Summary
Structures and Sequence Alignment
The best structural homolog that predicted by 2. P was
Q5RGS3
(Protein FAM74A1) with a FATCAT P-Value: 0.0405 and RMSD of 3.85 angstrom. The sequence alignment identity is 15.9%.
Structural alignment shown in left. Query protein Q8N976 colored as red in alignment, homolog Q5RGS3 colored as blue.
Query protein Q8N976 is also shown in right top, homolog Q5RGS3 showed in right bottom. They are colored based on secondary structures.
Q8N976 MISAHCSNLHFLGSSESPTLASQVGEITGTHHHTRLIFVFLVETGFHHV-GHAGLELLTSSDPPTLASRSAG-----I---T----GMSHRARPHGISRG 87 Q5RGS3 --------------------------------------------MWRELRGCPGGDVETAQ---RLSQRRRGKSSEAVPEKTWRAQRMSQR-R-----RG 47 Q8N976 EQVTLGLP----LELL--ECV---SW-PL--C-GSPLRRAQIVSTPPSPLAALRVPVGAEGW---------GGTEQ------------- 141 Q5RGS3 ES-SEAVPEKTWKELRNSETVPEKTWKQLRRCLQEDVERVQRLSL----LLHLAVFL----WIIIAINFSNSGVKSQSSTYLPSGKILK 127
Go Annotations
1. PB indicates the go terms that are found by both PROST and BLAST.2. P indicates the go terms that are found by only PROST.
3. B indicates the go terms that are only annotated by BLAST.
| Source | GO | Description |
|---|---|---|
| 2. P | GO:0042025 | host cell nucleus |
| 2. P | GO:0016056 | rhodopsin mediated signaling pathway |
| 2. P | GO:0120162 | positive regulation of cold-induced thermogenesis |
| 2. P | GO:0060789 | hair follicle placode formation |
| 2. P | GO:0070527 | platelet aggregation |
| 2. P | GO:0033650 | host cell mitochondrion |
| 2. P | GO:0046718 | viral entry into host cell |
| 2. P | GO:0050890 | cognition |
| 2. P | GO:0016020 | membrane |
| 2. P | GO:0039526 | modulation by virus of host apoptotic process |
| 2. P | GO:0060348 | bone development |
| 2. P | GO:0048589 | developmental growth |
| 2. P | GO:0033644 | host cell membrane |
| 2. P | GO:0019062 | virion attachment to host cell |
| 2. P | GO:0044192 | host cell mitochondrial inner membrane |
| 2. P | GO:0005085 | guanyl-nucleotide exchange factor activity |
| 2. P | GO:0019028 | viral capsid |
| 2. P | GO:0007189 | adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| 2. P | GO:0009966 | regulation of signal transduction |
| 2. P | GO:0039545 | suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity |
| 2. P | GO:0001726 | ruffle |
| 2. P | GO:0044164 | host cell cytosol |
| 3. B | GO:0048642 | negative regulation of skeletal muscle tissue development |
| 3. B | GO:0018026 | peptidyl-lysine monomethylation |
| 3. B | GO:0050821 | protein stabilization |
| 3. B | GO:0021549 | cerebellum development |
| 3. B | GO:0046548 | retinal rod cell development |
| 3. B | GO:0072015 | glomerular visceral epithelial cell development |
| 3. B | GO:0031870 | thromboxane A2 receptor binding |
| 3. B | GO:0015820 | leucine transport |
| 3. B | GO:0009925 | basal plasma membrane |
| 3. B | GO:2001020 | regulation of response to DNA damage stimulus |
| 3. B | GO:1901215 | negative regulation of neuron death |
| 3. B | GO:0007249 | I-kappaB kinase/NF-kappaB signaling |
| 3. B | GO:0090068 | positive regulation of cell cycle process |
| 3. B | GO:0035116 | embryonic hindlimb morphogenesis |
| 3. B | GO:0015175 | neutral amino acid transmembrane transporter activity |
| 3. B | GO:0001736 | establishment of planar polarity |
| 3. B | GO:0044666 | MLL3/4 complex |
| 3. B | GO:0043947 | obsolete positive regulation by host of symbiont catalytic activity |
| 3. B | GO:0015173 | aromatic amino acid transmembrane transporter activity |
| 3. B | GO:0036064 | ciliary basal body |
| 3. B | GO:0031647 | regulation of protein stability |
| 3. B | GO:0072175 | epithelial tube formation |
| 3. B | GO:0043584 | nose development |
| 3. B | GO:0008466 | glycogenin glucosyltransferase activity |
| 3. B | GO:0004181 | metallocarboxypeptidase activity |
| 3. B | GO:0016279 | protein-lysine N-methyltransferase activity |
| 3. B | GO:0051879 | Hsp90 protein binding |
| 3. B | GO:0044225 | apical pole of neuron |
| 3. B | GO:0005432 | calcium:sodium antiporter activity |
| 3. B | GO:1903801 | L-leucine import across plasma membrane |
| 3. B | GO:0060039 | pericardium development |
| 3. B | GO:1990184 | amino acid transport complex |
| 3. B | GO:1904292 | regulation of ERAD pathway |
| 3. B | GO:0033634 | positive regulation of cell-cell adhesion mediated by integrin |
| 3. B | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| 3. B | GO:0070062 | extracellular exosome |
| 3. B | GO:0016324 | apical plasma membrane |
| 3. B | GO:0018022 | peptidyl-lysine methylation |
| 3. B | GO:0043330 | response to exogenous dsRNA |
| 3. B | GO:0031528 | microvillus membrane |
| 3. B | GO:0102751 | UDP-alpha-D-glucose:glucosyl-glycogenin alpha-D-glucosyltransferase activity |
| 3. B | GO:0018027 | peptidyl-lysine dimethylation |
| 3. B | GO:1900037 | regulation of cellular response to hypoxia |
| 3. B | GO:0021532 | neural tube patterning |
| 3. B | GO:0006479 | protein methylation |
| 3. B | GO:0021670 | lateral ventricle development |
| 3. B | GO:0008589 | regulation of smoothened signaling pathway |
| 3. B | GO:0022408 | negative regulation of cell-cell adhesion |
| 3. B | GO:0000278 | mitotic cell cycle |
| 3. B | GO:0021772 | olfactory bulb development |
| 3. B | GO:0015827 | tryptophan transport |
| 3. B | GO:0032391 | photoreceptor connecting cilium |
| 3. B | GO:0005879 | axonemal microtubule |
| 3. B | GO:0015180 | L-alanine transmembrane transporter activity |
| 3. B | GO:0036057 | slit diaphragm |
| 3. B | GO:0097014 | ciliary plasm |
| 3. B | GO:0071558 | histone H3-tri/di-methyl-lysine-27 demethylase activity |
| 3. B | GO:0007162 | negative regulation of cell adhesion |
| 3. B | GO:0005829 | cytosol |
| 3. B | GO:0035610 | protein side chain deglutamylation |
| 3. B | GO:0035115 | embryonic forelimb morphogenesis |
| 3. B | GO:0098713 | leucine import across plasma membrane |
| 3. B | GO:0090102 | cochlea development |
| 3. B | GO:0045744 | negative regulation of G protein-coupled receptor signaling pathway |
| 3. B | GO:0034097 | response to cytokine |
| 3. B | GO:1990380 | Lys48-specific deubiquitinase activity |
| 3. B | GO:0032688 | negative regulation of interferon-beta production |
| 3. B | GO:1905515 | non-motile cilium assembly |
| 3. B | GO:1901799 | negative regulation of proteasomal protein catabolic process |
| 3. B | GO:0035253 | ciliary rootlet |
| 3. B | GO:0015823 | phenylalanine transport |
| 3. B | GO:0032534 | regulation of microvillus assembly |
| 3. B | GO:0035869 | ciliary transition zone |
| 3. B | GO:0038061 | NIK/NF-kappaB signaling |
| 3. B | GO:0022038 | corpus callosum development |
| 3. B | GO:0015190 | L-leucine transmembrane transporter activity |
| 3. B | GO:2000772 | regulation of cellular senescence |
| 3. B | GO:0071557 | histone H3-K27 demethylation |
| 3. B | GO:1904273 | L-alanine import across plasma membrane |
Homologs
1. PB indicates the homologs that are found by both PROST and BLAST.
2. P indicates homologs that are only found by PROST.
3. B indicates homologs that are only found by BLAST.
| Source | Homolog | Description | FATCAT p-val | PROST Evalue | BLAST Evalue |
|---|---|---|---|---|---|
| 1. PB | Q8N976 | Putative uncharacterized protein FLJ38264 | 0 | 2.57e-149 | 3.00e-97 |
| 2. P | P84996 | Protein ALEX | 8.92e-01 | 7.73e-03 | NA |
| 2. P | P20343 | Putative uncharacterized protein CysX | 2.93e-01 | 1.69e-05 | NA |
| 2. P | Q9HAA7 | Putative uncharacterized protein FLJ11871 | 1.53e-01 | 4.27e-18 | NA |
| 2. P | Q0A2D8 | Protein PB1-F2 | NA | 3.22e-02 | NA |
| 2. P | P25221 | Protein VP5 | NA | 3.13e-02 | NA |
| 2. P | P81302 | Uncharacterized protein MJ0047.1 | 4.90e-01 | 3.91e-03 | NA |
| 2. P | Q8N8H1 | Putative protein ZNF321 | 7.80e-02 | 4.81e-06 | NA |
| 2. P | P12660 | Purkinje cell protein 2 | 1.15e-01 | 2.63e-02 | NA |
| 2. P | P25561 | Putative uncharacterized protein YCL021W | 4.61e-01 | 6.36e-07 | NA |
| 2. P | A9CB96 | Fiber protein | NA | 1.89e-02 | NA |
| 2. P | Q03056 | Non-structural protein 6 | NA | 3.63e-02 | NA |
| 2. P | Q5RGS3 | Protein FAM74A1 | 4.05e-02 | 2.73e-03 | NA |
| 2. P | P03849 | Uncharacterized 6.8 kDa protein in replication origin region | 1.92e-01 | 2.85e-03 | NA |
| 3. B | Q68CZ1 | Protein fantom | 8.20e-01 | NA | 0.005 |
| 3. B | O00592 | Podocalyxin | 2.27e-01 | NA | 8.92e-09 |
| 3. B | P51957 | Serine/threonine-protein kinase Nek4 | 8.19e-01 | NA | 0.010 |
| 3. B | Q5SR53 | Putative uncharacterized protein PIK3CD-AS1 | 7.70e-02 | NA | 2.22e-05 |
| 3. B | Q04864 | Proto-oncogene c-Rel | 6.59e-01 | NA | 5.71e-09 |
| 3. B | Q8N2A0 | Putative uncharacterized protein encoded by LINC00269 | 3.00e-01 | NA | 2.01e-29 |
| 3. B | P08195 | 4F2 cell-surface antigen heavy chain | 6.56e-01 | NA | 2.38e-04 |
| 3. B | Q96MD7 | Uncharacterized protein C9orf85 | 1.06e-01 | NA | 4.48e-15 |
| 3. B | Q6ZUF6 | Putative uncharacterized protein encoded by LINC00336 | 3.49e-01 | NA | 3.99e-06 |
| 3. B | Q9Y2Z0 | Protein SGT1 homolog | 2.68e-01 | NA | 1.18e-09 |
| 3. B | Q9P281 | BAH and coiled-coil domain-containing protein 1 | 9.92e-01 | NA | 0.035 |
| 3. B | Q6B4Z3 | Histone demethylase UTY | 7.53e-01 | NA | 2.31e-08 |
| 3. B | Q5JPI9 | EEF1A lysine methyltransferase 2 | 5.06e-01 | NA | 1.97e-11 |
| 3. B | O15488 | Glycogenin-2 | 4.05e-01 | NA | 7.97e-04 |
| 3. B | Q9H2J1 | Uncharacterized protein ARRDC1-AS1 | 3.25e-01 | NA | 3.09e-08 |
| 3. B | Q3ZCU0 | Protein GVQW3 | 3.13e-01 | NA | 8.77e-09 |
| 3. B | Q8N769 | Uncharacterized protein C14orf178 | 6.85e-02 | NA | 1.21e-07 |
| 3. B | O94966 | Ubiquitin carboxyl-terminal hydrolase 19 | 9.34e-01 | NA | 4.61e-04 |
| 3. B | Q8WTZ3 | Zinc finger protein ENSP00000375192 | 1.39e-01 | NA | 2.04e-20 |
| 3. B | O14628 | Zinc finger protein 195 | 3.78e-01 | NA | 1.01e-08 |
| 3. B | Q6UX73 | UPF0764 protein C16orf89 | 4.79e-01 | NA | 2.64e-09 |
| 3. B | Q9NV72 | Zinc finger protein 701 | 2.49e-01 | NA | 9.83e-09 |
| 3. B | Q8NEM8 | Cytosolic carboxypeptidase 3 | 8.10e-01 | NA | 7.21e-07 |