Summary
Structures and Sequence Alignment
The best structural homolog that predicted by 3. B was
D2EAC2
(Zinc finger BED domain-containing protein 6) with a FATCAT P-Value: 0.00962 and RMSD of 3.32 angstrom. The sequence alignment identity is 7.9%.
Structural alignment shown in left. Query protein Q96FA7 colored as red in alignment, homolog D2EAC2 colored as blue.
Query protein Q96FA7 is also shown in right top, homolog D2EAC2 showed in right bottom. They are colored based on secondary structures.
Q96FA7 ---------------------------------------------------------------------------------------------------- 0 D2EAC2 MSVCTLSVPVSSISPGRRCSTFGDAGILGCVSINSNTDEDDVVEGKMVAEGANKETKLPAKKKRKKGLRIKGKRRRKKLILAKKFSKDLGSGRPVADAPA 100 Q96FA7 ---------------------------------------------------------------------------------------------------- 0 D2EAC2 SLASGAPEQDEESLFEGNIEKQIYLPSTRAKTSIVWHFFHVDPQYTWRAICNLCEKSVSRGKPGSHLGTSTLQRHLQARHSPHWTRANKFGVTNGEEDFT 200 Q96FA7 ---------------------------------------------------------------------------------------------------- 0 D2EAC2 LDLSLSPPSPGSNGSFEYIPTDSVDENRMGKKRDKSASDALRAKRGRFLIKSNIVKHALIPGTRAKTSAVWNFFYTDPQHISRAVCNICKRSVSRGRPGS 300 Q96FA7 ---------------------------------------------------------------------------------------------------- 0 D2EAC2 HLGTSTLQRHLQATHPIHWAVANKDSGAIGNGLDETETESSDLLNDTMPGEKSSGSQDLTAEDLSDSDTDEPPCLEVENRSESPIPVADQDNPVHAQERE 400 Q96FA7 ---------------------------------------------------------------------------------------------------- 0 D2EAC2 TTTHCENAAANQISQAVIQMIVEDLHPYNYFSTPAFQRFLQIVAPDYRLPSETYFFTKAVPQLYDSVREKIFLTLENVQSQKIHLTADIWTHDPSTDYFI 500 Q96FA7 ---------------------------------------------------------------------------------------------------- 0 D2EAC2 VTVHWVSLETASSPSNGGTPNFRKWAVLCVTGLAKDCLITNILQELNDQIGLWLSPNFLTPSFIVSDNSSNVVHAIKGGGFTHVPCFLHCLNIVIQDFFC 600 Q96FA7 ---------------------------------------------------------------------------------------M-----VVR---E 5 D2EAC2 EHKSIENMLVAARKTCHHFSHSVKARQILQEFQNDHQLPWKNLKQDETGHWISTFYMLKWLLEHCYSVHHSLGRASGVVLTSLQWTLMTYVCDILKPFEE 700 Q96FA7 A----SAAQASLSQVLPQLRYLHIF-LEQVHTHFQEQSVGERG--AAIQLAEGLARQLCTDCQLNKLFYREEFVLATLLDPCFKGKIEAILPWGPTDIDH 98 D2EAC2 ATQRVSVKTTGLNQVLPLIHHL-LFSLQRLREDFQ---V--RGITQALNLVDSLSLKLESDALLSAMLKSKHCILATLLDPCFKNSLEDFFPQG-ADLET 793 Q96FA7 WKQVLVYKVKEIRVSEYSLNSPSPLQSPRGLCVDPTRVAKSSGVEGRSQGEPL-QSSSHSGAFLLAQREKGLLESMGLLASERSGGSLS--TKSHW--AS 193 D2EAC2 YKQILA----E-EVCNYMESSP-------GAC----QISSS-----ETSG-PLVRLGTDS--F-TSIKE-G-TSSAGSLDS-SAAGSVAVGSKSSLLPAA 865 Q96FA7 I-IVKKYLWE--NETVGAQDDPLAYWEKKREAWPPSICLTPHRSL--L---------------------------------------------------- 236 D2EAC2 VAVVDEYFKEKYSELSGG-DDPLVYWQRKVSIWP---ALT-QVAIQYLSCPMCSWQSECMFTTNSHFHPKQIMNMDFDNIEQLIFLKMNLENVNYDYSTL 960 Q96FA7 -------------------- 236 D2EAC2 ILSWDPENKAVQSNEKEILP 980
Go Annotations
1. PB indicates the go terms that are found by both PROST and BLAST.2. P indicates the go terms that are found by only PROST.
3. B indicates the go terms that are only annotated by BLAST.
| Source | GO | Description |
|---|---|---|
| 3. B | GO:0061178 | regulation of insulin secretion involved in cellular response to glucose stimulus |
| 3. B | GO:0000976 | transcription cis-regulatory region binding |
| 3. B | GO:0060548 | negative regulation of cell death |
| 3. B | GO:0051148 | negative regulation of muscle cell differentiation |
| 3. B | GO:0045892 | negative regulation of transcription, DNA-templated |
| 3. B | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| 3. B | GO:0005730 | nucleolus |
| 3. B | GO:0006357 | regulation of transcription by RNA polymerase II |
| 3. B | GO:0001835 | blastocyst hatching |
| 3. B | GO:0046983 | protein dimerization activity |
| 3. B | GO:0045787 | positive regulation of cell cycle |
| 3. B | GO:0003309 | type B pancreatic cell differentiation |
Homologs
1. PB indicates the homologs that are found by both PROST and BLAST.
2. P indicates homologs that are only found by PROST.
3. B indicates homologs that are only found by BLAST.
| Source | Homolog | Description | FATCAT p-val | PROST Evalue | BLAST Evalue |
|---|---|---|---|---|---|
| 1. PB | Q96FA7 | ZBED6 C-terminal-like protein | 0 | 2.45e-138 | 4.50e-175 |
| 3. B | P86452 | Zinc finger BED domain-containing protein 6 | 3.51e-02 | NA | 2.46e-15 |
| 3. B | D2EAC2 | Zinc finger BED domain-containing protein 6 | 9.62e-03 | NA | 2.59e-14 |