regulation of T cell receptor signaling pathway
3. B GO:0007507 heart development
3. B GO:0051371 muscle alpha-actinin binding
3. B GO:0019828 aspartic-type endopeptidase inhibitor activity
3. B GO:0030334 regulation of cell migration
3. B GO:0031430 M band
3. B GO:0048514 blood vessel morphogenesis
3. B GO:0005911 cell-cell junction
3. B GO:0045995 regulation of embryonic development
3. B GO:0051788 response to misfolded protein
3. B GO:0031672 A band
3. B GO:0098003 viral tail assembly
3. B GO:0045214 sarcomere organization
3. B GO:0043256 laminin complex
3. B GO:0043194 axon initial segment
3. B GO:0030240 skeletal muscle thin filament assembly
3. B GO:0035633 maintenance of blood-brain barrier
3. B GO:0042805 actinin binding
3. B GO:1902951 negative regulation of dendritic spine maintenance
3. B GO:0030018 Z disc
3. B GO:0060441 epithelial tube branching involved in lung morphogenesis
3. B GO:0099642 retrograde axonal protein transport
3. B GO:0098737 protein insertion into plasma membrane
3. B GO:0009887 animal organ morphogenesis
3. B GO:0097493 structural molecule activity conferring elasticity
3. B GO:0005737 cytoplasm
3. B GO:0055013 cardiac muscle cell development
3. B GO:0070050 neuron cellular homeostasis
3. B GO:0044307 dendritic branch
3. B GO:0005859 muscle myosin complex
3. B GO:0099641 anterograde axonal protein transport
3. B GO:0031802 type 5 metabotropic glutamate receptor binding
3. B GO:0002020 protease binding
3. B GO:0000270 peptidoglycan metabolic process
3. B GO:0019901 protein kinase binding
3. B GO:0090694 Scc2-Scc4 cohesin loading complex
3. B GO:0060048 cardiac muscle contraction
3. B GO:0060419 heart growth
3. B GO:0055003 cardiac myofibril assembly
3. B GO:1903135 cupric ion binding
3. B GO:0042383 sarcolemma
3. B GO:0061304 retinal blood vessel morphogenesis
3. B GO:0005865 striated muscle thin filament
3. B GO:0006936 muscle contraction
3. B GO:0003007 heart morphogenesis
3. B GO:0045198 establishment of epithelial cell apical/basal polarity
3. B GO:1902938 regulation of intracellular calcium activated chloride channel activity
3. B GO:0050053 levansucrase activity
3. B GO:0008933 lytic transglycosylase activity
3. B GO:1902817 negative regulation of protein localization to microtubule
3. B GO:0043056 forward locomotion
3. B GO:0098932 disruption by virus of host cell wall peptidoglycan during virus entry
3. B GO:0004713 protein tyrosine kinase activity
3. B GO:0010950 positive regulation of endopeptidase activity
3. B GO:0007411 axon guidance
3. B GO:0150001 primary dendrite
3. B GO:0045859 regulation of protein kinase activity
3. B GO:0031674 I band
3. B GO:0006941 striated muscle contraction
3. B GO:1905406 positive regulation of mitotic cohesin loading
3. B GO:0043197 dendritic spine
3. B GO:0005102 signaling receptor binding
3. B GO:0005606 laminin-1 complex
3. B GO:0035011 melanotic encapsulation of foreign target
3. B GO:0032700 negative regulation of interleukin-17 production
3. B GO:0040017 positive regulation of locomotion
3. B GO:0008022 protein C-terminus binding
3. B GO:0048208 COPII vesicle coating
3. B GO:0099001 viral genome ejection through host cell envelope, long flexible tail mechanism
3. B GO:0009758 carbohydrate utilization
3. B GO:1905664 regulation of calcium ion import across plasma membrane
3. B GO:0002224 toll-like receptor signaling pathway
3. B GO:0043621 protein self-association
3. B GO:0051592 response to calcium ion
3. B GO:0055008 cardiac muscle tissue morphogenesis
3. B GO:0043010 camera-type eye development
3. B GO:0031114 regulation of microtubule depolymerization
3. B GO:1901897 regulation of relaxation of cardiac muscle
3. B GO:0003146 heart jogging
3. B GO:0043208 glycosphingolipid binding
3. B GO:0003300 cardiac muscle hypertrophy
3. B GO:0007155 cell adhesion
3. B GO:0007512 adult heart development
3. B GO:0050882 voluntary musculoskeletal movement
3. B GO:0031433 telethonin binding
3. B GO:0031594 neuromuscular junction
3. B GO:0030155 regulation of cell adhesion
3. B GO:0032703 negative regulation of interleukin-2 production
3. B GO:0060445 branching involved in salivary gland morphogenesis
3. B GO:0032224 positive regulation of synaptic transmission, cholinergic
3. B GO:0048769 sarcomerogenesis
3. B GO:0070885 negative regulation of calcineurin-NFAT signaling cascade
3. B GO:0005604 basement membrane
3. B GO:0050714 positive regulation of protein secretion
3. B GO:0000794 condensed nuclear chromosome
3. B GO:0035001 dorsal trunk growth, open tracheal system
3. B GO:0021591 ventricular system development
3. B GO:0036062 presynaptic periactive zone
3. B GO:2000010 positive regulation of protein localization to cell surface
3. B GO:0030241 skeletal muscle myosin thick filament assembly
3. B GO:0090647 modulation of age-related behavioral decline
3. B GO:1901379 regulation of potassium ion transmembrane transport
3. B GO:0055002 striated muscle cell development
3. B GO:0071921 cohesin loading
3. B GO:0062023 collagen-containing extracellular matrix
3. B GO:0048703 embryonic viscerocranium morphogenesis
3. B GO:0034087 establishment of mitotic sister chromatid cohesion
3. B GO:0035995 detection of muscle stretch
3. B GO:1903829 positive regulation of protein localization
3. B GO:0014037 Schwann cell differentiation
3. B GO:0050790 regulation of catalytic activity
3. B GO:0008093 cytoskeletal anchor activity
3. B GO:0030506 ankyrin binding

Homologs

1. PB indicates the homologs that are found by both PROST and BLAST.
2. P indicates homologs that are only found by PROST.
3. B indicates homologs that are only found by BLAST.

Source Homolog Description FATCAT p-val PROST Evalue BLAST Evalue
1. PB Q9NYA3 Golgin subfamily A member 6A 1.74e-11 2.39e-04 1.01e-29
1. PB Q8N9W4 Golgin subfamily A member 6-like protein 2 1.77e-07 5.01e-09 9.94e-138
1. PB H0YM25 Golgin subfamily A member 6-like protein 22 6.80e-13 5.40e-24 0.0
1. PB Q62839 Golgin subfamily A member 2 5.39e-10 1.28e-03 1.38e-33
1. PB Q8N7Z2 Golgin subfamily A member 6-like protein 1 0 1.30e-166 0.0
1. PB Q921M4 Golgin subfamily A member 2 9.42e-09 7.23e-03 4.76e-33
1. PB Q585H6 Flagellar attachment zone protein 1 4.25e-05 2.20e-02 0.017
1. PB A0A1B0GV03 Golgin subfamily A member 6-like protein 7 1.48e-12 2.79e-05 3.13e-106
1. PB A6NEM1 Golgin subfamily A member 6-like protein 9 5.15e-04 4.71e-02 3.38e-08
1. PB A6NDN3 Golgin subfamily A member 6B 1.68e-10 8.00e-05 1.49e-28
1. PB P0CG33 Golgin subfamily A member 6D 2.92e-11 3.40e-03 9.56e-29
1. PB A6NDK9 Golgin subfamily A member 6C 3.60e-09 3.47e-05 3.77e-29
1. PB A8MZA4 Golgin subfamily A member 6-like protein 6 0.00e+00 5.74e-77 0.0
2. P A2A6M5 Calcium-binding and coiled-coil domain-containing protein 2 2.96e-04 1.65e-03 NA
2. P Q9JL35 High mobility group nucleosome-binding domain-containing protein 5 7.62e-01 4.27e-02 NA
2. P Q5BJK8 Golgi integral membrane protein 4 5.18e-06 2.25e-02 NA
2. P Q9H094 Neuroblastoma breakpoint family member 3 1.84e-02 8.54e-03 NA
2. P Q9H321 Variable charge X-linked protein 3B 6.04e-01 9.21e-05 NA
2. P Q4A0V8 Uro-adherence factor A 9.83e-01 2.16e-03 NA
2. P Q5SRN2 Testis-expressed basic protein 1 2.20e-01 2.03e-03 NA
2. P O00461 Golgi integral membrane protein 4 1.11e-07 6.50e-03 NA
2. P Q5ZLS3 E3 ubiquitin-protein ligase BRE1A 1.34e-07 4.76e-02 NA
2. P Q8BXA1 Golgi integral membrane protein 4 1.20e-06 6.71e-03 NA
2. P P0DPF3 Neuroblastoma breakpoint family member 9 8.07e-02 8.54e-03 NA
2. P Q66HF9 Leucine-rich repeat flightless-interacting protein 1 3.39e-03 3.16e-02 NA
2. P Q95WA4 Spore wall protein 2 1.25e-02 5.38e-03 NA
2. P Q5DTM8 E3 ubiquitin-protein ligase BRE1A 3.09e-07 5.16e-03 NA
2. P Q5VTR2 E3 ubiquitin-protein ligase BRE1A 7.81e-08 1.84e-03 NA
2. P Q9H320 Variable charge X-linked protein 1 5.37e-01 3.08e-06 NA
2. P A2VDP1 E3 ubiquitin-protein ligase BRE1A 1.10e-07 7.08e-03 NA
2. P Q26005 Ring-infected erythrocyte surface antigen (Fragment) 8.81e-05 1.32e-02 NA
2. P Q6RHW0 Keratin, type I cytoskeletal 9 5.28e-06 4.31e-02 NA
2. P Q86RN8 Paramyosin 6.27e-09 4.71e-02 NA
2. P P51814 Zinc finger protein 41 3.80e-01 4.95e-02 NA
2. P O04492 Double-stranded RNA-binding protein 1 3.89e-01 4.67e-02 NA
2. P Q9NNX9 Variable charge X-linked protein 3 6.59e-01 8.72e-03 NA
2. P Q54KY8 Putative mediator of RNA polymerase II transcription subunit 9 1.53e-02 1.78e-02 NA
2. P Q06002 Filensin 1.61e-06 2.83e-05 NA
2. P Q5MJ10 Sperm protein associated with the nucleus on the X chromosome N2 3.36e-01 5.85e-03 NA
2. P A6NEY3 Putative golgin subfamily A member 6-like protein 3 1.82e-09 5.10e-06 NA
2. P P82970 High mobility group nucleosome-binding domain-containing protein 5 6.76e-01 3.18e-04 NA
2. P Q8MUF6 Paramyosin 1.72e-12 4.67e-02 NA
2. P D3YU32 Testis-expressed protein 13C-1 3.38e-02 1.54e-02 NA
3. B I6L899 Golgin subfamily A member 8R 2.65e-07 NA 2.83e-07
3. B Q8WZ42 Titin NA NA 3.55e-07
3. B A6NMD2 Golgin subfamily A member 8J 2.91e-07 NA 2.83e-06
3. B Q00174 Laminin subunit alpha NA NA 0.003
3. B F8WBI6 Golgin subfamily A member 8N 2.30e-07 NA 6.42e-10
3. B Q08379 Golgin subfamily A member 2 3.32e-10 NA 1.96e-39
3. B A6NI86 Golgin subfamily A member 6-like protein 10 3.89e-09 NA 5.14e-08
3. B F1QBY1 Nipped-B-like protein B NA NA 0.008
3. B Q60675 Laminin subunit alpha-2 NA NA 0.004
3. B P24043 Laminin subunit alpha-2 NA NA 9.18e-05
3. B H3BV12 Golgin subfamily A member 8Q 1.23e-07 NA 1.22e-09
3. B O64046 Probable tape measure protein NA NA 0.001
3. B Q21313 Laminin-like protein epi-1 NA NA 8.90e-06
3. B H3BPF8 Golgin subfamily A member 8S 2.13e-08 NA 9.85e-20
3. B Q70XJ9 Levansucrase 9.55e-01 NA 0.008
3. B A6NN73 Golgin subfamily A member 8C 2.68e-07 NA 7.56e-17
3. B A8MQT2 Golgin subfamily A member 8B 1.58e-07 NA 9.40e-10
3. B P27177 Major prion protein homolog 2.68e-01 NA 2.03e-06
3. B P27951 IgA FC receptor 6.50e-02 NA 0.032
3. B Q54EQ9 Putative uncharacterized protein DDB_G0291608 1.84e-01 NA 0.035
3. B D6RF30 Golgin subfamily A member 8K 1.21e-07 NA 3.84e-06
3. B Q6ZQQ6 WD repeat-containing protein 87 NA NA 3.55e-04
3. B H3BQL2 Golgin subfamily A member 8T 1.14e-08 NA 1.28e-07
3. B P19137 Laminin subunit alpha-1 NA NA 5.24e-05
3. B A6NCC3 Golgin subfamily A member 8O 3.53e-07 NA 5.36e-10
3. B A3LZ57 COPII coat assembly protein SEC16 8.55e-01 NA 5.37e-04
3. B P78559 Microtubule-associated protein 1A NA NA 2.02e-07
3. B Q8ILR9 Protein PF14_0175 NA NA 0.010
3. B O31976 SPbeta prophage-derived uncharacterized transglycosylase YomI 7.45e-03 NA 7.24e-04
3. B A7E2F4 Golgin subfamily A member 8A 4.12e-08 NA 1.34e-06
3. B Q4R9C9 Coiled-coil domain-containing protein 70 8.78e-06 NA 0.015
3. B H0YKK7 Putative golgin subfamily A member 6-like protein 19 4.48e-10 NA 5.69e-08
3. B A2ASS6 Titin NA NA 8.39e-06
3. B A6NC78 Putative golgin subfamily A member 8I 4.38e-08 NA 8.11e-07
3. B H3BSY2 Golgin subfamily A member 8M 2.89e-08 NA 8.54e-07
3. B P25391 Laminin subunit alpha-1 NA NA 0.003