Summary
Structures and Sequence Alignment
The best structural homolog that predicted by 3. B was
Q5CZ79
(Ankyrin repeat domain-containing protein 20B) with a FATCAT P-Value: 1.54e-08 and RMSD of 1.81 angstrom. The sequence alignment identity is 9.5%.
Structural alignment shown in left. Query protein Q8NF67 colored as red in alignment, homolog Q5CZ79 colored as blue.
Query protein Q8NF67 is also shown in right top, homolog Q5CZ79 showed in right bottom. They are colored based on secondary structures.
Q8NF67 ---------------------------------------------------------------------------------------------------- 0 Q5CZ79 MKLFGFGSRRGQTAEGSIDHVYTGSGYRIRDSELQKIHRAAVKGDAAEVERCLARRSGDLDARDKQHRTALHLACASGHVQVVTLLVNRKCQIDICDKEN 100 Q8NF67 ---------------------------------------------------------------------------------------------------- 0 Q5CZ79 RTPLIQAVHCQEEACAVILLKHGANPNLKDIYGNTALHYAVYSESTSLAEKLLSHGAHIEALDKDSNTPLLFAIICKKEKMVEFLLKKKASTHAVDRLRR 200 Q8NF67 ---------------------------------------------------------------------------------------------------- 0 Q5CZ79 SALMLAVYYDSPGIVSILLKQNIDVFAQDMCGRDAEDYAISHHLTKIQQQILEHKQKILKKEKSDVGSSDESAVSIFHELRVDSLPASDDKDLSVATKQC 300 Q8NF67 ---------------------------------------------------------------------------------------------------- 0 Q5CZ79 VPEKVSEPLPGPSHEKGNRIVNGQGEGPPAKHPSLKPTTGVEDPAVKGAVQRKNVQTLRAEQALPVASEEEQERHERSEKKQPQVKKGNNTNKSEKIQLS 400 Q8NF67 ---------------------------------------------------------------------------------------------------- 0 Q5CZ79 ENICDSTSSAAAGRLTQQRKIGKTYPQQFPKKLKEEHDKCTLKQENEEKTNVNMLYKKNREELERKEKQYKKEVEAKQLEPTVQSLEMKSKTARNTPNRD 500 Q8NF67 ---------------------------------------------------------------------------------------------------- 0 Q5CZ79 FHNHEETKGLMDENCILKADIAILRQEICTMKNDNLEKENKYLKDIKIVKETNAALEKYIKLNEEMITETAFRYQQELNDLKAENTRLNAELLKEKESKK 600 Q8NF67 ---------------------------------------------------------------------------------------------------- 0 Q5CZ79 RLEADIESYQSRLAAAIGKHSESVKTERNVKLALERTQDVSVQVEMSSAISKVKDENEFLTEQLSETQIKFNALKDKFRKTRDSLRKKSLALETVQNDLR 700 Q8NF67 --------MKEMYENAEDKVNNSTGKWSCVEERICHLQHENPCIEQQLDDVHQKEDHKEIVTNIQRGFIESGKKDLMLEEKNKKLMNECDHLKESLFQYE 92 Q5CZ79 KTQQQTQEMKEMYQNAEAKVNNSTGKWNCVEERICHLQRENAWLVQQLDDVHQKEDHKEIVTNIQRGFIESGKKDLVLEEKSKKLMNECDHLKESLFQYE 800 Q8NF67 REKAERVVVVRQLQQEAADSLKKLTMLESPLEGISHYHINLDETQVPKKKLFQVESQFDDLMVEKEAVSSKCVNLAKENQVFQQKLLSMKKVQQECEKLE 192 Q5CZ79 REKAEGVVSIKE-DKYFQTSRKKI---------------------------------------------------------------------------- 823 Q8NF67 EDKKMLEEEILNLKTHMENSMVELSKLQEYKSELDERAMQAVEKLEEIHLQEQAQYKKQLEQLNKDIIQLH 263 Q5CZ79 ----------------------------------------------------------------------- 823
Go Annotations
1. PB indicates the go terms that are found by both PROST and BLAST.2. P indicates the go terms that are found by only PROST.
3. B indicates the go terms that are only annotated by BLAST.
| Source | GO | Description |
|---|---|---|
| 3. B | GO:0098978 | glutamatergic synapse |
| 3. B | GO:0046627 | negative regulation of insulin receptor signaling pathway |
| 3. B | GO:0070373 | negative regulation of ERK1 and ERK2 cascade |
| 3. B | GO:0005813 | centrosome |
| 3. B | GO:0040015 | negative regulation of multicellular organism growth |
| 3. B | GO:0046621 | negative regulation of organ growth |
| 3. B | GO:0099626 | voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels |
| 3. B | GO:0015629 | actin cytoskeleton |
| 3. B | GO:0045599 | negative regulation of fat cell differentiation |
| 3. B | GO:0019217 | regulation of fatty acid metabolic process |
| 3. B | GO:0008200 | ion channel inhibitor activity |
| 3. B | GO:0030156 | benzodiazepine receptor binding |
| 3. B | GO:0019216 | regulation of lipid metabolic process |
| 3. B | GO:0060259 | regulation of feeding behavior |
| 3. B | GO:0042593 | glucose homeostasis |
| 3. B | GO:0044305 | calyx of Held |
Homologs
1. PB indicates the homologs that are found by both PROST and BLAST.
2. P indicates homologs that are only found by PROST.
3. B indicates homologs that are only found by BLAST.
| Source | Homolog | Description | FATCAT p-val | PROST Evalue | BLAST Evalue |
|---|---|---|---|---|---|
| 1. PB | Q8NF67 | Putative ankyrin repeat domain-containing protein 20A12 pseudogene | 0 | 3.29e-150 | 0.0 |
| 3. B | A6NC57 | Ankyrin repeat domain-containing protein 62 | 6.21e-07 | NA | 6.16e-11 |
| 3. B | Q5CZ79 | Ankyrin repeat domain-containing protein 20B | 1.54e-08 | NA | 3.98e-54 |
| 3. B | Q811D2 | Ankyrin repeat domain-containing protein 26 | 8.39e-05 | NA | 1.15e-41 |
| 3. B | Q9BXX2 | Ankyrin repeat domain-containing protein 30B | 1.21e-04 | NA | 7.38e-08 |
| 3. B | Q9JIR0 | Peripheral-type benzodiazepine receptor-associated protein 1 | 2.87e-03 | NA | 0.018 |
| 3. B | A2RUR9 | Coiled-coil domain-containing protein 144A | 2.25e-04 | NA | 1.94e-25 |
| 3. B | Q5VUR7 | Putative ankyrin repeat domain-containing protein 20A3 | 6.69e-08 | NA | 1.69e-53 |
| 3. B | Q9UPS8 | Ankyrin repeat domain-containing protein 26 | 2.72e-04 | NA | 3.74e-38 |
| 3. B | Q5SQ80 | Putative ankyrin repeat domain-containing protein 20A2 | 1.83e-08 | NA | 1.84e-53 |
| 3. B | Q5JPF3 | Ankyrin repeat domain-containing protein 36C | 9.67e-04 | NA | 4.00e-17 |
| 3. B | Q8IYA2 | Putative coiled-coil domain-containing protein 144C | 2.92e-05 | NA | 2.96e-25 |
| 3. B | Q9BXX3 | Ankyrin repeat domain-containing protein 30A | 1.45e-04 | NA | 3.09e-09 |
| 3. B | Q5TYW2 | Ankyrin repeat domain-containing protein 20A1 | 2.83e-08 | NA | 1.81e-53 |
| 3. B | A6QL64 | Ankyrin repeat domain-containing protein 36A | 4.92e-04 | NA | 2.67e-16 |
| 3. B | Q8N2N9 | Ankyrin repeat domain-containing protein 36B | 5.64e-05 | NA | 1.44e-16 |
| 3. B | A2A2Z9 | Ankyrin repeat domain-containing protein 18B | 5.76e-06 | NA | 1.44e-50 |
| 3. B | Q4UJ75 | Putative ankyrin repeat domain-containing protein 20A4 | 2.92e-07 | NA | 8.70e-53 |
| 3. B | Q8IVF6 | Ankyrin repeat domain-containing protein 18A | 3.44e-05 | NA | 4.59e-60 |