Results | PROST

Summary

Q8NA66

Homolog: P31322.
Function: cAMP-dependent protein kinase type II-beta regulatory subunit.

Statistics

Total GO Annotation: 75
Unique PROST Go: 60
Unique BLAST Go: 2

Total Homologs: 41
Unique PROST Homologs: 36
Unique BLAST Homologs: 3

Structures and Sequence Alignment

The best structural homolog that predicted by 2. P was P31322 (cAMP-dependent protein kinase type II-beta regulatory subunit) with a FATCAT P-Value: 1.58e-06 and RMSD of 2.91 angstrom. The sequence alignment identity is 21.6%.
Structural alignment shown in left. Query protein Q8NA66 colored as red in alignment, homolog P31322 colored as blue. Query protein Q8NA66 is also shown in right top, homolog P31322 showed in right bottom. They are colored based on secondary structures.

  Q8NA66 MPMS-SLPA---AILSHMT--AINNVPPPPL-----H--SI--PNLKKSKHINYGQLNALCHIRGQHSRSMSNILSA--HDTFMKQYP-K-VFLHQKPRL 81
  P31322 --MSIEIPAGLTELLQGFTVEVLRHQPADLLEFALQHFTRLQEENERKGT-ARFG------H-EG---RTWGDAGAAGGGGT-----PSKGVNFAEEPR- 81

  Q8NA66 PKLFKQEEQRELNEGKEESQHQQPDDSN--NIAVHVQR-AHGGHI---LYRPKRATEKFEEFLAILKKLPIHRTPYEHKTVWKFLKTIPDLTFQLND--K 173
  P31322 ------HSDSE-N-GEEE--EEEAADAGAFNAPV-INRFTRRASVCAEAYNPDEEEDDAE------SRI-IH--P---KT--------DDQRNRLQEACK 150

  Q8NA66 HLKTLSKTVFSETWLKGSTVVANDG-FYVILK-GLARPQTNVYKNLIE-GSDSPDSF--ISQ-SFHSFIWSEEFKNSTLAEMYLPSYDSMLSKWSTFGTL 267
  P31322 DI-LLFKNLDPE---QMSQVL--DAMFEKLVKEG---------EHVIDQGDDG-DNFYVIDRGTFDIYV-----KCDGVGRC-VGNYDNR----GSFGEL 224

  Q8NA66 EVMPQNESETQMFSVVTEDDCEILKIPAK--GYAKIKEEKIKLENMQKLKLIRMCPYYEEW----P---TLSIYE---LIALLKWKKFPPGH-------- 347
  P31322 ALM-YN---TPRAATITATS------PGALWGLDRVTFRRIIVKNNAK-KR-KM---YESFIESLPFLKSLEVSERLKVVDVIGTKVYNDGEQIIAQGDS 309

  Q8NA66 ----VIVESGNI-ISF--VG--YI--NSGC-----CNIYR-SIIGFVKLRSNKVKRSQKLVYMGKLK----EKESFGEISVLLQVPFTCTIITKKEVEMA 426
  P31322 ADSFFIVESGEVKITMKRKGKSEVEEN-GAVEIARCS--RGQYFGELALVTNK-PRAASAHAIGTVKCLAMDVQAF-E--RLLG-P--CMEIMKRNI--A 397

  Q8NA66 IIEDKDLFVA------------- 436
  P31322 TYEEQ-L-VALFGTNMDIVEPTA 418

Go Annotations

1. PB indicates the go terms that are found by both PROST and BLAST.
2. P indicates the go terms that are found by only PROST.
3. B indicates the go terms that are only annotated by BLAST.

Source	GO	Description
1. PB	GO:0010738	regulation of protein kinase A signaling
1. PB	GO:0030552	cAMP binding
1. PB	GO:0010603	regulation of cytoplasmic mRNA processing body assembly
1. PB	GO:0036278	positive regulation of transcription from RNA polymerase II promoter in response to nitrogen starvation
1. PB	GO:0045762	positive regulation of adenylate cyclase activity
1. PB	GO:0097271	protein localization to bud neck
1. PB	GO:0046580	negative regulation of Ras protein signal transduction
1. PB	GO:0061406	positive regulation of transcription from RNA polymerase II promoter in response to glucose starvation
1. PB	GO:0000785	chromatin
1. PB	GO:0005952	cAMP-dependent protein kinase complex
1. PB	GO:0043949	regulation of cAMP-mediated signaling
1. PB	GO:0004862	cAMP-dependent protein kinase inhibitor activity
1. PB	GO:0008603	cAMP-dependent protein kinase regulator activity
2. P	GO:0048149	behavioral response to ethanol
2. P	GO:0044853	plasma membrane raft
2. P	GO:0046007	negative regulation of activated T cell proliferation
2. P	GO:0043198	dendritic shaft
2. P	GO:0019904	protein domain specific binding
2. P	GO:0097224	sperm connecting piece
2. P	GO:0060258	negative regulation of filamentous growth
2. P	GO:0045475	locomotor rhythm
2. P	GO:0050804	modulation of chemical synaptic transmission
2. P	GO:0045859	regulation of protein kinase activity
2. P	GO:0031625	ubiquitin protein ligase binding
2. P	GO:0043197	dendritic spine
2. P	GO:0007143	female meiotic nuclear division
2. P	GO:0045121	membrane raft
2. P	GO:0008103	oocyte microtubule cytoskeleton polarization
2. P	GO:0030315	T-tubule
2. P	GO:0097546	ciliary base
2. P	GO:0007622	rhythmic behavior
2. P	GO:0030448	hyphal growth
2. P	GO:0046827	positive regulation of protein export from nucleus
2. P	GO:0036094	small molecule binding
2. P	GO:0005930	axoneme
2. P	GO:0045214	sarcomere organization
2. P	GO:0001707	mesoderm formation
2. P	GO:0001772	immunological synapse
2. P	GO:0043936	asexual sporulation resulting in formation of a cellular spore
2. P	GO:0098978	glutamatergic synapse
2. P	GO:0031594	neuromuscular junction
2. P	GO:0048471	perinuclear region of cytoplasm
2. P	GO:0098794	postsynapse
2. P	GO:0005771	multivesicular body
2. P	GO:0007612	learning
2. P	GO:0006631	fatty acid metabolic process
2. P	GO:0007419	ventral cord development
2. P	GO:2000480	negative regulation of cAMP-dependent protein kinase activity
2. P	GO:0007591	molting cycle, chitin-based cuticle
2. P	GO:2000253	positive regulation of feeding behavior
2. P	GO:0110034	negative regulation of adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway
2. P	GO:0001932	regulation of protein phosphorylation
2. P	GO:0045835	negative regulation of meiotic nuclear division
2. P	GO:0098693	regulation of synaptic vesicle cycle
2. P	GO:0043025	neuronal cell body
2. P	GO:0043945	positive regulation of asexual sporulation resulting in formation of a cellular spore
2. P	GO:1903538	regulation of meiotic cell cycle process involved in oocyte maturation
2. P	GO:0005813	centrosome
2. P	GO:0032991	protein-containing complex
2. P	GO:0048148	behavioral response to cocaine
2. P	GO:0060038	cardiac muscle cell proliferation
2. P	GO:0045202	synapse
2. P	GO:0097332	response to antipsychotic drug
2. P	GO:0097338	response to clozapine
2. P	GO:0031588	nucleotide-activated protein kinase complex
2. P	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway
2. P	GO:0035556	intracellular signal transduction
2. P	GO:0071361	cellular response to ethanol
2. P	GO:0031698	beta-2 adrenergic receptor binding
2. P	GO:0008355	olfactory learning
2. P	GO:0042802	identical protein binding
2. P	GO:0051784	negative regulation of nuclear division
2. P	GO:0034236	protein kinase A catalytic subunit binding
3. B	GO:0007283	spermatogenesis
3. B	GO:0005829	cytosol

Homologs

1. PB indicates the homologs that are found by both PROST and BLAST.
2. P indicates homologs that are only found by PROST.
3. B indicates homologs that are only found by BLAST.

Source	Homolog	Description	FATCAT p-val	PROST Evalue	BLAST Evalue
1. PB	Q8NA66	Cyclic nucleotide-binding domain-containing protein 1	0	3.31e-154	0.0
1. PB	P07278	cAMP-dependent protein kinase regulatory subunit	9.81e-06	7.30e-09	0.022
2. P	P00514	cAMP-dependent protein kinase type I-alpha regulatory subunit	1.32e-05	3.10e-02	NA
2. P	P07802	cAMP-dependent protein kinase type I-alpha regulatory subunit	1.18e-05	1.63e-02	NA
2. P	P36600	cAMP-dependent protein kinase regulatory subunit	1.34e-05	2.06e-05	NA
2. P	O59922	cAMP-dependent protein kinase regulatory subunit	4.26e-05	1.50e-09	NA
2. P	P81900	cAMP-dependent protein kinase type II regulatory subunit	1.57e-05	1.97e-02	NA
2. P	P31320	cAMP-dependent protein kinase regulatory subunit	5.73e-06	1.46e-05	NA
2. P	P12367	cAMP-dependent protein kinase type II-alpha regulatory subunit	4.31e-06	3.10e-04	NA
2. P	P00515	cAMP-dependent protein kinase type II-alpha regulatory subunit	4.35e-06	7.96e-04	NA
2. P	Q6BZG7	cAMP-dependent protein kinase regulatory subunit	6.20e-06	1.08e-07	NA
2. P	P16905	cAMP-dependent protein kinase type I regulatory subunit	1.14e-05	1.20e-02	NA
2. P	Q9HEP7	cAMP-dependent protein kinase regulatory subunit	1.38e-05	3.21e-12	NA
2. P	P12369	cAMP-dependent protein kinase type II-beta regulatory subunit	2.18e-06	1.67e-04	NA
2. P	P31323	cAMP-dependent protein kinase type II-beta regulatory subunit	1.25e-05	2.04e-03	NA
2. P	Q26619	cAMP-dependent protein kinase type II regulatory subunit	1.44e-05	7.67e-05	NA
2. P	O42794	cAMP-dependent protein kinase regulatory subunit	8.84e-05	5.06e-03	NA
2. P	Q8TF77	cAMP-dependent protein kinase regulatory subunit	1.11e-04	7.01e-06	NA
2. P	Q5REL1	cAMP-dependent protein kinase type I-alpha regulatory subunit	9.48e-06	4.60e-02	NA
2. P	P31319	cAMP-dependent protein kinase regulatory subunit	4.49e-06	7.79e-04	NA
2. P	P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	2.62e-05	3.84e-03	NA
2. P	P12368	cAMP-dependent protein kinase type II-alpha regulatory subunit	3.35e-06	3.62e-02	NA
2. P	Q75AM2	cAMP-dependent protein kinase regulatory subunit	4.00e-05	1.80e-07	NA
2. P	Q6CPK7	cAMP-dependent protein kinase regulatory subunit	2.02e-04	3.89e-06	NA
2. P	Q6C2X0	cAMP-dependent protein kinase regulatory subunit	2.73e-06	2.73e-08	NA
2. P	P49605	cAMP-dependent protein kinase regulatory subunit	2.41e-05	3.21e-05	NA
2. P	P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit	1.47e-05	4.60e-02	NA
2. P	O14448	cAMP-dependent protein kinase regulatory subunit	2.76e-05	1.12e-10	NA
2. P	Q9HEW1	cAMP-dependent protein kinase regulatory subunit	2.48e-05	7.52e-10	NA
2. P	Q9C1C2	cAMP-dependent protein kinase regulatory subunit	1.74e-05	5.04e-07	NA
2. P	P31322	cAMP-dependent protein kinase type II-beta regulatory subunit	1.58e-06	4.80e-05	NA
2. P	Q9C196	cAMP-dependent protein kinase regulatory subunit	1.49e-04	1.19e-13	NA
2. P	P31324	cAMP-dependent protein kinase type II-beta regulatory subunit	2.58e-05	5.14e-05	NA
2. P	Q96UX3	cAMP-dependent protein kinase regulatory subunit	2.26e-05	4.11e-08	NA
2. P	Q86ZN7	cAMP-dependent protein kinase regulatory subunit	2.05e-05	6.84e-05	NA
2. P	Q6FQL6	cAMP-dependent protein kinase regulatory subunit	9.25e-06	1.74e-12	NA
2. P	P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	2.20e-05	8.98e-05	NA
2. P	Q01386	cAMP-dependent protein kinase regulatory subunit	9.18e-06	6.82e-09	NA
3. B	Q95JR6	Cyclic nucleotide-binding domain-containing protein 2	3.69e-03	NA	0.039
3. B	Q9D5U8	Cyclic nucleotide-binding domain-containing protein 2	6.58e-03	NA	0.047
3. B	Q96M20	Cyclic nucleotide-binding domain-containing protein 2	2.88e-03	NA	0.002