Summary

Q8NET4

Homolog: Q32KG4.
Function: Retrotransposon Gag-like protein 9.

Statistics

Total GO Annotation: 30
Unique PROST Go: 23
Unique BLAST Go: 7

Total Homologs: 23
Unique PROST Homologs: 11
Unique BLAST Homologs: 10

Structures and Sequence Alignment

The best structural homolog that predicted by 1. PB was Q32KG4 (Retrotransposon Gag-like protein 9) with a FATCAT P-Value: 0.000259 and RMSD of 22.73 angstrom. The sequence alignment identity is 66.0%.
Structural alignment shown in left. Query protein Q8NET4 colored as red in alignment, homolog Q32KG4 colored as blue. Query protein Q8NET4 is also shown in right top, homolog Q32KG4 showed in right bottom. They are colored based on secondary structures. 

  Q8NET4 ---MSIPLHSLRFNNTMREENVEPQNKQMAFCRPMTETRADVQILHSHVQLPIVSTSASDPGGTSTQLMTSPVFDTMSAPLMGVPNSGALSPP------- 90
  Q32KG4 MADMSIPLHSLRFNNMMKEENGDPQNRGATFSRPMTETRAEVQILHSQLQLPVVSTSASDLEGTSTQLMTSPGFDSLSTPLMGAPHSGTLSPPLMSASDS 100

  Q8NET4 ------LMPASDSGALSPLLMPASDSGALSPLLMPALDSGTLSPLLSTSEYGVMSPGMMTIPDFGTMSATLMVAPDSAEISPLAMPAPSSGVVCTPIMST 184
  Q32KG4 GTLSPLLMPASDSGTLSPLLMPVSDSGTLSPLLMPASDSGTLSPLLSTSDYGLMSPGMMSIPDFGTMS-SLMAAPDSAEISPLAMPIQSSGVISAPIMST 199

  Q8NET4 SSSEAMSTPLMLAPDSGELSPILMQDMNPGVMSTQPVPAPSSEAMSPLQITDEDTEAMSKVLMTALASGEISSLLMSGTDSEAISSLIMSAVASGGTSPQ 284
  Q32KG4 SSSEA-S--LMLGSDPGEISPLLIPDMNPGVTSTPPMTAPGSEAMSPLQITDEDTEAMSKVLMTALASGEISSLLMSGTDSEAISSLIMSALASGETPAQ 296

  Q8NET4 PTSTQNSGGIPTPLMSDLDSGIMSSLLMSSPGSEVMSTPLLSVPDAGEMSTLPKPAPDAEAMSPALMTALPSGVMPTQTMPAPGSGAMSPWSTQNVDSEM 384
  Q32KG4 PTNPPESEGIPTVLMSGSDSAVMSSLPMPVSGSGAMPTPLLSIPDAGEIATLPKPVPDVEAMSPLLMTALTSTVMPSQLISASSSGVMSPDTTQNINSEV 396

  Q8NET4 MSNPPVRATASGVMSAPPVRALDSGAMSTP--LMGAPASGNMSTLQKTVPASGAMTTSLMTVPSSGVMSTEQMSATASRVMSAQLTMAKTSGAMPTGSMK 482
  Q32KG4 MSAPPIRVSSTGLMSTLPVRASDTAA--TPIQLMRVPASGNMSTSQKTVPVSGSMSTPLMAVTSPGAIFTEQMPSTASGTMSTHLTMPQTPGTMPIGFMK 494

  Q8NET4 AVAKQYKRATASGKMSTPLRRAPTSGAMSTQPVTATASETMSMPQLTVPASGSMSMLQMRAPVSEAMSMPQMRTMASGLTSAAQMKAMTSGAMSTPLMTA 582
  Q32KG4 --------STSNGAVSAQQIRCSVSGMMSTQPVIATASEIMSVSQSTVPTSGSVSTQKTRAPVSGPMSTTQIRTTASALTSTPQMRATASGTMSIPLMTA 586

  Q8NET4 QTSGSTSTLLMRDTASGVMSCPQMRSLASGALSKPLMTPKASGTMFTEKMTTTASEAMPTLLMRDTVSGALSMPQMTDTASGGLSASLMRDTASGAMSTS 682
  Q32KG4 KTSGSASTLLMRDTASGVISVPQMRAPGSGTVSKPLMTSKASG-MFMQQMTTAAFGATPTSLMRDTASGGLSMPQMTDPASGGMSTLLTRATASGTKSTS 685

  Q8NET4 QMTATVSGGMSMPLMRAQDPGVMPASLMRAKVSGKMLSQPMSTQDPGGMSMSP-MKSMTAGGMQMNSPTSDVMSTPTVRAWTSETMSTPLMRTSDPGERP 781
  Q32KG4 QMTATTSGGIFMPQTRLSGPGATSTPLMRATASEKMPSQAMNIQDSGGVS-TPLMRPVALGGVQM-------------RSQGSGTMSTPLLRASDSSEMS 771

  Q8NET4 SLLTRASSSGEMSLPLMRAPASGEIATP-LRSPAYGAMSAPQMTATASGMMSSMP-QVKAPISGAMSMPLTRSTASGGMSMPLMRAPDSRVTSTSQMMPT 879
  Q32KG4 MLLTKAPSSGERPLLLVRPPASGEIA-PHSRTPVYGTISAPHMTTTASGVMTMSPMKTSVPVS--ESATLLRPTDSGVMSIPLTRTPASRAKSRPQ-MAT 867

  Q8NET4 ASGDMCTLPVRAPASGGVS-SPLVRAPASGTMSTPLRRPSACE-TVSTELMRASASGHMSTAQTTAMVSGGMSKPLMRAPASGTMPMPLMSAMASGEMSM 977
  Q32KG4 ACGDMCPLPVRAPATAGISPSP-VRSPASSTLSTLLRRPS--DGAVTAELERV-----LGPAQFAAMTPGEMSKPLMRASAPGTTTMPLMSPMTSGEMSM 959

  Q8NET4 PLMETMASGATSTLQTSVANSRSMSLSQTTYTVSGRMATAPIRASASGARSTSFMRASVSGSMPMPLPRATASGCGMGMSMPQMTATDSRG-MSTPLMRA 1076
  Q32KG4 PLMKTTPSGTMSTLQTKVMSSRATSLPQPRNAASGVIANPPQRAPASGAGSTPLMRVSGSGMMSTPLLGATASG---GMSMPQM-APPTSGDMFSPLMRS 1055

  Q8NET4 SGPGTMSTPQTAFGVMSTP--EIKATDSGEASTSHINITASGSKPTSHMTATTPETAKPPPKEVPSFGMLTPALCYLLEEQEAARGSCSVEEEM-EIDEE 1173
  Q32KG4 PAPGIMSTPQTAFG-M-TPTLNVKATDSGEASTSHTRFTAPGSKSTPHMTSTAPEMKTPPPKEVPSFGMLTPALCYLLEEQEAARGSSSVEEDAEEIDEE 1153

  Q8NET4 KQMKGFLDDSERMAFLVSLHLGAAERWFILQMEVGEPLSHENKSFLRRSQGIYDSLSEIDILSAVLCHPKQGQKSVRQYATDFLLLARHLSWSDAILRTR 1273
  Q32KG4 KQMKGFLDDSEKMAFLVSLHLGAAERWSILQMEVGNPISSDNKAFLRRSQGLYDSLSEIDILSAVLCHPKQGKKSVRQYATDFLLLARHLSWSDAILRTR 1253

  Q8NET4 FLEGLSEAVTTKMGRIFLKVAGSLKELIDRSLYTECQLAEEKDSPGNSSQVLPTACKRNNEEAMGNELSSQQQTEEHQHVSKRCYYLKEHGDPQEGLHDH 1373
  Q32KG4 FLEGLSEAVTTKMGRIFLKVAGSLKELIDRSLYTECQLAEEKDSSGNSNQVVPTSCKRNNEEAMENELGSQQQTEE---VIKGTY---AHGF-------- 1339

  Q8NET4 LGQSTGHHQKAHTNK 1388
  Q32KG4 --------------- 1339

Go Annotations

1. PB indicates the go terms that are found by both PROST and BLAST.
2. P indicates the go terms that are found by only PROST.
3. B indicates the go terms that are only annotated by BLAST.
Source GO Description
2. P GO:0034237 protein kinase A regulatory subunit binding
2. P GO:0032039 integrator complex
2. P GO:0005811 lipid droplet
2. P GO:0030165 PDZ domain binding
2. P GO:0099503 secretory vesicle
2. P GO:0062023 collagen-containing extracellular matrix
2. P GO:0034472 snRNA 3'-end processing
2. P GO:0071933 Arp2/3 complex binding
2. P GO:0005201 extracellular matrix structural constituent
2. P GO:0016604 nuclear body
2. P GO:0005796 Golgi lumen
2. P GO:0030036 actin cytoskeleton organization
2. P GO:0009506 plasmodesma
2. P GO:0030197 extracellular matrix constituent, lubricant activity
2. P GO:0005788 endoplasmic reticulum lumen
2. P GO:0031424 keratinization
2. P GO:0080119 ER body organization
2. P GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation
2. P GO:0005777 peroxisome
2. P GO:0019725 cellular homeostasis
2. P GO:0009897 external side of plasma membrane
2. P GO:0010168 ER body
2. P GO:0001533 cornified envelope
3. B GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
3. B GO:0006915 apoptotic process
3. B GO:0030154 cell differentiation
3. B GO:0001890 placenta development
3. B GO:0008270 zinc ion binding
3. B GO:0005654 nucleoplasm
3. B GO:0003676 nucleic acid binding

Homologs

1. PB indicates the homologs that are found by both PROST and BLAST.
2. P indicates homologs that are only found by PROST.
3. B indicates homologs that are only found by BLAST.

Source Homolog Description FATCAT p-val PROST Evalue BLAST Evalue
1. PB Q8NET4 Retrotransposon Gag-like protein 9 0 3.90e-182 0.0
1. PB Q32KG4 Retrotransposon Gag-like protein 9 2.59e-04 7.83e-55 0.0
2. P O88492 Perilipin-4 9.20e-01 9.76e-05 NA
2. P Q5JRC9 Protein FAM47A 1.68e-01 1.14e-03 NA
2. P Q9LSB4 TSA1-like protein 6.07e-01 2.90e-03 NA
2. P A6QL64 Ankyrin repeat domain-containing protein 36A 1.30e-01 5.30e-03 NA
2. P Q9NXZ1 Sarcoma antigen 1 9.25e-01 1.24e-05 NA
2. P Q685J3 Mucin-17 NA 8.34e-05 NA
2. P Q96Q06 Perilipin-4 8.36e-01 1.32e-03 NA
2. P Q02505 Mucin-3A NA 2.83e-02 NA
2. P Q5XPK0 Scar-like domain-containing protein WAVE 5 2.42e-02 1.08e-03 NA
2. P Q5HY64 Putative protein FAM47C 9.85e-01 2.03e-02 NA
2. P P18175 Involucrin 5.36e-01 1.01e-02 NA
3. B Q7TN75 Retrotransposon-derived protein PEG10 5.70e-01 NA 3.03e-05
3. B A6NKG5 Retrotransposon-like protein 1 3.62e-01 NA 0.006
3. B Q505G4 Retrotransposon Gag-like protein 6 4.61e-01 NA 0.016
3. B Q5HYW3 Retrotransposon Gag-like protein 5 2.36e-01 NA 2.00e-07
3. B Q8N8U3 Retrotransposon Gag-like protein 3 3.63e-01 NA 1.51e-05
3. B Q5DTT4 Retrotransposon Gag-like protein 5 1.08e-01 NA 4.47e-06
3. B Q6ICC9 Retrotransposon Gag-like protein 6 4.80e-01 NA 0.017
3. B Q6P1Y1 Retrotransposon Gag-like protein 3 1.83e-01 NA 0.021
3. B Q52QI2 Retrotransposon-like protein 1 3.66e-01 NA 0.012
3. B Q86TG7 Retrotransposon-derived protein PEG10 1.94e-01 NA 5.66e-08